JP7480048B2 - キナーゼ依存的障害を処置するための化合物 - Google Patents

キナーゼ依存的障害を処置するための化合物 Download PDF

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JP7480048B2
JP7480048B2 JP2020540745A JP2020540745A JP7480048B2 JP 7480048 B2 JP7480048 B2 JP 7480048B2 JP 2020540745 A JP2020540745 A JP 2020540745A JP 2020540745 A JP2020540745 A JP 2020540745A JP 7480048 B2 JP7480048 B2 JP 7480048B2
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alkyl
alkoxy
compound
cycloalkyl
alkylene
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JP2021511357A5 (https=
JPWO2019148043A5 (https=
JP2021511357A (ja
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リン カンヌ バネン，
ミンナ ブイ，
ファミン ジャン，
ヨン ワン，
ウェイ シュー，
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エグゼリクシス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2020540745A 2018-01-26 2019-01-25 キナーゼ依存的障害を処置するための化合物 Active JP7480048B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862622702P 2018-01-26 2018-01-26
US201862622626P 2018-01-26 2018-01-26
US62/622,702 2018-01-26
US62/622,626 2018-01-26
PCT/US2019/015296 WO2019148043A1 (en) 2018-01-26 2019-01-25 Compounds for the treatment of kinase-dependent disorders

Publications (4)

Publication Number Publication Date
JP2021511357A JP2021511357A (ja) 2021-05-06
JP2021511357A5 JP2021511357A5 (https=) 2022-02-24
JPWO2019148043A5 JPWO2019148043A5 (https=) 2022-02-24
JP7480048B2 true JP7480048B2 (ja) 2024-05-09

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US (2) US11673897B2 (https=)
EP (1) EP3743417A1 (https=)
JP (1) JP7480048B2 (https=)
CN (1) CN111936487B (https=)
AU (1) AU2019212800B2 (https=)
CA (1) CA3088198A1 (https=)
MA (1) MA51679A (https=)
WO (1) WO2019148043A1 (https=)

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UA128476C2 (uk) * 2018-01-26 2024-07-24 Екселіксіс, Інк. Сполуки для лікування кіназозалежних розладів
TWI887405B (zh) 2020-04-30 2025-06-21 美商艾克塞里克斯公司 製備激酶抑制劑之方法
TW202241862A (zh) * 2021-02-01 2022-11-01 大陸商江蘇恆瑞醫藥股份有限公司 二甲醯胺類化合物、其製備方法及其在醫藥上的應用
KR20230147139A (ko) * 2021-02-17 2023-10-20 스프링웍스 테라퓨틱스, 인크. Mek 저해제인 n-((r)-2,3-다이하이드록시프로폭시)-3,4-다이플루오로-2-(2-플루오로-4-아이오도페닐아미노)-벤즈아마이드의 결정질 고체 및 이의 용도
WO2026074526A1 (en) * 2024-10-04 2026-04-09 Hetero Labs Limited 1,2-dicarboxamide compounds as kinase inhibitors

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US11673897B2 (en) 2023-06-13
AU2019212800A1 (en) 2020-08-20
US20210032263A1 (en) 2021-02-04
CN111936487A (zh) 2020-11-13
EP3743417A1 (en) 2020-12-02
CN111936487B (zh) 2024-07-09
CA3088198A1 (en) 2019-08-01
US20240150371A1 (en) 2024-05-09
AU2019212800B2 (en) 2024-05-23
WO2019148043A1 (en) 2019-08-01
JP2021511357A (ja) 2021-05-06
MA51679A (fr) 2020-12-02

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