JP7479293B2 - プテリジノン化合物およびその使用 - Google Patents

プテリジノン化合物およびその使用 Download PDF

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JP7479293B2
JP7479293B2 JP2020559365A JP2020559365A JP7479293B2 JP 7479293 B2 JP7479293 B2 JP 7479293B2 JP 2020559365 A JP2020559365 A JP 2020559365A JP 2020559365 A JP2020559365 A JP 2020559365A JP 7479293 B2 JP7479293 B2 JP 7479293B2
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pharma
compound
acceptable salt
ceutically acceptable
cancer
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JP2021522237A5 (https=
JP2021522237A (ja
JPWO2019209757A5 (https=
Inventor
デイビッド ジェイ． ラウファー，
ガイ ベミス，
マイケル ボイド，
デイビッド デイニンガー，
ホンボ デン，
ウォーレン ドルシュ，
ウェンシン グ，
ラッセル アール． フーバー，
マック アーサー ジュニア ジョンソン，
マーク ウィレム レデボーア，
ブライアン レッドフォード，
フランソワ マルタイス，
マリナ ペニー，
ダリン タケモト，
ネイサン ディー． ワール，
ティアンシェン ワン，
パン リー，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of JPWO2019209757A5 publication Critical patent/JPWO2019209757A5/ja
Priority to JP2023098522A priority Critical patent/JP2023116712A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020559365A 2018-04-24 2019-04-23 プテリジノン化合物およびその使用 Active JP7479293B2 (ja)

Priority Applications (1)

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JP2023098522A JP2023116712A (ja) 2018-04-24 2023-06-15 プテリジノン化合物およびその使用

Applications Claiming Priority (3)

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US201862661744P 2018-04-24 2018-04-24
US62/661,744 2018-04-24
PCT/US2019/028604 WO2019209757A1 (en) 2018-04-24 2019-04-23 Pteridinone compounds and uses thereof

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JP2021522237A JP2021522237A (ja) 2021-08-30
JP2021522237A5 JP2021522237A5 (https=) 2022-04-22
JPWO2019209757A5 JPWO2019209757A5 (https=) 2022-04-22
JP7479293B2 true JP7479293B2 (ja) 2024-05-08

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US (3) US11059826B2 (https=)
EP (1) EP3784669B1 (https=)
JP (2) JP7479293B2 (https=)
CN (1) CN112218865B (https=)
AR (1) AR114828A1 (https=)
AU (1) AU2019257651B2 (https=)
CA (1) CA3097774A1 (https=)
ES (1) ES2969982T3 (https=)
IL (1) IL278122B2 (https=)
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Cited By (1)

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JP2023116712A (ja) * 2018-04-24 2023-08-22 バーテックス ファーマシューティカルズ インコーポレイテッド プテリジノン化合物およびその使用

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WO2020010451A1 (en) * 2018-07-10 2020-01-16 Trillium Therapeutics Inc. Heteroaromatic-fused imidazolyl amides, compositions and uses thereof as sting agonists
SG11202107614PA (en) 2019-01-18 2021-08-30 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
AU2020209216A1 (en) 2019-01-18 2021-08-26 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof
PL3919491T3 (pl) * 2019-01-29 2025-10-20 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. Inhibitor akt
EP4045498B1 (en) * 2019-10-14 2025-12-03 The Regents of the University of California Broad spectrum anti-cancer compounds
US20230322767A1 (en) 2020-07-29 2023-10-12 Bayer Aktiengesellschaft Aryl substituted pyrrolo-pyridinones and therapeutic uses thereof
CN117088877A (zh) * 2020-10-28 2023-11-21 杭州阿诺生物医药科技有限公司 一种高活性Wnt通路抑制剂化合物
TW202334157A (zh) * 2022-01-29 2023-09-01 大陸商杭州阿諾生物醫藥科技有限公司 一種Ｗｎｔ通路抑制劑化合物
TW202333697A (zh) * 2022-01-30 2023-09-01 大陸商杭州阿諾生物醫藥科技有限公司 Ｗｎｔ通路抑制劑化合物
CN114436918B (zh) * 2022-02-23 2023-05-23 郑州大学 环丁-1-烯胺类化合物及其制备方法和在药物中的应用
CN117396482B (zh) * 2022-07-28 2026-02-27 杭州阿诺生物医药科技有限公司 一种Wnt通路抑制剂化合物
WO2024022365A1 (zh) * 2022-07-28 2024-02-01 杭州阿诺生物医药科技有限公司 一种Wnt通路抑制剂化合物
US20240217951A1 (en) * 2022-09-23 2024-07-04 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2023116712A (ja) * 2018-04-24 2023-08-22 バーテックス ファーマシューティカルズ インコーポレイテッド プテリジノン化合物およびその使用

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US12384790B2 (en) 2025-08-12
IL278122A (en) 2020-11-30
US20190322673A1 (en) 2019-10-24
ES2969982T3 (es) 2024-05-23
US11059826B2 (en) 2021-07-13
US20230312587A1 (en) 2023-10-05
WO2019209757A1 (en) 2019-10-31
US20220363685A1 (en) 2022-11-17
IL278122B1 (en) 2023-09-01
JP2023116712A (ja) 2023-08-22
TW202010744A (zh) 2020-03-16
US11572364B2 (en) 2023-02-07
EP3784669A1 (en) 2021-03-03
AU2019257651B2 (en) 2023-05-25
CA3097774A1 (en) 2019-10-31
TWI884914B (zh) 2025-06-01
EP3784669B1 (en) 2023-10-25
JP2021522237A (ja) 2021-08-30
IL278122B2 (en) 2024-01-01
AR114828A1 (es) 2020-10-21
CN112218865A (zh) 2021-01-12
AU2019257651A1 (en) 2020-10-15

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