JP7476517B2 - Anti-glycation agents - Google Patents
Anti-glycation agents Download PDFInfo
- Publication number
- JP7476517B2 JP7476517B2 JP2019205273A JP2019205273A JP7476517B2 JP 7476517 B2 JP7476517 B2 JP 7476517B2 JP 2019205273 A JP2019205273 A JP 2019205273A JP 2019205273 A JP2019205273 A JP 2019205273A JP 7476517 B2 JP7476517 B2 JP 7476517B2
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- JP
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- Prior art keywords
- polyamine
- acid
- extract
- containing extract
- soybean
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229960003434 xenysalate Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
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- 235000005074 zinc chloride Nutrition 0.000 description 1
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- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
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- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
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- ZNVKGUVDRSSWHV-UHFFFAOYSA-L zinc;4-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=C(S([O-])(=O)=O)C=C1.OC1=CC=C(S([O-])(=O)=O)C=C1 ZNVKGUVDRSSWHV-UHFFFAOYSA-L 0.000 description 1
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Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
本発明は、植物由来、好ましくは大豆胚芽由来ポリアミン含有抽出物の抗糖化剤に関する。さらに詳細には、タンパク質と糖の反応によって生じる糖化生成物の生成を抑制する効果のある抗糖化剤及び皮膚外用組成物に関する。 The present invention relates to an anti-glycation agent that is a polyamine-containing extract derived from a plant, preferably from soybean germ. More specifically, the present invention relates to an anti-glycation agent and a topical skin composition that are effective in suppressing the production of glycation products that arise from the reaction of proteins with sugars.
タンパク質と還元糖を混合して加熱すると、タンパク質のアミノ基と還元糖のカルボニル基との間が非酵素的に結合し、糖化産物が形成される。この反応はメイラード反応または糖化反応と呼ばれる。このタンパク質と還元糖の結合反応は、生体内においても起きており、糖化されたタンパク質は常に形成されている。 When proteins and reducing sugars are mixed and heated, non-enzymatic binding occurs between the amino groups of the proteins and the carbonyl groups of the reducing sugars, forming glycation products. This reaction is called the Maillard reaction or glycation reaction. This binding reaction between proteins and reducing sugars also occurs in living organisms, and glycated proteins are constantly being formed.
これらの糖化タンパク質は、最終的には終末糖化産物(Advanced Glycation End-products;AGEs)と呼ばれる不可逆的な化合物を形成する。AGEsは、グルコースだけではなく、グルコースの自動酸化及び分解産物などの種々の糖から生成される。AGEsとしては、ペントシジン、クロスリン、カルボキシメチルリジン、ピラジンなどが知られている。 These glycated proteins ultimately form irreversible compounds called advanced glycation end-products (AGEs). AGEs are produced not only from glucose, but also from various sugars such as the autoxidation and decomposition products of glucose. Known AGEs include pentosidine, crosslin, carboxymethyllysine, and pyrazine.
AGEsに関して、加齢と共に蓄積が認められること、皮膚の老化にも密接な関連があることが近年明らかとなってきた。皮膚のタンパク質で糖化反応が生じると、タンパク質中のリジン残基のアミノ基あるいはアルギニン残基のグアニジル基と糖のカルボニル基が非酵素的に反応し、AGEsが生成しタンパク質同士を架橋させてしまう。架橋構造が形成されると分子が硬くなり、皮膚本来の弾力性が失われる。また、架橋物を異物と判断し、タンパク質分解酵素の分泌量が増える。これらに起因して、肌のハリや弾力性が失われ、また肌が脆くなり、更にはシワ、たるみ、くすみが発生する。従って、タンパク質の糖化を阻害することは、これらの症状を予防・治療するのに有効であると考えられている。 It has become clear in recent years that AGEs accumulate with age and are closely related to skin aging. When glycation occurs in skin proteins, the amino groups of lysine residues or the guanidyl groups of arginine residues in the proteins react nonenzymatically with the carbonyl groups of sugars to produce AGEs, which cross-link proteins. When cross-linked structures are formed, the molecules become hard and the skin loses its natural elasticity. In addition, the skin recognizes the cross-linked material as a foreign body, and the secretion of proteolytic enzymes increases. As a result, the skin loses firmness and elasticity, becomes brittle, and wrinkles, sagging, and dullness occur. Therefore, inhibiting protein glycation is thought to be effective in preventing and treating these symptoms.
このような背景から、AGEs生成抑制作用を含むタンパク質の糖化反応を抑制する成分として、天然物を使用することに関する研究が進められている。例えば、特許文献1には、ブドレジャアキシラリス葉抽出物を有効成分として含むAGEs産生抑制作用が記載されている。特許文献2には、プロポリス又はその加工物を有効成分とするタンパク質の抗糖化剤が記載されている。特許文献3には、梅酢を含有する抗糖化化粧料が記載されている。 Against this background, research is being conducted into the use of natural products as ingredients that inhibit the glycation reaction of proteins, including the effect of inhibiting the production of AGEs. For example, Patent Document 1 describes an AGEs production inhibitory effect that contains Budreja axillaris leaf extract as an active ingredient. Patent Document 2 describes a protein anti-glycation agent that contains propolis or a processed product thereof as an active ingredient. Patent Document 3 describes an anti-glycation cosmetic that contains plum vinegar.
一方、製剤の多様化、処方配合上の選択肢の拡大といった観点や、メカニズムの異なる抗糖化剤を用いた相乗効果といった観点、より安全で高い有効性を有する抗糖化作用といった観点から、新規の抗糖化剤の開発が求められていることは言うまでもない。 On the other hand, it goes without saying that there is a demand for the development of new anti-glycation agents from the standpoint of diversifying formulations, expanding options for formulation combinations, synergistic effects using anti-glycation agents with different mechanisms, and safer and more effective anti-glycation effects.
本発明は、上記の背景を鑑み、タンパク質と糖の反応によって生じる糖化生成物の生成を抑制する作用を有する抗糖化剤を見出すことを課題とする。 In view of the above background, the present invention aims to find an anti-glycation agent that has the effect of suppressing the production of glycation products resulting from the reaction of proteins with sugars.
本発明者らは、上記事情に鑑み、タンパク質と糖の反応によって生じる糖化生成物の生成に対して、植物由来、特に大豆胚芽由来ポリアミン含有抽出物がその糖化反応を抑制する抗糖化症効果を有することを見出し、本発明を完成するに至った。 In view of the above circumstances, the present inventors discovered that a plant-derived, particularly a soybean germ-derived polyamine-containing extract has an anti-glycation effect that inhibits the glycation reaction that produces glycation products produced by the reaction of proteins with sugars, and thus completed the present invention.
即ち、本発明の概要は、以下の通りである。
項1.
植物由来ポリアミン含有抽出物を含有してなる抗糖化剤。
項2.
植物が大豆または小麦である、項1に記載の抗糖化剤。
項3.
植物由来ポリアミン含有抽出物が、大豆種子、大豆胚芽、大豆胚、大豆芽、小麦種子、小麦胚芽、小麦胚、小麦芽、豆乳及びオカラよりなる群から選択された少なくとも1種以上の材料由来である、項1または2に記載の抗糖化剤。
項4.
植物由来ポリアミン含有抽出物が、大豆胚芽由来ポリアミン含有抽出物である、項1~3のいずれかに記載の抗糖化剤。
項5.
ポリアミンとして、プトレシン、スペルミジン及びスペルミンからなる群から選ばれた少なくとも1種以上の化合物を含有する、項1~4のいずれかに記載の抗糖化剤。
項6.
タンパク質と糖の反応によって生じる糖化生成物の生成を抑制する作用を有する、項1~5のいずれかに記載の抗糖化剤。
項7.
ポリアミン濃度が0.00001~100mMである、項1~6のいずれかに記載の抗糖化剤。
項8.
ポリアミン濃度が0.00005~75mMである、項7に記載の抗糖化剤。
項9.
ポリアミン濃度が0.0001~50mMである、項7に記載の抗糖化剤。
項10.
項1~9のいずれかに記載の抗糖化剤を含有する皮膚外用組成物。
That is, the outline of the present invention is as follows.
Item 1.
An anti-glycation agent comprising a plant-derived polyamine-containing extract.
Item 2.
Item 2. The anti-glycation agent according to Item 1, wherein the plant is soybean or wheat.
Item 3.
Item 3. The anti-glycation agent according to Item 1 or 2, wherein the plant-derived polyamine-containing extract is derived from at least one material selected from the group consisting of soybean seeds, soybean germs, soybean embryos, soybean sprouts, wheat seeds, wheat germs, wheat embryos, wheat sprouts, soy milk, and soybean refuse.
Item 4.
Item 4. The anti-glycation agent according to any one of Items 1 to 3, wherein the plant-derived polyamine-containing extract is a soybean germ-derived polyamine-containing extract.
Item 5.
Item 5. The anti-glycation agent according to any one of Items 1 to 4, comprising, as a polyamine, at least one compound selected from the group consisting of putrescine, spermidine and spermine.
Item 6.
Item 6. The anti-glycation agent according to any one of Items 1 to 5, which has an effect of suppressing the production of glycation products caused by a reaction between protein and sugar.
Item 7.
Item 7. The anti-glycation agent according to any one of Items 1 to 6, wherein the polyamine concentration is 0.00001 to 100 mM.
Item 8.
Item 8. The anti-glycation agent according to Item 7, wherein the polyamine concentration is 0.00005 to 75 mM.
Item 9.
Item 8. The anti-glycation agent according to Item 7, wherein the polyamine concentration is 0.0001 to 50 mM.
Item 10.
Item 10. A composition for external use on skin, comprising the anti-glycation agent according to any one of Items 1 to 9.
本発明の植物由来ポリアミン含有抽出物を使用することにより、タンパク質と糖の反応によって生じる糖化生成物の生成を抑制することが期待でき、該効果を目的とした抗糖化剤及び皮膚外用剤を提供できる。 By using the plant-derived polyamine-containing extract of the present invention, it is expected that the production of glycation products caused by the reaction between proteins and sugars can be suppressed, and an anti-glycation agent and topical skin preparation that achieve this effect can be provided.
本発明は、植物由来ポリアミン含有抽出物による抗糖化効果を有する抗糖化剤に関する。さらに詳細には、タンパク質と糖の反応によって生じる糖化生成物の生成を抑制することを特徴とする抗糖化剤に関する。 The present invention relates to an anti-glycation agent having an anti-glycation effect by using a plant-derived polyamine-containing extract. More specifically, the present invention relates to an anti-glycation agent characterized by suppressing the production of glycation products resulting from the reaction of proteins with sugars.
ポリアミンは、第1級アミノ基を2つ以上有する脂肪族炭化水素の総称で生体内に普遍的に存在する天然物であり、20種類以上のポリアミンが見出されている。代表的なポリアミンとしてはプトレシン、スペルミジン、スペルミン等がある。ポリアミンの主な生理作用としては、(1)核酸との相互作用による核酸の安定化と構造変化、(2)種々の核酸合成系への促進作用、(3)タンパク質合成系の活性化(4)細胞膜の安定化や物質の膜透過性の強化、(5)活性酸素の消去、(6)細胞増殖の促進が知られている。 Polyamines are a general term for aliphatic hydrocarbons with two or more primary amino groups, and are natural products that are ubiquitous in living organisms. More than 20 types of polyamines have been found. Representative polyamines include putrescine, spermidine, and spermine. The main physiological effects of polyamines are known to be (1) stabilization and structural changes of nucleic acids through interactions with nucleic acids, (2) promotion of various nucleic acid synthesis systems, (3) activation of protein synthesis systems, (4) stabilization of cell membranes and enhancement of membrane permeability of substances, (5) elimination of active oxygen, and (6) promotion of cell proliferation.
ポリアミンは動物の内臓、穀類胚芽、豆類種子や、食用菌類に比較的多く含まれる。なかでも、大豆はポリアミンを豊富に含むことが知られており、ポリアミンの重要な供給源と考えられている。 Polyamines are found in relatively large amounts in animal organs, cereal germs, legume seeds, and edible fungi. Soybeans are known to be particularly rich in polyamines and are considered an important source of polyamines.
本発明で用いる植物由来ポリアミン含有抽出物の抽出法の例を以下に示す。抽出物における植物体の部位は主に樹皮を用いるが、これに特定せず全体を用いることもできる。また、以下に記載される例に限定されないのは言うまでもない。 An example of an extraction method for the plant-derived polyamine-containing extract used in the present invention is shown below. The part of the plant body used for the extract is mainly the bark, but the whole plant body can also be used without being limited to this. Needless to say, the method is not limited to the example described below.
本発明で用いる植物由来ポリアミン含有抽出物の例を以下に示す。抽出物における植物体の部位は主に胚芽を用いるが、これに特定せず全体を用いることもできる。 The following are examples of plant-derived polyamine-containing extracts used in the present invention. The part of the plant body used in the extract is mainly the germ, but the whole plant body can also be used without being limited to this.
本発明において、「大豆胚芽由来ポリアミン含有抽出物」とは、大豆胚芽から得られる(天然)ポリアミンを含む抽出物である。さらに詳細には、大豆胚芽から得られる3種類の(天然)プトレシン、スペルミジン、スペルミンを含む植物抽出物である。大豆胚芽由来ポリアミン含有抽出物に含有されるポリアミン濃度は、M(モル/リットル)では、通常は0.00001~100mM、好ましくは0.00005~75mM、より好ましくは0.0001~50mMである。また、重量%では、通常は0.0001~100%、好ましくは0.001~75%、より好ましくは0.01~50%である。 In the present invention, the "soybean germ-derived polyamine-containing extract" refers to an extract containing (natural) polyamines obtained from soybean germ. More specifically, it is a plant extract containing three types of (natural) putrescine, spermidine, and spermine obtained from soybean germ. The polyamine concentration in the soybean germ-derived polyamine-containing extract is usually 0.00001 to 100 mM, preferably 0.00005 to 75 mM, and more preferably 0.0001 to 50 mM, in moles/liter (M). In weight percent, it is usually 0.0001 to 100%, preferably 0.001 to 75%, and more preferably 0.01 to 50%.
大豆胚芽由来ポリアミン含有抽出物は、プトレシン、スペルミジン、スペルミンのポリアミン以外の天然有効成分を同時に含有することから、化学合成されたプトレシン、スペルミジン、スペルミンを個々に含有する組成物よりも抗糖化効果に優れることが推察される。天然有効成分としては、例えば、単糖、オリゴ糖等の糖類、ペプチド、蛋白質等が挙げられる。加えて大豆胚芽由来ポリアミン含有抽出物は水溶液であるため、個々のポリアミン化合物に比べて製造条件がマイルドであり、安全性の面でも高いメリットが期待される。 Since the soybean germ-derived polyamine-containing extract simultaneously contains natural active ingredients other than the polyamines putrescine, spermidine, and spermine, it is presumed that the extract has a superior anti-glycation effect than compositions that contain chemically synthesized putrescine, spermidine, and spermine individually. Examples of natural active ingredients include sugars such as monosaccharides and oligosaccharides, peptides, and proteins. In addition, since the soybean germ-derived polyamine-containing extract is an aqueous solution, the manufacturing conditions are milder than those for individual polyamine compounds, and it is expected to have great benefits in terms of safety.
本発明においてポリアミンとは、第1級アミノ基を2つ以上有する脂肪族炭化水素の総称である。生体内に普遍的に存在する天然物であり、20種類以上のポリアミンが見出されている。例えば、1,3-ジアミノプロパン、プトレシン、カダベリン、カルジン、スペルミジン、ホモスペルミジン、アミノプロピルカダベリン、テルミン、スペルミン、テルモスペルミン、カナバルミン、アミノペンチルノルスペルミジン、N,N-ビス(アミノプロピル)カダベリン、ホモスペルミン、カルドペンタミン、ホモカルドペンタミン、カルドヘキサミン、ホモカルドヘキサミンなどが挙げられる。代表的なポリアミンとしてはプトレシン、スペルミジン、スペルミン等が挙げられる。 In the present invention, polyamine is a general term for aliphatic hydrocarbons having two or more primary amino groups. It is a natural product that is ubiquitous in living organisms, and more than 20 types of polyamines have been found. Examples include 1,3-diaminopropane, putrescine, cadaverine, caldine, spermidine, homospermidine, aminopropylcadaverine, thermine, spermine, thermospermine, canavalmine, aminopentylnorspermidine, N,N-bis(aminopropyl)cadaverine, homospermine, caldopentamine, homocaldopentamine, caldohexamine, and homocaldohexamine. Representative polyamines include putrescine, spermidine, and spermine.
本発明において「プトレシン」は代表的なポリアミンの一つで生物体内に普遍的に存在する一般的な天然物であり、第一級アミノ基を2つ有する脂肪族炭化水素化合物である。「スペルミジン」は代表的なポリアミンの一つで生物体内に普遍的に存在する一般的な天然物であり、第一級アミノ基を3つ有する脂肪族炭化水素化合物である。「スペルミン」は代表的なポリアミンの一つで生物体内に普遍的に存在する一般的な天然物であり、第一級アミノ基を4つ有する脂肪族炭化水素化合物である。 In the present invention, "putrescine" is one of the representative polyamines, a common natural product that is ubiquitous in living organisms, and is an aliphatic hydrocarbon compound with two primary amino groups. "Spermidine" is one of the representative polyamines, a common natural product that is ubiquitous in living organisms, and is an aliphatic hydrocarbon compound with three primary amino groups. "Spermine" is one of the representative polyamines, a common natural product that is ubiquitous in living organisms, and is an aliphatic hydrocarbon compound with four primary amino groups.
ポリアミンは大豆胚芽以外の植物にも含まれており、例えば双子葉植物、単子葉植物、草本性植物、木本性植物、ウリ科植物、ナス科植物、イネ科植物、アブラナ科植物、マメ科植物、アオイ科植物、キク科植物、アカザ科植物、マメ科の植物が挙げられ、これらの植物からもポリアミン含有抽出物を調製可能である。さらに具体的には、サツマイモ、トマト、キュウリ、カボチャ、メロン、スイカ、タバコ、シロイヌナズナ、ピーマン、ナス、マメ、サトイモ、ホウレンソウ、ニンジン、イチゴ、ジャガイモ、イネ、トウモロコシ、アルファルファ、小麦、オオムギ、ダイズ、ナタネ、ソルガム、ユーカリ、ポプラ、ケナフ、杜仲、サトウキビ、シュガービート、キャッサバ、サゴヤシ、アカザ、ユリ、ラン、カーネーション、バラ、キク、ペチュニア、トレニア、キンギョソウ、シクラメン、カスミソウ、ゼラニウム、ヒマワリ、シバ、ワタ、エノキダケ、ホンシメジ、マツタケ、シイタケ、キノコ類、チョウセンニンジン、アガリクス、ウコン、オタネニンジン、柑橘類、緑茶、紅茶、ウーロン茶、バナナ、キウイ、納豆、豆乳、大豆エキス、小麦エキス、胚芽エキス、胚エキス、果汁、オカラ、コメ胚芽、小麦胚芽、オオムギ胚芽、大豆胚芽、トウモロコシ胚芽、マイロ胚芽、ヒマワリ胚芽などが挙げられる。 Polyamines are also found in plants other than soybean germ, such as dicotyledonous plants, monocotyledonous plants, herbaceous plants, woody plants, cucurbits, solanaceae, grasses, cruciferous plants, legumes, mallows, Asteraceae, Chenopodiaceae, and legumes, and polyamine-containing extracts can also be prepared from these plants. More specifically, sweet potato, tomato, cucumber, pumpkin, melon, watermelon, tobacco, Arabidopsis, bell pepper, eggplant, bean, taro, spinach, carrot, strawberry, potato, rice, corn, alfalfa, wheat, barley, soybean, rapeseed, sorghum, eucalyptus, poplar, kenaf, eucommia, sugarcane, sugar beet, cassava, sago palm, chenopodiaceae, lily, orchid, carnation, rose, chrysanthemum, petunia, torenia, and chrysanthemum. These include angelica, cyclamen, baby's breath, geranium, sunflower, turfgrass, cotton, enoki mushroom, shimeji mushroom, matsutake mushroom, shiitake mushroom, mushrooms, ginseng, agaricus, turmeric, ginseng, citrus fruits, green tea, black tea, oolong tea, banana, kiwi, natto, soy milk, soy extract, wheat extract, germ extract, germ extract, fruit juice, soybean lees, rice germ, wheat germ, barley germ, soy germ, corn germ, milo germ, sunflower germ, etc.
ポリアミンを抽出する大豆胚芽以外の植物としては、好ましくは、単子葉植物や双子葉植物がよく、さらに好ましくはイネ科植物やマメ科植物がよく、特に好ましい植物又はその加工品として、トウモロコシ、キノコ類、大豆、小麦、納豆、豆乳、オカラ、小麦胚芽、大豆胚芽、トウモロコシ胚芽、大豆エキス、小麦エキス、胚芽エキス、胚エキスが挙げられる。さらに好ましくは、大豆種子、大豆胚芽、大豆胚、大豆芽、小麦種子、小麦胚芽、小麦胚、小麦芽、豆乳、オカラが挙げられる。 Preferably, plants other than soybean germ from which polyamines are extracted are monocotyledonous or dicotyledonous plants, more preferably grasses or legumes, and particularly preferred plants or processed products thereof include corn, mushrooms, soybeans, wheat, natto, soy milk, okara, wheat germ, soybean germ, corn germ, soybean extract, wheat extract, germ extract, and germ extract. More preferred are soybean seeds, soybean germ, soybean embryos, soybean sprouts, wheat seeds, wheat germs, wheat embryos, wheat sprouts, soy milk, and okara.
大豆胚芽由来ポリアミン含有抽出物を得る植物組織としては、特に限定されない。好ましくは、種子形態、生育過程にあるものである。生育過程にある植物は全体、あるいは部分的な組織から得ることができる。得ることができる部位としては、特に限定されないが全樹、花、蕾、子房、果実、葉、子葉、茎、芽、根、種子、乾燥種子、胚、胚芽、根などである。好ましくは、果実、葉、茎、芽、種子、乾燥種子、胚芽、胚であり、特に好ましくは、種子、乾燥種子、胚芽、胚などである。 The plant tissue from which the soybean germ-derived polyamine-containing extract is obtained is not particularly limited. Preferably, it is in the form of a seed or in the process of growth. Plants in the process of growth can be obtained from the whole or partial tissue. Parts that can be obtained include, but are not limited to, the whole tree, flowers, buds, ovaries, fruits, leaves, cotyledons, stems, buds, roots, seeds, dried seeds, embryos, germs, roots, etc. Preferably, it is fruits, leaves, stems, buds, seeds, dried seeds, germs, embryos, and more preferably seeds, dried seeds, germs, embryos, etc.
大豆胚芽由来ポリアミン含有抽出物は大豆胚芽加工物であってもよい。その加工方法は、大豆胚芽を水、有機溶媒、水と有機溶媒の混合物などを用いて、低温、室温、加温条件下での含浸法、蒸留法、圧搾法、超音波法、超臨界流体法、亜臨界流体法などで抽出物を回収する。さらに植物や植物から回収した抽出物を発酵させるなどの加工処理した加工物なども含まれる。例えば、豆乳、オカラ、小麦粉、発酵エキス、納豆などが挙げられる。 The polyamine-containing extract derived from soybean germ may be a soybean germ processed product. The processing method involves recovering an extract from soybean germ using water, an organic solvent, or a mixture of water and an organic solvent under low temperature, room temperature, or heated conditions, impregnation, distillation, squeezing, ultrasonication, supercritical fluid method, subcritical fluid method, or the like. Furthermore, processed products obtained by fermenting plants or extracts recovered from plants are also included. Examples include soy milk, okara, wheat flour, fermented extract, and natto.
大豆胚芽由来ポリアミン含有抽出物を得る方法としては、大豆胚芽及び/又は大豆胚芽加工物に、酸性条件下になるように酸溶液を添加することにある。酸性条件下とは、pHが6以下の条件をいう。抽出時に、pHを酸性条件下にすることにより、組織から効率的かつ安定的なポリアミン組成物回収の効果が得られる。この効果は、pHが6以下であれば一様に得られるが、好ましくはpHが4以下であり、特に好ましくはpHが2以下である。下限については、使用する酸溶液の原液のpHで構わないので、特に制限されないが、好ましくはpH1~2である。 A method for obtaining a polyamine-containing extract derived from soybean germ involves adding an acid solution to soybean germ and/or a soybean germ processed product so that the soybean germ and/or the soybean germ processed product are under acidic conditions. "Acidic conditions" refers to conditions where the pH is 6 or less. By making the pH acidic during extraction, the effect of efficient and stable recovery of polyamine compositions from tissues can be obtained. This effect can be uniformly obtained if the pH is 6 or less, but a pH of 4 or less is preferable, and a pH of 2 or less is particularly preferable. There is no particular restriction on the lower limit, as it can be the pH of the original acid solution used, but a pH of 1 to 2 is preferable.
酸性条件下(酸水溶液)で抽出物を得ることで、エタノールやメタノールのような有機溶媒で回収した抽出物に比べてポリアミン量の回収率が高く、特に水に溶けにくい化合型ポリアミンは酸性条件によって水に可溶化でき、有機溶媒では抽出効率が低い遊離型ポリアミンの含量も向上する。ポリアミンは酸性条件下では優れた安定性を示し、抽出物中に含まれるポリアミンやその他の有効成分の安定性が向上する。さらに酸性条件下(酸水溶液)で抽出物を得ることで、ポリアミン以外の天然有効成分が同時に回収される。例えば、天然有効成分としては単糖、オリゴ糖等の糖類、ペプチド、蛋白質等が挙げられる。ポリアミンとポリアミン以外の天然有効成分を同時に含むことで抗糖化効果がより増強される。加えて回収した抽出物は水溶液であるため有機溶媒に比べて安全性の面でも高いメリットが期待される。 By obtaining an extract under acidic conditions (acid aqueous solution), the recovery rate of polyamines is higher than that of extracts obtained with organic solvents such as ethanol or methanol. In particular, compound polyamines, which are poorly soluble in water, can be solubilized in water under acidic conditions, and the content of free polyamines, which have low extraction efficiency in organic solvents, is also improved. Polyamines show excellent stability under acidic conditions, and the stability of polyamines and other active ingredients contained in the extract is improved. Furthermore, by obtaining an extract under acidic conditions (acid aqueous solution), natural active ingredients other than polyamines are simultaneously recovered. For example, natural active ingredients include monosaccharides, oligosaccharides, and other sugars, peptides, proteins, etc. The anti-glycation effect is further enhanced by the simultaneous inclusion of polyamines and natural active ingredients other than polyamines. In addition, since the recovered extract is an aqueous solution, it is expected to have a high safety advantage compared to organic solvents.
酸性条件下になるように添加する酸溶液としては、塩酸、硫酸、リン酸などの鉱酸、酢酸、プロピオン酸、酪酸、蓚酸、マロン酸、コハク酸、フマル酸、マレイン酸、リンゴ酸、乳酸、酒石酸、クエン酸、安息香酸などの有機酸および酸性水が挙げられるが、0.01N~6Nの塩酸、硫酸、硝酸、酢酸、リン酸、トリクロロ酢酸、スルホサリチル酸、ギ酸、クエン酸、乳酸や0.1~10%の過塩素酸などの無機酸や有機酸などである。 The acid solutions added to create acidic conditions include mineral acids such as hydrochloric acid, sulfuric acid, and phosphoric acid; organic acids such as acetic acid, propionic acid, butyric acid, oxalic acid, malonic acid, succinic acid, fumaric acid, maleic acid, malic acid, lactic acid, tartaric acid, citric acid, and benzoic acid; and acidic water, but examples of such inorganic and organic acids include 0.01N to 6N hydrochloric acid, sulfuric acid, nitric acid, acetic acid, phosphoric acid, trichloroacetic acid, sulfosalicylic acid, formic acid, citric acid, and lactic acid, as well as 0.1% to 10% perchloric acid.
大豆胚芽及び/又は大豆胚芽加工物に、酸性条件下になるように酸溶液を添加して、ポリフェノール吸着剤を添加した後に破砕、粉砕、混合を行うことで、大豆胚芽由来ポリアミン含有抽出物の回収量を高めることができる。特に組織の場合は細胞壁を有することから細胞壁に損傷を与えることが望ましい。大豆胚芽加工物の場合には、細胞壁を含まないことから特に細胞壁に損傷を与えるような破砕や粉砕を行う必要はない。破砕や粉砕を行う方法としては、例えば、ミキサー、ブレンダー、ホモジナイザー、乳鉢、超音波破砕機などを利用することができる。 The recovery amount of the soybean germ-derived polyamine-containing extract can be increased by adding an acid solution to soybean germ and/or soybean germ processed products to create acidic conditions, adding a polyphenol adsorbent, and then crushing, grinding, and mixing. In particular, in the case of tissue, it is desirable to damage the cell walls since they have cell walls. In the case of soybean germ processed products, since they do not contain cell walls, there is no need to crush or grind in a way that would damage the cell walls. Methods for crushing and grinding that can be used include, for example, mixers, blenders, homogenizers, mortars, and ultrasonic crushers.
大豆胚芽及び/又は大豆胚芽加工物に含まれていたポリアミンを酸溶液中(液体画分)に十分に抽出した後に遠心分離や濾過分離によって液体画分を残査や沈殿と分離する。回収された液体画分にはポリアミンが多く含まれており、「大豆胚芽由来ポリアミン含有抽出物」を得ることができる。 The polyamines contained in soybean germ and/or soybean germ processed products are thoroughly extracted into an acid solution (liquid fraction), and the liquid fraction is then separated from the residue and precipitate by centrifugation or filtration. The recovered liquid fraction contains a large amount of polyamines, and a "soybean germ-derived polyamine-containing extract" can be obtained.
植物由来ポリアミン含有抽出物は、抽出溶媒を減圧により留去すれば、濃縮された固形分を得ることができ、必要に応じて賦形剤を添加することもできる。抽出溶媒が無毒のもの、例えば水である場合は、抽出溶媒を含んだまま調剤に使用することもできるが、抽出溶媒を分離した抽出物を調剤に用いることもできる。抽出溶媒分離後の抽出物を適当な溶剤、例えば水に再溶解させて、調剤に使用することもできる。また、このようにして得た抽出物を精製手段、例えば分別抽出、二溶媒間の分配、適当な吸着剤による分別吸着/溶離ないしクロマトグラフィー等によって、精製ないし力価の向上を行うこともできる。 The plant-derived polyamine-containing extract can be concentrated into a solid content by distilling off the extraction solvent under reduced pressure, and an excipient can be added as necessary. When the extraction solvent is non-toxic, such as water, it can be used in preparations while still containing the extraction solvent, but the extract from which the extraction solvent has been separated can also be used in preparations. The extract from which the extraction solvent has been separated can also be redissolved in a suitable solvent, such as water, and used in preparations. The extract thus obtained can also be purified or its titer improved by purification means, such as fractional extraction, partitioning between two solvents, fractional adsorption/elution with a suitable adsorbent, or chromatography.
上記のように得られた植物由来ポリアミン含有抽出物は、そのまま抗糖化剤として利用しても良いが、皮膚外用組成物として配合して利用することが好ましい。植物由来ポリアミン含有抽出物を配合する濃度は、吸収程度、作用程度、製品形態、使用頻度などによって決められ、特に限定されるのもではないが、通常は0.00001~100mM、好ましくは0.00005~75mM、より好ましくは0.0001~50mMである。 The plant-derived polyamine-containing extract obtained as described above may be used as an anti-glycation agent as it is, but is preferably used by incorporating it into a composition for external use on the skin. The concentration of the plant-derived polyamine-containing extract is determined by the degree of absorption, the degree of action, the product form, the frequency of use, etc., and is not particularly limited, but is usually 0.00001 to 100 mM, preferably 0.00005 to 75 mM, and more preferably 0.0001 to 50 mM.
本発明の植物由来ポリアミン含有抽出物を含有する皮膚外用組成物は、植物由来ポリアミン含有抽出物を有効成分とするものである。本発明における植物由来ポリアミン含有抽出物の抗糖化効果は、植物由来ポリアミン含有抽出物に含まれるポリアミンを代表とする有効成分が、タンパク質と糖の反応を阻害すると考えられる。この抗糖化効果は、タンパク質と糖の反応によって生じる糖化生成物の指標としてカルボニル基を定量することで評価することができる。 The topical skin composition containing the plant-derived polyamine-containing extract of the present invention contains the plant-derived polyamine-containing extract as an active ingredient. The anti-glycation effect of the plant-derived polyamine-containing extract of the present invention is believed to be due to the active ingredients, such as polyamines, contained in the plant-derived polyamine-containing extract inhibiting the reaction between protein and sugar. This anti-glycation effect can be evaluated by quantifying carbonyl groups as an indicator of the glycation products produced by the reaction between protein and sugar.
本発明の抗糖化及び皮膚外用組成物は、植物由来ポリアミン含有抽出物以外に、本発明の効果を損なわない範囲で、その他の原料を含むことができる。そのような原料の例としては水、賦形剤、抗酸化剤、防腐剤、湿潤剤、粘稠剤、緩衝剤、吸着剤、溶剤、乳化剤、安定化剤、界面活性剤、滑沢剤、水溶性高分子、甘味料、矯味剤、酸味料、アルコール類等が挙げられる。また、本発明の抗糖化剤及び皮膚外用組成物は、本発明の効果を損なわない範囲で、その他の有効成分を含むことができる。有効成分の具体例として、例えば、抗酸化成分、老化防止成分、抗炎症成分、美白成分、細胞賦活化成分、ビタミン類、血行促進成分、保湿成分、DNAの損傷の予防及び/又は修復作用を有する成分、抗糖化成分、ペプチド又はその誘導体、アミノ酸又はその誘導体、ヒドロキノン配糖体及びそのエステル類等が挙げられる。 The anti-glycation agent and topical skin composition of the present invention may contain other raw materials in addition to the plant-derived polyamine-containing extract, provided that the effects of the present invention are not impaired. Examples of such raw materials include water, excipients, antioxidants, preservatives, humectants, thickeners, buffers, adsorbents, solvents, emulsifiers, stabilizers, surfactants, lubricants, water-soluble polymers, sweeteners, flavorings, acidulants, and alcohols. In addition, the anti-glycation agent and topical skin composition of the present invention may contain other active ingredients in a range that does not impair the effects of the present invention. Specific examples of active ingredients include, for example, antioxidant ingredients, anti-aging ingredients, anti-inflammatory ingredients, whitening ingredients, cell activation ingredients, vitamins, blood circulation promoting ingredients, moisturizing ingredients, ingredients that have an effect of preventing and/or repairing DNA damage, anti-glycation ingredients, peptides or derivatives thereof, amino acids or derivatives thereof, hydroquinone glycosides and esters thereof, etc.
本発明の抗糖化剤及び皮膚外用組成物は、植物由来ポリアミン含有抽出物の必須成分に加えて、必要に応じて本発明の効果を損なわない範囲内で、化粧品類、医薬部外品類、飲食品類、医薬品類等に使用される成分や添加剤を併用して配合することができる。 The anti-glycation agent and topical skin composition of the present invention can be formulated with, in addition to the essential components of the plant-derived polyamine-containing extract, components and additives used in cosmetics, quasi-drugs, food and beverages, pharmaceuticals, etc., as necessary within the scope that does not impair the effects of the present invention.
例えば、油脂類としては、アボガド油、アルモンド油、ウイキョウ油、エゴマ油、オリーブ油、オレンジ油、オレンジラファー油、ゴマ油、カカオ脂、カミツレ油、カロット油、キューカンバー油、牛脂、牛脂脂肪酸、ククイナッツ油、サフラワー油、大豆油、ツバキ油、トウモロコシ油、ナタネ油、パーシック油、ヒマシ油、綿実油、落花生油、タートル油,ミンク油、卵黄油、カカオ脂、パーム油、パーム核油、モクロウ、ヤシ油、牛脂、豚脂、硬化油、硬化ヒマシ油等が挙げられる。 For example, fats and oils include avocado oil, almond oil, fennel oil, perilla oil, olive oil, orange oil, orange raffaella oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, beef tallow, beef tallow fatty acids, kukui nut oil, safflower oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, Japan wax, coconut oil, beef tallow, lard, hardened oil, hardened castor oil, etc.
ロウ類としては、例えば、ミツロウ、カルナバロウ、鯨ロウ、ラノリン、液状ラノリン、還元ラノリン、硬質ラノリン、カンデリラロウ、モンタンロウ、セラックロウ等が挙げられる。 Examples of waxes include beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, and shellac wax.
鉱物油としては、例えば、流動パラフィン、ワセリン、パラフィン、オゾケライド、セレシン、マイクロクリスタンワックス、ポリエチレン末、スクワレン、スクワラン、プリスタン等が挙げられる。 Examples of mineral oils include liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microcrystalline wax, polyethylene powder, squalene, squalane, and pristane.
脂肪酸類としては、例えば、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘン酸、オレイン酸、12-ヒドロキシステアリン酸、ウンデシレン酸、トール油、ラノリン脂肪酸等の天然脂肪酸、イソノナン酸、カプロン酸、2-エチルブタン酸、イソペンタン酸、2-メチルペンタン酸、2-エチルヘキサン酸、イソペンタン酸等の合成脂肪酸が挙げられる。 Fatty acids include, for example, natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, and lanolin fatty acid, and synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, and isopentanoic acid.
アルコール類としては、例えば、エタノール、イソプロパノール、ラウリルアルコール、セタノール、ステアリルアルコール、オレイルアルコール、ラノリンアルコール、コレステロール、フィトステロール等の天然アルコール、2-ヘキシルデカノール、イソステアリルアルコール、2-オクチルドデカノール等の合成アルコール、酸化エチレン、エチレングリコール、ジエチレングリコール、トリエチレングリコール、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、ジエチレングリコールモノメチルエーテル、ジエチレングリコールモノエチルエーテル、ポリエチレングリコール、酸化プロピレン、プロピレングリコール、ポリプロピレングリコール、1,3-ブチレングリコール、グリセリン、バチルアルコール、ペンタエリトリトール、ソルビトール、マンニトール、ブドウ糖、ショ糖等の多価アルコール類等が挙げられる。 Examples of alcohols include natural alcohols such as ethanol, isopropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol; synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol; and polyhydric alcohols such as ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol, glycerin, batyl alcohol, pentaerythritol, sorbitol, mannitol, glucose, and sucrose.
エステル類としては、例えば、ミリスチン酸イソプロピル、パルミチン酸イソプロピル、ステアリン酸ブチル、ラウリン酸ヘキシル、ミリスチン酸ミリスチル、オレイン酸オレイル、オレイン酸デシル、ミリスチン酸オクチルドデシル、ジメチルオクタン酸ヘキシルデシル、乳酸セチル、乳酸ミリスチル、フタル酸ジエチル、フタル酸ジブチル、酢酸ラノリン、モノステアリン酸エチレングリコール、モノステアリン酸プロピレングリコール、ジオレイン酸プロピレングリコール等が挙げられる。 Examples of esters include isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, and propylene glycol dioleate.
金属セッケンとしては、例えば、ステアリン酸アルミニウム、ステアリン酸マグネシウム、ステアリン酸亜鉛、ステアリン酸カルシウム、パルミチン酸亜鉛、ミリスチン酸マグネシウム、ラウリン酸亜鉛、ウンデシレン酸亜鉛等が挙げられる。 Examples of metal soaps include aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, and zinc undecylenate.
ガム質及び水溶性高分子化合物としては、例えば、アラビアゴム、ベンゾインゴム、ダンマルゴム、グアヤク脂、アイルランド苔、カラヤゴム、トラガントゴム、キャロブゴム、クインシード、寒天、カゼイン、デキストリン、ゼラチン、ペクチン、デンプン、カラギーナン、カルボキシアルキルキチン、キトサン、ヒドロキシアルキルキチン、低分子キトサン、キトサン塩、硫酸化キチン、リン酸化キチン、アルギン酸及びその塩、ヒアルロン酸及びその塩、コンドロイチン硫酸、ヘパリン、エチルセルロース、メチルセルロース、カルボキシメチルセルロース、カルボキシエチルセルロース、カルボキシエチルセルロースナトリウム、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ニトロセルロース、結晶セルロース、ポリビニルアルコール、ポリビニルメチルエーテル、ポリビニルピロリドン、ポリビニルメタアクリレート、ポリアクリル酸塩、ポリエチレンオキサイドやポリプロピレンオキサイド等のポリアルキレンオキサイド又はその架橋重合物、カルボキシビニルポリマー、ポリエチレンイミン等が挙げられる。 Gum and water-soluble polymer compounds include, for example, gum arabic, gum benzoin, gum dammar, guaiac butter, Irish moss, gum karaya, gum tragacanth, carob gum, quince seed, agar, casein, dextrin, gelatin, pectin, starch, carrageenan, carboxyalkyl chitin, chitosan, hydroxyalkyl chitin, low molecular weight chitosan, chitosan salt, sulfated chitin, phosphorylated chitin, alginic acid and its salts, hyaluronic acid and its salts, chondroitin sulfate, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, polyvinyl methacrylate, polyacrylates, polyalkylene oxides such as polyethylene oxide and polypropylene oxide or crosslinked polymers thereof, carboxyvinyl polymers, polyethyleneimine, etc.
界面活性剤としては、例えば、アニオン界面活性剤(カルボン酸塩,スルホン酸塩,硫酸エステル塩,リン酸エステル塩)、カチオン界面活性剤(アミン塩,四級アンモニウム塩)、両性界面活性剤(カルボン酸型両性界面活性剤,硫酸エステル型両性界面活性剤,スルホン酸型両性界面活性剤,リン酸エステル型両性界面活性剤)、非イオン界面活性剤(エーテル型非イオン界面活性剤,エーテルエステル型非イオン界面活性剤,エステル型非イオン界面活性剤,ブロックポリマー型非イオン界面活性剤,含窒素型非イオン界面活性剤)、その他の界面活性剤(天然界面活性剤,タンパク質加水分解物の誘導体,高分子界面活性剤,チタン・ケイ素を含む界面活性剤,フッ化炭素系界面活性剤)等が挙げられる。 Surfactants include, for example, anionic surfactants (carboxylates, sulfonates, sulfate salts, phosphate salts), cationic surfactants (amine salts, quaternary ammonium salts), amphoteric surfactants (carboxylate amphoteric surfactants, sulfate amphoteric surfactants, sulfonate amphoteric surfactants, phosphate amphoteric surfactants), nonionic surfactants (ether type nonionic surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), and other surfactants (natural surfactants, derivatives of protein hydrolysates, polymeric surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants), etc.
ビタミン類としては、例えば、ビタミンA群ではレチノール、レチナール(ビタミンA1)、デヒドロレチナール(ビタミンA2)、カロチン、リコピン(プロビタミンA)、ビタミンB群では、チアミン塩酸塩、チアミン硫酸塩(ビタミンB1)、リボフラビン(ビタミンB2)、ピリドキシン(ビタミンB6)、シアノコバラミン(ビタミンB12)、葉酸類、ニコチン酸類、パントテン酸類、ビオチン類、コリン、イノシトール類、ビタミンC群では、アスコルビン酸及びその誘導体、ビタミンD群では、エルゴカルシフェロール(ビタミンD2)、コレカルシフェロール(ビタミンD3)、ジヒドロタキステロール、ビタミンE群では、トコフェロール及びその誘導体、ユビキノン類、ビタミンK群では、フィトナジオン(ビタミンK1)、メナキノン(ビタミンK2)、メナジオン(ビタミンK3)、メナジオール(ビタミンK4)等が挙げられる。 Examples of vitamins include vitamin A group retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, and lycopene (provitamin A); vitamin B group thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acids, nicotinic acids, pantothenic acids, biotins, choline, and inositols; vitamin C group ascorbic acid and its derivatives; vitamin D group ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), and dihydrotachysterol; vitamin E group tocopherol and its derivatives, and ubiquinones; and vitamin K group phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), and menadiol (vitamin K4).
アミノ酸としては、例えば、バリン、ロイシン、イソロイシン、トレオニン、メチオニン、フェニルアラニン、トリプトファン、リジン、グリシン、アラニン、アスパラギン、グルタミン、セリン、システイン、シスチン、チロシン、プロリン、ヒドロキシプロリン、アスパラギン酸、グルタミン酸、ヒドロキシリジン、アルギニン、オルニチン、ヒスチジン等や、それらの硫酸塩、リン酸塩、硝酸塩、クエン酸塩、あるいはピロリドンカルボン酸の如きアミノ酸誘導体等が挙げられる。 Amino acids include, for example, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine, and the like, as well as their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.
美白剤としては、例えば、アスコルビン酸又はその誘導体、イオウ、胎盤加水分解物、エラグ酸又はその誘導体、コウジ酸又はその誘導体、グルコサミン又はその誘導体、アルブチン又はその誘導体、ヒドロキシケイヒ酸又はその誘導体、グルタチオン、アルニカエキス、オウゴンエキス、ソウハクヒエキス、サイコエキス、ボウフウエキス、マンネンタケ菌糸体培養物又はその抽出物、シナノキエキス、モモ葉エキス、エイジツエキス、クジンエキス、ジユエキス、トウキエキス、ヨクイニンエキス、カキ葉エキス、ダイオウエキス、ボタンピエキス、ハマメリスエキス、マロニエエキス、オトギリソウエキス、油溶性カンゾウエキス等が挙げられる。 Examples of whitening agents include ascorbic acid or derivatives thereof, sulfur, placental hydrolysate, ellagic acid or derivatives thereof, kojic acid or derivatives thereof, glucosamine or derivatives thereof, arbutin or derivatives thereof, hydroxycinnamic acid or derivatives thereof, glutathione, arnica extract, Scutellaria root extract, Sophora japonica extract, Bupleurum extract, Ganoderma lucidum mycelium culture or extract thereof, Tilia extract, peach leaf extract, Ajing fruit extract, Sophora root extract, Jew's wort extract, Angelica acutiloba extract, Coix seed extract, persimmon leaf extract, Rhubarb extract, Peony extract, Hamamelis extract, Horse chestnut extract, Hypericum perforatum extract, oil-soluble licorice extract, etc.
保湿剤としては、例えば、ヒアルロン酸、ポリグルタミン酸、セリン、グリシン、スレオニン、アラニン、コラーゲン、加水分解コラーゲン、ヒドロネクチン、フィブロネクチン、ケラチン、エラスチン、ローヤルゼリー、コンドロイチン硫酸ヘパリン、グリセロリン脂質、グリセロ糖脂質、スフィンゴリン脂質、スフィンゴ糖脂質、リノール酸又はそのエステル類、エイコサペンタエン酸又はそのエステル類、ペクチン、ビフィズス菌発酵物、乳酸発酵物、酵母抽出物、レイシ菌糸体培養物又はその抽出物、小麦胚芽油、アボガド油、米胚芽油、ホホバ油、ダイズリン脂質、γ-オリザノール、ビロウドアオイエキス、ヨクイニンエキス、ジオウエキス、タイソウエキス、カイソウエキス、キダチアロエエキス、ゴボウエキス、マンネンロウエキス、アルニカエキス、小麦フスマ等が挙げられる。 Examples of moisturizing agents include hyaluronic acid, polyglutamic acid, serine, glycine, threonine, alanine, collagen, hydrolyzed collagen, hydronectin, fibronectin, keratin, elastin, royal jelly, chondroitin sulfate heparin, glycerophospholipid, glyceroglycolipid, sphingophospholipid, sphingoglycolipid, linoleic acid or its esters, eicosapentaenoic acid or its esters, pectin, bifidobacterium fermentation product, lactic acid fermentation product, yeast extract, ganoderma lucidum mycelium culture or its extract, wheat germ oil, avocado oil, rice germ oil, jojoba oil, soybean phospholipid, γ-oryzanol, bilberry extract, coix seed extract, rehmannia extract, taiso extract, kaiso extract, aloe arborescens extract, burdock extract, rose wax extract, arnica extract, wheat bran, etc.
育毛剤としては、例えば、ペンタデカン酸グリセリド、コレウスエキス、ゲンチアナエキス、マツカサエキス、ローヤルゼリーエキス、クマザサエキス、t-フラバノン、6-ベンジルアミノプリン、センブリエキス、塩化カルプロニウム、ミノキシジル、フィナステリド、アデノシン、ニコチン酸アミド、桑の根エキス、ジオウエキス、5-アミノレブリン酸等が挙げられる。 Hair growth agents include, for example, pentadecanoic acid glyceride, coleus extract, gentiana extract, matsukasa extract, royal jelly extract, kumazasa extract, t-flavanone, 6-benzylaminopurine, Swertia japonica extract, carpronium chloride, minoxidil, finasteride, adenosine, nicotinamide, mulberry root extract, rehmannia extract, and 5-aminolevulinic acid.
動物或いは植物、生薬の抽出物やエキスとしては、例えば、アセンヤク(阿仙薬)、アシタバ、アセロラ、アルテア、アルニカ、アボカド、アマチャ(甘茶)、アロエ、アロエベラ、イラクサ、イチョウ(銀杏葉,銀杏)、ウイキョウ(茴香)、ウコン(鬱金)、ウスバサイシン(細辛)、ウメ(烏梅)、ウラジロガシ、ウワウルシ、ノイバラ(営実)、ヒキオコシ(延命草)、オウギ(黄耆)、コガネバナ(オウゴン)、ヤマザクラ(桜皮)、キハダ(黄柏)、オウレン(黄連)、オタネニンジン(人参)、オトギリソウ(弟切草)、オドリコソウ、オランダガラシ、オレンジ、イトヒメハギ(遠志)、ウツボグサ(夏枯草)、ツルドクダミ(何首烏)、エンジュ(槐花)、ヨモギ(ガイ葉)、ガジュツ(莪朮)、クズ(葛根)、カノコソウ(吉草根)、カミツレ、キカラスウリ(瓜呂根)、カワラヨモギ(茵チン蒿)、カンゾウ(甘草)、フキタンポポ(款冬花,款冬葉)、キイチゴ、キウイ果実、キキョウ(桔梗)、キク(菊花)、キササゲ(梓実)、ミカン属植物果実(枳実)、タチバナ(橘皮)、キュウリ、ウドまたはシシウド(羌活,独活)、アンズ(杏仁)、クコ(地骨皮,枸杞子,枸杞葉)、クララ(苦参)、クスノキ、クマザサ、グレープフルーツ果実、ニッケイ(桂皮)、ケイガイ(ケイガイ)、エビスグサ(決明子)、マルバアサガオ又はアサガオ(ケン牛子)、ベニバナ(紅花)、ゴバイシ(五倍子)、コンフリー、コパイバ、クチナシ(山梔子)、ゲンチアナ、ホオノキ(厚朴)、ヒナタイノコズチ(牛膝)、ゴシュユ(呉茱萸)、ゴボウ、チョウセンゴミシ(五味子)、米、米ぬか、コムギ、ミシマサイコ(柴胡)、サフラン、サボンソウ、サンザシ(山ザ子)、サンショウ(山椒)、サルビア、サンシチニンジン(三七人参)、シイタケ(椎茸)、ジオウ(地黄)、シクンシ(使君子)、ムラサキ(紫根)、シソ(紫蘇葉,紫蘇子)、カキ(柿蒂)、シャクヤク(芍薬)、オオバコ(車前子,車前草)、ショウガ(生姜)、ショウブ(菖蒲)、トウネズミモチ(女貞子)、シモツケソウ、シラカバ、スイカズラ(金銀花,忍冬)、セイヨウキヅタ、セイヨウノコギリソウ、セイヨウニワトコ、アズキ(赤小豆)、ニワトコ(接骨木)、ゼニアオイ、センキュウ(川キュウ)、センブリ(当薬)、クワ(桑白皮,桑葉)、ナツメ(大棗)、ダイズ、タラノキ、チクセツニンジン(竹節人参)、ハナスゲ(知母)、ワレモコウ(地楡)、ドクダミ(十薬)、フユムシナツクサタケ(冬虫夏草)、トウガラシ、ホオズキ(登呂根)、タチジャコウソウ、リョクチャ(緑茶)、コウチャ(紅茶)、チョウジ(丁子)、ウンシュウミカン(陳皮)、ツバキ、ツボクサ、トウガラシ(番椒)、トウキ(当帰)、トウキンセンカ、ダイダイ(橙皮)、ワレモコウ(地楡)、トウモロコシ(南蛮毛)、トチュウ(杜仲,杜仲葉)、トマト、ナンテン(南天実)、ニンニク(大サン)、オオムギ(麦芽)、ハクセン(白蘚皮)、ジャノヒゲ(麦門冬)、パセリ、バタタ、ハッカ(薄荷)、ハマメリス、バラ、ビワ葉(枇杷葉)、マツホド(茯リョウ)、ブドウまたはその葉、ヘチマ、ボダイジュ、ボタン(牡丹皮)、ホップ、マイカイ(マイ瑰花)、松葉、マロニエ、マンネンロウ、ムクロジ、メリッサ、メリロート、ボケ(木瓜)、モヤシ、モモ(桃仁,桃葉)、ヒオウギ(射干)、ビンロウジュ(檳ロウ子)、メハジキ(益母草)、ヤグルマギク、ユキノシタ(虎耳草)、ヤマモモ(楊梅皮)、ヤシャブシ(矢車)、ハトムギ(ヨクイニン)、モウコヨモギ、ヤマヨモギ、ラベンダー、リンゴ果実、マンネンタケ(霊芝)、レモン果実、レンギョウ(連翹)、レンゲソウ、ゲンノショウコ(老鸛草)、ハシリドコロ(ロート根)、鶏トサカ、牛・人の胎盤抽出物、豚・牛の胃、十二指腸、或いは腸の抽出物若しくはその分解物、水溶性コラーゲン、水溶性コラーゲン誘導体、コラーゲン加水分解物、エラスチン、エラスチン加水分解物、水溶性エラスチン誘導体、シルク蛋白、シルク蛋白分解物、牛血球蛋白分解物等が挙げられる。 Extracts and extracts of animals, plants, and herbal medicines include, for example, Acacia oleracea, Angelica gracilis, Acerola, Altea, Arnica, Avocado, Amacha, Aloe, Aloe vera, Nettle, Ginkgo biloba, Fennel, Turmeric, Asian spiciness, Japanese plum, Quercus salicina, Uva-ursi, Rosa multiflora, Astragalus chinensis, Scutellaria baicalensis, Cherry bark, Phellodendron amplexicaule, and Scutellaria baicalensis. Coptis, Panax ginseng, Hypericum, Lamium, Watercress, Orange, Polygala tenuifolia, Prunella vulgaris, Houttuynia cordata, Sophora japonica, Artemisia anguicida, Zedoary, Pueraria lobata, Valerian root, Chamomile, Melon root, Artemisia capillaris, Licorice, Coltsfoot, Rubus serrata, Kiwi fruit, Platycodon grandiflorum, Chrysanthemum , Catalpa (catalpa fruit), Citrus fruit (citrus fruit), Tachibana (tachibana peel), Cucumber, Udo or Angelica jasmine (angelica), Apricot (apricot kernel), Wolfberry (wolfberry skin, wolfberry berry, wolfberry leaf), Sophora arborescens (bitter ginseng), Camphor tree, Kumazasa (Japanese bamboo grass), Grapefruit fruit, Cinnamon bark, Japanese laurel (cassia bark), Cassia jasmine (cassia berry), Japanese morning glory (Japanese morning glory), Safflower (safflower), Gobaishi (gobaishi gallnut), Comfrey, Copaiba, Gardenia jasmine (gardenia berry), Gentian, Magnolia obovata (magnolia) ), Chinese yarrow, Euonymus chinensis, Burdock, Schisandra chinensis, Rice, Rice bran, Wheat, Bupleurum chinensis, Saffron, Soapwort, Japanese hawthorn, Japanese pepper, Salvia, Sanshichi ginseng, Shiitake mushroom, Rehmannia rhizome, Licorice citrifolia, Purple root, Perilla frutescens, Chinese peony, Plantain, Ginger, Iris , Ligustrum japonicum, Spiraea japonica, Japanese white birch, honeysuckle, ivy, yarrow, elderberry, adzuki bean, elderberry, mallow, cnidium rhododendron, Swertia britannica, mulberry, jujube, soybean, elm, bamboo joint ginseng, anemone anaemone, elm, Houttuynia cordata, cordyceps sinensis, chili pepper, day lily Torokko root, Thyme, Green tea, Black tea, Clove, Unshu mandarin, Camellia, Centella asiatica, Chili pepper, Angelica acutiloba, Calendula officinalis, Orange peel, Elm tree, Corn, Eucommia ulmoides, Tomato, Nandina, Garlic, Barley, Malt, Ophiopogon japonicus, Parsley, Butterfly, Mint, Hamamelis , rose, loquat leaf, pine cone, grape or its leaves, loofah, linden tree, peony, hop, maikai, pine needles, horse chestnut, rosehip, soapberry, melissa, melilot, Japanese quince, bean sprouts, peach kernel, peach leaf, bean laurel, areca nut, amplexicaule, cornflower, saxifrage, bayberry, yasum, alder bark, alder, Job's tears, mugwort, mountain These include mugwort, lavender, apple fruit, Ganoderma lucidum (reishi), lemon fruit, forsythia (forsythia fruit), astragalus root, geranium herb, scoparia root, rooster comb, cow and human placenta extracts, pig and cow stomach, duodenum, or intestine extracts or hydrolyzates thereof, water-soluble collagen, water-soluble collagen derivatives, collagen hydrolyzates, elastin, elastin hydrolyzates, water-soluble elastin derivatives, silk protein, silk protein hydrolyzates, and bovine blood cell protein hydrolyzates.
微生物培養代謝物としては、例えば、酵母エキス、亜鉛含有酵母エキス、ゲルマニウム含有酵母エキス、セレン含有酵母エキス、マグネシウム含有酵母エキス、米醗酵エキス、ユーグレナ抽出物、脱脂粉乳の乳酸発酵物等が挙げられる。 Examples of microbial culture metabolites include yeast extract, zinc-containing yeast extract, germanium-containing yeast extract, selenium-containing yeast extract, magnesium-containing yeast extract, rice fermentation extract, Euglena extract, and lactic acid fermentation products of skim milk powder.
α-ヒドロキシ酸としては、例えば、グリコール酸、クエン酸、リンゴ酸、酒石酸、乳酸等が挙げられる。 Examples of alpha-hydroxy acids include glycolic acid, citric acid, malic acid, tartaric acid, and lactic acid.
無機顔料としては、例えば、無水ケイ酸、ケイ酸マグネシウム、タルク、カオリン、ベントナイト、マイカ、雲母チタン、オキシ塩化ビスマス、酸化ジルコニウム、酸化マグネシウム、酸化亜鉛、酸化チタン、炭酸カルシウム、炭酸マグネシウム、黄酸化鉄、ベンガラ、黒酸化鉄、グンジョウ、酸化クロム、水酸化クロム、カーボンブラック、カラミン等が挙げられる。 Examples of inorganic pigments include silicic acid anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjo, chromium oxide, chromium hydroxide, carbon black, and calamine.
紫外線吸収剤としては、例えば、p-アミノ安息香酸誘導体、サルチル酸誘導体、アントラニル酸誘導体、クマリン誘導体、アミノ酸系化合物、ベンゾトリアゾール誘導体、テトラゾール誘導体、イミダゾリン誘導体、ピリミジン誘導体、ジオキサン誘導体、カンファー誘導体、フラン誘導体、ピロン誘導体、核酸誘導体、アラントイン誘導体、ニコチン酸誘導体、ビタミンB6誘導体、オキシベンゾン、ベンゾフェノン、グアイアズレン、シコニン、バイカリン、バイカレイン、ベルベリン等が挙げられる。 Examples of ultraviolet absorbers include p-aminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, oxybenzone, benzophenone, guaiazulene, shikonin, baicalin, baicalein, berberine, etc.
収斂剤としては、例えば、乳酸、酒石酸、コハク酸、クエン酸、アラントイン、塩化亜鉛、硫酸亜鉛、酸化亜鉛、カラミン、p-フェノールスルホン酸亜鉛、硫酸アルミニウムカリウム、レソルシン、塩化第二鉄、タンニン酸等が挙げられる。 Examples of astringents include lactic acid, tartaric acid, succinic acid, citric acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, and tannic acid.
抗酸化剤としては、例えば、アスコルビン酸及びその塩、ステアリン酸エステル、トコフェロール及びそのエステル誘導体、ノルジヒドログアセレテン酸、ブチルヒドロキシトルエン(BHT)、ブチルヒドロキシアニソール(BHA)、パラヒドロキシアニソール、没食子酸プロピル、セサモール、セサモリン、ゴシポール等が挙げられる。 Examples of antioxidants include ascorbic acid and its salts, stearic acid esters, tocopherol and its ester derivatives, nordihydroguaiaretenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol, etc.
抗炎症剤としては、例えば、イクタモール、インドメタシン、カオリン、サリチル酸、サリチル酸ナトリウム、サリチル酸メチル、アセチルサリチル酸、塩酸ジフェンヒドラミン、d又はdl-カンフル、ヒドロコルチゾン、グアイアズレン、カマズレン、マレイン酸クロルフェニラミン、グリチルリチン酸及びその塩、グリチルレチン酸及びその塩等が挙げられる。 Examples of anti-inflammatory agents include ichthammol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d- or dl-camphor, hydrocortisone, guaiazulene, chamazulene, chlorpheniramine maleate, glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, etc.
殺菌・消毒薬としては、例えば、アクリノール、イオウ、塩化ベンザルコニウム、塩化ベンゼトニウム、塩化メチルロザニリン、クレゾール、グルコン酸カルシウム、グルコン酸クロルヘキシジン、スルファミン、マーキュロクロム、ラクトフェリン又はその加水分解物等が挙げられる。 Examples of germicides and disinfectants include acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolysates, etc.
頭髪用剤としては、例えば、二硫化セレン、臭化アルキルイソキノリニウム液、ジンクピリチオン、ビフェナミン、チアントール、カスタリチンキ、ショウキョウチンキ、トウガラシチンキ、塩酸キニーネ、強アンモニア水、臭素酸カリウム、臭素酸ナトリウム、チオグリコール酸等が挙げられる。 Hair products include, for example, selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castor tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, sodium bromate, and thioglycolic acid.
香料としては、例えば、ジャコウ、シベット、カストリウム、アンバーグリス等の天然動物性香料、アニス精油、アンゲリカ精油、イラン精油、イリス精油、ウイキョウ精油、オレンジ精油、カナンガ精油、カラウェー精油、カルダモン精油、グアヤクウッド精油、クミン精油、黒文字精油、ケイ皮精油、シンナモン精油、ゲラニウム精油、コパイババルサム精油、コリアンデル精油、シソ精油、シダーウッド精油、シトロネラ精油、ジャスミン精油、ジンジャーグラス精油、杉精油、スペアミント精油、西洋ハッカ精油、大茴香精油、チュベローズ精油、丁字精油、橙花精油、冬緑精油、トルーバルサム精油、バチュリー精油、バラ精油、パルマローザ精油、檜精油、ヒバ精油、白檀精油、プチグレン精油、ベイ精油、ベチバ精油、ベルガモット精油、ペルーバルサム精油、ボアドローズ精油、芳樟精油、マンダリン精油、ユーカリ精油、ライム精油、ラベンダー精油、リナロエ精油、レモングラス精油、レモン精油、ローズマリー精油、和種ハッカ精油等の植物性香料、その他合成香料等が挙げられる。 Fragrances include, for example, natural animal fragrances such as musk, civet, castoreum, and ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guaiac wood essential oil, cumin essential oil, black letter essential oil, cassia bark essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriander essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, and spearmint essential oil. , peppermint essential oil, anise essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, wintergreen essential oil, tolu balsam essential oil, butterbur essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, Japanese cypress essential oil, sandalwood essential oil, petitgrain essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, Peru balsam essential oil, bois de rose essential oil, camphor essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, Japanese peppermint essential oil, and other synthetic fragrances.
色素・着色剤としては、例えば、赤キャベツ色素、赤米色素、アカネ色素、アナトー色素、イカスミ色素、ウコン色素、エンジュ色素、オキアミ色素、柿色素、カラメル、金、銀、クチナシ色素、コーン色素、タマネギ色素、タマリンド色素、スピルリナ色素、ソバ全草色素、チェリー色素、海苔色素、ハイビスカス色素、ブドウ果汁色素、マリーゴールド色素、紫イモ色素、紫ヤマイモ色素、ラック色素、ルチン等が挙げられる。 Examples of pigments and coloring agents include red cabbage pigment, red rice pigment, madder pigment, annatto pigment, squid ink pigment, turmeric pigment, sophora japonica pigment, krill pigment, persimmon pigment, caramel, gold, silver, gardenia pigment, corn pigment, onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, seaweed pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple sweet potato pigment, purple yam pigment, lac pigment, and rutin.
甘味料としては、例えば、砂糖、甘茶、果糖、アラビノース、ガラクトース、キシロース、マンノース、麦芽糖、蜂蜜、ブドウ糖、ミラクリン、モネリン等が挙げられる。 Sweeteners include, for example, sugar, sweet tea, fructose, arabinose, galactose, xylose, mannose, maltose, honey, glucose, miraculin, monellin, etc.
栄養強化剤としては、例えば、貝殻焼成カルシウム、シアノコラバミン、酵母、小麦胚芽、大豆胚芽、卵黄粉末、ヘミセルロース、ヘム鉄等が挙げられる。 Nutritional supplements include, for example, calcined shell calcium, cyanocolabamin, yeast, wheat germ, soybean germ, egg yolk powder, hemicellulose, heme iron, etc.
その他、例えば、ホルモン類、金属イオン封鎖剤、pH調整剤、キレート剤、防腐・防バイ剤、清涼剤、安定化剤、乳化剤、動・植物性蛋白質及びその分解物、動・植物性多糖類及びその分解物、動・植物性糖蛋白質及びその分解物、血流促進剤、消炎剤・抗アレルギー剤、細胞賦活剤、角質溶解剤、創傷治療剤、増泡剤、増粘剤、口腔用剤、消臭・脱臭剤、苦味料、調味料、酵素等が挙げられる。 Other examples include hormones, sequestering agents, pH adjusters, chelating agents, preservatives and antifungals, cooling agents, stabilizers, emulsifiers, animal and vegetable proteins and their decomposition products, animal and vegetable polysaccharides and their decomposition products, animal and vegetable glycoproteins and their decomposition products, blood flow promoters, anti-inflammatory and anti-allergic agents, cell activators, keratolytic agents, wound healing agents, foaming agents, thickeners, oral agents, deodorizing agents, bittering agents, seasonings, enzymes, etc.
本発明の剤型は任意であり、アンプル状、カプセル状、粉末状、顆粒状、丸剤、錠剤状、固形状、液状、ゲル状、気泡状、乳液状、クリーム状、軟膏状、シート状、ムース状等の医薬部外品類、皮膚・頭髪用化粧品類及び浴用剤化、飲食品類、医薬品類に配合して用いることができる。 The formulation of the present invention may be any form, and may be incorporated into quasi-drugs such as ampoules, capsules, powders, granules, pills, tablets, solids, liquids, gels, foams, emulsions, creams, ointments, sheets, and mousses, skin and hair cosmetics, bath preparations, foods, beverages, and pharmaceuticals.
具体的に化粧品類、医薬部外品類としては、例えば内用・外用薬用製剤、化粧水、乳液、クリーム、軟膏、ローション、オイル、パック等の基礎化粧料、洗顔料や皮膚洗浄料、シャンプー、リンス、ヘアートリートメント、ヘアクリーム、ポマード、ヘアスプレー、整髪料、パーマ剤、ヘアートニック、染毛料、育毛・養毛料等の頭髪化粧料、ファンデーション、白粉、おしろい、口紅、頬紅、アイシャドウ、アイライナー、マスカラ、眉墨、まつ毛等のメークアップ化粧料、美爪料等の仕上げ用化粧料、香水類、浴用剤、その他、歯磨き類、口中清涼剤・含嗽剤、液臭・防臭防止剤、衛生用品、衛生綿類、ウエットティシュ等が挙げられる。 Specific examples of cosmetics and quasi-drugs include basic cosmetics such as internal and external medicinal preparations, lotions, milky lotions, creams, ointments, lotions, oils and packs, facial cleansers and skin cleansers, hair cosmetics such as shampoos, rinses, hair treatments, hair creams, pomades, hair sprays, hair styling products, perm products, hair tonics, hair dyes and hair growth and nourishing products, make-up cosmetics such as foundations, face powders, face powders, lipsticks, blushers, eye shadows, eyeliners, mascaras, eyebrow inks and eyelashes, finishing cosmetics such as nail polish, perfumes, bath products, toothpastes, mouth fresheners and mouthwashes, liquid odor and deodorant agents, hygiene products, sanitary cotton, wet tissues, etc.
飲食品類としては、例えば清涼飲料、炭酸飲料、栄養飲料、果実飲料、乳酸飲料等の飲料、アイスクリーム、アイスシャーベット、かき氷等の冷菓、そば、うどん、はるさめ、餃子の皮、しゅうまいの皮、中華麺、即席麺等の麺類、飴、キャンディー、ガム、チョコレート、錠菓、スナック菓子、ビスケット、ゼリー、ジャム、クリーム、焼き菓子、パン等の菓子類、カニ、サケ、アサリ、マグロ、イワシ、エビ、カツオ、サバ、クジラ、カキ、サンマ、イカ、アカガイ、ホタテ、アワビ、ウニ、イクラ、トコブシ等の水産物、かまぼこ、ハム、ソーセージ等の水産・畜産加工食品、粉乳、加工乳、発酵乳等の乳製品、サラダ油、てんぷら油、マーガリン、マヨネーズ、ショートニング、ホイップクリーム、ドレッシング等の油脂及び油脂加工食品、ソース、たれ等の調味料、カレー、シチュー、親子丼、お粥、雑炊、中華丼、かつ丼、天丼、うな丼、ハヤシライス、おでん、マーボドーフ、牛丼、ミートソース、玉子スープ、オムライス、餃子、シューマイ、ハンバーグ、ミートボール等のレトルトパウチ食品、種々の形態の健康・栄養補助食品、保健機能食品、錠剤、カプセル剤、ドリンク剤、トローチ等が挙げられる。 Food and beverage products include, for example, soft drinks, carbonated drinks, nutritional drinks, fruit drinks, lactic acid drinks, and other beverages; ice cream, ice sherbet, shaved ice, and other cold desserts; soba, udon, vermicelli, gyoza wrappers, shumai wrappers, Chinese noodles, instant noodles, and other noodles; candy, candy, gum, chocolate, candy tablets, snacks, biscuits, jelly, jam, cream, baked goods, bread, and other sweets; seafood products such as crab, salmon, clams, tuna, sardines, shrimp, bonito, mackerel, whale, oysters, pacific saury, squid, ark shells, scallops, abalone, sea urchin, salmon roe, and tokobushi; and water products such as kamaboko, ham, and sausages. These include processed livestock and animal products, dairy products such as powdered milk, processed milk, and fermented milk, fats and oils and processed foods such as salad oil, tempura oil, margarine, mayonnaise, shortening, whipped cream, and dressings, seasonings such as sauces and sauces, retort pouch foods such as curry, stew, oyakodon, porridge, porridge, Chinese rice bowl, katsudon, tendon, unadon, hayashi rice, oden, mabo dolph, beef bowl, meat sauce, egg soup, omelet rice, gyoza, shumai, hamburger steak, and meatballs, various forms of health and nutritional supplements, health functional foods, tablets, capsules, drinks, and lozenges.
本発明の抗糖化剤及び皮膚外用組成物は、ヒトに対して好適に適用されるものであるが、それぞれの作用効果が期待できる限り、ヒト以外の動物に対して適用することもできる。 The anti-glycation agent and topical skin composition of the present invention are suitable for use in humans, but can also be used in animals other than humans as long as their respective functional effects can be expected.
本発明において、化粧料の態様は、特に限定されないが、例えば、洗顔料、洗浄料、化粧水(例えば、美白化粧水)、クリーム(例えば、バニシングクリーム、コールドクリーム)、乳液、ゲル、美容液、パック(例えば、ゼリー状ピールオフタイプ、ペースト状拭き取りタイプ、粉末状洗い流しタイプ)、フェイスマスク、クレンジング、ファンデーション、口紅、リップクリーム、リップグロス、リップライナー、頬紅、化粧下地、シェービングローション、サンスクリーン、アフターサンローション、デオドラントローション、ボディローション(ハンドケアローション、フットケアローションを含む)、ボディオイル等が挙げられる。 In the present invention, the form of the cosmetic is not particularly limited, but examples include facial cleansers, cleansers, lotions (e.g., whitening lotions), creams (e.g., vanishing cream, cold cream), milk lotions, gels, beauty serums, packs (e.g., jelly-like peel-off types, paste-like wipe-off types, powder-like wash-off types), face masks, cleansers, foundations, lipsticks, lip balms, lip glosses, lip liners, blushers, makeup bases, shaving lotions, sunscreens, after-sun lotions, deodorant lotions, body lotions (including hand care lotions and foot care lotions), body oils, etc.
以下、本発明を実施例に基づき、より詳細に説明する。なお、本発明は実施例に特に限定されるものではない。 The present invention will be described in more detail below based on examples. Note that the present invention is not particularly limited to the examples.
製造例1:大豆胚芽由来ポリアミン含有抽出物の調製
1kgの大豆胚芽(フォーユー製)に希釈内部標準液(1,7-diaminoheptane、内部標準量=10μmol)、5Lの1N塩酸溶液を加えて室温下で1時間放置した。その後、ポリフェノール吸着剤であるポリクラールVT(ISP製)を80g添加し、ホモジナイザーでダイズ胚芽を十分に破砕後、室温下で1時間放置して酸性条件下で抽出した。破砕物を2℃、22,000×gで30分間遠心分離して液体画分を採取し、30%の水酸化ナトリウム溶液で中和して本液を大豆胚芽由来ポリアミン含有抽出物とした。大豆胚芽由来ポリアミン含有抽出物は電気透析装置(アシライザー, アストム製)により脱塩を行い、凍結乾燥により濃縮した。この粉末を30%ブチレングリコール溶液に5.0%となるように溶解し、大豆胚芽由来ポリアミン含有抽出物として種々の評価に用いた。
Production Example 1: Preparation of soybean germ-derived polyamine-containing extract Diluted internal standard solution (1,7-diaminoheptane, internal standard amount = 10 μmol) and 5 L of 1N hydrochloric acid solution were added to 1 kg of soybean germ (manufactured by For You) and left at room temperature for 1 hour. Then, 80 g of polychlor VT (manufactured by ISP), which is a polyphenol adsorbent, was added, and the soybean germ was sufficiently crushed with a homogenizer, and then left at room temperature for 1 hour to extract under acidic conditions. The crushed material was centrifuged at 2°C and 22,000 x g for 30 minutes to collect a liquid fraction, which was neutralized with a 30% sodium hydroxide solution to obtain a soybean germ-derived polyamine-containing extract. The soybean germ-derived polyamine-containing extract was desalted using an electrodialysis device (Acilyser, manufactured by Astom) and concentrated by freeze-drying. This powder was dissolved in a 30% butylene glycol solution to a concentration of 5.0%, and used for various evaluations as a soybean germ-derived polyamine-containing extract.
実施例1:糖化抑制試験
前記大豆胚芽由来ポリアミン含有抽出物を被験試料として用い、下記試験方法により糖化抑制試験を実施した。
Example 1: Glycation inhibition test Using the above soybean germ-derived polyamine-containing extract as a test sample, a glycation inhibition test was carried out according to the following test method.
10mLのPBSに対し、牛血清アルブミン(BSA;RIAグレード)を1.6g、およびD-グルコースを3.0gの割合で溶解させたBSA-グルコース混合液を調製した。該溶液を0.45μmフィルターでろ過した後、該溶液に対して、製造例1で得た被験試料を10%添加し、45℃にて10日間インキュベーションした。なお、コントロール添加区として、上記試料中にBGが30%含まれるため、30%BG溶液を10%添加した水準を調製した。なお、同様に調製した混合試料を-80℃にて保存し、陰性コンロール群とした。10日後、各反応液を精製水にて10倍希釈し、96穴マイクロプレートに100μLずつ分注した。次いで、終濃度250μmol/LのNBD-H(4-Hydrazino-7-nitro-2,1,3-benzoxadiazole Hydrazine)を、終濃度0.025%のトリフルオロ酢酸存在下で添加した。遮光環境下にて、室温で15分反応させ、蛍光強度をマイクロプレートリーダーにて測定した(Ex/Em=470nm/550nm)。反応液中のカルボニル基量は、プロピオンアルデヒドによって同時に作成した検量線より求めた。 A BSA-glucose mixture was prepared by dissolving 1.6 g of bovine serum albumin (BSA; RIA grade) and 3.0 g of D-glucose in 10 mL of PBS. The solution was filtered through a 0.45 μm filter, and the test sample obtained in Production Example 1 was added to the solution at 10% and incubated at 45°C for 10 days. As a control addition group, a level was prepared in which 10% of a 30% BG solution was added, since the above sample contained 30% BG. A mixed sample prepared in the same manner was stored at -80°C and used as a negative control group. After 10 days, each reaction solution was diluted 10 times with purified water and dispensed into a 96-well microplate at 100 μL each. Next, NBD-H (4-Hydrazino-7-nitro-2,1,3-benzoxadiazole hydrazine) was added at a final concentration of 250 μmol/L in the presence of trifluoroacetic acid at a final concentration of 0.025%. The reaction was allowed to proceed for 15 minutes at room temperature in a dark environment, and the fluorescence intensity was measured using a microplate reader (Ex/Em = 470 nm/550 nm). The amount of carbonyl groups in the reaction solution was determined from a calibration curve created at the same time using propionaldehyde.
得られた結果を表1及び図1に示す。被験試料添加区について、コントロール添加区と比較して、カルボニル基の有意な減少が確認された。このことから、タンパク質と糖の反応によって生じる糖化生成物の生成を抑制することが確認された。 The results are shown in Table 1 and Figure 1. A significant decrease in carbonyl groups was confirmed in the test sample-added area compared to the control-added area. This confirmed that the production of glycation products caused by the reaction of proteins with sugars was suppressed.
実施例2:皮膚外用組成物の処方
以下に、本発明における大豆胚芽由来ポリアミン含有抽出物を含有する皮膚外用組成物としての処方例を示す。これらの製剤は、いずれも大豆胚芽由来ポリアミン含有抽出物に起因する抗糖化効果が期待され、抗糖化剤として有効なものである。
Example 2: Formulation of a skin topical composition The following are examples of formulations of a skin topical composition containing the soybean germ-derived polyamine-containing extract of the present invention. All of these preparations are expected to have an anti-glycation effect due to the soybean germ-derived polyamine-containing extract, and are effective as anti-glycation agents.
化粧水
下記組成に従い、化粧水を常法により調製した。
・精製水・・・89.80g
・グリセリン・・・3.00g
・フェノキシエタノール・・・0.20g
・ブチレングリコール・・・5.00g
・ペンチレングリコール・・・1.00g
・大豆胚芽由来ポリアミン含有抽出物・・・1.00g
Toner A toner was prepared in a conventional manner according to the following composition.
・Purified water・・・89.80g
・Glycerin...3.00g
・Phenoxyethanol...0.20g
Butylene glycol...5.00g
・Pentylene glycol...1.00g
・Soybean germ-derived polyamine-containing extract...1.00g
ジェル
下記組成に従い、ジェルを常法により調製した。
・精製水・・・88.50g
・カルボマー・・・0.30g
・キサンタンガム・・・0.10g
・アルギニン・・・0.40g
・グリセリン・・・5.00g
・フェノキシエタノール・・・0.20g
・ブチレングリコール・・・5.00g
・大豆胚芽由来ポリアミン含有抽出物・・・0.50g
Gel A gel was prepared in the usual manner according to the following composition.
・Purified water・・・88.50g
・Carbomer...0.30g
・Xanthan gum...0.10g
・Arginine: 0.40g
・Glycerin...5.00g
・Phenoxyethanol...0.20g
Butylene glycol...5.00g
・Soybean germ-derived polyamine-containing extract...0.50g
クリーム
下記組成に従い、クリームを常法により調製した。
・精製水・・・58.50g
・ブチレングリコール・・・10.00g
・グリセリン・・・5.00g
・フェノキシエタノール・・・0.20g
・エチルヘキシルグリセリン・・・0.20g
・スクワラン・・・10.00g
・オリーブ油・・・10.00g
・ベヘニルアルコール・・・2.50g
・ペンタステアリン酸ポリグリセリル-10・・・1.90g
・ステアロイル乳酸Na・・・0.60g
・パルミチン酸セチル・・・1.00g
・大豆胚芽由来ポリアミン含有抽出物・・・0.10g
Cream A cream was prepared in a conventional manner according to the following composition.
・Purified water・・・58.50g
Butylene glycol...10.00g
・Glycerin...5.00g
・Phenoxyethanol...0.20g
・Ethylhexylglycerin...0.20g
・Squalane...10.00g
・Olive oil・・・10.00g
・Behenyl alcohol...2.50g
・Polyglyceryl-10 pentastearate...1.90g
・Sodium stearoyl lactate...0.60g
・Cetyl palmitate...1.00g
・Soybean germ-derived polyamine-containing extract...0.10g
本発明の植物由来ポリアミン含有抽出物を含有する皮膚外用組成物を利用することにより、タンパク質と糖の反応によって生じる糖化生成物の生成を抑制することが可能となり、抗糖化症剤としての利用が期待される。特に化粧品、あるいは医薬部外品として、皮膚外用組成物への適用が可能である。 By using a topical skin composition containing the plant-derived polyamine-containing extract of the present invention, it is possible to inhibit the production of glycation products resulting from the reaction between proteins and sugars, and it is expected to be used as an anti-glycation agent. In particular, it can be applied to topical skin compositions as cosmetics or quasi-drugs.
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US20110236512A1 (en) | 2009-09-28 | 2011-09-29 | Toyo Boseki Kabushiki Kaisha | Stress-reducing agent including plant-derived polyamine-containing extract serving as active component |
WO2014091988A1 (en) | 2012-12-11 | 2014-06-19 | キッコーマン株式会社 | Fermented soymilk extract and fermented hypocotyl extract |
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US20110236512A1 (en) | 2009-09-28 | 2011-09-29 | Toyo Boseki Kabushiki Kaisha | Stress-reducing agent including plant-derived polyamine-containing extract serving as active component |
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