JP7463410B2 - アポリポタンパク質ｂアンタゴニスト - Google Patents
アポリポタンパク質ｂアンタゴニスト Download PDFInfo
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- JP7463410B2 JP7463410B2 JP2021574936A JP2021574936A JP7463410B2 JP 7463410 B2 JP7463410 B2 JP 7463410B2 JP 2021574936 A JP2021574936 A JP 2021574936A JP 2021574936 A JP2021574936 A JP 2021574936A JP 7463410 B2 JP7463410 B2 JP 7463410B2
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/06—Antihyperlipidemics
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
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- C12N2310/53—Physical structure partially self-complementary or closed
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- C12N2330/00—Production
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
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- Molecular Biology (AREA)
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- Biomedical Technology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
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- Hematology (AREA)
- Diabetes (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1909500.9A GB201909500D0 (en) | 2019-07-02 | 2019-07-02 | Antagonist |
| GB1909500.9 | 2019-07-02 | ||
| GBGB1910526.1A GB201910526D0 (en) | 2019-07-23 | 2019-07-23 | Antagonist |
| GB1910526.1 | 2019-07-23 | ||
| GB2000906.4 | 2020-01-22 | ||
| GBGB2000906.4A GB202000906D0 (en) | 2020-01-22 | 2020-01-22 | Antagonist |
| PCT/GB2020/051573 WO2021001646A2 (en) | 2019-07-02 | 2020-06-30 | Apolipoprotein b antagonist |
Publications (4)
| Publication Number | Publication Date |
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| JP2022537987A JP2022537987A (ja) | 2022-08-31 |
| JPWO2021001646A5 JPWO2021001646A5 (https=) | 2023-07-07 |
| JP2022537987A5 JP2022537987A5 (https=) | 2023-07-07 |
| JP7463410B2 true JP7463410B2 (ja) | 2024-04-08 |
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| GB202020534D0 (en) * | 2020-12-23 | 2021-02-03 | Argonaute Rna Ltd | Conjugate |
| US20250304966A1 (en) * | 2020-12-23 | 2025-10-02 | Argonaute RNA Limited | Treatment of cardiovascular disease |
| WO2023041508A2 (en) * | 2021-09-14 | 2023-03-23 | Argonaute RNA Limited | Treatment of cardiovascular disease |
| GB2618915B (en) * | 2022-05-18 | 2024-08-14 | Argonaute Rna Ltd | Treatment of cardiovascular disease |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008514632A (ja) | 2004-09-24 | 2008-05-08 | アルナイラム ファーマシューティカルズ インコーポレイテッド | ＡｐｏＢのＲＮＡｉ調節およびその使用 |
| JP2011517676A (ja) | 2008-03-27 | 2011-06-16 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | インビボでｒｎａ干渉を媒介するための組成物および方法 |
| US20110195127A1 (en) | 2009-07-01 | 2011-08-11 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing apolipoprotein b |
| US20120136040A1 (en) | 2005-05-25 | 2012-05-31 | The University Of York | Hybrid interfering rna |
| US20150025122A1 (en) | 2009-10-12 | 2015-01-22 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10264976B2 (en) * | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
| KR20230043114A (ko) * | 2020-06-24 | 2023-03-30 | 사프렘 테크놀로지스 비.브이. | Galnac과 사포닌의 접합체, 상기 접합체 및 galnac-올리고뉴클레오티드 접합체를 포함하는 치료적 조성물 |
| US20250304966A1 (en) * | 2020-12-23 | 2025-10-02 | Argonaute RNA Limited | Treatment of cardiovascular disease |
-
2020
- 2020-06-30 US US17/620,973 patent/US20230027604A1/en not_active Abandoned
- 2020-06-30 CN CN202080048130.6A patent/CN114072503A/zh active Pending
- 2020-06-30 JP JP2021574936A patent/JP7463410B2/ja active Active
- 2020-06-30 WO PCT/GB2020/051573 patent/WO2021001646A2/en not_active Ceased
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008514632A (ja) | 2004-09-24 | 2008-05-08 | アルナイラム ファーマシューティカルズ インコーポレイテッド | ＡｐｏＢのＲＮＡｉ調節およびその使用 |
| US20120136040A1 (en) | 2005-05-25 | 2012-05-31 | The University Of York | Hybrid interfering rna |
| JP2011517676A (ja) | 2008-03-27 | 2011-06-16 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | インビボでｒｎａ干渉を媒介するための組成物および方法 |
| US20110195127A1 (en) | 2009-07-01 | 2011-08-11 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing apolipoprotein b |
| US20150025122A1 (en) | 2009-10-12 | 2015-01-22 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
Non-Patent Citations (6)
| Title |
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| ALLISON, Simon J. and MILNER, Jo，Molecular Therapy Nucleic Acids，2014年01月21日，Vol. 2, Article No. e141，DOI: 10.1038/mtna.2013.68 |
| JIANG, Ming et al.，Nucleic Anids Research，2005年10月01日，Vol. 33, Issue 18, Article No. e151，DOI: 10.1093/nar/gni144 |
| MATSUDA, Shigeo et al.， ，ACS Chemical Biology，2015年03月02日，Vol. 10, No. 5，pp. 1181-1187，DOI: 10.1021/cb501028c |
| NAIR, Jayaprakash K. et al.，Journal of American Chemical Society，2014年12月01日，Vol. 136, Issue 49，pp. 16958-16961，DOI: 10.1021/ja505986a |
| PRAKASH, Thazha P. et al.，Nucleic Acids Research，2014年07月29日，Vol. 42, Issue 13，pp. 8796-8807，DOI: 10.1093/nar/gku531 |
| SPRINGER, Aaron D. and DOWDY, Steven，Nucleic Acid Therapeutics，2018年06月01日，Vol. 28, No. 3，pp. 109-118，DOI: 10.1089/nat.2018.0736 |
Also Published As
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| CA3143404C (en) | 2024-03-05 |
| GB202010004D0 (en) | 2020-08-12 |
| US20230027604A1 (en) | 2023-01-26 |
| WO2021001646A3 (en) | 2021-02-18 |
| EP3965781A2 (en) | 2022-03-16 |
| GB2585278A (en) | 2021-01-06 |
| CA3143404A1 (en) | 2021-01-07 |
| CN114072503A (zh) | 2022-02-18 |
| GB2585278B (en) | 2022-03-16 |
| JP2022537987A (ja) | 2022-08-31 |
| WO2021001646A2 (en) | 2021-01-07 |
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