JP7461875B2 - 病気の症状の治療又は予防に使用するための抗アドレノメデュリン（ａｄｍ）バインダー - Google Patents

病気の症状の治療又は予防に使用するための抗アドレノメデュリン（ａｄｍ）バインダー Download PDF

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JP7461875B2
JP7461875B2 JP2020517143A JP2020517143A JP7461875B2 JP 7461875 B2 JP7461875 B2 JP 7461875B2 JP 2020517143 A JP2020517143 A JP 2020517143A JP 2020517143 A JP2020517143 A JP 2020517143A JP 7461875 B2 JP7461875 B2 JP 7461875B2
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adm
antibody
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ベルクマン アンドレアス
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アドレノメト アクチェンゲゼルシャフト
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics

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JP2020517143A 2017-09-25 2018-09-25 病気の症状の治療又は予防に使用するための抗アドレノメデュリン（ａｄｍ）バインダー Active JP7461875B2 (ja)

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EP17192999.5 2017-09-25
EP17192999 2017-09-25
EP17203370 2017-11-23
EP17203370.6 2017-11-23
PCT/EP2018/075987 WO2019057992A2 (en) 2017-09-25 2018-09-25 ANTI-ADRENOMEDULIN (ADM) BINDER FOR USE IN TREATING OR PREVENTING THE SYMPTOMS OF A DISEASE

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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021038078A1 (en) 2019-08-30 2021-03-04 4TEEN4 Pharmaceuticals GmbH Therapy guidance and/or therapy monitoring for treatment of shock
EP3871689A1 (en) * 2020-02-26 2021-09-01 sphingotec GmbH Anti-adm-antibodies binding to the free n-terminus for accelerated transition of adm-gly to bio-adm in patients with adm-gly/ bio-adm ratio above a threshold and combination with vitamin c
CA3168978A1 (en) * 2020-02-27 2021-09-02 Andreas Bergmann Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy or prevention of shock
US20210285949A1 (en) * 2020-03-16 2021-09-16 Sphingotec Gmbh Pro-adrenomedullin or fragment thereof in patients infected with corona virus and treatments with binder against adrenomedullin
CN111893085A (zh) * 2020-08-04 2020-11-06 北京臻溪谷医学研究中心（有限合伙） 一种通过干细胞体外分化获得人工皮肤的方法及其应用
KR20250040987A (ko) * 2022-07-20 2025-03-25 상하이 제유 파마슈티칼 컴퍼니 리미티드 항-아드레노메둘린 비중화 항체, 이의 제조 방법 및 응용
WO2025152915A1 (zh) * 2024-01-16 2025-07-24 上海济煜医药科技有限公司 抗肾上腺髓质素抗体在预防或治疗脑卒中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015502930A (ja) 2011-11-16 2015-01-29 アドレノメト アクチェンゲゼルシャフト 慢性若しくは急性疾患又は急性病態に罹患している患者の死亡リスクを低減するための抗アドレノメデュリン（ＡＤＭ）抗体、抗ＡＤＭ抗体フラグメント又は抗ＡＤＭ非Ｉｇ足場
JP2016521351A (ja) 2013-03-20 2016-07-21 シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング 血圧降下治療をガイドするアドレノメジュリン

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ES2139598T3 (es) 1990-07-10 2000-02-16 Medical Res Council Procedimientos para la produccion de miembros de parejas de union especifica.
JPH07503132A (ja) 1991-12-17 1995-04-06 ジェンファーム　インターナショナル，インコーポレイティド 異種抗体を産生することができるトランスジェニック非ヒト動物
US6818418B1 (en) 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
CN1628126A (zh) 2001-08-30 2005-06-15 比奥雷克西斯药物公司 经修饰的运铁蛋白融合蛋白
PT2298278E (pt) 2002-06-07 2016-02-25 Dyax Corp Prevenção e redução da perda de sangue e resposta inflamatória
CA2543360A1 (en) 2003-10-24 2005-05-06 Joost A. Kolkman Ldl receptor class a and egf domain monomers and multimers
US20100028995A1 (en) 2004-02-23 2010-02-04 Anaphore, Inc. Tetranectin Trimerizing Polypeptides
AU2005287557B2 (en) 2004-09-21 2011-10-13 Biontech Ag Use of microproteins as tryptase inhibitors
ES2373832T3 (es) 2007-12-19 2012-02-09 Affibody Ab Polipéptido derivado de proteína a y capaz de unirse a pdgf.
NZ592591A (en) 2008-11-03 2012-04-27 Molecular Partners Ag Binding proteins comprising ankyrin repeast domains that inhibit the vegf-a receptor interaction
CA2772162C (en) 2009-08-27 2018-05-22 Covagen Ag Anti-il-17a fynomers and medical uses thereof
CN102711810B (zh) * 2009-11-30 2015-04-22 詹森生物科技公司 效应子功能已消除的抗体Fc区突变体
BR112012014417B1 (pt) 2009-12-14 2021-11-09 Scil Proteins Gmbh Proteínas ubiquitinas modificadas tendo uma atividade de ligação específica para o extradomínio b de fibronectina
AU2011263786B2 (en) 2010-06-08 2014-11-13 Astrazeneca Ab Tear lipocalin muteins binding IL-4 R alpha
BR112014011670B1 (pt) * 2011-11-16 2021-05-25 Adrenomed Ag anticorpo anti-adrenomedulina (adm) ou fragmento de anticorpo anti-adm ou um arcabouço de proteína não-igg anti-adm que se liga à adrenomedulina e formulação farmacêutica
PL3553084T3 (pl) * 2011-11-16 2023-04-17 Adrenomed Ag Przeciwciało przeciwko adrenomedulinie (adm) lub fragment przeciwciała przeciwko adm lub szkielet przeciwko adm inny niż ig do profilaktyki lub zmniejszania zaburzenia czynności narządu lub niewydolności narządu u pacjenta cierpiącego na przewlekłą lub ostrą chorobę lub ostry stan
US9140696B2 (en) * 2011-11-16 2015-09-22 Adrenomed Ag Anti-adrenomedullin (ADM) antibody or anti-ADM antibody fragment or anti-ADM non-IG scaffold for reducing the risk of mortality in a patient having a chronic or acute disease or acute condition
HRP20191771T1 (hr) 2011-11-16 2019-12-27 Adrenomed Ag Anti-adrenomedulin (adm) antitijelo ili fragment anti-adm antitijela ili anti-adm non-ig skela za uporabu u terapiji akutne bolesti ili akutnog stanja pacijenta za stabiliziranje cirkulacije
US11596699B2 (en) * 2016-04-29 2023-03-07 CureVac SE RNA encoding an antibody
KR20190120174A (ko) * 2016-12-16 2019-10-23 아드레노메드 아게 울혈의 중재 및 치료가 필요한 환자에서 울혈의 중재 및 치료에 사용하기 위한 항-아드레노메둘린 (ADM) 항체 또는 항-ADM 항체 단편 또는 항-ADM 비-Ig 스캐폴드

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015502930A (ja) 2011-11-16 2015-01-29 アドレノメト アクチェンゲゼルシャフト 慢性若しくは急性疾患又は急性病態に罹患している患者の死亡リスクを低減するための抗アドレノメデュリン（ＡＤＭ）抗体、抗ＡＤＭ抗体フラグメント又は抗ＡＤＭ非Ｉｇ足場
JP2016521351A (ja) 2013-03-20 2016-07-21 シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング 血圧降下治療をガイドするアドレノメジュリン

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
BLET, A. et al，Hemodynamics effects of adrecizumab in sepsis RAT，Intensive Care Medicine Experimental，2015年，Vol.3(Suppl.1)，A618
ClinicalTrials.gov[online]，2017年03月20日，検索日：２０２２年９月１日、URL:https://clinicaltrials.gov/ct2/history/NCT03083171?V_2=View#StudyPageTop
GEVEN, C. et al，Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects，Br J Clin Pharmacol，2018年06月01日，Vol.84，pp.2129-2141
GEVEN, C.B.C.A.G. et al，Safety, tolerability and pharmacokinetics/-dynamics of the anti-adrenomedullin antibody Adrecizumab: a first in man study，Intensive Care Medicine Experimental ，2017年09月20日，Vol.5(suppl.2):44，0427
KIERS, D. et al.，Characterization of a model of systemic inflammation in humans in vivo elicited by continuous infusion of endotoxin.，Sci. Rep.，2017年01月05日，Vol.7 Article Number:40149，p.1-10
MARINO, R. et al，Plasma adrenomedullin is associated with short-term mortality and vasopressor requirement in patients admitted with sepsis，Critical Care，2014年，Vol.18，R34
PRADHAN, S. et al，The role of C-reactive protein as a diagnostic predictor of sepsis in a multidisciplinary Intensive Care Unit of a tertiary care center in Nepal，Indian J Crit Care Med，2016年，Vol.20，pp.417-420
RAVI, V. et al，Correlation of Tumor Necrosis Factor Levels in the Serum adn Cerebrospinal Fluid With Clinical Outcome in Japanese Encephalitis Patients，Journal of Medical Virology，1997年，Vol.51，pp.132-136
SUZANA, M. A. et al，C-Reactive Protein Levels Correlate With Mortality and Organ Failure in Critically III Patients，CHEST，2003年，vol.123(6)，pp.2043-2049
THIELE, C. et al，Effects of a non-neutralizing humanized monoclonal anti-adrenomedullin antibody in a porcine two-hit model of hemorrhage and septic shock，Critical Care，2018年03月29日，Vol.22(Suppl.1):82，P107
WEBER, J. et al，Sandwich Immunoassay for Bioactive Plasma Adrenomedullin，JALM，2017年09月01日，pp.222-233
北村 和雄，アドレノメデュリンの展開研究，心臓，2013年，Vol.45，pp.1496-1502
小林和道，Patient-Centeredの促進に伴うPatient Reported Outcomeの新薬開発への適用に関する研究，医薬産業政策研究所 リサーチペーパー・シリーズ，2015年03月，No.64，pp.1-124， https://www.jpma.or.jp/opir/research/rs_064/pb1snq0000001178-att/pdf_article_064_01.pdf

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