JP7458981B2 - 抗体-薬物コンジュゲートとチューブリン阻害剤の組み合わせ - Google Patents
抗体-薬物コンジュゲートとチューブリン阻害剤の組み合わせ Download PDFInfo
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- JP7458981B2 JP7458981B2 JP2020535747A JP2020535747A JP7458981B2 JP 7458981 B2 JP7458981 B2 JP 7458981B2 JP 2020535747 A JP2020535747 A JP 2020535747A JP 2020535747 A JP2020535747 A JP 2020535747A JP 7458981 B2 JP7458981 B2 JP 7458981B2
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- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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| US20240261424A1 (en) * | 2020-03-30 | 2024-08-08 | National Cancer Center | Antibody drug conjugate |
| CA3195117A1 (en) * | 2020-10-09 | 2022-04-14 | Jerome Thomas Mettetal Ii | Combination of antibody-drug conjugate and parp1 selective inhibitor |
| WO2022099762A1 (zh) * | 2020-11-12 | 2022-05-19 | 博瑞生物医药(苏州)股份有限公司 | 一种抗体偶联物中间体及其制备方法 |
| JP7564958B2 (ja) * | 2020-12-18 | 2024-10-09 | シャンハイ フダン-チャンジャン バイオ-ファーマシューティカル カンパニー リミテッド | B7-h3を標的とする抗体薬物複合体、その製造方法と使用 |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| US20240392033A1 (en) * | 2021-08-24 | 2024-11-28 | Kunshan Xinyunda Biotech Co., Ltd. | Antibody-drug conjugate conjugated via breakable linker |
| AU2022347380A1 (en) * | 2021-09-15 | 2024-04-11 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate for use in methods of treating chemotherapy-resistant cancer |
| KR20250012631A (ko) * | 2022-05-24 | 2025-01-24 | 다이이찌 산쿄 가부시키가이샤 | 항-cdh6 항체-약물 접합체의 투약 |
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| KR20250173601A (ko) * | 2023-03-31 | 2025-12-10 | 다이이찌 산쿄 가부시키가이샤 | 항 CDH6 항체-약물 콘주게이트와 HIF-2α 저해제의 조합 |
| CN119546347A (zh) * | 2023-06-29 | 2025-02-28 | 石药集团巨石生物制药有限公司 | 抗体-药物偶联物及其用途 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014057687A1 (ja) | 2012-10-11 | 2014-04-17 | 第一三共株式会社 | 抗体-薬物コンジュゲート |
| WO2015098099A1 (ja) | 2013-12-25 | 2015-07-02 | 第一三共株式会社 | 抗trop2抗体-薬物コンジュゲート |
| WO2015115091A1 (ja) | 2014-01-31 | 2015-08-06 | 第一三共株式会社 | 抗her2抗体-薬物コンジュゲート |
| WO2015155998A1 (en) | 2014-04-10 | 2015-10-15 | Daiichi Sankyo Company, Limited | Anti-her3 antibody-drug conjugate |
| JP2017524364A (ja) | 2014-08-12 | 2017-08-31 | ノバルティス アーゲー | 抗cdh6抗体薬物コンジュゲート |
| US20170252458A1 (en) | 2016-03-02 | 2017-09-07 | Eisai Co., Ltd. | Eribulin-based antibody-drug conjugates and methods of use |
| WO2018135501A1 (ja) | 2017-01-17 | 2018-07-26 | 第一三共株式会社 | 抗gpr20抗体及び抗gpr20抗体-薬物コンジュゲート |
| JP2018520140A (ja) | 2015-06-25 | 2018-07-26 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | 抗hla‐drまたは抗trop‐2抗体と微小管阻害剤、parp阻害剤、ブルトンキナーゼ阻害剤またはホスホイノシチド3‐キナーゼ阻害剤との併用は癌の治療効果を有意に改善する |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| DK1071700T3 (da) | 1998-04-20 | 2010-06-07 | Glycart Biotechnology Ag | Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet |
| AU3672800A (en) | 1999-04-09 | 2000-11-14 | Kyowa Hakko Kogyo Co. Ltd. | Method for controlling the activity of immunologically functional molecule |
| KR100850389B1 (ko) | 1999-06-25 | 2008-08-04 | 제넨테크, 인크. | 인간화 항-ErbB2 항체 및 항-ErbB2 항체를 사용한치료 방법 |
| HU231090B1 (hu) | 2000-10-06 | 2020-07-28 | Kyowa Kirin Co., Ltd. | Antitest-kompozíciót termelő sejt |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| CA2486285C (en) | 2004-08-30 | 2017-03-07 | Viktor S. Goldmakher | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
| WO2006071441A2 (en) | 2004-11-30 | 2006-07-06 | Curagen Corporation | Antibodies directed to gpnmb and uses thereof |
| KR20150126978A (ko) | 2005-06-20 | 2015-11-13 | 피에스엠에이 디벨롭먼트 캄파니, 엘엘씨 | Psma 항체-약물 접합체 |
| AR056857A1 (es) | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos |
| CA2647632C (en) | 2006-03-27 | 2017-06-27 | University Of Maryland Biotechnology Institute | Glycoprotein synthesis and remodeling by enzymatic transglycosylation |
| HRP20131113T1 (hr) | 2007-02-16 | 2014-01-17 | Merrimack Pharmaceuticals, Inc. | Protutijela protiv erbb3 i njihova uporaba |
| SI2211904T1 (sl) | 2007-10-19 | 2016-12-30 | Seattle Genetics, Inc. | CD19 vezavna sredstva in njihove uporabe |
| AR076284A1 (es) | 2009-04-29 | 2011-06-01 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
| BR112014019825B1 (pt) | 2012-02-10 | 2021-08-24 | University Of Maryland, Baltimore | Glicoengenharia quimioenzimática de anticorpos e fragmentos fc dos mesmos |
| ES2782248T3 (es) | 2012-10-19 | 2020-09-11 | Daiichi Sankyo Co Ltd | Conjugado de anticuerpo y fármaco producido por la unión a través de un enlazador que tiene estructura hidrófila |
| CN103239455A (zh) | 2012-12-24 | 2013-08-14 | 苏州大学 | 有协同治疗效果和高载药量的多组分纳米药物的制备方法 |
| JP2017114763A (ja) | 2014-03-26 | 2017-06-29 | 第一三共株式会社 | 抗cd98抗体−薬物コンジュゲート |
| ES2754348T3 (es) | 2014-04-10 | 2020-04-17 | Daiichi Sankyo Co Ltd | Conjugado de (anticuerpo anti-HER2)-fármaco |
| EP3262071B8 (en) | 2014-09-23 | 2022-05-18 | F. Hoffmann-La Roche AG | Method of using anti-cd79b immunoconjugates |
| AU2016286898B2 (en) | 2015-06-29 | 2022-12-08 | Daiichi Sankyo Company, Limited | Method for selectively manufacturing antibody-drug conjugate |
| EP3349796A4 (en) | 2015-09-17 | 2019-05-29 | ImmunoGen, Inc. | THERAPEUTIC COMBINATIONS WITH ANTI-FOLR1 IMMUNOCONJUGATES |
| JP2018537536A (ja) | 2015-12-09 | 2018-12-20 | ナント ホールディングス アイピー エルエルシーNant Holdings IP, LLC | Her2陽性転移性乳癌の治療のための組成物および方法 |
| KR20250040100A (ko) | 2016-12-12 | 2025-03-21 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트와 면역 체크 포인트 저해제의 조합 |
| TW202532106A (zh) | 2017-05-15 | 2025-08-16 | 日商第一三共股份有限公司 | 抗體-藥物結合物之製造方法 |
| KR102816741B1 (ko) | 2017-08-31 | 2025-06-04 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트의 개량 제조 방법 |
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Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014057687A1 (ja) | 2012-10-11 | 2014-04-17 | 第一三共株式会社 | 抗体-薬物コンジュゲート |
| WO2015098099A1 (ja) | 2013-12-25 | 2015-07-02 | 第一三共株式会社 | 抗trop2抗体-薬物コンジュゲート |
| WO2015115091A1 (ja) | 2014-01-31 | 2015-08-06 | 第一三共株式会社 | 抗her2抗体-薬物コンジュゲート |
| WO2015155998A1 (en) | 2014-04-10 | 2015-10-15 | Daiichi Sankyo Company, Limited | Anti-her3 antibody-drug conjugate |
| JP2017524364A (ja) | 2014-08-12 | 2017-08-31 | ノバルティス アーゲー | 抗cdh6抗体薬物コンジュゲート |
| JP2018520140A (ja) | 2015-06-25 | 2018-07-26 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | 抗hla‐drまたは抗trop‐2抗体と微小管阻害剤、parp阻害剤、ブルトンキナーゼ阻害剤またはホスホイノシチド3‐キナーゼ阻害剤との併用は癌の治療効果を有意に改善する |
| US20170252458A1 (en) | 2016-03-02 | 2017-09-07 | Eisai Co., Ltd. | Eribulin-based antibody-drug conjugates and methods of use |
| WO2018135501A1 (ja) | 2017-01-17 | 2018-07-26 | 第一三共株式会社 | 抗gpr20抗体及び抗gpr20抗体-薬物コンジュゲート |
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| KR20210042120A (ko) | 2021-04-16 |
| AU2019320336A1 (en) | 2021-03-04 |
| CA3108754A1 (en) | 2020-02-13 |
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| EP3834843A1 (en) | 2021-06-16 |
| CN112512587A (zh) | 2021-03-16 |
| AU2025226765A1 (en) | 2025-09-25 |
| EP3834843A4 (en) | 2022-05-11 |
| WO2020031936A1 (ja) | 2020-02-13 |
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