JP7429688B2 - シールド剤およびそれらの使用 - Google Patents

シールド剤およびそれらの使用 Download PDF

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Publication number
JP7429688B2
JP7429688B2 JP2021515616A JP2021515616A JP7429688B2 JP 7429688 B2 JP7429688 B2 JP 7429688B2 JP 2021515616 A JP2021515616 A JP 2021515616A JP 2021515616 A JP2021515616 A JP 2021515616A JP 7429688 B2 JP7429688 B2 JP 7429688B2
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JP
Japan
Prior art keywords
cancer
compound
contrast agent
effective amount
agent conjugate
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JP2021515616A
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English (en)
Japanese (ja)
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JP2022501383A (ja
JP2022501383A5 (https=
Inventor
クリストファー・ポール・リーモン
イオンチョ・ラドスラヴォフ・ヴラホフ
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Endocyte Inc
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Endocyte Inc
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Publication of JP2022501383A5 publication Critical patent/JP2022501383A5/ja
Priority to JP2023204832A priority Critical patent/JP7748438B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2021515616A 2018-09-21 2019-09-19 シールド剤およびそれらの使用 Active JP7429688B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023204832A JP7748438B2 (ja) 2018-09-21 2023-12-04 シールド剤およびそれらの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862734690P 2018-09-21 2018-09-21
US62/734,690 2018-09-21
PCT/US2019/051903 WO2020061293A1 (en) 2018-09-21 2019-09-19 Shielding agents and their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023204832A Division JP7748438B2 (ja) 2018-09-21 2023-12-04 シールド剤およびそれらの使用

Publications (3)

Publication Number Publication Date
JP2022501383A JP2022501383A (ja) 2022-01-06
JP2022501383A5 JP2022501383A5 (https=) 2022-09-29
JP7429688B2 true JP7429688B2 (ja) 2024-02-08

Family

ID=69887812

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021515616A Active JP7429688B2 (ja) 2018-09-21 2019-09-19 シールド剤およびそれらの使用
JP2023204832A Active JP7748438B2 (ja) 2018-09-21 2023-12-04 シールド剤およびそれらの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023204832A Active JP7748438B2 (ja) 2018-09-21 2023-12-04 シールド剤およびそれらの使用

Country Status (5)

Country Link
US (1) US20210323985A1 (https=)
EP (1) EP3853213A4 (https=)
JP (2) JP7429688B2 (https=)
CN (1) CN113166087B (https=)
WO (1) WO2020061293A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201590783A1 (ru) * 2012-11-15 2015-11-30 Эндосайт, Инк. Конъюгаты для доставки лекарственных средств и способы лечения заболеваний, вызванных клетками, экспрессирующими psma
EP3533473A3 (en) 2013-11-14 2019-12-18 Endocyte, Inc. Compounds for positron emission tomography
CN112368024A (zh) 2018-04-17 2021-02-12 恩多塞特公司 治疗癌症的方法
CN114096264B (zh) 2019-05-20 2025-03-14 因多塞特股份有限公司 制备psma缀合物的方法
US20250332265A1 (en) * 2021-11-09 2025-10-30 Case Western Reserve University Psma targeted conjugate compounds and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170226141A1 (en) 2014-08-06 2017-08-10 The Johns Hopkins University Prodrugs of prostate specific membrane antigen (psma) inhibitor
JP2017530109A (ja) 2014-09-08 2017-10-12 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 前立腺癌についてのｐｓｍａを標的とした放射性核種治療中の臓器の保護
JP2020530007A (ja) 2017-04-11 2020-10-15 ザ・ジョンズ・ホプキンス・ユニバーシティ Ｐｓｍａ標的化ガンイメージングまたは放射線療法中の健康組織保護のための２−ｐｍｐａのプロドラッグ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2097111B1 (en) 2006-11-08 2015-07-15 Molecular Insight Pharmaceuticals, Inc. Heterodimers of glutamic acid
PL2187965T3 (pl) 2007-08-17 2020-05-18 Purdue Research Foundation Koniugaty wiążący psma ligand-łącznik i sposoby ich zastosowania
WO2012174136A1 (en) * 2011-06-15 2012-12-20 Cancer Targeted Technology Llc Chelated psma inhibitors
EA201590783A1 (ru) * 2012-11-15 2015-11-30 Эндосайт, Инк. Конъюгаты для доставки лекарственных средств и способы лечения заболеваний, вызванных клетками, экспрессирующими psma
EP3456700A1 (en) 2013-10-18 2019-03-20 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170226141A1 (en) 2014-08-06 2017-08-10 The Johns Hopkins University Prodrugs of prostate specific membrane antigen (psma) inhibitor
JP2017530109A (ja) 2014-09-08 2017-10-12 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 前立腺癌についてのｐｓｍａを標的とした放射性核種治療中の臓器の保護
JP2020530007A (ja) 2017-04-11 2020-10-15 ザ・ジョンズ・ホプキンス・ユニバーシティ Ｐｓｍａ標的化ガンイメージングまたは放射線療法中の健康組織保護のための２−ｐｍｐａのプロドラッグ

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Pavel Majer et al.，Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II(GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA)，Journal of Medicinal Chemistry，2016年，59巻，2810-2819頁
Theranostics，2016年，Vol.6, No.6, pp.849-861

Also Published As

Publication number Publication date
CN113166087A (zh) 2021-07-23
EP3853213A1 (en) 2021-07-28
EP3853213A4 (en) 2022-07-06
JP2024028840A (ja) 2024-03-05
US20210323985A1 (en) 2021-10-21
JP7748438B2 (ja) 2025-10-02
JP2022501383A (ja) 2022-01-06
WO2020061293A1 (en) 2020-03-26
CN113166087B (zh) 2024-05-10

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