JP7411709B2 - Oil-in-water emulsion composition - Google Patents

Description

The present invention not only improves the firmness and elasticity of the skin and provides an excellent feeling of use without stickiness, but also reduces nicotinic acid amide powdering after water evaporates, while providing an oil-in-water product with excellent emulsion stability. The present invention relates to a type emulsion composition.

Skin develops spots, wrinkles, sagging, pigmentation, etc. due to internal factors such as aging and stress, and external factors such as ultraviolet rays and dry air. Among these, many people want to improve morphological changes such as wrinkles and sagging, as they greatly affect the impression of appearance. Many drugs have been proposed to prevent and improve wrinkles and sagging. Among these, nicotinamide is a vitamin, is highly safe, and is known to have an anti-aging effect on the skin (Patent Documents 1 and 2). However, it is known that containing a large amount of nicotinic acid amide causes an undesirable feel during use, such as stickiness, and improvements have been made to this problem (Patent Document 3).

Japanese Patent Application Publication No. 10-130135 Japanese Patent Application Publication No. 10-1414 Special Publication No. 2003-502435

Patent Document 3, which attempts to suppress the stickiness of nicotinic acid amide, is a technique that contains both a branched chain hydrocarbon and a highly malleable oil such as a liquid ester emollient, but the effect was insufficient. However, when an oil-in-water emulsion composition was prepared, there was a problem that creaming occurred over time.
Furthermore, in a composition containing a large amount of nicotinic acid amide, when a volatile component such as water is blended, as the water evaporates, nicotinic acid amide precipitates as crystals, causing powder blowing. was newly discovered. This powdering of nicotinic acid amide occurred, for example, in areas where moisture evaporates over time, particularly around the mouth of the container and near the protrusion mechanism of the dispenser. When nicotinic acid amide powdering occurs around the mouth of the container, when the cosmetic is taken out from the mouth of the container, nicotinic acid amide crystals are mixed in, resulting in extremely poor usability. Furthermore, if nicotinamide powder occurs near the ejecting mechanism of the dispenser, it will become clogged within the mechanism, leading to the problem that the cosmetic cannot be ejected.

In view of these circumstances, the present inventors have conducted intensive research to solve the above problems, and have surprisingly found that when nicotinic acid amide is contained at a high concentration of 1 to 10% by mass, phospholipid It has been found that by simultaneously containing nicotinic acid amide and a polyhydric alcohol, crystal precipitation of nicotinic acid amide after water evaporation can be suppressed and powder blowing can be improved.
On top of that, it contains nicotinic acid amide at a high concentration of 1 to 10% by mass, and further contains 0.1 to 2% by mass of phospholipids, 0.02 to 1% by mass of a nonionic surfactant with an HLB of 7 or more, 25 An oil-in-water emulsion composition containing an oil agent that is liquid at ℃, 5 to 20% by mass of polyhydric alcohol, and water has an excellent effect on imparting firmness and elasticity to the skin, and has good emulsion stability over time. They found that the stickiness during use was reduced, and the powder blowing of nicotinic acid amide after water evaporation was further improved, and the present invention was completed.

That is, the present invention provides the following components (A) to (F):
(A) Nicotinic acid amide 1-10% by mass
(B) Phospholipid 0.1-2% by mass
(C) Nonionic surfactant with HLB of 7 or more 0.02 to 1% by mass
(D) Oil agent that is liquid at 25°C (E) Polyhydric alcohol 5-20% by mass
(F) An oil-in-water emulsion composition containing water is provided.

In the present invention, the component (C) may be one or more selected from polyoxyethylene castor oil, polyoxyethylene alkyl ether phosphoric acid, polyoxyethylene phytosterol ether, and polyoxyethylene cholesteryl ether.
The present invention may further contain component (G) a higher alcohol that is solid or semi-solid at 25°C.
In the present invention, the mass ratio (A)/((B)+(C)) of the component (A), component (B), and component (C) may be 1 to 10.
In the present invention, the content mass ratio (A)/((D)+(E)) of the component (A), component (D), and component (E) may be 0.05 to 0.5. .
The oil-in-water emulsion composition of the present invention may be used as a cosmetic or an external preparation for the skin.

The oil-in-water emulsion composition of the present invention improves skin firmness and elasticity, has good emulsion stability over time, and also improves stickiness during use and powdering of nicotinic acid amide after water evaporates. It is something that

The present invention will be explained in detail below. Note that in this specification, "~" means a range that includes the numbers before and after it. In addition, numerical values expressed in % are based on mass, unless otherwise specified.

Component (A): Nicotinic acid amide Component (A) nicotinic acid amide in the present invention is an amide compound of nicotinic acid (vitamin B3/niacin). Nicotinic acid amide is a water-soluble vitamin, a known substance that is one of the vitamin B group, and can be extracted from natural products (such as rice bran) or synthesized by known methods. Specifically, those listed in the 15th revised Japanese Pharmacopoeia 2008 can be used.

In the present invention, the content of component (A) is 1 to 10% by mass (hereinafter, "mass%" is simply abbreviated as "%") in order to improve the firmness and elasticity of the skin and suppress stickiness. ~10% is preferred, and 4-9% is particularly preferred. If the content of component (A) is less than 1%, the effect of imparting firmness and elasticity to the skin will not be excellent, and if it exceeds 10%, the product will be sticky during use and have a poor feel.

Component (B): Phospholipid Unless otherwise specified, the phospholipid component (B) used in the present invention has a central skeleton of glycerin or sphingosine, in which a fatty acid and phosphoric acid are bonded, and an alcohol is ester bonded to the phosphoric acid. It refers to something that has a structure. Fatty acids constituting phospholipids include saturated and unsaturated carboxylic acids having 7 to 22 carbon atoms. Alcohols constituting phospholipids often contain nitrogen, such as choline, ethanolamine, inositol, and serine. The present invention includes soybean lecithin extracted from natural soybeans and egg yolks, egg yolk lecithin and/or hydrogenated lecithin obtained by hydrogenating these (hydrogenated lecithin), hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, synthetic phospholipids, etc. Those commonly known as phospholipids can be used. More specifically, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylinositol, and the like can be preferably used. One type or two or more types can be used from among these.
Specifically, hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, hydrogenated phosphatidylcholine, hydrogenated phosphatidylserine, etc. may be mentioned, and lysophospholipids with one fatty acid group removed from phospholipids may also be used, which can be hydrogenated. It may also be a hydrogenated lysophospholipid. Examples of commercially available hydrogenated phospholipids include Resinol S-10, Resinol S-10EZ, Resinol S-10M, Resinol S-10EX, Resinol S-PIE (manufactured by Nikko Chemicals), and COATSOME NC-21 (NOF). Phospholipon 100H, Phospholipon 90H, Phospholipon 80H, Phospholipon 90G (manufactured by Phospholipid), etc. Examples of hydrogenated lysophospholipids include LP70H (manufactured by Nippon Fine Chemical Co., Ltd.), SLP-White LysoH, and SLP-LPC 70H (all manufactured by Tsuji Oil Co., Ltd.).

In the present invention, the content of component (B) is 0.1 to 2% from the viewpoint of improving skin firmness and elasticity, as well as improving stickiness and emulsion stability, and furthermore, 0.1%. ~1.5% is preferred, and 0.15~1% is more preferred. If the content of component (B) is less than 0.1%, the effect of imparting firmness and elasticity to the skin will not be excellent and emulsion stability will deteriorate. Moreover, when the content of component (B) exceeds 2%, the product becomes extremely sticky during use and has a poor feeling of use.

Component (C): Nonionic surfactant having an HLB of 7 or more The nonionic surfactant having an HLB of 7 or more as component (C) in the present invention is an important component for efficiently emulsifying oily components. When the HLB of the nonionic surfactant is less than 7, emulsion stability is not excellent and stickiness during use is large. For better emulsion stability, HLB is preferably 7 to 19, more preferably 8 to 18, particularly preferably 9 to 18.
Here, HLB (Hydphile-Lipophile Balance) in the present invention is an index indicating the balance between hydrophilicity and lipophilicity, and is calculated by the following (Formula 1) by Oda and Teramura et al.
HLB=(ΣInorganic value/ΣOrganic)×10...(Formula 1)
Here, ΣInorganic value/ΣOrganicity is called IOB (Inorganic-Organic balance), and is based on the "inorganic value" and "organic value" set for each type of atom and functional group. It can be calculated by integrating the "inorganic value" and "organic value" of atoms and functional groups that constitute organic compounds such as agents (Yoshio Koda, "Organic Concept Diagram - Basics and Applications", (See pages 11-17, published by Sankyo Publishing, 1984).
Nonionic surfactants having an HLB of 7 or more are not particularly limited, but specific examples include polyglyceryl fatty acid ester, polyoxyethylene castor oil, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, etc. polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glyceryl fatty acid ester such as polyoxyethylene glyceryl monooleate, polyoxyethylene glyceryl monoisostearate, polyethylene glycol fatty acid ester such as polyethylene glycol monoisostearate, polyoxyethylene alkyl Ether, polyoxyethylene alkyl ether phosphoric acid, polyoxypropylene alkyl ether, polyoxypropylene alkyl ether phosphoric acid, polyoxyethylene alkyl phenyl ether, polyoxyethylene phytostanol ether, polyoxyethylene phytosterol ether, polyoxyethylene cholestanol ether , polyoxyethylene cholesteryl ether, and polyoxyethylene-added nonionic surfactants such as polyoxyalkylene-modified organopolysiloxane, and one or more of these can be used. Among these, polyoxyethylene castor oil derivatives, polyoxyethylene alkyl ether phosphoric acid, polyoxyethylene phytosterol ether, polyoxyethylene One or more types selected from cholesteryl ether are preferable, and one or two or more types selected from polyoxyethylene phytosterol ether and polyoxyethylene cholesteryl ether are particularly more preferable.
Polyoxyethylene castor oil is a compound obtained by adding oxyethylene to castor oil or hydrogenated castor oil, or further adding a fatty acid (hereinafter, polyoxyethylene is referred to as POE, and the number in parentheses is , may indicate the average number of added moles of oxyethylene). Polyoxyethylene castor oil is not particularly limited as long as it has an HLB of 7 or more, but specifically, POE (10) hydrogenated castor oil, POE (20) hydrogenated castor oil, POE (30) hydrogenated castor oil. , POE (40) hydrogenated castor oil, POE (50) hydrogenated castor oil, POE (60) hydrogenated castor oil, POE (80) hydrogenated castor oil, POE (100) hydrogenated castor oil, monoisostearic acid POE (50) hydrogenated castor Examples include oils, and one or more of these can be appropriately selected and used depending on the purpose. From the viewpoint of further improving stickiness and maintaining better stability over time, it is preferable to select one with 20 to 50 moles of polyoxyethylene added, more preferably POE (40) hydrogenated castor oil, One or more types selected from monoisostearic acid POE (50) and hydrogenated castor oil.
Polyoxyethylene alkyl ether phosphoric acid is a triester compound of polyoxyethylene alkyl ether and phosphoric acid. Polyoxyethylene alkyl ether phosphoric acid is not particularly limited as long as it has an HLB of 7 or more, but the fatty acid chain length preferably ranges from 8 to 22 carbon atoms, more preferably from 10 to 18 carbon atoms. Note that the fatty acid may be either saturated or unsaturated, and may be linear or branched. The polyoxyethylene chain preferably ranges from 1 to 20, more preferably from 2 to 12. For example, polyoxyethylene lauryl ether phosphoric acid, polyoxyethylene myristyl ether phosphoric acid, polyoxyethylene cetyl ether phosphoric acid, polyoxyethylene stearyl ether phosphoric acid, polyoxyethylene oleyl ether phosphoric acid, polyoxyethylene behenyl ether phosphoric acid, Examples include polyoxyethylene alkyl (10-15) ether phosphoric acid, polyoxyethylene dialkyl (12-15) ether phosphoric acid, polyoxyethylene tricetyl ether phosphoric acid, polyoxyethylene tristearyl ether phosphoric acid, etc. They may be used alone or in combination of two or more. Among these, one or more selected from polyoxyethylene cetyl ether phosphoric acid and polyoxyethylene stearyl ether phosphoric acid are preferred in that they can further improve stickiness and maintain better stability over time. preferable.
Polyoxyethylene phytosterol ether and polyoxyethylene cholesteryl ether refer to compounds in which phytosterol and cholesterol are ether bonded to polyoxyethylene, respectively. Although not particularly limited as long as HLB is 7 or more, more specifically, polyoxyethylene phytosterol ethers include POE (5) phytosterol, POE (10) phytosterol, POE (20) phytosterol, POE (25) phytosterol, and Examples of polyoxyethylene cholesteryl ether include POE (10) cholesteryl ether, POE (15) cholesteryl ether, POE (20) cholesteryl ether, POE (24) cholesteryl ether, and POE (30) cholesteryl. Examples include ether, and these can be used alone or in combination of two or more, if necessary. Among these, POE (5) phytosterol, POE (10) phytosterol, POE (20) phytosterol, POE (25) phytosterol, POE can further improve stickiness and maintain better stability over time. One or more selected from (30) phytosterol, POE (10) cholesteryl ether, and POE (15) cholesteryl ether are preferred.

The content of component (C) is 0.02 to 1%, preferably 0.02 to 0.8%, more preferably 0.03 to 0.0%, from the viewpoint of improving stickiness and emulsion stability. .7%, more preferably 0.04 to 0.6%. If the content of component (C) is less than 0.02%, the effect of imparting firmness and elasticity to the skin will not be excellent and emulsion stability will deteriorate. Moreover, if the content of component (B) exceeds 1%, the product becomes extremely sticky during use and has a poor feeling of use.

Component (D): Oil that is liquid at 25°C In the present invention, the "liquid" of component (D), an oil that is liquid at 25°C, means that it is measured using a B-type viscometer (rotor No. 1) at 25°C and 1 atmosphere. Refers to a viscosity value of 7000 mPa·s or less when measured in 2). Oils that are liquid at 25°C are not particularly limited, and include volatile, non-volatile, animal oil, vegetable oil, synthetic oil, etc., regardless of origin, hydrocarbons, oils and fats, and ester oils that also contain ultraviolet absorbers. Examples include fatty acids, higher alcohols, silicone oils, fluorine oils, and lanolin derivatives.

Specifically, oils and fats such as olive oil, castor oil, mink oil, macadamian nut oil, avocado oil, and medufoam oil, jojoba oil, diisobutyl adipate, 2-hexyldecyl adipate, and di-2-heptyl adipate. Undecyl, alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol di-2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, trimethylol tri-2-ethylhexanoate Propane, pentaerythritol tetra-2-ethylhexanoate, cetyl 2-ethylhexanoate, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, triethyl citrate, 2-ethylhexyl succinate, stearic acid Isocetyl, butyl stearate, diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl lactate, myristyl lactate, isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, Pentaerythritol fatty acid ester, isononyl isononanoate, isotridecyl isononanoate, isopropyl myristate, isopropyl palmitate, 2-octyldodecyl myristate, 2-hexyldecyl myristate, myristyl myristate, hexyldecyl dimethyloctanoate, ethyl laurate, laurine Hexyl acid, 2-ethylhexyl methoxycinnamate, diisostearyl malate, glyceryl tri-2-ethylhexanoate, glyceryl tri(caprylic/capric) acid, glyceryl tricaprate, glyceryl triisostearate, diglyceryl diisostearate, tri Diglyceryl isostearate, diglyceryl tetraisostearate, decaglyceryl decaisostearate, glyceryl triisopalmitate, glyceryl trimyristate, diglyceryl isostearate myristate, tritridecyl trimellitate, N-lauroyl-L-glutamic acid-2- Esters such as octyldodecyl ester, N-lauroyl-L-glutamate di(phytostearyl/2-octyldodecyl), fatty acids such as isotearic acid and oleic acid, higher alcohols such as oleyl alcohol and isostearyl alcohol, acetic acid lanolin , lanolin fatty acid isopropyl, lanolin derivatives such as lanolin alcohol, polar oils such as low polymerization degree dimethylpolysiloxane, high polymerization degree dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, octamethylcyclotetrasiloxane, fluorine Silicone oils such as modified organopolysiloxane, fluorine oils such as perfluorodecane, perfluorooctane, perfluoropolyether, isododecane, isohexadecane, light liquid isoparaffin, liquid paraffin, heavy liquid isoparaffin, α-olefin oligomer , squalane, polyisobutylene, polybutene, and other hydrocarbons, and one or more of these can be used as required. These can be used alone or in combination of two or more, if necessary.

The content of component (D) in the cosmetic of the present invention is not particularly limited, but is preferably 0.1 to 20%, more preferably from the viewpoint of improving stickiness, improving emulsion stability, and suppressing powdering of nicotinic acid amide. is 0.5 to 10%, more preferably 1 to 5%.

Component (E): Polyhydric Alcohol The polyhydric alcohol of the component (E) in the present invention is a compound having two or more hydroxyl groups in the molecule. Component (E) is useful for improving skin firmness and elasticity, improving stickiness, improving emulsion stability over time, and suppressing nicotinic acid amide powdering. Component (E) specifically includes polypropylene glycols such as propylene glycol, dipropylene glycol, and tripropylene glycol, butylene glycols such as 1,3-butylene glycol and 1,4-butylene glycol, and 1,2-pentanediol. , pentanediol such as 1,3-pentanediol, polyglycerin such as glycerin, diglycerin, triglycerin, tetraglycerin, maltitose, maltitol, sucrose, fructose, mannitol containing three or more hydroxyl groups in the molecule. , xylitol, sorbitol, maltotriose, threitol, erythritol, polyethylene glycol, and glucose derivatives such as polyoxyalkylene alkyl glycoside, among which one or more can be appropriately selected and used. can. Among these, 1,3-butylene glycol and glycerin are preferred from the viewpoint of improving emulsion stability and suppressing nicotinic acid amide powdering during water evaporation.
The content of component (E) in the cosmetic of the present invention is 5 to 20% from the viewpoint of improving stickiness, improving emulsion stability over time, and further suppressing powdering of nicotinic acid amide during water evaporation. , 7 to 18% is preferable, and 10 to 18% is more preferable. When the content of component (E) is less than 5%, the emulsion stability over time deteriorates and it is not possible to suppress the powder blowing of nicotinic acid amide during water evaporation. When the content of component (E) exceeds 20%, the emulsion stability over time deteriorates and the emulsion becomes extremely sticky, resulting in poor usability.

Component (F): Water Component (F) water used in the present invention is included to form an oil-in-water emulsion composition, and is not particularly limited as long as it is commonly used in cosmetics. In addition to water, purified water, hot spring water, deep sea water, or steam-distilled water from plants may be used, and one or more of these may be appropriately selected and used as required. Further, the content is not particularly limited, and can be contained depending on the amount of other components as appropriate, and is preferably 30 to 90%.

Component (G): Higher alcohol that is solid or semi-solid at 25°C Component (G) in the present invention, which is solid or semi-solid at 25°C, is a formula that is solid or semi-solid at 25°C and 1 atm. It is a saturated or unsaturated straight chain or branched alcohol represented by ROH (R is an alkyl or alkenyl group). "Semi-solid" means a viscosity of 7000 when measured with a B-type viscometer (rotor No. 2) at 25°C and 1 atm.
Refers to those exceeding mPa・s. Component (G) is not an essential component, but its inclusion is preferable since it further improves emulsion stability. Component (G) is not particularly limited, but specifically includes cetyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol (1-docosanol), myristyl alcohol, cetostearyl alcohol, batyl alcohol, chimyl alcohol, cholesterol, and phytosterol. etc. Among these, stearyl alcohol, behenyl alcohol (1-docosanol), cetostearyl alcohol, cholesterol, and phytosterol are preferred because they make emulsion droplets finer and further improve emulsion stability.

The content of component (G) in the present invention is not particularly limited, but from the viewpoint of improving stickiness, improving emulsion stability over time, and suppressing nicotinic acid amide powdering during water evaporation, the content is from 0.005 to 0.005. 1% is preferred, 0.01 to 0.8% is more preferred, and 0.02 to 0.5% is even more preferred.

The oil-in-water emulsion composition of the present invention contains the above-mentioned components (A) to (F), and in some cases component (G) in a predetermined mass, so that it has an excellent effect of imparting firmness and elasticity to the skin, and improves skin elasticity over time. The emulsion stability is good, and stickiness during use and powder blowing caused by crystal precipitation of nicotinic acid amide after water evaporation is improved.

Here, from the viewpoint of suppressing powder blowing of nicotinic acid amide, the content mass ratio (A)/((B)+ (C)) is preferably 1 to 10, more preferably 2 to 9. In addition, in terms of suppressing powder blowing of nicotinic acid amide and reducing stickiness during use, the content mass ratio (A)/((D) + (E)) of component (A) and components (D) and (E) is It is preferably from 0.05 to 0.5, more preferably from 0.1 to 0.4.

The oil-in-water emulsion composition of the present invention can be produced without any particular limitations as long as it is a known emulsification method. Specific examples include a dispersion emulsification method, a phase inversion emulsification method, a phase inversion temperature emulsification method, and the like. In terms of obtaining an oil-in-water emulsion composition with excellent emulsion stability over time, a preferred production method is to exemplify components (B), (C), (E), and in some cases, component ( G), other oily components are heated and mixed, and then the heated component (D) is added and mixed to perform emulsification, and then components (A), (F), and in some cases, other oily components are added and mixed. Examples include a manufacturing method in which an aqueous component is added and mixed.

In addition to the above-mentioned components, the oil-in-water emulsion composition of the present invention contains optional components contained in ordinary cosmetics, such as lower alcohols, and ingredients other than component (E). Water-based components, oil-based components other than components (B), (D), and (G), powder, water-soluble polymers, film forming agents, surfactants other than component (C), oil-soluble gelling agents, organic modification It can contain clay minerals, resins, colorants, ultraviolet absorbers, preservatives, antibacterial agents, fragrances, antioxidants, pH adjusters, chelating agents, beauty ingredients, and the like.

The oil-in-water emulsion composition of the present invention can be made into various dosage forms by using it in combination with other ingredients. Specifically, it can be carried out in various dosage forms such as liquid, gel, paste, cream, and solid.

The oil-in-water emulsion composition of the present invention can be used as a cosmetic for various purposes. For example, skin care cosmetics such as lotion, emulsion, cream, serum, massage agent, pack agent, hand cream, body lotion, body cream, sunscreen, foundation, eye shadow, eye liner, mascara, eyebrow, concealer, lipstick. Examples include finishing cosmetics such as lip balms, hair mist, treatments, hair creams, and other hair cosmetics. Examples of how to use it include using it on your hands, fingers, cotton, and impregnating it into a nonwoven fabric.

The oil-in-water emulsion composition of the present invention can also be used as an external skin preparation. Examples include external liquids, external gels, creams, ointments, liniments, lotions, poultices, plasters, sprays, aerosols, and the like. Moreover, the method of use thereof can be mentioned in the same way as for the above-mentioned cosmetics.

The present invention will be described in more detail below with reference to Examples, but the present invention is not limited thereto. Unless otherwise specified, the content is expressed in mass % based on the system containing the component.

Examples 1 to 13, Comparative Examples 1 to 14: Oil-in-water emulsion compositions Oil-in-water emulsion compositions having the formulations shown in Tables 1 to 4 below were prepared, and the results showed skin firmness and elasticity, non-stickiness, and powdering. The absence of oxidation and emulsion stability were evaluated by the following methods. The results are also shown in Tables 1 to 4.

(Production method)
A: Components (7) to (15) and components (22) to (26) are uniformly dissolved and mixed at 70°C.
B: Components (16) to (21) are uniformly dissolved and mixed at 70°C.
C: Components (1) to (6) and components (27) to (32) are uniformly dissolved and mixed at 70°C.
D: Emulsification was performed by adding and mixing B to A, and then, after adding and mixing C, the mixture was cooled to 40° C. to obtain an oil-in-water emulsion composition.

(Evaluation item)
stomach. Skin firmness and elasticity. No stickiness c. No powder blowing. Emulsion stability

(Evaluation method)
[About A and B (sensory evaluation)]
A panel of 10 women in their 20s to 40s who have received training in sensory evaluation and can perform evaluations based on certain standards were selected. For each sample, a specialized panel evaluates the firmness, elasticity, and lack of stickiness of the skin when it is applied to the skin using the following absolute evaluation scale, and gives a score based on the total score of all the panel members. The average value was calculated and judged according to the following four-stage criteria.

(B. Evaluation of skin firmness and elasticity)
Absolute evaluation criteria (score): (evaluation)
6 points: I feel that my skin is very firm and elastic 5 points: I feel that my skin is firm and elastic 4 points: I feel that my skin is somewhat firm and elastic 3 points: Average 2 points: Not very firm・I don't feel that my skin has elasticity 1 point: I don't feel that my skin has firmness or elasticity 4-level evaluation criteria (Judgment): (Average score)
◎: More than 5 points: Very good ○: More than 3.5 points and 5 points or less: Good △: More than 2 points and 3.5 points or less: Slightly poor ×: 2 points or less: Poor

(B. Evaluation of stickiness)
Absolute evaluation criteria (score): (evaluation)
5 points: Does not feel sticky 4 points: Almost does not feel sticky 3 points: Feels slightly sticky 2 points: Feels sticky 1 point: Feels very sticky 4-level evaluation criteria (judgment): (average score)
◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points and 3 points or less: Slightly poor ×: 2 points or less: Poor

(C. Evaluation of lack of powder blowing)
Each sample (1 g/cm ² ) was applied to a plastic petri dish and heated in a high-temperature thermostat at 40°C for 24 hours to evaporate water. After that, check the state of the residue on the petri dish by touching it with your finger. Judgment was made using the following two-stage criteria.
Two-stage judgment criteria (judgment): (condition)
○: There is no feeling of a foreign body when touching the remaining material (no powdering): Good ×: There is a feeling of a foreign body when touching the remaining material (no powdering): Poor

(D. Evaluation of emulsion stability)
Each sample was stored in a constant temperature bath at 40° C. for 6 months, and the condition within 6 months was visually confirmed and judged according to the following criteria.
4-stage judgment criteria (Judgment): (Appearance condition)
◎: No change within 6 months: Very good ○: No creaming observed within 1 month,
Creaming is observed within 6 months: Good △: Creaming is not observed within 1 week, but
Creaming observed within 1 month: Slightly poor ×: Creaming observed within 1 week: Poor

As is clear from the results in Tables 1 to 4, the oil-in-water emulsion compositions of Examples 1 to 13 have better skin firmness and elasticity and less stickiness than the oil-in-water emulsion compositions of Comparative Examples 1 to 14. It was excellent in terms of stability, no powdering, and emulsion stability.
Furthermore, compared to Comparative Example 4 containing nicotinic acid amide, sodium ascorbate, and sodium metasilicate, which are ingredients excellent in "improving effect on skin firmness" and "improving effect on skin wrinkles" shown in Patent Document 2, When comparing Example 1, Example 1 was superior in all aspects of skin firmness and elasticity, no stickiness, no powdering, and emulsion stability.
Among them, it is surprising that Example 1 had excellent emulsion stability, and Comparative Example 3, which contained another water-soluble polar substance in place of component (A) nicotinic acid amide in Example 1, Regarding samples 4, 5, and 6, the emulsion stability deteriorated in all cases. Therefore, it was suggested that among water-soluble polar substances, nicotinic acid amide in particular can maintain good emulsion stability.

Example 14: Oil-in-water emulsified cream (ingredients) (%)
1.1,3-butylene glycol 12.0
2. Glycerin 5.0
3. Purified water remaining amount 4. Nicotinic acid amide 6.0
5. Sodium ascorbate 0.5
6. Sodium metasilicate 0.05
7. Hydrogenated lecithin (Note 1) 0.5
8. Hydrogenated lysolecithin (Note 3) 0.5
9. Polyoxyethylene sorbitan monooleate (20E.O.) (HLB=13.9)
0.5
10. Glyceryl tri(caprylic/capric) acid 2.0
11. Ceramide 2 0.1
12. Astaxanthin 0.1
13. Tocopherol 0.01
14. Cetostearyl alcohol 2.0
15. Behenyl alcohol 1.0
16. Glycerin monostearate 1.0
17. Methyl paraoxybenzoate 0.05
18. Carbomer 0.15
19. Xanthan gum 0.1
20. Sodium hydroxide 0.004
21. Fragrance 0.05
(Note 3) LP70H (manufactured by Nippon Fine Chemical Co., Ltd.)

(Production method)
A: Components (1) to (6) are uniformly dissolved and mixed at 70°C.
B: Components (7) to (16) are uniformly dissolved and mixed at 80°C.
C: Add B to A and emulsify at 70°C.
D: After adding and mixing components (17) to (21) to C, the mixture was cooled to 40°C to obtain an oil-in-water emulsion cream.

The oil-in-water emulsion cream of Example 14 was excellent in all aspects of skin firmness and elasticity, no stickiness, no powdering, and emulsion stability.

Example 15: Oil-in-water base
(Ingredients) (%)
1.1,3-butylene glycol 7.0
2. Dipropylene glycol 5.0
3. Triethanolamine 0.4
4. Purified water remaining amount 5. Nicotinic acid amide 6.0
6. Hydrogenated lecithin (Note 1) 0.4
7. Stearic acid 1.0
8. PEG-80 hydrogenated castor oil (HLB: 14.6) 0.2
9. Sorbitan sesquiisostearate (HLB: 4.5) 0.1
10. Cetyl 2-ethylhexanoate 2.0
11. Cetostearyl alcohol 0.3
12. Behenyl alcohol 0.5
13. Methyl paraoxybenzoate 0.02
14. Talc 0.4
15. Hydrous silica 0.1
16. Mica 1.3
17. Titanium oxide 6.0
18. Iron oxide 0.1
19. Acrylic acid/alkyl methacrylate copolymer (Note 2) 0.3
20. Xanthan gum 0.1
21. Sodium hydroxide 0.008
22. Glycine 0.01
23. Arginine 0.01
24. Fragrance 0.01

(Production method)
A: Components (1) to (5) are uniformly dissolved and mixed at 70°C.
B: Components (6) to (13) are uniformly dissolved and mixed at 80°C.
C: Add B to A and emulsify at 70°C.
D: After adding and mixing components (14) to (24) to C, the mixture was cooled to 40°C to obtain an oil-in-water base.

The oil-in-water base of Example 15 was excellent in all aspects of skin firmness and elasticity, no stickiness, no powdering, and emulsion stability.

Example 16: Oil-in-water serum
(Ingredients) (%)
1.1,3-butylene glycol 5.0
2. Glycerin 5.0
3. Purified water remaining amount 4. Nicotinic acid amide 6.0
5. Hydrogenated lecithin (Note 4) 0.4
6. Hydroxylated lecithin solution (Note 5) 0.2
7. Triceteareth 4-phosphate (HLB:10.5) 0.15
8. Squalane 5.0
9. Linoleic acid 0.05
10. Ceramide 3 0.1
11. Tocopherol 0.01
12. Cetostearyl alcohol 0.5
13. Oleyl alcohol 1.0
14. Methyl paraoxybenzoate 0.01
15. Carbomer 0.15
16. (Sodium acrylate/Na acryloyldimethyltaurine) copolymer solution (Note 6)
0.1
17. Sodium hydroxide 0.05
18. Ethanol 5.0
19. Sodium hyaluronate 0.01
20. Hydrolyzed hyaluronic acid 0.01
21. Hydrolyzed collagen 0.01
22. Glycosyltrehalose 0.1
23. Fragrance 0.1
(Note 4) Resinol S-10EZ (manufactured by Nikko Chemicals)
(Note 5) Resinol WS-50 (manufactured by Nikko Chemicals)
(Note 6) SIMULGEL EG (manufactured by SEPIC)

(Production method)
A: Components (1) to (4) are uniformly dissolved and mixed at 70°C.
B: Components (5) to (13) are uniformly dissolved and mixed at 80°C.
C: Add B to A and emulsify at 70°C.
D: After adding and mixing components (14) to (23) to C, the mixture was cooled to 40°C to obtain an oil-in-water serum.

The oil-in-water serum of Example 16 was excellent in all aspects of skin firmness and elasticity, no stickiness, no powdering, and emulsion stability.

Claims (9)

The following ingredients (A) to (F):
(A) Nicotinic acid amide 1-10% by mass
(B) Phospholipid 0.1-2% by mass
(C) Nonionic surfactant with HLB of 7 or more 0.02 to 1% by mass
(D) Oil agent that is liquid at 25°C (E) Polyhydric alcohol (However, component (B) is a phospholipid that corresponds to polyhydric alcohol; component (C) is a nonionic surfactant with an HLB of 7 or more. Among the agents, monoisostearic acid POE (50) hydrogenated castor oil; component (G) higher alcohols that are solid or semi-solid at 25°C, excluding polyhydric alcohols) 5 to 20% by mass
(F) Contains water;
The component (C) is one or two selected from monoisostearate POE (50), hydrogenated castor oil, a triester compound of polyoxyethylene alkyl ether and phosphoric acid, polyoxyethylene phytosterol ether, and polyoxyethylene cholesteryl ether. The above oil-in-water emulsion composition. The following ingredients (A) to (F):
(A) Nicotinic acid amide 1-10% by mass
(B) Phospholipid 0.1-2% by mass
(C) Nonionic surfactant with HLB of 7 or more 0.02 to 1% by mass
(D) Oil agent that is liquid at 25°C (E) Polyhydric alcohol (However, component (B) is a phospholipid that corresponds to polyhydric alcohol; component (C) is a nonionic surfactant with an HLB of 7 or more. Among the agents, POE monoisostearate (50) hydrogenated castor oil; component (C) among the nonionic surfactants with an HLB of 7 or more, polyoxyethylene sorbitan monooleate (20E.O.); component (G) (higher alcohols that are solid or semi-solid at 25°C, excluding polyhydric alcohols) 5-20% by mass
(F) Contains water;
The component (C) is monoisostearate POE (50), hydrogenated castor oil, a triester compound of polyoxyethylene alkyl ether and phosphoric acid, polyoxyethylene phytosterol ether, polyoxyethylene cholesteryl ether, and polyoxyethylene sorbitan monooleate. One or more types selected from (20E.O.),
When the component (C) contains polyoxyethylene sorbitan monooleate (20E.O.), the content mass ratio (A)/(( An oil-in-water emulsion composition in which D)+(E)) is 0.1 to 0.5. The oil-in-water emulsion composition according to claim 1 or 2, further comprising component (G) a higher alcohol that is solid or semi-solid at 25°C. The oil-in-water emulsion composition according to claim 3, wherein the content of the component (G) is 0.01 to 0.8% by mass. 5. The composition according to claim 1, wherein the content mass ratio (A)/((B)+(C)) of the component (A), component (B), and component (C) is 1 to 10. Oil-in-water emulsion composition. Any one of claims 1 to 5, wherein the content mass ratio (A)/((D)+(E)) of the component (A), component (D), and component (E) is 0.05 to 0.5. An oil-in-water emulsion composition described in Crab. The oil-in-water emulsion composition according to any one of claims 1 to 6, wherein the content of the component (D) is 0.5 to 10% by mass. The oil-in-water emulsion composition according to any one of claims 1 to 7, wherein the component (C) is one or more selected from polyoxyethylene phytosterol ether and polyoxyethylene cholesteryl ether. The oil-in-water emulsion composition according to any one of claims 1 to 8, which is a cosmetic or an external skin preparation.