JP7411549B2 - 組合された非侵襲的および低侵襲的な機械的エネルギ標的化 - Google Patents
組合された非侵襲的および低侵襲的な機械的エネルギ標的化 Download PDFInfo
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Description
超音波または衝撃波を用いる非侵襲的治療は、一般的に、たとえば腎臓結石および前立腺がんといったさまざまな疾患の治療に使用されている。それらは、機械的な波の供給源が治療対象の患者の身体の外部にあるため、処置が非侵襲的であると見なされ得るので、魅力的である。機械的エネルギ源を適切に設計することにより、通常は機械的な波を体内の治療の標的に収束させることができる。しかしながら、この技術には限界がある。たとえば、治療の標的の正確な位置を得ることは、使用する撮像方法の限界のために難しい場合がある。また、エネルギは、収束する波自体の物理的限界、および、波が伝播する先のさまざまな組織および器官内部の異質性のために、所望の標的位置に正確に収束しない場合がある。さらなる例では、標的におけるエネルギ密度が、所望の治療を達成するのに十分ではない場合がある。
第1の広範な局面によると、機械的な波を送って身体の血管内に存在する病変を治療するためのシステムが提供され、上記システムは、上記身体の外部から機械的な波を発生させるための外部機械的波源と、上記血管に挿入可能な波向装置とを備え、上記波向装置は、上記外部機械的波源によって発生した上記機械的な波を受け、標的方向に従って上記機械的な波を方向転換するためのものである。
別の実施形態において、上記波向装置は、上記外部機械的波源から受けた上記機械的な波を屈折させるように適合される。
一実施形態において、上記波向装置は、医用画像上で見える少なくとも1つのマーカを備える。
一実施形態において、上記放射線不透過性材料は、白金、金、タングステンのうちの1つと、それらの組合せと、上記白金、上記金および上記タングステンのうちの1つがドープされたポリマーとを備える。
別の実施形態において、上記波向装置は上記細長い部材と一体である。
別の広範な局面によると、病変を治療するための方法が提供され、上記方法は、波向装置を身体の血管に挿入することを備え、上記血管は治療対象の病変を備え、上記方法はさらに、上記波向装置を上記治療対象の病変に隣接して位置決めすることと、上記身体の外部に位置する外部機械的波源を用いて機械的な波を発生させ、上記機械的な波を上記波向装置に向けて伝播させることと、上記波向装置において、上記機械的な波を方向転換して上記治療対象の病変に集中させることとを備える。
別の実施形態において、上記機械的な波を方向転換するステップは、上記機械的な波を屈折させることを備え、上記波向装置は、上記外部機械的波源から受けた上記機械的な波を屈折させて集中させるように適合される。
一実施形態において、上記波向装置は、医用画像上で見える少なくとも1つのマーカを備える。
一実施形態において、上記放射線不透過性材料は、白金、金、タングステンのうちの1つと、それらの組合せと、上記白金、上記金および上記タングステンのうちの1つがドープされたポリマーとを備える。
別の実施形態において、上記波向装置は上記細長い部材と一体である。
本明細書において、機械的な波は、任意の振幅、持続時間、波形、周波数、および/またはその他を有する信号であると理解されねばならない。たとえば、機械的な波は、高/低振幅、短い/長い持続時間、異なる波形、および任意の周波数成分を有し得る。
なお、添付の図面を通して同様の特徴は同様の参照番号で特定される。
Claims (19)
- 高振幅かつ短持続時間のパルス化された機械的な波を送って身体の血管内に存在する病変を治療するためのシステムであって、
前記身体の外部から高振幅かつ短持続時間のパルス化された機械的な波を発生させ、かつ、前記高振幅かつ短持続時間のパルス化された機械的な波を身体を通って波向装置まで伝播させるために構成され、前記高振幅かつ短持続時間のパルス化された機械的な波は1MPaから1000MPaの間の振幅および1/fcの持続時間でありfcは20kHzと10MHzとの間の中心周波数である、外部機械的波源と、
前記血管に挿入可能な前記波向装置とを備え、前記波向装置は前記血管内で前記外部機械的波源に対してかつ前記病変に対して位置決め可能かつ方向付け可能であり、前記波向装置は、
前記外部機械的波源によって発生した前記高振幅かつ短持続時間のパルス化された機械的な波を受け、
標的方向に従った前記病変上の焦点に向けて前記高振幅かつ短持続時間のパルス化された機械的な波を方向転換かつ集中して、1MPaから1000MPaの間の振幅および1/fcの持続時間でありfcは20kHzと10MHzとの間の中心周波数である前記高振幅かつ短持続時間のパルス化された機械的な波を用いて前記病変を治療するために構成された、システム。 - 前記波向装置は、前記外部機械的波源から受けた前記高振幅かつ短持続時間のパルス化された機械的な波を前記病変上に反射するように適合される、請求項1に記載のシステム。
- 前記波向装置は、凹形状、球形状、半球形状、および放物線形状のうちの1つを有する少なくとも1つの部分を備える、請求項1に記載のシステム。
- 前記波向装置は、水の音響インピーダンスよりも大きい音響インピーダンスを有する反射材料で構成される、および被覆される、のうちの一方である、請求項2に記載のシステム。
- 前記波向装置は音響ミラーを備える、請求項2に記載のシステム。
- 前記波向装置は、前記外部機械的波源から受けた前記高振幅かつ短持続時間のパルス化された機械的な波を屈折させるように適合される、請求項1に記載のシステム。
- 前記波向装置は、水の音響インピーダンスとは異なる音響インピーダンスを有する材料で構成される、請求項6に記載のシステム。
- 前記波向装置は、前記高振幅かつ短持続時間のパルス化された機械的な波を屈折方向に従って屈折させるように、かつ、屈折した前記高振幅かつ短持続時間のパルス化された機械的な波を焦点に収束させるように適合される、請求項6に記載のシステム。
- 前記波向装置は、医用画像上で見える少なくとも1つのマーカを備える、請求項1に記載のシステム。
- 前記マーカは放射線不透過性材料で構成される、請求項9に記載のシステム。
- 前記波向装置は膨張可能なバルーンを備え、前記システムは、前記膨張可能なバルーンの内部に流体を注入して前記バルーンの形状を変化させるために前記膨張可能なバルーンに流体接続された流体源をさらに備える、請求項1に記載のシステム。
- 前記膨張可能なバルーンは音響レンズおよび音響ミラーのうちの一方として動作するように適合される、請求項11に記載のシステム。
- 細長い部材をさらに備え、前記波向装置は前記細長い部材に着脱可能にまたは一体に固定されている、請求項1に記載のシステム。
- 前記細長い部材はバルーンおよびカテーテルのうちの一方を備える、請求項13に記載のシステム。
- 前記波向装置が前記身体の前記血管に挿入されると前記波向装置の位置および向きのうちの少なくとも一方を追跡するための位置追跡装置をさらに備える、請求項1に記載のシステム。
- 前記位置追跡装置はX線撮像装置および超音波撮像装置のうちの一方を備える、請求項15に記載のシステム。
- 前記位置追跡装置は、前記波向装置によって反射された高振幅かつ短持続時間のパルス化された機械的な波を検出するための機械的波検出器を備え、前記波向装置の前記位置および前記向きのうちの前記少なくとも一方は、前記機械的波検出器によって検出された高振幅かつ短持続時間のパルス化された機械的な波の振幅、位相および遅延のうちの少なくとも1つに従って求められる、請求項15に記載のシステム。
- 前記波向装置は機械的エネルギを蓄積するまたは復帰させるための機械的な共振構造を備える、請求項1に記載のシステム。
- 前記波向装置は、前記外部機械的波源から受けた前記高振幅かつ短持続時間のパルス化された機械的な波を集中させるように適合される、請求項1に記載のシステム。
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PCT/IB2018/059831 WO2019111239A1 (en) | 2017-12-08 | 2018-12-10 | Combined non-invasive and minimally-invasive mechanical energy targeting |
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US11311454B2 (en) * | 2019-03-28 | 2022-04-26 | Softwave Tissue Regeneration Technologies, Llc | Handheld acoustic shock wave or pressure pulse application device and methods of use |
US10792054B1 (en) | 2019-07-11 | 2020-10-06 | Eduardo Lorenzo | Catheter for thromboembolic disease with mechanic waves, injection and ejection |
US20210171887A1 (en) * | 2019-11-11 | 2021-06-10 | Vivax Bio, Llc | Apparatus and method for levitational biofabrication of organ and tissue engineered constructs using tissue spheroids and magnetoacoustic bifield |
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JP3068730B2 (ja) * | 1993-06-03 | 2000-07-24 | アロカ株式会社 | 超音波治療装置 |
US5595178A (en) * | 1994-10-02 | 1997-01-21 | Hmt High Medical Technologies Gmbh | System, method and apparatus for treatment of degenerative bone |
US6022309A (en) * | 1996-04-24 | 2000-02-08 | The Regents Of The University Of California | Opto-acoustic thrombolysis |
WO2000000252A1 (en) * | 1998-06-30 | 2000-01-06 | Origin Medsystems, Inc. | Apparatus and method for inducing vibrations in a living body |
US20050070961A1 (en) * | 2003-07-15 | 2005-03-31 | Terumo Kabushiki Kaisha | Energy treatment apparatus |
US8750983B2 (en) * | 2004-09-20 | 2014-06-10 | P Tech, Llc | Therapeutic system |
ES2642785T3 (es) * | 2004-10-06 | 2017-11-20 | Guided Therapy Systems, L.L.C. | Sistema para tratamiento térmico controlado de tejido superficial humano |
EP1921976A2 (en) * | 2005-08-12 | 2008-05-21 | University of Washington | Method and apparatus for preparing organs and tissues for laparoscopic surgery |
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CN101683549B (zh) * | 2008-09-28 | 2012-07-11 | 重庆海扶(Hifu)技术有限公司 | 一种超声波发生装置及含有该装置的超声治疗系统 |
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US10322178B2 (en) * | 2013-08-09 | 2019-06-18 | The Trustees Of Columbia University In The City Of New York | Systems and methods for targeted drug delivery |
US10080906B2 (en) * | 2015-09-30 | 2018-09-25 | Btl Holdings Limited | Methods and devices for tissue treatment using mechanical stimulation and electromagnetic field |
US9974983B2 (en) * | 2015-11-12 | 2018-05-22 | SonaCare Medical, LLC | Tissue stabilization for therapeutic ultrasound |
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CN111491578A (zh) | 2020-08-04 |
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US20200383692A1 (en) | 2020-12-10 |
JP2021505271A (ja) | 2021-02-18 |
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