JP7409668B2 - Surface decontamination preparation - Google Patents

Description

Cross-reference of related applications

This is based on U.S. Provisional Patent Application Nos. 62/618,095, 62/618,096, 62/618,098, and 62/618,100, filed on January 17, 2018. and PCT International Patent Application No. 62/618,104. This application further claims priority to U.S. Nonprovisional Patent Application No. 16/209,960, filed on December 4, 2018, which is based on the PCT Application No. 16/209,960, filed on June 15, 2018. A continuation of International Patent Application No. PCT/US18/37817, which claims priority to U.S. Provisional Patent Application No. 62/520,372, filed June 15, 2017. . The disclosures of the above applications are herein incorporated by reference in their entirety.

The first need in decontamination is to facilitate the exposure of pathogens/agents/contaminants/toxins to the reactive mechanisms designed to defeat them. On the surface, this means
Requires inducing the ability to desorb a substance from a surface, or enabling hydraulic mobility (displacement) of a substance, or forcing a substance to become vulnerable to hydraulic pressure (dissolution).

Harmful substances can penetrate deeply into the reticular grain structure of microscopic surfaces and become difficult to displace. Simply using water or other solvents may not present a suitable physiochemical environment sufficient to overcome the forces that hold or shield the substance in place.

Embodiments of the invention are based on two basic patented products (DF-200 and An improved chemical formulation and method of administering SSDX-12) is described. These two products are standalone treatments for decontamination strategies. The combination of the two in concert with each other presents a unique approach to decontamination and disinfection strategies.

SSDX-12 is a high potency decontamination soap used specifically for the safe decontamination of aircraft. To achieve that claim, SSDX-12 was required to demonstrate corrosion resistance in aircraft metal alloys and sensitive equipment. Products were also required to remove chemical weapons residues to acceptable standards. While the products were demonstrably effective in treating target surfaces, the challenge of remediating the now dissolved and mobile chemical agents remained. In many situations, it is simply not permissible to rinse the treated product into the environment.

D7 Formula (hereinafter "D7" or "D7 Formula") is for treating surfaces contaminated with bacteria, viruses, mold, mildew, toxic industrial chemicals, chemical warfare agents, and other pathogenic and hazardous agents. It is a highly effective decontamination/disinfectant used in D7 has the ability to solubilize normally water-insoluble targets and expose them to chemical oxidation either directly or in the region of self-assembled micellar structures embodied in the formulation. Can facilitate rapid chemical remediation of threats.

In one example, the D7 formulation extends the technology to include both oxidation and reduction reactions. In addition, D7 incorporates the treatment of toxic industrial chemicals. This is also the first reference to bleach activators.

In another example, D7 extends into the area of mold, disinfection, and sterilization. Chemicals are not altered or modified. In fact, D7 is closest to the utility the product enjoys today.

Additionally, D7 advances the chemical landscape for DF-200. In addition, it incorporates response rate data for various toxic agents. This is also an improvement over the original DF-100 compared to its performance over mustard agents in terms of reaction time and specificity. In one embodiment, D7 also combines different bleach activators.

The synergy of effectiveness of these two decontamination strategies is a step forward in the state of the art of decontamination and surface remediation, providing much-needed improvements in these methods.

SSDX-12 achieves a physiochemical agent that is safe, environmentally harmless, and does not leave much regret behind, which can enable favorable conditions for the removal or deshielding of pathogens/drugs/contaminants/toxins. designed to. With the application of SSDX-12, the causative agent can be hydraulically removed or rendered vulnerable to hydraulic pressure.

In one example, SSDX-12 is C. sub. 8-22 oxidized alkyldimethylamine surfactant, C. sub. 6-12 oxidized alkyldimethylamine surfactant, C. sub. 8-18 alkyl polyethylene glycol sorbitan fatty ester surfactant, and C.8-18 alkyl polyethylene glycol sorbitan fatty ester surfactant; sub. Detergent compositions such as 12-14 secondary alcohol ethoxylate surfactants may be included. C. sub. The 8-18 alkyl polyethylene glycol sorbitan fatty ester surfactant is a C.I. sub. 8-18 Alkyl Polyethylene Glycol Sorbitan Fatty Ester Surfactant Contains from 0 to about 20 ethoxylate groups per molecule. C. sub. 12-14 Secondary alcohol ethoxylate surfactant is C.I. sub. 12-14 Secondary Alcohol Ethoxylate Surfactant Contains from about 14 to about 16 ethoxylate groups per molecule.

In yet another embodiment, a cleaning composition for cleaning the exterior surfaces of a vehicle is provided. The cleaning composition contains about 0.1% to about 5% C.I. sub. 8-16 oxidized alkyldimethylamine surfactant, from about 0.1% to about 5% by weight C.I. sub. 6-10 oxidized alkyldimethylamine surfactant, from about 0.1% to about 5% by weight C.I. sub. 10-14 polyethylene glycol sorbitan fatty ester surfactant, and C.I. sub. 12-14 Secondary Alcohol Ethoxylate Surfactant From about 0.1% to about 5% by weight of C.I. containing about 14 to about 16 ethoxylate groups per molecule. sub. Contains 12-14 secondary alcohol ethoxylate surfactants. C. sub. The 10-14 alkyl polyethylene glycol sorbitan fatty ester surfactant is a C.I. sub. 8-18 Alkyl polyethylene glycol sorbitan fatty ester surfactant containing from 0 to about 6 ethoxylate groups per molecule. C. sub. 12-14 Secondary alcohol ethoxylate surfactant is C.I. sub. 12-14 Secondary Alcohol Ethoxylate Surfactant Contains from about 14 to about 16 ethoxylate groups per molecule. C. sub. 8-16 oxidized alkyldimethylamine surfactant, C. sub. 6-10 oxidized alkyldimethylamine surfactant, C. sub. 10-14 alkyl polyethylene glycol sorbitan fatty ester surfactant, and C.I. sub. The 12-14 secondary alcohol ethoxylate surfactants are provided in a 1:1:1:1 ratio in the cleaning composition. The cleaning composition is effective for removing chemical warfare agents from the exterior surfaces of a vehicle after application thereto.

In one application, a method of cleaning the exterior surfaces of a vehicle using the cleaning composition described above may be applied. The method includes providing a cleaning composition, applying the cleaning composition to an exterior surface of a vehicle, and rinsing the exterior surface of the vehicle with water.

However, once displaced from its microscopic perch, the material can then be exposed to a reaction spectrum (photoelectric radiation, oxidation, chemical modification by external substances) that promotes its chemical transformation. In other words, the fact that SSDX-12 could be applied as a cleaning composition, for example to the surface of a vehicle, does not mean that the dissolution solution is non-toxic or environmentally friendly. That is, in this state, the toxin becomes highly vulnerable to natural forces, which promotes its inevitable fall towards its lowest energy state.

Concrete surfaces may appear solid from our perspective, but when viewed under a microscope, they can be composed of a complex network of channels. This is the same as a porous surface. Detailed investigation reveals mazes in many cases. Delivery of chemicals to this microscopic environment requires that its significant surface tension be overcome. Surface tension is a property of a liquid that defines how it spreads over a surface and how well it penetrates a surface. The unique formulation elements of D7 make it possible to obtain very low surface tension values at the surface. These values are not equilibrium values, but rather dynamic values. The turbulent solution created by the foaming that decomposes the hydrogen peroxide will continuously return to its original state at the leading edge of its penetration into the surface. These transient ultra-low surface tension values allow deeper penetration of the active chemicals embodied in D7. A cationic quaternary amine surfactant, combined with an alkaline pH carbonate buffer system, positions a pathway for more effective osmotic delivery of the complex cleaning chemicals embodied in D7. The product behaves in a manner similar to the mechanism behind hydraulic fracturing without high pressure pumps.

Alkaline carbonates (potassium based) interact primarily with negatively biased surfaces.

Quaternary amines strongly adsorb on their negatively biased surfaces.

Hydraulic channels are opened to allow delivery of cleaning power in the form of water, peroxide, and other formulated nonionic species.

D7 offers advantages over conventional technology in its ability to penetrate/eradicate biofilms over conventional forms. In one example, biofilms consist of a secreted chemical matrix that protects pathogen colonies from invading threats. These films have trophic, respiratory, and transpiration pathways, the exact nature of which is the subject of intense investigation. The physiochemical solution properties of D7 interact in such a way that their surfaces are efficiently and thoroughly disrupted. The solubility properties and oxidation from peroxide and peracetic acid species effectively "pry" open the surface of the film and, in some cases, help break down the functional pathways that lead to terminal failure. Biofilms effectively organize water in the secreted extracellular matrix, which is often destroyed by the D7 washing mechanism.

The D7 embodiment describes an improved chemical formulation designed for the decontamination, disinfection, and regeneration of surfaces exposed to chemical, biological, and toxic industrial contaminants and residues. This formulation advances the prior art by extending the efficacy spectrum, reducing processing time, modifying chemical properties, allowing for lower effective doses, and thereby expanding the table of chemical agents that can be remediated. Improve. The formulations described herein can also be applied at variable concentrations to achieve decontamination purposes (cleaning, decontamination, disinfection, high level disinfection, mold remediation, biofilm remediation, targeted decontamination).

It is the intent of this effort to target D7 embodiments to incremental variants designed to perform specific tasks. In one embodiment, aspects of the invention may be formulated with first generation versions of quaternary amines (ADBACs). It is believed that broadening the types of quaternary amines may provide benefits, either in efficacy against a broader range of pathogens or greater efficacy against biofilms. Of the two, biofilm efficacy is likely to be the outstanding value proposition.

Additionally, D7 provides a simple ingredient list. D7 is not made with foreign components. It is constructed from common, non-hazardous, and readily available materials. Their combination produces a net effect that is greater than the simple sum of each.

The physical properties embodied in D7 partly explain its success. Things like dynamic surface tension, critical micelle concentration, micelle aggregation number, solvolysis potential, and solution polarity all contribute to the puzzling behavior of D7.

One of the more compelling effects of D7 results from micelle formation. These micelles function as miniature reaction factories where toxic substances react with activated oxygen species to neutralize or render them harmless.

As a starting point, the application of D7 in response to biofilm problems is considered to be of valuable utility to customers. Breaking down the biofilm-protected bacterial colony virtually guarantees breaking down the prokaryotic bacteria themselves. A table of the efficacy of D7 on various organisms is shown below.

Observing the relationships of the quaternary generation, the following comparison is appropriate.

5th generation quaternary amine. This category is a mixture of 1st and 4th generation. When considering changes in different first generation chemistries along with fourth generation variants, innovation options can rapidly increase. In one embodiment, the D7 formulation comprises:

In one embodiment, the fifth generation surfactant and dimethyl dialkyl quaternary amine present an improved structure for the micelles developed in the D7 formulation.

These surfactants can modify the Gouy-Chapman-Stern layer to the point of improved and improved ability to more rapidly solubilize drugs into micelles.

In one example, the surfactant may modify the Gouy-Chapman-Stern layer, which may be related to the rate at which the drug is decontaminated, or the extent of its decontamination.

This embodiment of the invention may have different physical properties. The effectiveness profile of this version will also be different. The development of the efficacy profile should be from a diluted version, perhaps a 1:100 dilution of the final product, to the complete version. Diluted versions may be considered for surfaces that are already clean and free of biofilm. In one embodiment, concentrated versions may be considered for situations where gross fouling is more prevalent (live animal facilities, processing plants, places where biofilms are likely to be present). Various embodiments of the invention for different dilutions (bacteria, biofilm, spray effectiveness) may allow different levels of application in addition to that disclosed in FIG. 1.

This improvement over the prior art allows for the design of full-spectrum products that can address demanding cleaning and decontamination situations such as those encountered in food contact situations. In those situations, the product can be applied to the target surface, usually as a spray and wipe, distributing the cleaning/purification formulation over the entire surface. In one embodiment, aspects of the invention may require approval from a regulatory supervisory authority prior to use. In this case, this is commonly known as a "leave-in" product. There are legal limits on the labeling ingredients that are acceptable for this type of use. It is the embodied intention of this improvement to enable this type of use. The full strength version of the product is intended for use in highly compromised environments such as live animal housing where significant gross soiling is expected. This represents the other end of the product spectrum. Regulatory oversight is also a requirement for embodiments of pest control agents. It is anticipated that there will be many situations between these two extremes where strength controlled products meet needs. An example of such an aspect is given in the spectrum above.

In many cases, it is necessary to facilitate a more rapid transition to a less harmful state. Pathogens, toxic industrial chemicals, or other undesirable substances exist unchallenged in the surrounding environment except by their reactive agents common to their surroundings. Natural measures for the treatment of infestations include predation by organisms, hydrolysis by water, photolysis by electromagnetic radiation, absorption by substrates, and shielding of pathogens by environmental films, to name a few. If the pathogen is soluble in water, a simple rinse may be sufficient. The kinetic time frame of these effects can range from immediate to very long periods of slow transition. Delivery of reactive chemical activities in the form of oxidation or nucleophilic substitution is a well-known and effective processing strategy in general practice. This is the route by which many drugs deliver their effective doses. When a material is oxidized, it is generally more susceptible to environmental attenuation through one or more of the mechanisms described above. Delivering oxidative activity to a target is not always straightforward. For example, the use of bleach is a common method in many areas for disinfection and decontamination. Bleach is an aqueous solution and its ability to penetrate and engage pathogens is limited to the physiochemical barrier embodied on the substrate being treated. If the active killer cannot come into reactive proximity with the target pathogen, nothing will happen. For this reason, disinfection and decontamination agents are formulated with substances whose ability overcomes the physiochemical barriers of interfacial tension and surface energy to enable delivery of substances into reactive proximity. Additionally, substances that are not soluble in water may not be susceptible to reactions based on limited exposure to reactive conditions.

D7, as shown above, is a formulation that overcomes physiochemical barriers to deliver reactive oxidative species to pathogenic targets and, thanks to its design, aids in its ability to dissolve resistant agents, They are vulnerable there to oxidation by the mechanism embodied in D7. This new version of the formulation is an improvement over the previous version and represents a more robust and effective ability to perform decontamination/disinfection tasks. By changing the surfactant properties of the formulation, we can show faster decontamination times and a more complete breakdown of the protective pathogen layer, resulting in better purification results.

D7 is a decontamination agent that delivers chemical oxidative energy in a safe diluted form for the purpose of promoting the oxidation of toxins to less harmful or completely harmless decomposition products. D7 chemically processes toxins by promoting oxidation, thus accelerating the decontamination process. By itself, D7 would function to promote decontamination. Application of SSDX-12 before D7 improves the net effect by allowing displacement of the adsorbed material.

In one embodiment, a 30:1 equivalent dose ratio of D7 to SSDX-12 is desired to achieve a target result with proper properties and efficacy for surface decontamination.

The foregoing description and drawings merely describe and illustrate the invention, and the invention is not limited thereto. Although the specification has been described with reference to particular implementations or embodiments, many details are set forth for purposes of illustration. Accordingly, the foregoing is merely illustrative of the principles of the invention. For example, the invention may take other specific forms without departing from its spirit or essential characteristics. The arrangements described are illustrative and not limiting. It will be understood by those skilled in the art that the present invention is susceptible to additional implementations or embodiments, and that some of these details described in this application may be modified considerably without departing from the basic principles of the invention. . Thus, those skilled in the art may devise various arrangements not expressly described or illustrated herein, but which embody the principles of the invention and are therefore within its scope and spirit. You will understand what you can do.

Although various embodiments have been described above, it should be understood that such disclosure is presented by way of example only and not limitation. Accordingly, the breadth and scope of the present compositions and methods should not be limited by any of the exemplary embodiments described above, but should be defined only in accordance with the following claims and their equivalents. .

After having fully described the present compositions and methods herein, one of ordinary skill in the art will recognize that broad and equivalent ranges of conditions, formulations, and other parameters can be used without affecting those scopes or any embodiment thereof. You will understand that it can be implemented within. All cited patents, patent applications, and publications are fully incorporated by reference in their entirety.

Claims (1)

A chemical formulation consisting of a mixture of parts A, B and C and the formulation ,
The A part ranges from 0.1 to 4.00% of the A part , and includes 32% n-alkyl-(40% C12, 50% C14, 10% C16) dimethylbenzylammonium chloride, 24% 80% active ingredients consisting of -n-octyldecyldimethylammonium chloride, 12% di-n-octyldimethylammonium chloride and 12% di-n-decyldimethylammonium chloride;
N,N,N,N',N'-pentamethyl-N'-(tallowalkyl)-trimethylenediammonium dichloride (50% active ingredient) in the range of 0.05 to 2.00% of moiety A ;
glycol ether DB in the range of 0.4 to 1.60% of the A part ;
isobutanol in the range of 0.025 to 1.00% of part A ;
Propylene glycol in the range of 0.5 to 20.00% of part A ;
lauryl alcohol in the range of 0.02 to 0.80% of part A ;
potassium bicarbonate USP anhydrous in the range of 0.3 to 12.00% of Part A ;
Caustic potash in the range of 0.0425 to 1.70% of part A ;
Water in the range of 56.90 to 98.56% of part A ,
The B part contains hydrogen peroxide in a range of 0.2 to 8.00% of the B part ;
Water in the range of 99.8 to 85% of part B ,
The C portion contains a bleach accelerator in the range of 0.05 to 2.00% of the C portion ;
The formulation comprises a C _8-22 oxidized alkyl dimethylamine surfactant, a C _6-12 oxidized alkyl dimethyl amine surfactant, a C _8-18 alkyl polyethylene glycol sorbitan fatty ester surfactant, and a C _12-14 secondary Includes alcohol ethoxylate surfactants, among which C _8-18 alkyl polyethylene glycol sorbitan fatty ester surfactants contain 0 to 20 ethoxylate groups per C _8-18 alkyl polyethylene glycol sorbitan fatty ester surfactant molecule. The C _12-14 secondary alcohol ethoxylate surfactant contains 14 to 16 ethoxylate groups per C _12-14 secondary alcohol ethoxylate surfactant molecule;
A chemical formulation, characterized in that the ratio of the mixture of part A, part B, and part C to the preparation is 30:1.