JP7406263B2 - 改変アデノウイルス及びこれを含む医薬 - Google Patents

改変アデノウイルス及びこれを含む医薬 Download PDF

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JP7406263B2
JP7406263B2 JP2021507412A JP2021507412A JP7406263B2 JP 7406263 B2 JP7406263 B2 JP 7406263B2 JP 2021507412 A JP2021507412 A JP 2021507412A JP 2021507412 A JP2021507412 A JP 2021507412A JP 7406263 B2 JP7406263 B2 JP 7406263B2
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gene
adenovirus
cells
enhancer
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JPWO2020189749A1 (zh
JPWO2020189749A5 (zh
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史裕 東野
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Hokkaido University NUC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • A61K35/761Adenovirus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/50Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2021507412A 2019-03-20 2020-03-19 改変アデノウイルス及びこれを含む医薬 Active JP7406263B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019053895 2019-03-20
JP2019053895 2019-03-20
PCT/JP2020/012196 WO2020189749A1 (ja) 2019-03-20 2020-03-19 改変アデノウイルス及びこれを含む医薬

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JPWO2020189749A1 JPWO2020189749A1 (zh) 2020-09-24
JPWO2020189749A5 JPWO2020189749A5 (zh) 2022-03-10
JP7406263B2 true JP7406263B2 (ja) 2023-12-27

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US (1) US20220152133A1 (zh)
EP (1) EP3943113A4 (zh)
JP (1) JP7406263B2 (zh)
CN (1) CN113573741A (zh)
CA (1) CA3135295A1 (zh)
TW (1) TWI819203B (zh)
WO (1) WO2020189749A1 (zh)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002525063A (ja) 1998-09-10 2002-08-13 キャリドン,インコーポレイティド 細胞状態特異的反応エレメントを含むアデノウイルスベクター及びその使用方法
JP2016160249A (ja) 2015-03-05 2016-09-05 国立大学法人北海道大学 腫瘍溶解改変アデノウイルス、疾患治療用改変ウイルス及びこれらを含むウイルス製剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9017672B2 (en) * 2012-05-11 2015-04-28 Immunicum Aktiebolag Hexon Tat-PTD modified adenovirus and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002525063A (ja) 1998-09-10 2002-08-13 キャリドン,インコーポレイティド 細胞状態特異的反応エレメントを含むアデノウイルスベクター及びその使用方法
JP2016160249A (ja) 2015-03-05 2016-09-05 国立大学法人北海道大学 腫瘍溶解改変アデノウイルス、疾患治療用改変ウイルス及びこれらを含むウイルス製剤

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ELOIT M. et al.,Isogenic adenoviruses type 5 expressing or not expressing the E1A gene: efficiency as virus vectors in the vaccination of permissive and non-permissive species,Journal of General Virology,1995年,vol.76,p.1583-1589
HALBERT D. N. et al.,Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff,Journal of Virology,1985年,vol.56, no.1,p.250-257
HEARING P. et al.,The adenovirus type 5 E1A enhancer contains two functionally distinct domains: one is specific for E1A and the other modulates all early units in Cis,Cell,1986年,vol.45,p.229-236
MIKAWA Y. et al.,Conditionally replicative adenovirus controlled by the stabilization system of AU-rich elements containing mRNA,Cancers,2020年05月11日,vol.12,e.1205

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US20220152133A1 (en) 2022-05-19
TW202102677A (zh) 2021-01-16
WO2020189749A1 (ja) 2020-09-24
TWI819203B (zh) 2023-10-21
EP3943113A1 (en) 2022-01-26
JPWO2020189749A1 (zh) 2020-09-24
CN113573741A (zh) 2021-10-29
EP3943113A4 (en) 2023-05-10
CA3135295A1 (en) 2020-09-24

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