JP7387623B2 - 標的タンパク質を安定して発現できる組換えウイルス - Google Patents

標的タンパク質を安定して発現できる組換えウイルス Download PDF

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JP7387623B2
JP7387623B2 JP2020551267A JP2020551267A JP7387623B2 JP 7387623 B2 JP7387623 B2 JP 7387623B2 JP 2020551267 A JP2020551267 A JP 2020551267A JP 2020551267 A JP2020551267 A JP 2020551267A JP 7387623 B2 JP7387623 B2 JP 7387623B2
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gene
polynucleotide
recombinant virus
ehv
orf43
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JPWO2019179345A5 (https=
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JP2021518152A (ja
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グアンガン マー
セン ユアン
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ベーリンガー インゲルハイム フェトメディカ (チャイナ) カンパニー リミテッド
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2710/16011Herpesviridae
    • C12N2710/16711Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
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    • C12N2770/32011Picornaviridae
    • C12N2770/32111Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32121Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32111Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2770/32011Picornaviridae
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    • C12N2770/32123Virus like particles [VLP]
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    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32111Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2020551267A 2018-03-19 2019-03-14 標的タンパク質を安定して発現できる組換えウイルス Active JP7387623B2 (ja)

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CN2018079410 2018-03-19
CNPCT/CN2018/079410 2018-03-19
PCT/CN2019/078057 WO2019179345A1 (en) 2018-03-19 2019-03-14 Recombinant virus capable of stably expressing target proteins

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JP2021518152A JP2021518152A (ja) 2021-08-02
JPWO2019179345A5 JPWO2019179345A5 (https=) 2022-03-17
JP2021518152A5 JP2021518152A5 (https=) 2022-03-17
JP7387623B2 true JP7387623B2 (ja) 2023-11-28

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US (1) US11904010B2 (https=)
EP (1) EP3768831A4 (https=)
JP (1) JP7387623B2 (https=)
KR (1) KR102785418B1 (https=)
CN (1) CN111902535B (https=)
AU (1) AU2019237413C1 (https=)
CA (1) CA3094416A1 (https=)
MX (1) MX2020009720A (https=)
WO (1) WO2019179345A1 (https=)

Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
CA3094416A1 (en) * 2018-03-19 2019-09-26 Boehringer Ingelheim Vetmedica (China) Co., Ltd. Recombinant virus capable of stably expressing target proteins
CA3162622A1 (en) * 2019-11-25 2021-06-03 Baylor College Of Medicine Selective expansion of gene-targeted cells
CN112430625B (zh) * 2020-11-23 2022-08-05 武汉枢密脑科学技术有限公司 含有变异猪伪狂犬病病毒gD蛋白基因的重组腺相关病毒转移载体、病毒及其制备和应用

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN107723281A (zh) 2017-09-09 2018-02-23 中国农业科学院哈尔滨兽医研究所 表达猪圆环病毒2型Cap蛋白的重组猪瘟兔化弱毒疫苗株及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4110962A1 (de) * 1991-04-05 1992-10-08 Bayer Ag Equine herpesviren (ehv), die fremd-dna enthalten, verfahren zu ihrer herstellung und ihre verwendung in impfstoffen
MX9206981A (es) * 1991-12-06 1994-08-31 Whitehead Biomedical Inst Vacunas de recombinantes y metodo para producirlas.
GB9927353D0 (en) * 1999-11-19 2000-01-19 Cantab Pharma Res Virus preparation and use
EP2468768A3 (en) * 2005-07-21 2012-10-31 Abbott Laboratories Multiple gene expression including sorf contructs and methods with polyproteins, pro-proteins, and proteolysis
BRPI0618441B8 (pt) * 2005-11-10 2021-07-27 Genvec Inc vetor adenoviral
CN101444622A (zh) * 2008-06-06 2009-06-03 中国人民解放军军事医学科学院军事兽医研究所 以猪伪狂犬病病毒为载体的日本血吸虫基因重组活疫苗生产工艺及制品
RU2546247C2 (ru) 2013-06-06 2015-04-10 Автономная некоммерческая организация "Научно-исследовательский институт диагностики и профилактики болезней человека и животных" (АНО "НИИ ДПБ") Вакцина против чумы, аденовирусных инфекций, парвовирусного и коронавирусного энтеритов, лептоспироза и бешенства собак
MA42640B1 (fr) * 2015-11-23 2021-06-30 Merial Inc Protéines de fusion de dmdv et e2 et leurs utilisations
EA202092164A1 (ru) * 2018-03-19 2021-02-10 Бёрингер Ингельхайм Ветмедика Гмбх Новый ehv с инактивированным ul18 и/или ul8
CA3094416A1 (en) * 2018-03-19 2019-09-26 Boehringer Ingelheim Vetmedica (China) Co., Ltd. Recombinant virus capable of stably expressing target proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107723281A (zh) 2017-09-09 2018-02-23 中国农业科学院哈尔滨兽医研究所 表达猪圆环病毒2型Cap蛋白的重组猪瘟兔化弱毒疫苗株及其应用

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AIDS Research and Human Retroviruses,2010年,Vol. 26,p.A-122,P19.09,DOI: 10.1089/aid.2010.9998
Antiviral Research,2012年,Vol. 96,p.288-295,DOI: 10.1016/j.antiviral.2012.09.019
Archives of Virology,2010年,Vol. 155,p.723-731,DOI: 10.1007/s00705-010-0648-6
Journal of Biotechnology,2006年,Vol. 123,p.13-21,DOI: 10.1016/j.jbiotec.2005.10.022
Journal of Virology,2003年,Vol. 77,p.5598-5606,DOI: 10.1128/jvi.77.10.5598-5606.2003

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Publication number Publication date
US11904010B2 (en) 2024-02-20
CN111902535A (zh) 2020-11-06
EP3768831A4 (en) 2022-01-05
MX2020009720A (es) 2021-01-08
AU2019237413B2 (en) 2025-08-07
AU2019237413A1 (en) 2020-09-24
US20210353734A1 (en) 2021-11-18
KR20200135412A (ko) 2020-12-02
CA3094416A1 (en) 2019-09-26
RU2020133457A (ru) 2022-04-19
CN111902535B (zh) 2024-08-27
WO2019179345A1 (en) 2019-09-26
EP3768831A1 (en) 2021-01-27
KR102785418B1 (ko) 2025-03-26
JP2021518152A (ja) 2021-08-02
AU2019237413C1 (en) 2025-10-30

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