JP7386174B2 - Ｈｅｒ２エクソン１９変異を有するがん細胞に対する抗腫瘍活性を有する化合物 - Google Patents

Ｈｅｒ２エクソン１９変異を有するがん細胞に対する抗腫瘍活性を有する化合物 Download PDF

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JP7386174B2
JP7386174B2 JP2020551912A JP2020551912A JP7386174B2 JP 7386174 B2 JP7386174 B2 JP 7386174B2 JP 2020551912 A JP2020551912 A JP 2020551912A JP 2020551912 A JP2020551912 A JP 2020551912A JP 7386174 B2 JP7386174 B2 JP 7386174B2
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her2
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ジャクリーン ロビショー
ジョン ブイ． ヘイマッハ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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JP2020551912A 2018-03-27 2019-03-27 Ｈｅｒ２エクソン１９変異を有するがん細胞に対する抗腫瘍活性を有する化合物 Active JP7386174B2 (ja)

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US201862648629P 2018-03-27 2018-03-27
US62/648,629 2018-03-27
US201862688049P 2018-06-21 2018-06-21
US62/688,049 2018-06-21
PCT/US2019/024353 WO2019191279A2 (en) 2018-03-27 2019-03-27 Compounds with anti-tumor activity against cancer cells bearing her2 exon 19 mutations

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JP2021519306A JP2021519306A (ja) 2021-08-10
JP2021519306A5 JP2021519306A5 (enExample) 2022-04-01
JP7386174B2 true JP7386174B2 (ja) 2023-11-24

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US (1) US20210361655A1 (enExample)
EP (1) EP3773551B1 (enExample)
JP (1) JP7386174B2 (enExample)
KR (1) KR102899689B1 (enExample)
CN (1) CN112088000A (enExample)
AU (1) AU2019243738B2 (enExample)
BR (1) BR112020019251A2 (enExample)
CA (1) CA3094108A1 (enExample)
IL (1) IL277373A (enExample)
MX (1) MX2020010121A (enExample)
PH (1) PH12020551495A1 (enExample)
RU (1) RU2020134932A (enExample)
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KR20210107023A (ko) * 2018-12-21 2021-08-31 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 암 치료를 위한 조합 요법
US20220143023A1 (en) * 2019-03-29 2022-05-12 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 insertions
US12629375B2 (en) 2019-03-29 2026-05-19 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing HER2 exon 21 insertions
JP7709384B2 (ja) * 2019-04-17 2025-07-16 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム チロシンキナーゼ阻害剤耐性ｅｇｆｒ変異を有するがんに対する化合物

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RU2020134932A (ru) 2022-04-27
BR112020019251A2 (pt) 2021-01-12
EP3773551B1 (en) 2024-10-16
US20210361655A1 (en) 2021-11-25
KR102899689B1 (ko) 2025-12-12
CN112088000A (zh) 2020-12-15
KR20200136417A (ko) 2020-12-07
AU2019243738A1 (en) 2020-10-08
AU2019243738B2 (en) 2024-05-30
WO2019191279A2 (en) 2019-10-03
JP2021519306A (ja) 2021-08-10
WO2019191279A3 (en) 2019-11-07
IL277373A (en) 2020-11-30
PH12020551495A1 (en) 2021-09-01
MX2020010121A (es) 2021-01-08
EP3773551A4 (en) 2022-03-23
SG11202009498RA (en) 2020-10-29
EP3773551A2 (en) 2021-02-17
CA3094108A1 (en) 2019-10-03

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