JP7383717B2 - 保存剤系およびそれらを含む組成物 - Google Patents
保存剤系およびそれらを含む組成物 Download PDFInfo
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- JP7383717B2 JP7383717B2 JP2021547711A JP2021547711A JP7383717B2 JP 7383717 B2 JP7383717 B2 JP 7383717B2 JP 2021547711 A JP2021547711 A JP 2021547711A JP 2021547711 A JP2021547711 A JP 2021547711A JP 7383717 B2 JP7383717 B2 JP 7383717B2
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- 239000000203 mixture Substances 0.000 title claims description 117
- 230000002335 preservative effect Effects 0.000 title claims description 29
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- KQTIIICEAUMSDG-UHFFFAOYSA-N tricarballylic acid Chemical compound OC(=O)CC(C(O)=O)CC(O)=O KQTIIICEAUMSDG-UHFFFAOYSA-N 0.000 claims description 17
- 239000013543 active substance Substances 0.000 claims description 14
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- SMVRDGHCVNAOIN-UHFFFAOYSA-L disodium;1-dodecoxydodecane;sulfate Chemical group [Na+].[Na+].[O-]S([O-])(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC SMVRDGHCVNAOIN-UHFFFAOYSA-L 0.000 description 4
- 239000003974 emollient agent Substances 0.000 description 4
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- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 4
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 3
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- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
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- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
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- 125000004432 carbon atom Chemical group C* 0.000 description 2
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- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 description 2
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- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
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- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
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- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
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- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 description 1
- ISDGWTZFJKFKMO-UHFFFAOYSA-N 2-phenyl-1,3-dioxane-4,6-dione Chemical class O1C(=O)CC(=O)OC1C1=CC=CC=C1 ISDGWTZFJKFKMO-UHFFFAOYSA-N 0.000 description 1
- 229940100484 5-chloro-2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical class OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
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- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
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- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
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- 125000000217 alkyl group Chemical group 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
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- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical class NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 1
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- YSJGOMATDFSEED-UHFFFAOYSA-M behentrimonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[N+](C)(C)C YSJGOMATDFSEED-UHFFFAOYSA-M 0.000 description 1
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- NZZIMKJIVMHWJC-UHFFFAOYSA-N dibenzoylmethane Chemical class C=1C=CC=CC=1C(=O)CC(=O)C1=CC=CC=C1 NZZIMKJIVMHWJC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A61Q1/02—Preparations containing skin colorants, e.g. pigments
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- A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
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- A—HUMAN NECESSITIES
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- A61Q1/02—Preparations containing skin colorants, e.g. pigments
- A61Q1/10—Preparations containing skin colorants, e.g. pigments for eyes, e.g. eyeliner, mascara
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
パーソナルケア組成物が口腔ケアのために送達される場合、パーソナルケア組成物は、研磨剤、増粘剤、保湿剤または経口的に許容される界面活性剤であり得る、化粧品として許容される基剤を含む。製品は、軟膏、ゲル、歯磨き剤またはマウスウォッシュの形態で送達され得る。
本発明の別の好ましい態様によれば、組成物は、ヘアケアのために使用され得る。これを送達し得る1つの媒体がシャンプーの媒体である。本発明の組成物、特にシャンプーは、アニオン性界面活性剤、例えば、アルキルサルフェートおよび/またはエトキシル化アルキルサルフェート界面活性剤とともに製剤化される。これらのアニオン性界面活性剤は、1~20%、好ましくは2~16%のレベルで存在するのが好ましい。好ましいアルキルサルフェートは、好ましくはナトリウム、カリウム、アンモニウムまたは置換アンモニウムなどの可溶化カチオンとの塩の形態のC8~18アルキルサルフェート、さらに好ましくはC12~18アルキルサルフェートである。好ましいエトキシル化アルキルサルフェートアニオン性界面活性剤は、ナトリウムラウリルエーテルサルフェート(SLES)である。0.5~3、好ましくは1~3の平均エトキシル化度を有するSLESが特に好ましい。本発明の組成物は、両性界面活性剤、好ましくはベタイン界面活性剤、好ましくはアルキルアミドプロピルベタイン界面活性剤、例えばコカミドプロピルベタインをさらに含むことが好ましい。好ましい実施形態では、組成物は、0.1~10重量%のベタイン界面活性剤を含む。
本発明の組成物は、スキンケアに使用され得る。スキンケア組成物は、皮膚に局所塗布するのに適したトナー、ローション、クリーム、ムース、スクラブ、セラムまたはゲルを含む任意の形態であり得る。組成物は、スキンローション、クリーム、制汗剤、デオドラント、リップスティック、ファンデーション、マスカラ、サンレスタナーおよび日焼け止めローションなどのリーブオン製品であり得る。スキンケア組成物は、一般に、共溶媒として作用するエモリエントオイルを含む。好適なエモリエントオイルには、例えば、アルコキシル化芳香族アルコールと脂肪カルボン酸とのエステル、ポリグリコールまたはジオールと脂肪カルボン酸とのエステル、例えば、カプリル酸/カプリン酸トリグリセリド、脂肪アルコールと脂肪酸とのエステル、ベンジルアルコールのアルコキシル化誘導体およびそれらの混合物が含まれる。好ましくは、エモリエントオイルはカプリル酸/カプリン酸トリグリセリドである。
本発明の保存剤系は、好ましくは、皮膚洗浄組成物に含まれる。数秒から数分程度と塗布時間が短く、その後、組成物が水ですすぎ落とされるか、拭き取られる場合、そのような組成物は、皮膚洗浄組成物またはウォッシュオフ組成物として知られている。そのような組成物には、外観、洗浄、臭気制御または一般的な美観も改善するために人体に塗布される任意の製品が含まれる。本発明の皮膚洗浄用組成物は、液体、ローション、クリーム、フォーム、スクラブ、ゲル、バー、手洗い製品、洗顔製品または身体洗浄製品の形態であり得る。
単独および混合物中の阻害性抗微生物剤の様々な挙動は、部分濃度および部分阻害濃度(FIC)の概念を使用して広く研究されてきた。例えば、JRW Lambert and R Lambert,J.Appl.Microbiol 95,734(2003);T.Jadavji,CG Prober and R Cheung,Antimicrobial Agents and Chemotherapy 26,91(1984)、および国際公開第2004/006876号を参照されたい。これらのパラメーターは、以下のように定義することができる:
FC(成分a)=混合物中の試験した成分aの濃度/MIC(単一活性物質として試験した成分a)
FIC(成分a)=MIC(混合物中の試験した成分a)/MIC(単一活性物質として試験した成分a)
抗微生物剤間の相互作用は、組合せの効果が、単独で試験した場合の個々の成分の同じ総濃度に対して得られるものと同等であるか、それよりも大きいか、それよりも小さいかに応じて、相加的であり得るか、相乗的であり得るか、場合により拮抗的であり得る。
ΣFIC=FIC(成分1)+FIC(成分2)
その結果:
ΣFIC≧1は、相加的または拮抗的な活性に対応する
ΣFIC<1は相乗的な活性に対応する
同等の方法には、Kull,F.C.;Eisman,P.C.;Sylwestrowicz,H.D.and Mayer,R.L.,in Applied Microbiology 9:538-541(1961)によって記載された工業的に許容された方法である相乗効果指数(SI)の計算がある。
Claims (4)
- (a)ベンズヒドロキサム酸またはトリカルバリル酸から選択される第2の活性物質と組み合わせて安息香酸ナトリウムを含む保存剤系と、
(b)界面活性剤と、
を含む組成物であって、
前記第2の活性物質がベンズヒドロキサム酸である場合、前記第2の活性物質と安息香酸ナトリウムとの重量比が1:8~1:2の範囲であり、
前記第2の活性物質がトリカルバリル酸である場合、前記第2の活性物質と安息香酸ナトリウムとの重量比が1:8~4:1の範囲であり、
前記組成物がパーソナルクレンジング組成物である、組成物。 - 前記組成物の重量の0.01~5%の前記保存剤系を含む、請求項1に記載の組成物。
- 前記組成物のpHが3.5よりも高く11.0未満である、請求項1または2のいずれか一項に記載の組成物。
- 前記安息香酸ナトリウムおよび前記第2の活性物質が、保存される前記組成物に加えられる前に予備混合される、請求項1から3のいずれか一項に記載の組成物を保存する方法。
Applications Claiming Priority (3)
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EP19157769.1 | 2019-02-18 | ||
EP19157769 | 2019-02-18 | ||
PCT/EP2020/053226 WO2020169372A1 (en) | 2019-02-18 | 2020-02-10 | Preservative systems and compositions comprising them |
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JP2022521189A JP2022521189A (ja) | 2022-04-06 |
JP7383717B2 true JP7383717B2 (ja) | 2023-11-20 |
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US (1) | US20220192951A1 (ja) |
EP (1) | EP3927308B1 (ja) |
JP (1) | JP7383717B2 (ja) |
CN (1) | CN113365600B (ja) |
BR (1) | BR112021013487A2 (ja) |
CA (1) | CA3130016A1 (ja) |
MX (1) | MX2021009870A (ja) |
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US3427381A (en) | 1966-11-23 | 1969-02-11 | Procter & Gamble | Oral compositions for retarding dental plaque formation comprising benzohydroxamic acid |
JP2005272364A (ja) | 2004-03-25 | 2005-10-06 | Kao Corp | 毛髪化粧料 |
CN104278528B (zh) | 2014-10-20 | 2016-06-22 | 苏州庄爵服饰有限公司 | 用于抗皱面料的整理方法 |
CN107935092A (zh) | 2017-11-06 | 2018-04-20 | 广东省资源综合利用研究所 | 一种羟肟酸生产废水资源化的方法 |
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US3446630A (en) * | 1965-10-08 | 1969-05-27 | Pfizer & Co C | Process for preserving edibles |
US5250299A (en) * | 1991-09-23 | 1993-10-05 | Haarmann & Reimer Corp. | Synergistic antimicrobial compositions |
WO2004006876A1 (en) | 2002-07-15 | 2004-01-22 | Unilever Plc | Hair and/or scalp treatment composition |
US7414016B1 (en) * | 2007-11-01 | 2008-08-19 | The Clorox Company | Acidic cleaning compositions |
EP2349191B2 (en) * | 2008-11-25 | 2016-12-21 | The Procter and Gamble Company | Oral care compositions comprising spherical fused silica |
CN104278525B (zh) * | 2014-09-09 | 2016-06-29 | 宁波先锋新材料股份有限公司 | 一种具有消光和高阻燃效果的遮阳复合材料及其制备方法 |
WO2016138217A1 (en) * | 2015-02-26 | 2016-09-01 | Johnson & Johnson Consumer Inc. | Compositions comprising combinations of organic acids |
CN107920517A (zh) * | 2015-08-18 | 2018-04-17 | 高露洁-棕榄公司 | 基于有机酸的防腐剂体系 |
EP3402574A1 (en) * | 2016-02-19 | 2018-11-21 | Colgate-Palmolive Company | Personal care compositions |
BR112019012551B1 (pt) * | 2016-12-27 | 2022-11-01 | Colgate-Palmolive Company | Enxaguante bucal bifásico |
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- 2020-02-10 EP EP20704022.1A patent/EP3927308B1/en active Active
- 2020-02-10 CA CA3130016A patent/CA3130016A1/en active Pending
- 2020-02-10 US US17/426,004 patent/US20220192951A1/en active Pending
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US3427381A (en) | 1966-11-23 | 1969-02-11 | Procter & Gamble | Oral compositions for retarding dental plaque formation comprising benzohydroxamic acid |
JP2005272364A (ja) | 2004-03-25 | 2005-10-06 | Kao Corp | 毛髪化粧料 |
CN104278528B (zh) | 2014-10-20 | 2016-06-22 | 苏州庄爵服饰有限公司 | 用于抗皱面料的整理方法 |
CN107935092A (zh) | 2017-11-06 | 2018-04-20 | 广东省资源综合利用研究所 | 一种羟肟酸生产废水资源化的方法 |
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EP3927308B1 (en) | 2022-09-21 |
CN113365600B (zh) | 2023-05-23 |
JP2022521189A (ja) | 2022-04-06 |
BR112021013487A2 (pt) | 2021-09-14 |
CN113365600A (zh) | 2021-09-07 |
ZA202104787B (en) | 2023-01-25 |
MX2021009870A (es) | 2021-09-14 |
CA3130016A1 (en) | 2020-08-27 |
US20220192951A1 (en) | 2022-06-23 |
EP3927308A1 (en) | 2021-12-29 |
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