JP7372740B2 - 細胞生存性及び／又は細胞増殖を低減するための薬物の組み合わせ - Google Patents
細胞生存性及び／又は細胞増殖を低減するための薬物の組み合わせ Download PDFInfo
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- JP7372740B2 JP7372740B2 JP2018559826A JP2018559826A JP7372740B2 JP 7372740 B2 JP7372740 B2 JP 7372740B2 JP 2018559826 A JP2018559826 A JP 2018559826A JP 2018559826 A JP2018559826 A JP 2018559826A JP 7372740 B2 JP7372740 B2 JP 7372740B2
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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| WO2005011597A2 (en) | 2003-07-29 | 2005-02-10 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
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| EP2169071A1 (en) * | 2008-09-29 | 2010-03-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Rodent cancer model for human FGFR4 Arg388 polymorphism |
| AR079257A1 (es) | 2009-12-07 | 2012-01-04 | Novartis Ag | Formas cristalinas de 3-(2,6-dicloro-3-5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas |
| WO2011090738A2 (en) | 2009-12-29 | 2011-07-28 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
| RU2012134637A (ru) | 2010-01-14 | 2014-02-20 | Йейл Юниверсити | Ингибиторы рецепторных тирозинкиназ (rtk) и способы их применения |
| WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
| AR085934A1 (es) | 2011-04-08 | 2013-11-06 | Ab Science | Tratamiento de mieloma multiple con masitinib |
| CN102816162B (zh) | 2011-06-10 | 2016-04-27 | 中国科学院广州生物医药与健康研究院 | 嘧啶并嘧啶酮类化合物及其药用组合物和应用 |
| CN103106630A (zh) * | 2011-11-10 | 2013-05-15 | 李红彬 | 生态城市规划 |
| JP2015506944A (ja) | 2012-01-18 | 2015-03-05 | ジェネンテック， インコーポレイテッド | Ｆｇｆ１９修飾薬を使用する方法 |
| KR102032007B1 (ko) | 2012-02-28 | 2019-10-14 | 아스텔라스세이야쿠 가부시키가이샤 | 질소 함유 방향족 헤테로환 화합물 |
| CN103306509A (zh) * | 2012-03-06 | 2013-09-18 | 李尚喜 | 未来城市区域定向建设与施工 |
| RU2496937C1 (ru) * | 2012-03-12 | 2013-10-27 | Лев Иванович Гаранин | Способ обустройства антарктиды |
| SG11201500125QA (en) | 2012-07-11 | 2015-02-27 | Blueprint Medicines Corp | Inhibitors of the fibroblast growth factor receptor |
| CN105307657B (zh) | 2013-03-15 | 2020-07-10 | 西建卡尔有限责任公司 | 杂芳基化合物和其用途 |
| CA2908098A1 (en) | 2013-03-15 | 2014-09-25 | Celgene Avilomics Research, Inc. | Mk2 inhibitors and uses thereof |
| US9783504B2 (en) | 2013-07-09 | 2017-10-10 | Dana-Farber Cancer Institute, Inc. | Kinase inhibitors for the treatment of disease |
| AR097455A1 (es) | 2013-08-28 | 2016-03-16 | Astellas Pharma Inc | Composición farmacéutica que contiene compuesto de pirimidina como un ingrediente activo |
| PH12016500676B1 (en) | 2013-10-18 | 2022-07-20 | Eisai R&D Man Co Ltd | Pyrimidine fgfr4 inhibitors |
| RS63405B1 (sr) | 2013-10-25 | 2022-08-31 | Blueprint Medicines Corp | Inhibitori receptora faktora rasta fibroblasta |
| US9695165B2 (en) | 2014-01-15 | 2017-07-04 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| CN104099840B (zh) * | 2014-07-28 | 2016-07-13 | 池昭新 | 一种添加自然地貌的城镇规划模式 |
| KR102548229B1 (ko) | 2015-04-14 | 2023-06-27 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 결정질 fgfr4 억제제 화합물 및 그의 용도 |
| CN113105454B (zh) | 2016-05-20 | 2022-10-11 | 江苏豪森药业集团有限公司 | Fgfr4抑制剂、其制备方法和应用 |
| CN108884097B (zh) | 2016-05-20 | 2021-05-28 | 浙江海正药业股份有限公司 | 嘧啶类衍生物、其制备方法和其在医药上的用途 |
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Non-Patent Citations (4)
| Title |
|---|
| Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ、２００８年、Ｖｏｌ．６８、Ｎｏ．７、ｐ．２３９１－２３９９ |
| Ｃａｎｃｅｒ、２００８年、Ｖｏｌ．１１２、Ｎｏ．１２、ｐ．２７３３－２７３９ |
| Ｆｒｏｎｔ．Ｐｈａｒｍａｃｏｌ．、２０１５年、６：１８１ |
| 国際公開第２０１５／５７９３８号 |
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| WO2017196854A1 (en) | 2017-11-16 |
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| US11357769B2 (en) | 2022-06-14 |
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