JP7372740B2 - 細胞生存性及び／又は細胞増殖を低減するための薬物の組み合わせ - Google Patents
細胞生存性及び／又は細胞増殖を低減するための薬物の組み合わせ Download PDFInfo
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- JP7372740B2 JP7372740B2 JP2018559826A JP2018559826A JP7372740B2 JP 7372740 B2 JP7372740 B2 JP 7372740B2 JP 2018559826 A JP2018559826 A JP 2018559826A JP 2018559826 A JP2018559826 A JP 2018559826A JP 7372740 B2 JP7372740 B2 JP 7372740B2
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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| TWI546290B (zh) | 2008-06-27 | 2016-08-21 | 賽基艾維洛米斯研究股份有限公司 | 雜芳基化合物及其用途 |
| EP2169071A1 (en) | 2008-09-29 | 2010-03-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Rodent cancer model for human FGFR4 Arg388 polymorphism |
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| BR112012016992A2 (pt) | 2010-01-14 | 2019-09-24 | Univ Yale | "funcionalidade que se liga a uma interface de contato assimétrico de um recpetor de tirosina quinase (rtk), hibridoma, composição farmacêutica, uso de uma quantidade efixaz da funcionalidade, método para identificar uma funcionalidade que se liga a uma interface de contato assimétrico de um receptor de tirosina quinase (rtk), e, molécula pequena". |
| WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
| US20140051662A1 (en) | 2011-04-08 | 2014-02-20 | Ab Science | Treatment of multiple myeloma with masitinib |
| CN102816162B (zh) | 2011-06-10 | 2016-04-27 | 中国科学院广州生物医药与健康研究院 | 嘧啶并嘧啶酮类化合物及其药用组合物和应用 |
| CN103106630A (zh) * | 2011-11-10 | 2013-05-15 | 李红彬 | 生态城市规划 |
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| EA026953B1 (ru) | 2012-02-28 | 2017-06-30 | Астеллас Фарма Инк. | Азотсодержащее ароматическое гетероциклическое соединение |
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| RU2496937C1 (ru) * | 2012-03-12 | 2013-10-27 | Лев Иванович Гаранин | Способ обустройства антарктиды |
| SMT202100451T1 (it) | 2012-07-11 | 2021-09-14 | Blueprint Medicines Corp | Inibitori del recettore di crescita dei fibroblasti |
| JP2016518316A (ja) | 2013-03-15 | 2016-06-23 | セルジーン アビロミクス リサーチ， インコーポレイテッド | Ｍｋ２阻害剤およびそれらの使用 |
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| AR097455A1 (es) | 2013-08-28 | 2016-03-16 | Astellas Pharma Inc | Composición farmacéutica que contiene compuesto de pirimidina como un ingrediente activo |
| MX378288B (es) | 2013-10-18 | 2025-03-10 | Eisai R&D Man Co Ltd | Inhibidores de pirimidina del fgfr4. |
| CA2928042C (en) | 2013-10-25 | 2022-05-10 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| MA38393B1 (fr) | 2014-03-13 | 2018-11-30 | Sanofi Sa | Composés hétéroaryle et utilisations associées |
| CN104099840B (zh) * | 2014-07-28 | 2016-07-13 | 池昭新 | 一种添加自然地貌的城镇规划模式 |
| SG10201810057UA (en) | 2015-04-14 | 2018-12-28 | Eisai R&D Man Co Ltd | Crystalline fgfr4 inhibitor compound and uses thereof |
| CN113234072B (zh) | 2016-05-20 | 2022-11-04 | 江苏豪森药业集团有限公司 | Fgfr4抑制剂、其制备方法和应用 |
| JP6667014B2 (ja) | 2016-05-20 | 2020-03-18 | 浙江海正薬業股▲ふん▼有限公司Ｚｈｅｊｉａｎｇ Ｈｉｓｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ ＣＯ．，ＬＴＤ． | ピリミジン誘導体、その調製方法および医療での使用 |
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Non-Patent Citations (4)
| Title |
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| Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ、２００８年、Ｖｏｌ．６８、Ｎｏ．７、ｐ．２３９１－２３９９ |
| Ｃａｎｃｅｒ、２００８年、Ｖｏｌ．１１２、Ｎｏ．１２、ｐ．２７３３－２７３９ |
| Ｆｒｏｎｔ．Ｐｈａｒｍａｃｏｌ．、２０１５年、６：１８１ |
| 国際公開第２０１５／５７９３８号 |
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| JP2022160654A (ja) | 2022-10-19 |
| JP2019515010A (ja) | 2019-06-06 |
| US20190117640A1 (en) | 2019-04-25 |
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