JP7369113B2 - 癌胎児性抗原結合タンパク質、関連する化合物および方法 - Google Patents

癌胎児性抗原結合タンパク質、関連する化合物および方法 Download PDF

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JP7369113B2
JP7369113B2 JP2020503056A JP2020503056A JP7369113B2 JP 7369113 B2 JP7369113 B2 JP 7369113B2 JP 2020503056 A JP2020503056 A JP 2020503056A JP 2020503056 A JP2020503056 A JP 2020503056A JP 7369113 B2 JP7369113 B2 JP 7369113B2
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amino acid
seq
acid sequence
binding domain
polypeptide
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JP2020530770A5 (enExample
JP2020530770A (ja
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ビアンヴニュ，デビッド
ヘルナンデス－ホヨス，ガブリエラ
ミッシャー，リンダ
ミッシェル，ダニエル
フリッツェル，サラ
ヴァラス，ローラ
エルマーク，ピーター
サール，アンナ
フュルブリング，クリスティーナ
シャンツ，ローラ フォン
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アプティーボ リサーチ アンド デベロップメント エルエルシー
アリゲーター・バイオサイエンス・アーベー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5152—Tumor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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JP2020503056A 2017-07-20 2018-07-20 癌胎児性抗原結合タンパク質、関連する化合物および方法 Active JP7369113B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762535107P 2017-07-20 2017-07-20
US62/535,107 2017-07-20
US201762575820P 2017-10-23 2017-10-23
US62/575,820 2017-10-23
US201862648072P 2018-03-26 2018-03-26
US62/648,072 2018-03-26
PCT/EP2018/069850 WO2019016402A1 (en) 2017-07-20 2018-07-20 BINDING PROTEINS BINDING AT 5T4 AND 4-1BB, COMPOSITIONS AND METHODS RELATED THERETO

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JP2020530770A5 JP2020530770A5 (enExample) 2021-08-26
JP7369113B2 true JP7369113B2 (ja) 2023-10-25

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KR (1) KR102649757B1 (enExample)
CN (1) CN111148763B (enExample)
AU (1) AU2018304585B2 (enExample)
BR (1) BR112020001180A2 (enExample)
CA (1) CA3070272A1 (enExample)
CO (1) CO2020001654A2 (enExample)
IL (1) IL272103B2 (enExample)
MX (1) MX2020000583A (enExample)
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PH (1) PH12020500137A1 (enExample)
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US11725060B2 (en) 2017-07-20 2023-08-15 Aptevo Reserch and Development LLC Antigen binding proteins binding to 5T4 and 4-1BB and related compositions and methods
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