JP7350850B2 - 外科的外植組織サンプルを保存するシステムおよび方法 - Google Patents
外科的外植組織サンプルを保存するシステムおよび方法 Download PDFInfo
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Description
2 ボリュメトリックセンサー
3 電子デバイス
4 第1のプリンタ
5 第1のバーコードリーダー
7 壁
8 支持体
9 台座
21 構造
22 電子制御パネル
23 第2のプリンタ
24 入口ダストフィルタ
25 第1の棚
26 第2の棚
27 陥凹部
28 ノズル保持ヘッド
29 垂直ガイド
30 ベルト
31、32 ノズル
33 開口部
34 ポンプ
35 第3の棚
36 真空ポンプ
37 キャニスター
38 レベルセンサー
39 フィルタ
40 吸着カップ
41 第4の棚
42 バイオハザードアブソリュートフィルタ、アブソリュートバイオハザード入口フィルタ
43 ガイド
44 ドロワー
45 キャニスター
50 蓋
51 逆止弁
53 基部
54 モーター
55 自由端
56 下側部分
57 上側部分
58 孔
59 孔
61 横方向開口部
63 弁帽
64 陥凹部
66 螺旋状バネ
280 ノズル保持ヘッド
300 V字型カップリング
310 ノズル
311 ホース
313 チューブ
Claims (15)
- 外科的外植組織サンプルを保存するためのシステムであって、
- 異なるサイズの複数の容器(C1、C2、C3、C4)の中から選択された容器に組織サンプルを入れるための第1のパッキングステーションであって、制御用電子プロセッサ(1)、組織(T)または外科的外植された他の臓器の体積を測定するためのボリュメトリックセンサー(2)、第1のプリンタ(4)、第1のバーコードリーダー(5)、密閉蓋(50)を備えた異なるサイズの前記容器(C1、C2、C3、C4)が載置される棚を有するキャビネット(10)を備える第1のパッキングステーションと、
- 前記選択された容器に防腐剤を充填するための充填システムを備える最終パッキングステーションであって、前記充填システムは垂直ガイド(29)上に移動可能に装着されているノズル保持ヘッド(28)を備え、前記ノズル保持ヘッド(28)は前記選択された容器を充填するための少なくとも1つのノズル(31)を有する、最終パッキングステーションと、
を備え、
前記選択された容器の前記密閉蓋(50)は、逆止弁(51)を装備する開口部(33)を備え、前記ノズル(31)は、前記逆止弁(51)内に挿入されることを意図されていることを特徴とするシステム。 - 前記逆止弁(51)は、
- 前記密閉蓋(50)の下に位置決めされ、螺旋状バネ(66)および弁帽(63)を含む下側部分(56)であって、底部および側部開口部(60)に孔(58)を有する、下側部分(56)と、
- 前記下側部分(56)に連結され、前記密閉蓋(50)の上に位置決めされ、前記弁帽(63)によって閉じられることを意図されている陥凹部(64)内に前記下側部分(56)の前記孔(58)と同心の孔(59)を備えている上側部分(57)とを備える請求項1に記載のシステム。 - 前記ノズル(31)は、前記螺旋状バネ(66)を用いてバネ仕掛けされている前記弁帽(63)に対して前記逆止弁(51)の前記上側部分(57)の前記孔(59)に挿入されることを意図されている端部(55)を有し、前記端部(55)は前記ノズル(31)が前記逆止弁(51)に挿入されたときに防腐剤が出るための横方向の開口部(61)および近位通路(62)を備える遠位部分を有する請求項2に記載のシステム。
- 前記第1のパッキングステーションは、外植組織サンプルの体積に基づき前記容器(C1、C2、C3、C4)を選択するためのソフトウェアがインストールされている電子デバイス(3)をさらに備える請求項1に記載のシステム。
- 前記外植組織サンプルの前記体積は、前記ボリュメトリックセンサー(2)によって前記ソフトウェアに供給される請求項4に記載のシステム。
- 前記第1のパッキングステーションは、前記外植組織サンプルのための計量器と、前記外植組織サンプルの前記体積に基づき容器(C1、C2、C3、C4)を選択するための前記ソフトウェアにおける外植された組織の各タイプに対する比較重量および体積テーブルとを備える請求項4に記載のシステム。
- 前記防腐剤は、固定剤防腐剤溶液である請求項1に記載のシステム。
- 前記固定剤防腐剤溶液は、ホルムアルデヒドに基づく請求項7に記載のシステム。
- 前記防腐剤は、不活性ガスの混合物である請求項1に記載のシステム。
- 前記防腐剤は、不活性ガスである請求項1に記載のシステム。
- 外科的外植組織のサンプルを保存する方法であって、
- 異なるサイズの複数の容器(C1、C2、C3、C4)の間で組織サンプルを保存するのに適している容器を選択するステップと、
- 前記組織サンプルを保存するために必要な防腐剤の量を、その質量に基づき計算するステップと、
- 前記選択された容器の認識のために前記選択された容器を最初にラベル付けするステップと、
- 前記選択された容器内に前記組織サンプルを挿入するステップと、
- 前記選択された容器を最終パッキングステーションに移送するステップと、
- 前記選択された容器に前記計算された量の防腐剤を充填するステップと、
- 前記容器の第2のラベル付けを行うステップであって、前記第2のラベルは、診断のために検査されるべき前記組織サンプルを保存するための正しい時間を計算するために用いられるパッキングの日時を含んでいる、ステップとを含み、
- 前記容器の前記選択は、ボリュメトリックセンサー(2)によって、前記組織サンプルの体積の評価に基づき行われ、
- 前記組織サンプルを保管するために使用される、固有のバーコード、または第1のバーコードを備える前記容器(C1、C2、C3、C4)の前記体積は、制御電子コンピュータ(1)によって自動的に処方され、
- 前記選択された容器の密閉は、逆止弁(51)を有する密閉蓋(50)を装備する前記選択された容器内に前記組織サンプルを挿入した直後に実行され、
- 前記容器に前記防腐剤を充填するステップは、前記選択された容器の前記密閉蓋(50)の前記逆止弁(51)に挿入された充填システムのノズル(31)によって行われることを特徴とする方法。 - 前記防腐剤は、固定剤防腐剤溶液である請求項11に記載の方法。
- 前記固定剤防腐剤溶液は、ホルムアルデヒドに基づく請求項12に記載の方法。
- 前記防腐剤は、不活性ガスの混合物である請求項11に記載の方法。
- 前記防腐剤は、不活性ガスである請求項11に記載の方法。
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PCT/IB2019/055995 WO2020016727A2 (en) | 2018-07-18 | 2019-07-14 | System and method of preserving a surgically explanted tissue sample |
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EP3620772B1 (en) * | 2018-09-06 | 2021-10-13 | Milestone S.r.l. | System and method for filling a closed container with a fixative solution |
WO2021011406A1 (en) * | 2019-07-12 | 2021-01-21 | Moore Martie Kenneth | Prep table food bag |
IT202100002909A1 (it) | 2021-02-10 | 2022-08-10 | Bios Health Diagnostics S R L | Coperchio di contenitore dotato di apertura passante richiudibile |
IT202100013283A1 (it) | 2021-05-21 | 2022-11-21 | Bios Health Diagnostics S R L | Coperchio di contenitore e corrispondente iniettore atto a riempire un contenitore |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120294782A1 (en) | 2011-05-19 | 2012-11-22 | Milestone S.R.L. | Fixation and storage of biological organic samples |
WO2013043109A2 (en) | 2011-09-19 | 2013-03-28 | GISKE, Christian Georg | Device and method for processing a patient sample |
WO2017114598A1 (en) | 2015-12-28 | 2017-07-06 | Mecatron Automazione S.R.L. | Automatic machine for the packaging, preservation and transport of surgical, histological, autopsy and cytological specimens by healthcare workers in safety |
JP2018512569A (ja) | 2015-02-20 | 2018-05-17 | ベンタナ メディカル システムズ, インコーポレイテッド | 流体に浸漬される組織試料を保管および移送するための組立体 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3512526B2 (ja) * | 1995-06-30 | 2004-03-29 | アークレイ株式会社 | 検体吸引装置 |
AU2006203717B2 (en) * | 2001-04-13 | 2009-12-24 | Novian Health, Inc | Apparatus and method for delivering ablative laser energy and determining the volume of tumor mass destroyed |
CA2737608A1 (en) * | 2007-09-19 | 2009-03-26 | Wayne State University | Device for collection and preservation of tissue or stool samples |
US20090105611A1 (en) * | 2007-10-23 | 2009-04-23 | Becton, Dickinson And Company | Closed Kit for Tissue Containment and Stabilization for Molecular and Histopathology Diagnostics |
DE602007007224D1 (de) | 2007-12-13 | 2010-07-29 | Milestone Srl | Verfahren zur Gewebebewahrung |
WO2014028622A1 (en) * | 2012-08-15 | 2014-02-20 | Intuitive Surgical Operations, Inc. | Specimen removal bag and methods of using same |
ITVA20130067A1 (it) | 2013-12-20 | 2015-06-21 | Rivac Srl | Sistema di anticontaminazione e di sicurezza per l'operatore, applicato a macchine termosigillatrici per il riempimento e la sigillatura di contenitori con liquidi. |
RU2577996C2 (ru) * | 2014-07-04 | 2016-03-20 | Общество с ограниченной ответственностью "ИнПрес" | Способ консервации биоматериала |
DE202015006982U1 (de) * | 2015-09-29 | 2016-12-30 | Manfred Kiefer | Behältnisse für die Gewebefixierung mit Formalin |
EP3374273A1 (en) * | 2015-11-13 | 2018-09-19 | EOS Srl | Labelling machine for containers of biological and microbiological samples |
EP3339866B1 (en) | 2016-12-21 | 2020-04-08 | Milestone S.r.l. | Measuring apparatus |
EP3620772B1 (en) * | 2018-09-06 | 2021-10-13 | Milestone S.r.l. | System and method for filling a closed container with a fixative solution |
-
2019
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120294782A1 (en) | 2011-05-19 | 2012-11-22 | Milestone S.R.L. | Fixation and storage of biological organic samples |
WO2013043109A2 (en) | 2011-09-19 | 2013-03-28 | GISKE, Christian Georg | Device and method for processing a patient sample |
JP2018512569A (ja) | 2015-02-20 | 2018-05-17 | ベンタナ メディカル システムズ, インコーポレイテッド | 流体に浸漬される組織試料を保管および移送するための組立体 |
WO2017114598A1 (en) | 2015-12-28 | 2017-07-06 | Mecatron Automazione S.R.L. | Automatic machine for the packaging, preservation and transport of surgical, histological, autopsy and cytological specimens by healthcare workers in safety |
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