JP7336557B2 - 幹細胞の培養及び治療のための培地、方法、細胞、及び分泌因子 - Google Patents
幹細胞の培養及び治療のための培地、方法、細胞、及び分泌因子 Download PDFInfo
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Description
<特定の定義>
<培地>
<TLR4リガンド>
<TLR3リガンド>
<追加の薬剤>
<アセチルコリン(AcH)>
<αメラニン細胞刺激ホルモン(MSH)>
<メラトニン(MEL)>
<セロトニン(5-HT)>
<グルタミン酸塩(GLU)>
<ノリエピネフリン(NEPI)>
<ヒスタミン(HIS)>
<リポキシンA4(LXA4)>
<ロイコトリエンB4(LTB4)>
<低酸素>
<多能性幹細胞>
<間葉幹細胞>
<タイプ1極性化多能性幹細胞>
<タイプ2極性化多能性幹細胞>
<細胞均一性>
<方法>
<分泌炎症誘発因子>
<分泌抗炎症因子>
<分泌因子の分離>
<分泌炎症誘発細胞外小胞>
<分泌抗炎症細胞外小胞>
<細胞外小胞の分離>
<治療方法>
<自己免疫及び炎症性疾患>
<癌>
<投与スケジュール>
<薬学的に許容可能な賦形剤、希釈剤、及びキャリア>
<実施例>
<実施例1-Toll様受容体及び特定誘導体の組み合わせによる間葉幹細胞起爆の強化>
<実施例2-起爆間葉幹細胞で分泌された因子の解析>
<実施例3-起爆海洋幹細胞によって分泌される細胞外小胞のタンパク質含有量の解析>
Claims (18)
- 免疫学的に極性化された間葉幹細胞集団を作成する方法であって、間葉幹細胞集団を、低酸素条件下で、
(a)Toll様受容体3(TLR3)リガンドと、
(b)グルタミン酸塩とを含む培地に接触させることを含み、
免疫学的に極性化された間葉幹細胞集団が、前記培地に接触されていない細胞集団に比して高いレベルでCXCL9を発現する、方法。 - TLR3リガンドは、ポリ(I:C)、ポリ(A:U)、又はこれらの組み合わせを含む請求項1に記載の方法。
- TLR3リガンドの濃度が10pg/mL±10%~100μg/mL±10%である、請求項1に記載の方法。
- グルタミン酸塩の濃度が10nM±10%~1mM±10%である、請求項1に記載の方法。
- 培地がエリスロポエチンをさらに含む請求項1に記載の方法。
- エリスロポエチンの濃度が0.5ng/mLである、請求項4に記載の方法。
- 低酸素条件が11%未満の酸素を含む、請求項1に記載の方法。
- 低酸素条件が0.5%~2%の酸素を含む、請求項7に記載の方法。
- 低酸素条件が、前記培地における低酸素模倣の存在を含む、請求項7に記載の方法。
- 低酸素模倣が、塩化コバルト、デスフェリオキサミン、又はこれらの組み合わせである、請求項9に記載の方法。
- 塩化コバルトの濃度が10μM±10%~1mM±10%である、請求項10に記載の方法。
- デスフェリオキサミンの濃度が10μM±10%~1mM±10%である、請求項10に記載の方法。
- 抗炎症特性を有する、免疫学的に極性化された間葉幹細胞集団であって、請求項1~12のいずれか一項に記載の方法によって作成される、免疫学的に極性化された間葉幹細胞集団。
- 炎症性又は自己免疫の疾患の処置において使用するための、請求項13に記載の免疫学的に極性化された間葉幹細胞集団。
- 炎症性又は自己免疫の疾患が関節リウマチ、糖尿病性神経障害、クローン病、急性肺障害、多発性硬化症、急性視神経炎又はクラッベ病である、請求項14に記載の免疫学的に極性化された間葉幹細胞集団。
- 医薬組成物であって、
(a)請求項13に記載の免疫学的に極性化された間葉幹細胞集団と、
(b)薬学的に許容可能な賦形剤、希釈剤、又はキャリアと、
を含む、医薬組成物。 - 炎症性又は自己免疫の疾患の処置において使用するための、請求項16に記載の医薬組成物。
- 炎症性又は自己免疫の疾患が関節リウマチ、糖尿病性神経障害、クローン病、急性肺障害、多発性硬化症、急性視神経炎又はクラッベ病である、請求項17に記載の医薬組成物。
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