JP7333306B2 - 検定を行う装置 - Google Patents
検定を行う装置 Download PDFInfo
- Publication number
- JP7333306B2 JP7333306B2 JP2020503045A JP2020503045A JP7333306B2 JP 7333306 B2 JP7333306 B2 JP 7333306B2 JP 2020503045 A JP2020503045 A JP 2020503045A JP 2020503045 A JP2020503045 A JP 2020503045A JP 7333306 B2 JP7333306 B2 JP 7333306B2
- Authority
- JP
- Japan
- Prior art keywords
- disc
- magnet
- microfluidic system
- microfluidic
- assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/50—Clamping means, tongs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/025—High gradient magnetic separators
- B03C1/031—Component parts; Auxiliary operations
- B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
- B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0803—Disc shape
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
- B01L2300/1844—Means for temperature control using fluid heat transfer medium using fans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00158—Elements containing microarrays, i.e. "biochip"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0444—Rotary sample carriers, i.e. carousels for cuvettes or reaction vessels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
- G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Fluid Mechanics (AREA)
- Electrochemistry (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Description
本発明の実施形態は磁気ビーズを含む微小流体システムで検定を行う装置を提供する。この装置は、微小流体システムを装着することができる基台と、磁石を有し、微小流体システムが前記基台に装着されると微小流体システム内に入っている磁気ビーズの動きに直接に影響を及ぼすようになっている1つ以上の作動部、それに前記1つ以上の磁石と装着後の前記微小流体システムの相対的動きを制御して、前記基台に装着された微小流体システムを横断する望ましい進路を前記磁石がたどることができるようになっている制御手段を含む。前記磁石は前記基台に装着された微小流体システムの任意のx座標およびy座標に配置できる。前記装置はさらにa)x軸に沿って磁石を動かすことができるようになっている少なくとも1つの回転作動部および/またはb)前記基台に装着された微小流体システムを段階的に動かす手段を含む。
Claims (42)
- 磁気ビーズを含む微小流体システム中で検定を行う装置であって、
微小流体システムを装着することができる基台、
前記基台は前記微小流体システムを含む検定円盤を受け、かつ前記検定円盤を制御可能に回転させるようになっている回転盤を含み、
磁石を有し、微小流体システムが前記基台に装着されると前記微小流体システム内に入っている磁気ビーズの動きに直接に影響を及ぼすようになっている1つ以上の作動部、お よび
前記1つ以上の磁石と装着後の前記微小流体システムの相対的動きと、前記1つ以上の作動部と前記回転盤とを制御して、前記基台に装着された前記微小流体システムを横断する望ましい進路を前記磁石がたどることができるようになっている制御手段を含み、
前記作動部は回転作動部を含み、
前記磁石は前記基台に装着された前記微小流体システムの任意のx座標およびy座標に配置可能で、前記装置はさらに
前記基台に装着された前記微小流体システムを段階的に動かす手段を含む、装置。 - 前記装置は、前記基台に装着された前記微小流体システムを回転可能に動かす手段を含む、請求項1に記載の装置。
- 前記基台に装着された前記微小流体システムの前記段階的な動きは不連続な回転により達成される、請求項1に記載の装置。
- 前記作動部は直進作動部を含む、請求項1~3のいずれか1項に記載の装置。
- 前記装置は1つの駆動軸表面に回転作動部と直進作動部を含む、請求項1~4のいずれか1項に記載の装置。
- 前記装置は前記基台に装着された前記微小流体システムの上方に配置可能な磁石および/または前記基台に装着された前記微小流体システムの下方に配置可能な磁石を含む、請 求項1~5のいずれか1項に記載の装置。
- 前記装置は前記磁石を前記微小流体システムから離す手段を含む、請求項6に記載の装置。
- 前記磁石を前記微小流体システムから離す前記手段は前記駆動軸がx軸周りに回転できるようになっている回転作動部を含む、請求項7に記載の装置。
- 前記磁石は前記基台に装着された前記微小流体システム表面と接触し、または前記基台に装着された前記微小流体システムの表面から一定の間隔に保持される、請求項1~8のいずれか1項に記載の装置。
- 前記磁石はばね部材に装着される、請求項1~9のいずれか1項に記載の装置。
- 前記磁石は調整式装着組立品に装着される、請求項1~9のいずれか1項に記載の装置。
- 前記調整式装着組立品は前記回転作動部および/または直進作動部の一部に配置された調整式磁石保持材と貫通孔付き板を含む、請求項11に記載の装置。
- 前記貫通孔付き板は第1の係合部分を含み、前記調整式磁石保持材は前記貫通孔付き板の前記第1の係合部分と係合するようになっている第2の係合部分を含む、請求項12に記載の装置。
- 前記貫通孔付き板の前記第1の係合部分はねじ部分を含み、前記調整式磁石保持材の前記第2の係合部分は対応するねじ部分を含む、請求項13に記載の装置。
- 前記調整式装着組立品はz軸に沿った位置に前記磁石を配置できるようになっている、請求項11~14のいずれか1項に記載の装置。
- 前記磁石は前記微小流体システムの表面に接触している、請求項10~15のいずれか1項に記載の装置。
- 前記回転盤は、前記基台に装着された前記微小流体システムが回転する間、前記微小流体システムの1つ以上の特定部分に熱を加える1つ以上の加熱器モジュールを含む、請求 項1~16のいずれか1項に記載の装置。
- 前記回転盤はさらに
必要とされる加熱器を選択して前記加熱器の温度を制御する加熱器制御部、および
命令および/または加熱パラメーターを前記加熱器制御部に無線で伝達できるようにする赤外線送受信機を含む、請求項1~17のいずれか1項に記載の装置。 - 前記回転盤はさらに前記回転盤に対する前記検定円盤の正しい配置を容易にする手段を含む、請求項1~18のいずれか1項に記載の装置。
- 前記手段は前記回転盤に心棒を含み、前記心棒は前記検定円盤の心棒穴に対応し、前記心棒は前記検定円盤のハブ表面の縦方向凸部に対応する縦溝を有する、請求項19に記載の装置。
- 前記心棒の前記縦溝の水平方向の大きさは縦方向下向きに小さくなる、請求項20に記載の装置。
- 前記手段は前記回転盤表面に位置決め凸部を含み、前記位置決め凸部は、前記検定円盤表面、必要であれば前記検定円盤の近傍または前記検定円盤の外縁付近に設けられた対応 する位置決め凹部と嵌合される、請求項19に記載の装置。
- 前記回転盤に対して前記検定円盤を位置決めする前記手段は請求項20または21、および請求項22に請求される通りである、請求項19に記載の装置。
- 前記回転盤はさらに前記検定円盤を前記回転盤に固定する締付け手段を含む、請求項1~23のいずれか1項に記載の装置。
- 前記締付け手段は前記検定円盤を前記回転盤に対して保持する機械的玉軸受け締付け機構を含む、請求項24に記載の装置。
- 前記締付け手段は磁気手段を含み、前記磁気手段は前記回転盤に対する定位置に前記検定円盤を保持し、および/または前記検定円盤を正しい位置に調整および/または案内す る、請求項24または25に記載の装置。
- 前記磁気手段は前記回転盤内部の両極方向に配置された円盤磁石を含み、前記円盤磁石は前記検定円盤内部の両極方向に配置された円盤磁石に対応する、請求項26に記載の装置。
- 前記回転盤は電力を前記回転盤内の加熱器モジュールに伝達する無線電力伝達手段を含む電力伝達組立品を含む、請求項1~27のいずれか1項に記載の装置。
- 前記赤外線送受信機は1つ以上の赤外線発信部と1つ以上の赤外線受信部を含む、請求項18~27のいずれか1項に記載の装置。
- 前記赤外線送受信機は4つの赤外線発信部を含む、請求項29に記載の装置。
- 前記4つの赤外線発信部は等間隔に配置され、前記回転盤の中心ハブを囲む、請求項30に記載の装置。
- 1つ以上の加熱器モジュールが設けられる、請求項18~31のいずれか1項に記載の装置。
- 前記加熱器モジュールは独立して制御される、請求項32に記載の装置。
- 前記加熱器に供給される電力は要求に応じて前記加熱器の間で共用かつ分配できる、請求項32または33に記載の装置。
- 前記回転盤は固定コイル部品と回転コイル部品を含む電力伝達組立品を含み、前記固定コイル部品は軸方向に合致する前記回転コイル部品の下方に装着される、請求項1~34のいずれか1項に記載の装置。
- 請求項1~35のいずれか1項に記載の装置を含む検定ユニット。
- 前記検定中に前記検定円盤が配置される室内の周囲温度を上昇または降下させる手段をさらに含む、請求項36に記載の検定ユニット。
- 前記手段はファンヒーターまたはクーラーである、請求項37に記載の検定ユニット。
- 請求項1~25のいずれか1項に記載の装置または請求項36~38のいずれか1項に記載の検定ユニットと、前記装置に装着されるようになっている検定円盤の組み合わせ。
- 検定を行うための請求項1~39に記載の装置の使用。
- 検定を行う方法であって、
i)複数の磁気ビーズを含む微小流体システムを含む検定円盤を回転盤に装着する工程、および
ii)前記検定円盤の任意のx座標およびy座標に磁石を配置するように前記磁石を作動部表面に設ける工程を含み、
前記作動部は回転作動部を含む、
方法。 - 前記磁石を動かしつつ、前記検定円盤のx平面およびy平面の望ましい軌跡を前記磁石がたどるように前記検定円盤を回転させることで前記磁気ビーズが前記微小流体システム の一部を通過する工程をさらに含む、請求項41に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1711804.3 | 2017-07-21 | ||
GBGB1711804.3A GB201711804D0 (en) | 2017-07-21 | 2017-07-21 | Apparatus for conducting an assay |
PCT/GB2018/052054 WO2019016562A1 (en) | 2017-07-21 | 2018-07-20 | APPARATUS FOR PERFORMING AN ASSAY |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2020527238A JP2020527238A (ja) | 2020-09-03 |
JP7333306B2 true JP7333306B2 (ja) | 2023-08-24 |
Family
ID=59771837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020503045A Active JP7333306B2 (ja) | 2017-07-21 | 2018-07-20 | 検定を行う装置 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20210146361A1 (ja) |
EP (1) | EP3655782A1 (ja) |
JP (1) | JP7333306B2 (ja) |
CN (1) | CN111630392A (ja) |
AU (1) | AU2018303796B2 (ja) |
CA (1) | CA3070661A1 (ja) |
GB (2) | GB201711804D0 (ja) |
WO (1) | WO2019016562A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020076659A1 (en) * | 2018-10-08 | 2020-04-16 | Accure Health Inc. | Automated assay processing methods and systems |
CN115750608B (zh) * | 2022-11-21 | 2024-06-18 | 杭州电子科技大学 | 一种具有微流道冷却功能的螺杆泵轴承装置 |
CN117505098B (zh) * | 2023-12-29 | 2024-04-30 | 天津芥子生物技术有限公司 | 一种用于多维轨道位置调节的控制方法、系统及轨道系统 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008064753A (ja) | 2006-09-05 | 2008-03-21 | Samsung Electronics Co Ltd | 遠心力基盤の蛋白質検出用の微細流動装置及びそれを備える微細流動システム |
US20120295366A1 (en) | 2009-08-03 | 2012-11-22 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Diagnostic system |
US20160195523A1 (en) | 2014-01-27 | 2016-07-07 | Fannin Innovation Studio, Inc. | Discontinuous fluidic systems for point-of-care analyte measurement |
WO2017019625A1 (en) | 2015-07-24 | 2017-02-02 | Novel Microdevices, Llc (Dba Novel Devices) | Sample processing device comprising magnetic and mechanical actuating elements using linear or rotational motion and methods of use thereof |
WO2017085472A1 (en) | 2015-11-16 | 2017-05-26 | Mast Group Limited | Apparatus for conducting an assay |
JP2017523907A (ja) | 2014-12-02 | 2017-08-24 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 微小流体工学システムにおける磁性粒子の分散および蓄積 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5222808A (en) * | 1992-04-10 | 1993-06-29 | Biotrack, Inc. | Capillary mixing device |
CA2405353A1 (en) * | 2001-09-26 | 2003-03-26 | Mike Trzecieski | Multi axis component actuator |
DE102005039175A1 (de) * | 2005-08-18 | 2007-02-22 | Qiagen Gmbh | Vorrichtung und Verfahren zum Abtrennen von magnetischen Partikeln aus einer Flüssigkeit |
US20080271799A1 (en) * | 2005-09-20 | 2008-11-06 | Koninklijke Philips Electronics, N.V. | Microfluidic Regulating Device |
EP2004541A1 (en) * | 2006-03-13 | 2008-12-24 | Gyros Patent Ab | Enhanced magnetic particle steering |
EP1939629A3 (en) * | 2006-08-11 | 2011-03-09 | Samsung Electronics Co., Ltd. | Centrifugal Force Based Magnet Position Control Device and Disk-Shaped Micro Fluidic System |
KR101422572B1 (ko) * | 2006-09-05 | 2014-07-30 | 삼성전자주식회사 | 핵산 검출을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템 |
US8672532B2 (en) * | 2008-12-31 | 2014-03-18 | Integenx Inc. | Microfluidic methods |
EP2253958B1 (en) * | 2009-05-18 | 2013-04-17 | F. Hoffmann-La Roche AG | Centrifugal force based microfluidic system and method for the automated analysis of samples |
JP2011013043A (ja) * | 2009-06-30 | 2011-01-20 | Beckman Coulter Inc | 磁性粒子移送装置および磁性粒子移送方法 |
EP2864051B1 (en) * | 2012-06-25 | 2020-09-23 | The General Hospital Corporation | Sorting particles using high gradient magnetic fields |
TWI545323B (zh) * | 2014-10-31 | 2016-08-11 | 紹興普施康生物科技有限公司 | 一種離心式磁性粒子操縱與檢測裝置及其運作方法 |
-
2017
- 2017-07-21 GB GBGB1711804.3A patent/GB201711804D0/en not_active Ceased
-
2018
- 2018-07-20 CA CA3070661A patent/CA3070661A1/en active Pending
- 2018-07-20 CN CN201880061295.XA patent/CN111630392A/zh active Pending
- 2018-07-20 JP JP2020503045A patent/JP7333306B2/ja active Active
- 2018-07-20 GB GB1811872.9A patent/GB2566149B/en active Active
- 2018-07-20 EP EP18749079.2A patent/EP3655782A1/en active Pending
- 2018-07-20 US US16/632,738 patent/US20210146361A1/en not_active Abandoned
- 2018-07-20 WO PCT/GB2018/052054 patent/WO2019016562A1/en active Application Filing
- 2018-07-20 AU AU2018303796A patent/AU2018303796B2/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008064753A (ja) | 2006-09-05 | 2008-03-21 | Samsung Electronics Co Ltd | 遠心力基盤の蛋白質検出用の微細流動装置及びそれを備える微細流動システム |
US20120295366A1 (en) | 2009-08-03 | 2012-11-22 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Diagnostic system |
US20160195523A1 (en) | 2014-01-27 | 2016-07-07 | Fannin Innovation Studio, Inc. | Discontinuous fluidic systems for point-of-care analyte measurement |
JP2017523907A (ja) | 2014-12-02 | 2017-08-24 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 微小流体工学システムにおける磁性粒子の分散および蓄積 |
WO2017019625A1 (en) | 2015-07-24 | 2017-02-02 | Novel Microdevices, Llc (Dba Novel Devices) | Sample processing device comprising magnetic and mechanical actuating elements using linear or rotational motion and methods of use thereof |
WO2017085472A1 (en) | 2015-11-16 | 2017-05-26 | Mast Group Limited | Apparatus for conducting an assay |
Also Published As
Publication number | Publication date |
---|---|
WO2019016562A1 (en) | 2019-01-24 |
RU2020104093A (ru) | 2021-08-23 |
GB2566149B (en) | 2022-08-03 |
GB201711804D0 (en) | 2017-09-06 |
GB201811872D0 (en) | 2018-09-05 |
JP2020527238A (ja) | 2020-09-03 |
RU2020104093A3 (ja) | 2022-03-01 |
EP3655782A1 (en) | 2020-05-27 |
AU2018303796A1 (en) | 2020-02-13 |
GB2566149A (en) | 2019-03-06 |
AU2018303796B2 (en) | 2024-04-04 |
CN111630392A (zh) | 2020-09-04 |
CA3070661A1 (en) | 2019-01-24 |
US20210146361A1 (en) | 2021-05-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7333306B2 (ja) | 検定を行う装置 | |
US10654038B2 (en) | Nucleic acid analysis apparatus | |
EP2488303B1 (en) | Heating, shaking, and magnetizing apparatus | |
EP2144716B1 (en) | Sample handling devices and method | |
US11524298B2 (en) | Digital microfluidics devices and methods of use thereof | |
BRPI0613794A2 (pt) | sistemas para processar dispositivos de processamento de amostra e método de processamento de material de amostra | |
WO2013140917A1 (ja) | 液体クロマトグラフ分析装置及びその温度制御方法 | |
US20150027555A1 (en) | Microfluidic platform and method for controlling the same | |
JP6776350B2 (ja) | 分析を行うための装置 | |
JP6124492B2 (ja) | クロマトグラフィー用の加熱式ロータリーバルブ | |
RU2783853C2 (ru) | Устройство для проведения анализа | |
CN107703177A (zh) | 一种显微镜热台及显微熔点测量仪 | |
CN115079741A (zh) | 微流体芯片温控装置 | |
Wu et al. | Multi-layer thermoelectric-temperature-mapping microbial incubator designed for geo-biochemistry applications | |
WO2024035936A2 (en) | Device for the actuation of magnetic particles within reaction vessels |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200306 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20210713 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20210712 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20220713 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220719 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20221017 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230117 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230412 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20230725 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230814 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7333306 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |