JP7330716B2 - Method for suppressing discoloration of composition containing amino acid or its salt and vitamin C, powder composition, granules, and tablet - Google Patents

Description

TECHNICAL FIELD The present invention relates to a method for inhibiting discoloration of a composition containing amino acids or salts thereof and vitamin C, as well as powder compositions, granules, and tablets.

In recent years, with irregular eating habits and heightened awareness of beauty, the demand for products such as nutritional supplements and supplements containing nutrients such as amino acids, vitamins, and minerals has increased in order to efficiently supply necessary nutrients. ing.

Conventionally, the above products have a problem that the color tone of the products changes during storage due to the components contained in the products. Such a change in color tone of the product has the problem of lowering the value of the product in terms of appearance and properties.

So far, as a method for preventing the color tone of tablets from changing during storage, a method has been proposed in which granules containing a water-absorbing amino acid are coated with an ethanol-soluble and poorly water-soluble coating agent, and the obtained tablets are coated with sugar. (See Patent Document 1, for example).
The above proposal is a technique to prevent physical contact of each raw material by coating. Due to the coating, there is a problem that the amount to be blended is increased in order to contain the desired amount in the tablet as compared with the case where the tablet is not coated.

In addition, since nutritional supplements and supplements contain various ingredients, there are various ingredients that affect the color tone of the product, and it is necessary to develop technologies according to the target ingredients.

To date, no technology has been provided that can easily suppress changes in color tone of products caused by the coexistence of an amino acid or a salt thereof and vitamin C, and there is a strong demand for its prompt provision. ing.

JP 2005-298373 A

An object of the present invention is to solve the above-mentioned conventional problems and to achieve the following objects. That is, the present invention provides a method for suppressing discoloration of a composition containing an amino acid or a salt thereof and vitamin C, which can easily suppress a change in color tone of a composition containing an amino acid or a salt thereof and vitamin C, and a method for suppressing discoloration of a composition containing an amino acid or a salt thereof and vitamin C. An object is to provide a powder composition, granules and tablets containing inhibited amino acids or salts thereof and vitamin C.

In order to solve the above-mentioned problems, the present inventors conducted intensive studies and found that the color tone of a composition containing an amino acid or a salt thereof and vitamin C can be obtained by a simple method of contacting a silicate with an amino acid or a salt thereof and vitamin C. It has been found that the change in can be suppressed.

The present invention is based on the findings of the present inventors, and means for solving the above problems are as follows. Namely
<1> A method for suppressing discoloration of an amino acid or a salt thereof and a vitamin C-containing composition, comprising:
The discoloration is a discoloration caused by the coexistence of the amino acid or salt thereof and the vitamin C,
A method for inhibiting discoloration of a composition containing an amino acid or a salt thereof and vitamin C, comprising bringing a silicate as a discoloration inhibitor for inhibiting discoloration into contact with the amino acid or a salt thereof and vitamin C.
<2> A method for suppressing discoloration of the amino acid or its salt and vitamin C-containing composition according to <1>, further comprising bringing vitamin E into contact.
<3> A powder composition comprising an amino acid or a salt thereof, vitamin C, and a silicate as a discoloration inhibitor.
<4> The powder composition according to <3>, further comprising vitamin E.
<5> A granule characterized by containing an amino acid or a salt thereof, vitamin C, and a silicate as a discoloration inhibitor.
<6> The granules according to <5>, further containing vitamin E.
<7> A tablet comprising at least one of the powder composition according to any one of <3> to <4> and the granules according to any one of <5> to <6>. is.

EFFECTS OF THE INVENTION According to the present invention, the above-mentioned problems in the conventional art can be solved, the above-mentioned objects can be achieved, and an amino acid or an amino acid capable of easily suppressing a change in color tone of a composition containing an amino acid or a salt thereof and vitamin C. It is possible to provide a method for suppressing discoloration of a salt and a vitamin C-containing composition, and a powder composition, granules, and tablets containing vitamin C and an amino acid or a salt thereof whose color change is suppressed.

(Powder composition)
The powder composition of the present invention contains at least an amino acid or a salt thereof, vitamin C, and a silicate as a discoloration inhibitor, and if necessary further contains other ingredients.

<Amino acid or its salt>
The amino acid or salt thereof is not particularly limited and can be appropriately selected depending on the intended purpose. Threonine, valine, glycine, histidine, aspartic acid, cysteine (including aspects of cystine; hereinafter the same), tyrosine, tryptophan are preferred, and alanine, isoleucine, leucine, methionine, phenylalanine, serine, threonine, valine, glycine, histidine , cysteine is more preferred.
The salt of the amino acid is not particularly limited and can be appropriately selected depending on the intended purpose. and a salt with a base of
The amino acids or salts thereof may be used singly or in combination of two or more.
A commercially available product can be appropriately used as the amino acid or salt thereof.

The content of the amino acid or its salt in the powder composition is not particularly limited and can be appropriately selected according to the purpose. ) is preferably 1% to 50,000%, more preferably 5% to 10,000%, and particularly preferably 10% to 1,000%. When the content is within the preferred range, it is advantageous in terms of satisfying the intake amount for the purpose of component supplementation. Moreover, when the amount of amino acids to be added is too large, the flavor is affected.

<Vitamin C>
The vitamin C is not particularly limited and can be appropriately selected depending on the intended purpose. acid 2-glucoside, ascorbyl stearate, ascorbate phosphate and the like. These may be used individually by 1 type, and may use 2 or more types together.
A commercially available product can be appropriately used as the vitamin C.

The content of the vitamin C in the powder composition is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.1% by mass to 80% by mass, and 1% by mass to 70% by mass. is more preferred, and 5% by mass to 60% by mass is particularly preferred. When the content is within the preferred range, it is advantageous in terms of satisfying the intake amount for the purpose of component supplementation.

<Silicate>
The said silicate is mix|blended as a discoloration inhibitor.
The silicate is not particularly limited and can be appropriately selected depending on the purpose. Examples include calcium silicate, magnesium silicate, aluminum metasilicate, magnesium aluminometasilicate, and magnesium aluminosilicate. mentioned. These may be used individually by 1 type, and may use 2 or more types together. Among these, calcium silicate is preferable because it can be used in general foods.
A commercially available product can be appropriately used as the silicate.

The median diameter (d50) of the calcium silicate is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 18 μm to 32 μm.
The loose bulk density of the calcium silicate is not particularly limited and can be appropriately selected according to the purpose, but is preferably 0.07 g/mL to 0.15 g/mL.
The oil absorption of the calcium silicate is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 300 mL/100 g to 550 mL/100 g.
Examples of calcium silicate satisfying the median diameter (d50), loose bulk density, and oil absorption include calcium silicate represented by the following formula (1).
_{2CaO.mSiO2.nH2O ...} Formula (1)
However, in the above formula (1), 1<m<2 and 2<n<3.
Examples of commercially available products of the calcium silicate include Fluorite R (manufactured by Tomita Pharmaceutical Co., Ltd.).

The content of the silicate in the powder composition is not particularly limited and can be appropriately selected according to the purpose. , preferably at least 0.5%, more preferably 1% to 5,000%, even more preferably 4% to 3,000%, and particularly preferably 20% to 2,000%. When the content is within the preferred range, it is advantageous in that the effect of suppressing color tone change is enhanced.

<Other ingredients>
Other ingredients in the powder composition are not particularly limited as long as they do not impair the effects of _the present _invention , and can be appropriately selected according to the purpose. B ₆ , vitamin B ₁₂ , niacin, pantothenic acid, folic acid, biotin, vitamin D, vitamin E, hesperidin, inositol, and other vitamins other than vitamin C; peptide-containing products containing milk-derived peptides such as casein hydrolysate, chicken Peptide-containing substances containing animal-derived peptides such as cartilage-derived extracts, peptide-containing substances containing plant-derived peptides such as maca extract and sesame extract, peptide-containing substances containing seaweed-derived peptides such as wakame extract and kelp extract, shark cartilage extract Peptide-containing substances such as peptide-containing substances containing fish-derived peptides such as extracts, salmon nasal cartilage extracts, tuna extracts; Minerals; functional ingredients such as coenzyme Q10, α-lipoic acid, L-carnitine, collagen, hyaluronic acid, elastin, turmeric, glucosamine, chondroitin; various polyphenols; stearic acid, calcium stearate, magnesium stearate, sodium stearyl fumarate , sucrose fatty acid ester, talc, fine silicon dioxide, light anhydrous silicic acid, hydrous silicon dioxide, vegetable oil, lubricants such as hydrogenated oil; disintegrants such as sodium starch glycolate; lactose, brewer's yeast, dextrin, corn starch, etc. excipients; natural polysaccharides such as pullulan, gum arabic, xanthan gum, guar gum, alginic acid; powdered cellulose; crystalline cellulose; Cellulose derivatives such as propylcellulose and hydroxypropylmethylcellulose; sugar alcohols such as reduced maltose syrup, xylitol, sorbitol, mannitol and maltitol; disaccharides such as trehalose, palatinose and isomalt; soybean polysaccharides; agents; coloring agents such as titanium oxide and iron oxide; pH adjusters or buffers such as phytic acid, citric acid, succinic acid, sodium citrate, sodium acetate, DL-malic acid, phosphoric acid and disodium phosphate; inhibitors and the like. These may be used individually by 1 type, and may use 2 or more types together.
Among the other components, it is preferable that vitamin E is included because it can suppress discoloration of the composition toward yellow.
Commercially available products can be used as appropriate for the other components.
The content of other components in the powder composition is not particularly limited and can be appropriately selected depending on the purpose.

The vitamin E is not particularly limited and can be appropriately selected depending on the intended purpose. d-α-tocopherol, l-α-tocopherol acetate, tocotrienol and the like. These may be used individually by 1 type, and may use 2 or more types together.
Commercially available vitamin E can be used as appropriate.

The content of the vitamin E in the powder composition is not particularly limited and can be appropriately selected according to the purpose. 0.1% is preferred, 0.8% to 2,000% is more preferred, 2% to 500% is even more preferred, and 4% to 200% is particularly preferred. When the content is within the preferred range, it is advantageous in that the effect of suppressing color tone change can be enhanced synergistically.

<Method for producing powder composition>
A method for producing the powder composition is not particularly limited, and a known method can be appropriately selected, and examples thereof include a method of mixing each component.
By mixing the components, the amino acid or salt thereof and the vitamin C can be brought into contact with the silicate and, if necessary, the other components.

The mixing may be performed once or may be performed in multiple steps.
The mixing can be performed using a known device, and examples of the device include a container tumbler (manufactured by Yamazaki Metal Industry Co., Ltd.), a V-type mixer (manufactured by Tokuju Kosakusho Co., Ltd.), a Bole container mixer (Kotobuki Kogyo Co., Ltd.) and the like.
Conditions such as temperature and time for the mixing are not particularly limited and can be appropriately selected.

The shape, structure, and size of the powder are not particularly limited and can be appropriately selected according to the purpose.

The powder composition can suppress a change in color tone, particularly a red color change, caused by the reaction between an amino acid or a salt thereof and vitamin C, and can prevent a decrease in the value of a product. Inclusion of vitamin E can further suppress discoloration toward yellow.

The method for confirming the change in color tone of the powder composition is not particularly limited and can be appropriately selected according to the purpose. can.

The powder composition may be used as a dietary supplement or supplement, or as a raw material for producing granules or tablets.

(granule)
The granules of the present invention contain at least an amino acid or a salt thereof, vitamin C, and a silicate as a discoloration inhibitor, and optionally contain other ingredients.

<Amino acid or salt thereof>
The amino acid or its salt is not particularly limited and can be appropriately selected depending on the intended purpose. is mentioned.

The content of the amino acid or its salt in the granules is not particularly limited and can be appropriately selected according to the purpose. Quantities similar to Quantity.

<Vitamin C>
The vitamin C is not particularly limited and can be appropriately selected depending on the intended purpose.

The content of the vitamin C granules is not particularly limited and can be appropriately selected according to the purpose. quantity.

<Silicate>
The silicate is not particularly limited and can be appropriately selected depending on the intended purpose. be done.

The content of the silicate in the granules is not particularly limited and can be appropriately selected depending on the purpose. Similar quantities are included.

<Other ingredients>
The other components are not particularly limited as long as they do not impair the effects of the present invention, and can be appropriately selected according to the purpose. The same thing as a thing is mentioned.

The content of the other ingredients in the granules is not particularly limited and can be appropriately selected according to the purpose. Similar quantities are included.

The granules may be coated with a coating substrate, but are preferably uncoated.

<Method for producing granules>
The method for producing the granules is not particularly limited as long as a mixture containing the amino acid or salt thereof, the vitamin C, the silicate, and optionally the other ingredients is granulated. A known method can be appropriately selected, and examples thereof include a fluidized bed granulation method, an agitation granulation method, a dry granulation method, and the like.
When mixing or granulating the components, the amino acid or salt thereof and the vitamin C can be brought into contact with the silicate and, if necessary, the other components.

Specific examples of the granulation method include a method of kneading, kneading, and/or stirring the above components and spraying an appropriately selected binder.

The binder is not particularly limited and can be appropriately selected depending on the intended purpose. , xylitol, maltitol, and sugar alcohols such as sorbitol. These may be used individually by 1 type, and may use 2 or more types together.
Commercially available products can be appropriately used as the binder.

The binder is preferably a solution or dispersion (hereinafter sometimes referred to as "spray liquid") for spraying.
The solvent used for dissolving or dispersing the binder is not particularly limited and can be appropriately selected according to the type of binder used. Examples include water, ethanol, and mixed solvents thereof. be done.

The viscosity of the spray liquid and the concentration of the binder (solid content concentration) in the spray liquid are not particularly limited and can be appropriately selected according to the purpose.
The method of spraying the spray liquid is not particularly limited and can be appropriately selected according to the purpose. and methods to do so.
The spraying conditions (spraying amount, size of mist particles to be sprayed, spraying time, spraying interval, etc.) are not particularly limited, and known conditions can be appropriately selected.

The granulation may be performed once or may be performed in multiple steps.
The granulation can be performed using a known device, and examples of the device include a spray granulator, a fluid bed granulator, and a device capable of granulating raw materials with a binder.
Conditions such as temperature and time for the granulation are not particularly limited and can be appropriately selected according to the purpose.

The shape, structure, and size of the granules (hereinafter sometimes referred to as "granules") are not particularly limited and can be appropriately selected according to the purpose.

The granules can suppress a change in color tone, particularly a discoloration toward red, caused by the reaction between an amino acid or a salt thereof and vitamin C, and can prevent a decrease in product value. Inclusion of vitamin E can further suppress discoloration toward yellow.

The method for confirming the change in color tone of the granules is not particularly limited and can be appropriately selected according to the purpose. For example, it can be confirmed by measuring the color difference using a spectral color difference meter.

The granules may be used as dietary supplements or supplements, or may be used as raw materials for the manufacture of tablets.

(tablet)
The tablet of the present invention contains at least one of the powder composition of the present invention and the granules of the present invention, and if necessary further contains other ingredients.

The total content of at least one of the powder composition and the granules in the tablet is not particularly limited, and can be appropriately selected according to the content of each component in the tablet.

For example, the content of an amino acid or a salt thereof in a tablet is not particularly limited and can be appropriately selected depending on the intended purpose.
In addition, the content of vitamin C in the tablet is not particularly limited and can be appropriately selected depending on the intended purpose.

The content of the silicate in the tablet can be appropriately selected according to, for example, the content of vitamin C in the tablet.

The content of vitamin E in the tablet can be appropriately selected according to, for example, the content of vitamin C in the tablet.

A mode in which the powder composition in the tablet consists only of the amino acid or a salt thereof, the vitamin C, the silicate, and optionally the vitamin E further suppresses changes in the color tone of the tablet. It is preferable in that it is possible to
A mode in which the granules in the tablet consist only of the amino acid or a salt thereof, the vitamin C, the silicate, the binder, and, if necessary, the vitamin E prevents the color tone of the tablet from changing. It is preferable in that it can be suppressed more.

Other ingredients in the tablet are not particularly limited as long as they do not impair the effects of the present invention, and can be appropriately selected according to the purpose. The same as those described above can be mentioned.
The content of other ingredients in the tablet is not particularly limited and can be appropriately selected depending on the purpose.

The tablets may be sugar-coated, but are preferably not sugar-coated.

<Tablet manufacturing method>
A method for producing the tablet is not particularly limited, and a known method can be appropriately selected.
Since the tablet of the present invention contains at least one of the powder composition of the present invention and the granules of the present invention, the amino acid or salt thereof, the vitamin C, the silicate, and, if necessary, the other are contacted during the manufacturing process.

The tableting in the production of the tablet can be performed using a known device, and examples of the device include a tableting machine (e.g., HT-APSS type, HT-AP-MS type, HT-X-SS type , HT-X-MS type (manufactured by Hata Iron Works Co., Ltd.); VEL5, VIRGO, AQUARIUS, LIBRA (manufactured by Kikusui Seisakusho Co., Ltd.).

Conditions such as compression pressure in the production of the tablet are not particularly limited and can be appropriately selected according to the purpose.

The shape, structure, and size of the tablet are not particularly limited and can be appropriately selected according to the purpose.

The tablet can suppress the change in color tone, particularly the discoloration toward red, caused by the reaction between the amino acid or its salt and vitamin C, and can prevent the deterioration of the value of the product. Inclusion of vitamin E can further suppress discoloration toward yellow. The tablets also have excellent tablet hardness.

The method for confirming the change in color tone of the tablet is not particularly limited and can be appropriately selected according to the purpose. For example, it can be confirmed by measuring the color difference using a spectral color difference meter.

The tablets can be used as dietary supplements and supplements.

(Method for suppressing discoloration of composition containing amino acid or salt thereof and vitamin C)
The method for suppressing discoloration of a composition containing an amino acid or a salt thereof and vitamin C of the present invention (hereinafter sometimes referred to as a "method for suppressing discoloration") is achieved by coexistence of the amino acid or salt thereof and the vitamin C. A method for suppressing discoloration that occurs, which preferably includes at least contacting a silicate as a discoloration suppressing agent with an amino acid or a salt thereof and vitamin C, and further including contacting vitamin E.

The aspect of the composition in the method for inhibiting discoloration is not particularly limited and can be appropriately selected depending on the intended purpose. Examples thereof include powder, granules, tablets and the like.

The method for contacting the amino acid or salt thereof, the vitamin C, the silicate, and, if necessary, the vitamin E is not particularly limited, and a known method can be appropriately selected. For example, it can be carried out by the methods described in the above <Method for producing powder composition>, <Method for producing granules>, and <Method for producing tablet>.

According to the method for suppressing discoloration, it is possible to easily suppress a change in color tone, particularly a discoloration in the direction of red, caused by the reaction between an amino acid or a salt thereof and vitamin C, without coating. It is possible to prevent a decrease in product value. Furthermore, when vitamin E is contained, discoloration toward yellow of the composition can also be suppressed.

The method for confirming the change in color tone of the composition is not particularly limited, and can be appropriately selected according to the purpose. For example, it can be confirmed by measuring the color difference using a spectral color difference meter. .

The present invention will be specifically described below with reference to test examples, but the present invention is not limited to these test examples.

(Test example 1)
Various amino acids in the amounts shown in Table 1 below, vitamin C (ascorbic acid, manufactured by Tohoku Pharmaceutical Group Co., Ltd.), and silicate (calcium silicate (Fluorite R, manufactured by Tomita Pharmaceutical Co., Ltd.)) were mixed in a plastic bag to obtain a mixture (hereinafter sometimes referred to as "sample immediately after mixing").
To the mixture, 4 mL of a mixture of water and ethanol (volume ratio: water: ethanol = 3: 7) was sprayed, mixed, and then dried at 60 ° C. for 6 hours in a shelf dryer (hereinafter, " It is sometimes referred to as "sample after shelf drying"). This mixture simulates granulation.

The color difference (Δa*) between the sample immediately after mixing and the sample after shelf drying was measured using a spectral color difference meter SE6000 (manufactured by Nippon Denshoku Industries Co., Ltd.). The results are shown in Table 1 below.

From the results in Table 1, the sample containing silicate shows a smaller change in the positive direction of the Δa* value than the sample containing no silicate, indicating that the sample can be prevented from discoloring in the red direction. confirmed.

(Test example 2)
Amino acids, vitamin C (sodium ascorbate, manufactured by Tohoku Pharmaceutical Group Co., Ltd.), silicate (calcium silicate (Fluorite R, manufactured by Tomita Pharmaceutical Co., Ltd.)), crystals in the amounts shown in Table 2 below. A sample immediately after mixing and a sample after shelf drying were prepared in the same manner as in Test Example 1 except that cellulose (Seolus UF-F702, manufactured by Asahi Kasei Corporation) was used.
The results of color difference measured in the same manner as in Test Example 1 are shown in Table 2 below.

From the results in Table 2, it was confirmed that even when the type of vitamin C was changed, the sample containing silicate could similarly suppress the discoloration toward red.

(Test example 3)
Amino acids, vitamin C (ascorbic acid, manufactured by Tohoku Pharmaceutical Group Co., Ltd.), silicate (calcium silicate (Fluorite R, manufactured by Tomita Pharmaceutical Co., Ltd.)), vitamin E in the amounts shown in Table 3 below. A sample immediately after mixing and a sample after shelf drying were prepared in the same manner as in Test Example 1 except that 20% powder (Riken Dry E Mix F-20, manufactured by Riken Vitamin Co., Ltd.) was used.
The results of color difference measured in the same manner as in Test Example 1 are shown in Table 3 below.

From the results in Table 3, the sample containing vitamin E in addition to the silicate shows less change in Δb* in the + direction than the sample containing no vitamin E, and the sample discolors in the yellow direction. was also confirmed to be suppressed.

(Test example 4)
Amino acids, vitamin C (ascorbic acid, manufactured by Tohoku Pharmaceutical Group Co., Ltd.), silicate (calcium silicate (Fluorite R, Tomita Pharmaceutical Co., Ltd.) in the amounts described in Tables 4-1 to 4-3 below A sample immediately after mixing and a sample after tray drying were prepared in the same manner as in Test Example 1, except that ) was used.
The results of color difference measured in the same manner as in Test Example 1 are shown in Tables 4-1 to 4-3 below.

From the results in Tables 4-1 to 4-3, it was confirmed that even when the amount of silicate was changed, discoloration toward red could be similarly suppressed.

(Test Example 5)
Amino acids, vitamin C (ascorbic acid, manufactured by Tohoku Pharmaceutical Group Co., Ltd.), silicate (calcium silicate (Fluorite R, Tomita Pharmaceutical Co., Ltd.) in the amounts described in Tables 5-1 to 5-3 below )), Vitamin E 20% powder (Riken Dry E Mix F-20, manufactured by Riken Vitamin Co., Ltd.) was used in the same manner as in Test Example 1, immediately after mixing and after shelf drying. was prepared.
The results of color difference measured in the same manner as in Test Example 1 are shown in Tables 5-1 to 5-3 below.

From the results in Tables 5-1 to 5-3, it was confirmed that even when the amount of vitamin E was changed, discoloration toward yellow could be similarly suppressed.

(Test example 6)
Using a tableting machine (VEL5, manufactured by Kikusui Seisakusho Co., Ltd.), the tableting powder having the composition shown in Table 6 below was filled and pressed at a pressure of 6 kg/cm ² by a conventional method, and the tablets were processed into tablets with a diameter of 8 mm and a curvature of 8 mm. Round tablets with a radius (R) of 6.5 mm and 200 mg/tablet were obtained.
The hardness of the tablet was measured using a fully automatic tablet measurement Multicheck 5.1 (manufactured by ERWEKA). The results are shown in Table 6 below.
The details of each component are as follows.
・Vitamin C (ascorbic acid, manufactured by Tohoku Pharmaceutical Group Co., Ltd.)
・ Silicate (calcium silicate (Fluorite R, manufactured by Tomita Pharmaceutical Co., Ltd.))
・ Crystalline cellulose (Seolus UF-F702, manufactured by Asahi Kasei Corporation) (binder)
・ Calcium stearate (manufactured by Sakai Chemical Industry Co., Ltd.) (lubricant)

After storing the obtained tablets at room temperature (about 20 ° C.) for 18 hours or under the following storage conditions (1), the color difference (Δa*) between the product stored at room temperature and the sample stored under storage conditions (1) was It was measured using a spectral color difference meter SE6000 (manufactured by Nippon Denshoku Industries Co., Ltd.). The results are shown in Table 6 below.
[Storage conditions (1)]
After storage at 40°C and 75% relative humidity for 3 hours, storage at 60°C for 15 hours.

From the results in Table 6, it was confirmed that the sample containing silicate could suppress discoloration in the direction of red in the same manner as in the case of tablets.
Moreover, it was confirmed that the addition of a silicate increases the tablet hardness and makes it possible to obtain a good tablet.

Claims (7)

A method for suppressing discoloration of an amino acid or a salt thereof and a vitamin C-containing composition,
The discoloration is a discoloration caused by the coexistence of the amino acid or salt thereof and the vitamin C,
Contacting a silicate as a discoloration inhibitor that suppresses the discoloration with the amino acid or salt thereof and the vitamin C,
The amino acid or salt thereof is at least one amino acid or salt thereof selected from the group consisting of leucine, threonine, valine, isoleucine, methionine, phenylalanine, serine, histidine, glycine, alanine, and tryptophan. A method for suppressing discoloration of an amino acid or a salt thereof and a vitamin C-containing composition. Furthermore, the discoloration suppression method of the amino acid or its salt and vitamin C containing composition of Claim 1 including contacting with vitamin E. containing an amino acid or a salt thereof, vitamin C, and a silicate as a discoloration inhibitor,
wherein the amino acid or salt thereof is only at least one amino acid or salt thereof selected from the group consisting of leucine, threonine, valine, isoleucine, methionine, phenylalanine, serine , glycine , and alanine A powder composition for 4. The powder composition of claim 3, further comprising vitamin E. containing an amino acid or a salt thereof, vitamin C, and a silicate as a discoloration inhibitor,
wherein the amino acid or salt thereof is only at least one amino acid or salt thereof selected from the group consisting of leucine, threonine, valine, isoleucine, methionine, phenylalanine, serine , glycine , and alanine granules. 6. Granules according to claim 5, further comprising vitamin E. containing at least one of the powder composition according to any one of claims 3 and 4 and the granules according to any one of claims 5 and 6,
The amino acid or its salt contained in the tablet is only at least one amino acid or its salt selected from the group consisting of leucine, threonine, valine, isoleucine, methionine, phenylalanine, serine , glycine , and alanine . A tablet characterized by