JP5791304B2 - Vitamin C reaction suppression method and food products containing vitamin C - Google Patents

Description

  The present invention relates to foods containing vitamin Cs (ascorbic acid and salts thereof), and more particularly to a technique for suppressing the occurrence of problems such as browning (discoloration) of vitamin Cs.

  Conventionally, as disclosed in Patent Document 1, the problem of browning (discoloration) of vitamin Cs has been pointed out for foods to which vitamin Cs (ascorbic acid and salts thereof) are added. Patent Document 1 discloses that glycerol is used to stabilize foods and suppress browning (see Patent Document 1).

JP-A-6-30746

  The inventors have been studying techniques for inhibiting browning in relation to the production of foods containing vitamin C, but within the scope of the study, glycerol should be actively added to foods. Therefore, it was necessary to take measures to prevent browning of vitamin C by a new method.

  In addition to the vitamin Cs, the foods we are particularly considering are supposed to contain amino acids and proteins, but when vitamins C and amino acids or proteins come into physical contact, Maillard Browning will be promoted by the reaction. For this reason, the inventors noticed that it is necessary to surely suppress the contact between vitamin Cs and amino acids and proteins in order to suppress this Maillard reaction.

  In order to solve the above-mentioned problems, the present invention proposes a novel technique for a method for suppressing the reaction of vitamin Cs.

  The problem to be solved by the present invention is as described above. Next, means for solving the problem will be described.

That is, as described in claim 1,
A method for producing a food containing vitamin C and amino acids and / or protein,
The amino acids and the Vitamin C, and / or, in the previous step than the protein is mixed,
Step of coating with calcium compounds to the Vitamin C is carried out,
It is set as the manufacturing method of the foodstuff containing vitamin C.

Moreover, as described in claim 2,
The step of coating the vitamin C with calcium is as follows:
Suppose that it is performed by spraying a granulating spray solution onto a granulating powder composed of a mixture containing vitamin C and calcium.

Moreover, as described in claim 3 ,
The 50% particle size (median diameter) of the vitamin C is 50 μm or more and 500 μm or less.

Moreover, as described in claim 4 ,
The 50% particle size (median diameter) of the calcium is 0.1 μm or more and 80 μm or less.

  According to the effect of the present invention, since vitamin Cs are coated with calcium, it is possible to suppress vitamin Cs from coming into direct contact (physical or mechanical) with other substances, Problems such as vitamin C browning due to contact with other substances can be suppressed.

The figure explaining coat | covering vitamin Cs with calcium. The figure explaining the example of browning. The figure explaining this invention which has the process of coat | covering vitamin C with calcium. The figure explaining the conventional manufacturing method which does not have the process of coat | covering vitamin C with calcium.

Next, embodiments of the invention will be described.
The method for suppressing the reaction of vitamins C according to the present invention includes:
By covering vitamin C with calcium,
It suppresses contact between vitamin C and other substances.

  According to this, since vitamin Cs are covered with calcium, it is possible to prevent vitamin Cs from coming into direct contact with other substances (physically or mechanically). It is possible to suppress problems such as vitamin C browning due to contact with.

  FIG. 1 schematically shows that vitamin Cs 1 are covered with calciums 2. By interposing calciums 2 between other substances 3 and vitamins C 1, This explains that the reaction between vitamin C 1 and other substance 3 is suppressed. The other substance 3 is assumed to be, for example, amino acids as described later.

In addition, as a kind of vitamin C,
Granules obtained by granulating ascorbic acid, ascorbic acid, and derivatives thereof are conceivable. Examples of the derivatives include sodium ascorbate, calcium ascorbate, and ascorbyl palmitate.
One of these may be used alone, or two or more of these may be used in combination.

In addition, as a state of vitamin C to be coated,
Granules, powders, solids, semisolids, and the like are conceivable, and can be appropriately selected depending on the processing step, the form of the final product, and the like.

In addition, as a kind of calcium,
Examples include calcium carbonate, calcium magnesium carbonate, calcium phosphate, and calcium oxide. Moreover, the following can be considered as a raw material for foods in accordance with these, for example.
As calcium carbonate, shell uncalcined calcium, salmon calcium, eggshell calcium, and the like can be considered.
Dolomite and the like can be considered as being in line with calcium magnesium carbonate.
Fish calcium and the like can be considered as being in line with calcium phosphate.
As calcium oxide, shell fired calcium, etc. can be considered.
One of these may be used alone, or two or more of these may be used in combination.

In addition, as the state of calcium when coating,
A powder form, a granular form, etc. can be considered.

  Further, as shown in FIG. 1, when vitamin C 1 is coated with calcium 2, a binder 4 (binder) may be used to enhance the binding between vitamin C 1 and calcium 2. preferable. Examples of the binder 4 include dextrin, starch, thickening polysaccharide (guar gum, xanthan gum, tara gum, gum arabic, carrageenan, locust bean gum, etc.), agar, pectin, alginic acid, and salts thereof, water-soluble cellulose derivatives, And so on.

  In addition, the product itself obtained by coating vitamin Cs with calcium as described above, or the form of a product containing the product, for example, tablets, granules, powders, capsules It can be in the form of a drug. In addition, the use of the product is not limited to food use, and may be for pharmaceutical use or quasi-drug use, and is not particularly limited. In addition, the products for each of these uses are collectively referred to as “food products” in this specification. In addition, the meaning of the term “product” includes so-called intermediate products used as raw materials in addition to so-called final products that are directly consumed by consumers.

  And in the products described above, since reactions such as the browning of vitamin C are suppressed, the appearance of the product is not impaired by the browning, and also the fragrance and nutritional value are suppressed. It becomes possible to do.

Below, it demonstrates using an Example.
In the following examples, granules in which vitamin Cs were coated with calciums were produced, and tablets using the granules were produced. And it decided to evaluate by using the browning condition in a tablet as an index.

<Example 1>
First, the materials listed in Table 1 were used as raw materials for producing tablets.
About each raw material shown by Table 1, the particle size distribution of each raw material was measured using the laser diffraction scattering method ("Microtrack MT3000II" by Nikkiso Co., Ltd.). The measured numerical value is the 50% particle diameter (median diameter) of the particle size distribution. In Table 1, raw materials used in other than Example 1 are also shown.

(1) Preparation of granules Ascorbic acid ("VC granule-97" manufactured by BASF Japan KK) is used as vitamin C, and calcium raw material ("shell calcinated calcium" manufactured by NC Corporation) is used as calcium. did. Ascorbic acid and calcium raw material are mixed at a mass ratio of 1: 3, and dextrin (“Paindex (registered trademark) # 100” manufactured by Matsutani Chemical Co., Ltd.) as a granulating binder is 10 to 20 with respect to the calcium raw material. % (Weight% concentration) to obtain a granulated powder.
In addition, dextrin (“Paindex (registered trademark) # 100” manufactured by Matsutani Chemical Co., Ltd.) was prepared as a spray for granulation, and a 10% aqueous solution (weight% concentration) was prepared to obtain a spray.

  In addition, by using dextrin and other binders, calcium having poor compression moldability (calcium raw material) can be changed to granules having high compression moldability. For this reason, the addition amount of binders (crystalline cellulose etc.) required at the time of a subsequent tableting process can be suppressed, and the tablet granulation can be measured.

  Then, using a fluidized bed granulating apparatus ("fluidized bed granulator MP-01" manufactured by POWREC Co., Ltd.), a functional material for granulation (granulation powder comprising a mixture of ascorbic acid, calcium raw material and dextrin) ) Was granulated according to a conventional method while uniformly spraying the spray solution described above. At that time, the supply air temperature was 70 ° C., and the spray rate of the spray liquid was 4 to 6 ml / min. In the granulation process here, ascorbic acid (vitamin Cs 1) shown in FIG. 1 is coated with a calcium raw material (calciums 2). In this specification, this granulation process can be defined as “coating treatment of vitamin Cs with calcium” or “pretreatment before tableting”.

  The obtained granulated product is dried at a temperature of 90 ° C. until the water content becomes 2% or less (weight% concentration). Acid / calcium containing granules were obtained.

(2) Preparation of tablets In the obtained ascorbic acid / calcium-containing granules, amino acid mix powder (manufactured by Kyowa Hakko), vitamin mix powder (manufactured by Tomita Pharmaceutical Co., Ltd.), mineral mix powder (manufactured by Tomita Pharmaceutical Co., Ltd.), crystals Cellulose (manufactured by Asahi Kasei Chemicals Corporation) and calcium stearate (manufactured by Sakai Chemical Industry Co., Ltd.) as a lubricant were mixed to obtain a tableting powder.
The tableting powder was tableted using a tableting machine ("HT-AP12SS-U" manufactured by Hata Iron Works Co., Ltd.) to obtain a tablet with a 9 mm round diameter of 330 mg.

(3) Evaluation of changes in tablet appearance The obtained tablets were allowed to stand in a constant temperature and humidity chamber at a temperature of 40 ° C. and a humidity of 75% for 3 hours in an open petri dish. Clear spots were generated on the tablet surface at that time. It was judged visually. The evaluation results of Example 1 are shown in Table 2.
Table 2 also shows Examples 2 to 11 and Comparative Examples 1 to 4 described below.
Further, in the evaluation, “◯” indicates that no spots are generated, “Δ” indicates that spots are slightly observed, and “×” indicates that spots are clearly observed.
In addition, FIG. 2 is for demonstrating the image of this spot 5, and the external appearance of the tablet 6 * 6 immediately after tableting shows the uniform color of one color resembling milky white, depending on reaction. It shows that reddish brown spots 5 and 5 appear.

<Examples 2 to 5>
A tablet was prepared in the same manner as in Example 1 except that the ratio of the calcium raw material to vitamin C was changed as shown in the column of “VC: Ca ratio of granulated portion” in Table 2, and the appearance change was made. Evaluated.

<Examples 6 to 8>
Calcium raw materials,
Example 6: Calcium magnesium carbonate ("Dolomite" manufactured by NC Corporation),
Example 7: Magnesium oxide ("NC calcination shell" manufactured by NC Corporation),
Example 8: Calcium phosphate (“Fish Calcium” manufactured by NC Corporation),
A tablet was prepared in the same manner as in Example 1 except that the change in appearance was evaluated.

<Example 9>
The obtained ascorbic acid / calcium-containing granules were mixed with a collagen raw material (manufactured by Nippi Co., Ltd.) and calcium stearate (manufactured by Sakai Chemical Industry Co., Ltd.) as a lubricant to obtain a tableting powder.

<Examples 10 to 11>
Ascorbic acid type,
Example 10: Na ascorbate (manufactured by BASF Japan Ltd.),
Example 11: Ascorbic acid 100 mesh (manufactured by BASF Japan Ltd.),
A tablet was prepared in the same manner as in Example 1 except that the change in appearance was evaluated.

<Comparative Example 1>
In this comparative example, the “coating treatment with calcium” and the “pretreatment before tableting” in the above examples are not performed.
That is, in Comparative Example 1, dextrin (Matsutani Chemical Co., Ltd.) was used as a calcium raw material and a granulating binder by using a fluidized bed granulator ("fluidized bed granulator MP-01" manufactured by Paulec Co., Ltd.). Sprayed liquid (10% aqueous solution of the above dextrin) is uniformly sprayed on the granulated powder to which “Paindex (registered trademark) # 100” manufactured by the company is added in an amount of 10 to 20% with respect to the calcium raw material. Granulated according to the method.
And this granulated calcium-containing granule, ascorbic acid ("VC granule-97" manufactured by BASF Japan), amino acid mix powder (manufactured by Kyowa Hakko), vitamin mix powder (manufactured by Tomita Pharmaceutical Co., Ltd.) Mineral mix powder (produced by Tomita Pharmaceutical Co., Ltd.), crystalline cellulose (produced by Asahi Kasei Chemicals Corporation), and calcium stearate (manufactured by Sakai Chemical Industry Co., Ltd.) as a lubricant were mixed to obtain a tableting powder.
The tableting powder was tableted using a tableting machine ("HT-AP12SS-U" manufactured by Hata Iron Works Co., Ltd.) to obtain a tablet with a 9 mm round diameter of 330 mg.

<Comparative Example 2>
As shown in Table 2, the other ingredients are
Comparative Example 2: Collagen (Nippi Co., Ltd.)
A tablet was prepared in the same manner as in Comparative Example 1 except that the change in appearance was evaluated.

<Comparative Example 3>
A tablet was prepared in the same manner as in Example 1 except that dextrin ("Paindex (registered trademark) # 100" manufactured by Matsutani Chemical Industry Co., Ltd.) was added in place of the calcium raw material to be added to the granulation part. Prepared and measured changes in appearance. The results are shown in Table 2.

<Comparative Example 4>
A tablet was prepared in the same manner as in Example 1 except that heavy magnesium oxide (manufactured by Tomita Pharmaceutical Co., Ltd.) was added instead of the calcium raw material to be added to the granulation part, and the appearance change was measured. . The results are shown in Table 2.

<Summary of evaluation>
As is apparent from Table 2, in each example, the evaluation was “◯” except that the evaluation in Example 4 was “Δ”.
On the other hand, in the comparative examples, since “coating treatment with calcium of vitamin C” or “pretreatment before tableting” was not carried out, both were evaluated as “x”.
From this, it was confirmed that browning can be suppressed by covering vitamin C with calcium.

  Furthermore, in each Example except Example 9, amino acids are used as a raw material of a tablet. Here, as apparent with reference to Comparative Example 1, when vitamin C comes in contact with amino acids, browning by the Maillard reaction is promoted. However, since vitamin Cs are covered with calcium, it was confirmed that vitamin Cs were prevented from coming into contact with amino acids, and accompanying this, browning was suppressed. That is, even in a situation where browning is likely to occur, it was confirmed that browning can be suppressed by coating vitamins C with calcium.

  Furthermore, in Example 9, collagen, which is a protein, is used as a raw material for tablets. Here, as is clear from Comparative Example 2, when vitamin C comes into contact with protein (collagen), browning by the Maillard reaction is promoted. However, in Example 9, since vitamin Cs are covered with calcium, it is suppressed that vitamin Cs come into contact with protein (collagen), and browning is suppressed accordingly. Was confirmed. That is, even in a situation where browning is likely to occur, it was confirmed that browning can be suppressed by coating vitamins C with calcium.

  In Example 9, collagen was used as a raw material that could be a typical protein, but in addition to collagen, whey protein (whey) made from milk, casein, powder made from soybeans, chicken eggs It is also possible to use powder made from egg whites.

  In addition, the test conditions were an environment with a temperature of 40 ° C. and a humidity of 75%, and the environment was more severe than the environment in general food storage conditions, that is, an environment in which browning was likely to occur. However, even in this case, an example in which an evaluation of “◯” was obtained could be confirmed. As a result, it was confirmed that browning can be suppressed even under severe conditions such as being placed in a hot and humid environment for a long period of time. In particular, for foods that consumers consume directly, the appearance (appearance) impression is also important, so it can be said that it is preferable to reduce the probability of browning by implementing the present invention.

And the following embodiment can be considered from examination of the above Example.
That is,
A method of inhibiting the reaction of vitamin C by coating vitamin C with calcium.

  A binder is used to bind vitamins C and calcium.

  In this case, the 50% particle size (median diameter) of vitamin C is 50 μm or more and 500 μm or less, and preferably 100 μm or more and 400 μm or less.

  The 50% particle diameter (median diameter) of calcium is 0.1 μm or more and 80 μm or less, preferably 5 μm or more and 30 μm or less. Here, the intention of setting the 50% particle size (median diameter) of the calciums used to be smaller than the 50% particle size (median diameter) of the vitamin Cs is that the calciums are evenly distributed around the vitamin Cs. For making it easy to coat vitamin C with calcium.

Further, it is considered that the granulating binder to be added to the granulation part is used in a weight ratio of 8% to 25%, more preferably 10% to 20% with respect to calcium.
In addition to the addition, as a spray liquid used in the fluidized bed granulator, the binder for granulation is 1% to 10%, more preferably 3% to 8% by weight ratio with respect to calcium. It is conceivable to use a spray solution (aqueous solution).
In addition, as a binder for granulation, dextrin, starch, thickening polysaccharide (guar gum, xanthan gum, tara gum, gum arabic, carrageenan, locust bean gum, etc.), agar, pectin, alginic acid, and salts thereof, Water-soluble cellulose derivatives are also conceivable.

  Further, it is conceivable that the moisture value of the granulated granule at the end of spraying of the above-mentioned spray liquid is set to 4% or more and 10% or less, more preferably 6% or more and 8% or less.

  Moreover, the product granulated by the above embodiment can be processed into tablets together with other substances (raw materials) such as amino acids. In addition, the type of amino acid used as a raw material is not particularly limited, but for food, it is conceivable that it is appropriately selected from essential amino acids. In addition, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, if specifically described as candidates for “amino acids” , Proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine, and the like, and amino acid derivatives such as sulfates, phosphates, nitrates, citrates, or pyrrolidone carboxylic acids. .

And in the manufacturing method of products, such as such a tablet, it can be considered as the following embodiment.
That is,
A method for producing a food product including vitamins C and calcium,
It includes a step of coating vitamin Cs with calcium.

Moreover, it is a manufacturing method of food products including vitamin C,
In the step prior to the mixing of vitamins C and amino acids and / or proteins,
The step of coating vitamin Cs with calciums is to be carried out.

FIG. 3 shows the manufacturing method of the present application in order to help understanding of the method according to the present invention.
The upper part manufacturing method 1 of FIG. 3 shows an example of the manufacturing method of the present application when vitamin Cs and amino acids are used as raw materials. The granulation step including the treatment of coating vitamins C with calcium is This is performed independently of the type of granulation process. Thereby, since vitamin C is coat | covered with calcium before amino acids and vitamin C contact, it becomes possible to suppress a contact with an amino acid and vitamin C.

  Similarly, the present production method 2 shown in the middle of FIG. 3 shows an example of the present production method in the case where vitamin Cs and proteins are used as raw materials, and includes a process of coating vitamin Cs with calcium. The process is performed independently of the protein granulation process. Thereby, since vitamin C is coat | covered with calcium before protein and vitamin C contact, it becomes possible to suppress a contact with protein and vitamin C.

  Furthermore, the production method 3 shown in the lower part of FIG. 3 shows an example of the production method in the case where vitamin Cs, amino acids, and proteins are used as raw materials, and a treatment for coating vitamin Cs with calcium is shown. The granulating step is performed independently of the granulating step of amino acids or proteins. As a result, since amino acids and proteins are coated with calcium before vitamin Cs come into contact with vitamin C, it is possible to suppress amino acids and proteins from coming into contact with vitamin Cs. It will be. In the example in the lower part of FIG. 3, the amino acids and the protein are granulated separately, but it is also possible to granulate a mixture of the amino acids and the protein.

In contrast to the above manufacturing method of the present application, in the conventional manufacturing method 1 shown in the upper part of FIG. 4, granulation of calcium and granulation of amino acids are performed individually, and then vitamin C and other raw materials, Are to be mixed. In this case, since amino acids and vitamin C come into contact with each other, browning of vitamin C is a concern. Similarly, in the conventional production method No. 2 of interruption shown in FIG. 4, an example in which protein granulation is performed individually is shown.
Further, in the conventional production method No. 3 shown in the lower part of FIG. 4, since all raw materials such as calcium, amino acids, protein, and vitamin C are granulated together, even in this case, amino acids and proteins and vitamin C are used. Since the species will come into contact, the browning of vitamin C will be a concern.

  The present invention is widely applicable as a technique for suppressing the reaction of vitamin Cs and suppressing browning.

1 Vitamin C 2 Calcium 3 Other substance 4 Binder 5 Spot 6 Tablet

Claims (4)

A method for producing a food containing vitamin C and amino acids and / or protein,
The amino acids and the Vitamin C, and / or, in the previous step than the protein is mixed,
Step of coating with calcium compounds to the Vitamin C is carried out,
A method for producing a food containing vitamin Cs. The step of coating the vitamin C with calcium is as follows:
It is performed by spraying a granulation spray liquid on the granulation powder consisting of a mixture containing the vitamin C and calcium, and granulating.
The manufacturing method of the foodstuff containing the vitamin C of Claim 1 characterized by the above-mentioned. The 50% particle diameter (median diameter) of the vitamin C is 50 μm or more and 500 μm or less.
The manufacturing method of the foodstuff containing the vitamin C of Claim 1 or Claim 2 characterized by the above-mentioned. The 50% particle diameter (median diameter) of the calcium is 0.1 μm or more and 80 μm or less.
The manufacturing method of the foodstuff containing the vitamin C as described in any one of Claims 1 thru | or 3 characterized by the above-mentioned.

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