JP5948089B2 - Vitamin mineral-containing tablet and method for producing the same - Google Patents

Description

  The present invention relates to a vitamin mineral-containing tablet containing vitamin C and iron and a method for producing the same.

  In recent years, with the increasing awareness of irregular diets and beauty, there is an increasing demand for dietary supplements and supplements containing vitamins and minerals in order to supplement nutrients such as vitamins and minerals that are lacking in the diet. Further, as these dosage forms, tablets that can be taken easily are preferred.

However, coexistence of vitamins and minerals in tablets causes undesirable chemical interactions due to their physical contact, resulting in reduced nutritional efficacy and changes in the appearance of the tablets such as spots (brown spots) and browning. There is a problem. In particular, since vitamin C is easily affected by inorganic iron, tablets containing these are prone to browning and black spots, resulting in a problem that the commercial value is reduced.
Therefore, conventionally, vitamin C and inorganic iron are often not co-mixed in the formulation, and even if co-mixed, the content per tablet is about 5% by mass to 10% by mass of vitamin C. The iron content was about 0.2% by mass to 0.3% by mass, and the iron content was very small.

As a method for concealing the browning or black spots of the tablet, measures such as making it difficult to visually observe the appearance change by coloring the tablet using a colored coating or a pigment (colorant) on the tablet have been performed.
However, in this correspondence, although the problem of the appearance of the tablet can be solved, it is a problem in that the decrease in the efficacy of the nutritional component cannot be prevented.

To solve this problem, a method has been proposed in which a tablet containing vitamin C and iron is mixed with dicalcium phosphate anhydride to make the tablet a low moisture environment and suppress the occurrence of black spots (Patent Literature). 1).
However, the amount of anhydrous and / or hydrated dicalcium phosphate used as a food additive in foods is defined as less than 1% by mass as the calcium content, and the amount that can be incorporated as a binder is extremely high. There is a problem that there are few. Nutritional supplements and supplements are desired to be able to ingest many nutrients with a small intake (number of tablets), so this proposed technique is not suitable for containing a large amount of vitamins and minerals per tablet. It is.

In addition, in powdered soy protein foods, a method of preventing the occurrence of black spots by coating one or both of vitamin C and iron with hardened fats, sugars, proteins, etc. has been proposed (see Patent Document 2). ).
However, the chemical interaction caused by the physical contact between the vitamin C and the iron is greatly different between the powder and granule state and the tablet state. It is not possible to suppress the occurrence of
In other words, since tablets are compression-molded during processing, vitamin C and iron are forcibly forced in a minute environment with a strong tableting pressure that is not applied in a powder or granule state. Since the contacted vitamin C and iron that have been further contacted do not leave thereafter, these chemical interactions continue to progress, and the occurrence of browning and black spots cannot be suppressed. On the other hand, in the state of powder or granule, the contact probability between vitamin C and iron is extremely low compared to the case of tablets, there is no forced contact as in the case of tablets, and vitamin C Even when iron and iron come into contact with each other, the chemical interaction does not always proceed because they may be dispersed and separated. Therefore, the proposed method cannot solve the problems of browning and black spots inherent to tablets.

  Therefore, even when vitamin C and iron are forcibly brought into contact in a minute environment by compression molding to contain vitamin C and iron at a high content and processing into tablets. The present situation is that it is strongly desired to provide a vitamin-mineral-containing tablet capable of suppressing the browning of tablets and the occurrence of black spots and a method for producing the same.

JP 2010-518822 A Japanese Patent No. 3807660

  An object of the present invention is to solve the above-described problems and achieve the following objects. That is, in the present invention, when vitamin C and iron are forcibly brought into contact with each other in a minute environment by compression molding to contain vitamin C and iron at a high content and processing into tablets. Even so, it is an object to provide a vitamin-mineral-containing tablet capable of suppressing the browning of tablets and the occurrence of black spots and a method for producing the same.

Means for solving the problems are as follows. That is,
<1> A vitamin-mineral-containing tablet containing at least vitamin C and iron, wherein the iron content is 1% by mass or more per tablet, stored at a temperature of 60 ° C. and a relative humidity of 0% for 3 days A vitamin mineral-containing tablet characterized in that the color difference ΔEab * between the previous color of the tablet surface and the color of the tablet surface after storage for 3 days at a temperature of 60 ° C. and a relative humidity of 0% is 12.0 or less. is there.
<2> The vitamin mineral-containing tablet according to <1>, wherein the iron content is 4% by mass or more per tablet.
<3> The vitamin-mineral-containing tablet according to any one of <1> to <2>, wherein the coated iron-containing granule and the coated vitamin C-containing granule are tableted.
<4> The vitamin mineral-containing tablet according to any one of <1> to <3>, wherein the mass ratio of iron and vitamin C (iron: vitamin C) is 1: 0.1 to 30.
<5> A granulating step for granulating vitamin C and iron, a coating step for coating the granulated vitamin C and the granulated iron, respectively, and the coated vitamin C and the coated iron A method for producing a vitamin-mineral-containing tablet comprising at least a mixture preparation step for preparing a mixture by mixing and a tableting step for tableting the mixture.

  According to the present invention, the above-mentioned problems can be solved and the above-mentioned object can be achieved, and a high content of vitamin C and iron, and compression processing for processing into tablets, To provide a vitamin-mineral-containing tablet that can suppress the browning of tablets and the occurrence of black spots even when vitamin C and iron are forcibly contacted in a rough environment and a method for producing the same it can.

FIG. 1 is a photograph showing an example of the appearance of vitamin mineral-containing tablets of Examples and Comparative Examples. FIG. 2A is a diagram showing an example of the appearance of the vitamin mineral-containing powder of Comparative Example 6. FIG. 2B is a diagram showing an example of the appearance of the vitamin mineral-containing powder of Comparative Example 7. FIG. 2C is a diagram showing an example of the appearance of the vitamin mineral-containing powder of Comparative Example 8.

(Vitamin mineral-containing tablets)
The vitamin mineral-containing tablet of the present invention (hereinafter sometimes simply referred to as “tablet”) contains at least vitamin C and iron, and further contains other components as necessary.
The vitamin mineral-containing tablet of the present invention comprises a color of the tablet surface before storage for 3 days at a temperature of 60 ° C. and a relative humidity of 0%, and a color of the tablet surface after storage for 3 days at a temperature of 60 ° C. and a relative humidity of 0%. The color difference ΔEab * is 12.0 or less. Moreover, there is no black spot.

<Vitamin C>
Examples of the vitamin C include ascorbic acid and derivatives thereof, or salts thereof.
The salt of ascorbic acid is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include sodium ascorbate, calcium ascorbate, potassium ascorbate, and magnesium ascorbate.
There is no restriction | limiting in particular as a derivative | guide_body of the said ascorbic acid, According to the objective, it can select suitably, For example, ester bodies of ascorbic acid, such as ascorbyl palmitate and ascorbic acid phosphate, etc. are mentioned.
These may be used alone or in combination of two or more.

  The state of the vitamin C raw material is not particularly limited and can be appropriately selected according to the method for producing the vitamin-mineral-containing tablet, the form of the final product, and the like. For example, granules, powders, solids, Examples include semi-solid forms. Among these, powder and granule are preferable, and granule is particularly preferable.

Even when the vitamin C is coated (coated) and tableted with the iron, direct contact with the iron can be prevented, and browning and black spots of the tablet can be prevented. It is preferable at the point which can suppress generation | occurrence | production of this.
The material used for the coating of vitamin C (hereinafter sometimes referred to as “coating material”) is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include known thickeners. .

  The thickener is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include polysaccharides such as dextrin, guar gum, xanthan gum, locust bean gum, gum arabic, and pullulan; cellulose, methylcellulose, ethylcellulose, Cellulose derivatives such as carboxymethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, low-substituted hydroxypropylcellulose; proteins such as gelatin, casein, starch, carboxymethylstarch; alginic acid such as sodium alginate, ammonium alginate, potassium alginate or the like Its salt; gelatin; polyvinyl alcohol, polyethylene oxide, polyethylene glycol, ethylene propylene butyl Kkuporima, sodium polyacrylate, polymer compounds such as polyvinylpyrrolidone and the like. These may be used alone or in combination of two or more.

  Moreover, the said vitamin C may be coat | covered with components other than the said thickener. Examples of components other than the thickener include, for example, calcium carbonate (shell shell uncalcined calcium, salmon calcium, eggshell calcium, etc.), calcium carbonate magnesium (dolomite, etc.), calcium phosphate (fish fish, etc.), calcium oxide (shell shell calcined calcium, etc.) ), Etc .; polyphenols such as flavonoids (catechin, anthocyanin, tannin, etc.), phenols (chlorogenic acid, ellagic acid, curcumin, etc.); vegetable oils extracted from rapeseed, soybean, sunflower, oil palm, etc. Is mentioned.

  Among these, as the coated vitamin C, vitamin C coated with polysaccharides, cellulose derivatives, calciums and the like are preferable, and vitamin C coated with pullulan, hydroxypropylmethylcellulose, calcium carbonate, and the like are more preferable.

The coated vitamin C may be referred to as vitamin C having a coating layer. In the present invention, the coating layer is not particularly limited as long as physical contact between the vitamin C and the iron can be reduced or suppressed, and browning and black spots on the vitamin mineral-containing tablet surface can be suppressed. It can be appropriately selected depending on the case.
Accordingly, the coverage of the coating layer is not particularly limited and can be appropriately selected according to the purpose. The coating layer is continuous (the whole of the vitamin C is covered). Alternatively, it may be discontinuous (a part of the vitamin C is covered). The thickness of the coating layer is not particularly limited and may be appropriately selected depending on the purpose. The thickness may be uniform or non-uniform.

  In the vitamin C having the coating layer, the content of the coating material is not particularly limited and may be appropriately selected depending on the intended purpose, but is 0.5% by mass to 5% by mass with respect to the vitamin C. % Is preferable, and 1% by mass to 3% by mass is more preferable. When the content of the coating layer is less than 0.5% by mass, the exposed portion of the vitamin C is too much to easily react with the iron, so that the color difference may not be obtained. Further, if the content of the coating material exceeds 5% by mass, granulation and / or coating time is greatly extended, which is not suitable for production, and tableting failure due to excessive granulation of granules is caused. It may occur, the tablet mass may become too large, and the dosage may become worse.

  In addition, when the said coating material is calcium, as content of this calcium, 0.5 mass part-5 mass parts are preferable with respect to the said vitamin C1 mass part, and 1 mass part-4 mass parts are. More preferred. If the calcium content is less than 0.5 parts by mass, the exposed portion of the vitamin C is too much to easily react with the iron, so that the color difference may not be obtained. If it exceeds 5 parts by mass, the granulation and / or coating time will be greatly extended, making it unsuitable for production, causing tableting failure due to the granulated granule becoming too large, and tablet mass becoming too large. , The feeling of taking may be worse.

As the vitamin C, commercially available products can be used. Examples of the commercially available products include vitamin C-containing granules-97, L-ascorbic acid, sodium L-ascorbate, and calcium L-ascorbate (all of which are BASF Japan stocks). Company-made), L-ascorbic acid, sodium L-ascorbate, calcium L-ascorbate (all manufactured by Fuso Chemical Co., Ltd.), and the like. These are uncoated vitamin C.
As said coated vitamin C, a commercial item may be used and the vitamin C coated by the coating process of the manufacturing method of the vitamin mineral containing tablet of this invention mentioned later may be sufficient.
Examples of the commercially available coated vitamin C include VC-80R (manufactured by NOF Chemical Co., Ltd.), VC-90R (manufactured by NOF Chemical Co., Ltd.), and ascorbic acid-95R (manufactured by NOF Chemical Co., Ltd.). , Vitacoat C-95, Vitacoat C-70 (all manufactured by Yokohama Oil & Fat Co., Ltd.) and the like.
Moreover, what was coat | covered with the coating | coated process of the manufacturing method of the vitamin-mineral containing tablet of this invention mentioned later further mentioned later of the said coated vitamin C commercial item may be sufficient.

There is no restriction | limiting in particular as content of vitamin C in the said vitamin-mineral containing tablet, Although it can select suitably according to the objective, 3 mass% or more is preferable per tablet and 10 mass% or more is more preferable.
There is no restriction | limiting in particular as an upper limit of content of the said vitamin C, Although it can select suitably according to the objective, 50 mass% or less is a mixing | blending balance with the iron in the said vitamin mineral containing tablet, tableting It is preferable at points, such as property, and 40 mass% or less is more preferable.

<Iron>
The iron may be in an element (Fe ⁰ ) state, an iron cation (Fe ²⁺ , Fe ³⁺ ) state, or an iron-containing compound state.
The iron-containing compound is not particularly limited and may be appropriately selected depending on the intended purpose. For example, ferric ammonium citrate, ferric chloride, ferric citrate, ferric phosphate, pyrroline Ferrous acid, ferric pyrophosphate, ferric sulfate, ferrous ascorbate, ferrous carboxylate, ferrous citrate, ferrous fumarate, ferrous gluconate, ferrous lactate , Ferrous sulfate, ferric hydroxide, ferric oxide and the like. These may be used alone or in combination of two or more. Among these, ferric pyrophosphate is preferable because iron pyrophosphate has high solubility in water and has been used as an iron supplement for children and the elderly.

  The state of the iron raw material is not particularly limited and may be appropriately selected depending on the processing step, the form of the final product, and the like, and examples thereof include granular, powdery, solid, and semisolid forms. .

Even when the iron is coated (coated) and tableted with the vitamin C, direct contact with the vitamin C can be prevented. It is preferable at the point which can suppress generation | occurrence | production of a spot.
There is no restriction | limiting in particular as a material (henceforth a "coating material") used for the said iron coating | cover, According to the objective, it can select suitably, A well-known thickener etc. are mentioned. As said thickener, the thing similar to the said vitamin C is mentioned suitably.

The coated iron may be referred to as iron having a coating layer. In the present invention, the coating layer is not particularly limited as long as physical contact between the vitamin C and the iron can be reduced or suppressed, and browning and black spots on the vitamin mineral-containing tablet surface can be suppressed. It can be appropriately selected depending on the case.
Therefore, there is no restriction | limiting in particular as a coverage of the said coating layer, According to the objective, it can select suitably, This coating layer is what was continuous (what covered the whole said iron), Alternatively, it may be discontinuous (a part of the iron is covered). The thickness of the coating layer is not particularly limited and may be appropriately selected depending on the purpose. The thickness may be uniform or non-uniform.

  In the iron having the coating layer, the content of the coating material is not particularly limited and may be appropriately selected according to the purpose. However, the content of iron is 0.5% by mass to 5% by mass. Preferably, 1% by mass to 3% by mass is more preferable. If the content of the coating layer is less than 0.5% by mass, the exposed portion of the iron is too much to easily react with the vitamin C, so that the color difference may not be obtained. Further, if the content of the coating material exceeds 5% by mass, granulation and / or coating time is greatly extended, which is not suitable for production, and tableting failure due to excessive granulation of granules is caused. It may occur, the tablet mass may become too large, and the dosage may become worse.

As the iron, commercially available products can be used. Examples of the commercially available products include ferric pyrophosphate, ferrous gluconate (all manufactured by Tomita Pharmaceutical Co., Ltd.), ferrous sulfate (Furukawa Chemicals Co., Ltd.). Manufactured). These are uncoated iron.
As the coated iron, a commercially available product may be used, or iron coated in the coating step of the method for producing a vitamin-mineral-containing tablet of the present invention described later.
Examples of the coated iron commercial products include Sun Active Fe-P80, Sun Active Fe-12 (all manufactured by Taiyo Kagaku Co., Ltd.), and FP-80R (manufactured by NOF Chemical Co., Ltd.).
Moreover, what was coat | covered with the coating | coated process of the manufacturing method of the vitamin-mineral containing tablet of this invention mentioned later further mentioned later of the said coated iron commercial item may be sufficient.

The content of the iron in the vitamin mineral-containing tablet is not particularly limited as long as it is 1% by mass or more per tablet, and can be appropriately selected according to the purpose, but is preferably 4% by mass or more, 7 mass% or more is more preferable.
There is no restriction | limiting in particular as an upper limit of content of the said iron, Although it can select suitably according to the objective, 50 mass% or less is a mixing | blending balance with the vitamin C in the said vitamin mineral containing tablet, tableting It is preferable at points, such as property, and 40 mass% or less is more preferable.

  Here, the mass ratio of the iron and the vitamin C (vitamin C / iron) in the vitamin mineral-containing tablet is not particularly limited and can be appropriately selected according to the purpose. 30 is preferable, and 0.5 to 15 is more preferable. If the mass ratio is less than 0.1, the content of vitamin C is too small, and vitamin C may not be blended uniformly into the vitamin mineral-containing tablet. If it exceeds 30, the tablet mass will increase. Too much, the feeling of taking may be worse.

<Other ingredients>
The other components are not particularly limited and may be appropriately selected depending on the purpose. For example, vitamins other than vitamin C, minerals other than iron, amino acids, functional components, various polyphenols, Examples of the agent include a disintegrating agent, a disintegrating agent, an excipient, a binder, a fixing agent, a coloring agent, a pH adjusting agent, a buffering agent, and an antioxidant.

Examples of the vitamins include vitamin A, vitamin B group, vitamin D, vitamin E, folic acid, niacin, pantothenic acid, hesperidin, inositol and the like.
Examples of the mineral include calcium, zinc, magnesium, manganese, copper, selenium, chromium, and molybdenum.
Examples of the functional component include coenzyme Q10, α-lipoic acid, L-carnitine and the like.
Examples of the lubricant include stearic acid, calcium stearate, magnesium stearate, sodium stearyl fumarate, sucrose fatty acid ester, talc, fine silicon dioxide, light anhydrous silicic acid, hydrous silicon dioxide, vegetable oil and fat, and hardened oil. Is mentioned.
Examples of the excipient include lactose, brewer's yeast, dextrin, starch such as corn starch, and the like.
Examples of the binder include crystalline cellulose, crystalline cellulose / fine silicon oxide, cellulose derivatives, sugar alcohol, and reduced maltose syrup.
Examples of the colorant include titanium oxide and iron oxide.
Examples of the pH adjusting agent and the buffering agent include sodium citrate, sodium acetate, sodium phosphate and the like.
These may be used alone or in combination of two or more.

  There is no restriction | limiting in particular as content of the said other component, unless the effect of this invention is impaired, It can select suitably according to the objective.

  There is no restriction | limiting in particular as the mass of one tablet of the said vitamin mineral containing tablet, Although it can select suitably according to the number of the components to mix | blend etc., 150 mg-460 mg are preferable and 200 mg-400 mg are more preferable. If the mass is less than 150 mg, the daily recommended number of grains increases and the dosage is inferior, and the handleability of the tablet may be inferior. If it exceeds 460 mg, the tablet may be too large to be ingested. is there.

There is no restriction | limiting in particular as a shape of the said vitamin-mineral containing tablet, Although it can select suitably according to the objective, A round tablet, a triangular tablet, other deformed tablets, etc. are mentioned.
There is no restriction | limiting in particular as an average diameter of the said vitamin-mineral containing tablet, Although it can select suitably according to the objective, 6 mm-18 mm are preferable at the point of the ease of taking, and 7 mm-10 mm are more preferable.
There is no restriction | limiting in particular as thickness of the said vitamin mineral containing tablet, Although it can select suitably according to the objective, 2 mm-7 mm are preferable at the point of the ease of taking, and 3 mm-6 mm are more preferable.

<Tablet physical properties>
The tablet surface color of the vitamin-mineral-containing tablet is stored at a temperature of 60 ° C. and a relative humidity of 0% for 3 days and stored for 3 days at a temperature of 60 ° C. and a relative humidity of 0% for 3 days. The subsequent color difference ΔEab * from the tablet surface color is 12.0 or less, but the ΔEab * is preferably 10.0 or less, and particularly preferably 8.5 or less. When the ΔEab * exceeds 12.0, the efficacy of the component may be reduced, or the tablet may be browned to impair the appearance of the product. On the other hand, when the color difference ΔEab * is within the range of 12.0 or less, it is advantageous in that the appearance is not impaired by browning.
The color difference ΔEab * = 0 is the color of the tablet surface before storage for 3 days at a temperature of 60 ° C. and a relative humidity of 0%, and the color of the tablet surface after storage for 3 days at a temperature of 60 ° C. and a relative humidity of 0%. In order to show that there is no difference, the lower the color difference ΔEab *, the better, and the lower limit value is meaningless.
The ΔEab * is measured with, for example, a spectrocolorimeter (for example, CM-5, manufactured by Konica Minolta Holdings, Inc.), a spectroscopic color difference meter (for example, SE-2000, manufactured by Nippon Denshoku Industries Co., Ltd.), or the like. be able to.

  In addition, the vitamin mineral-containing tablets are not only browned, but are conventionally compression-molded for processing into tablets, so that vitamin C and iron are forcibly brought into contact in a minute environment. , Which does not have black spots on the tablet surface caused by chemical interaction between the vitamin C and the iron, and is black even after storage for 3 days at a temperature of 60 ° C. and a relative humidity of 0%. Spots do not occur. Whether or not the tablet has black spots can be determined visually.

  The method for producing the vitamin mineral-containing tablet is not particularly limited, and a known tablet molding method (tablet method) can be used. The coated iron-containing granule (coated iron-containing granule), The coated vitamin C-containing granule (coated vitamin C-containing granule) is preferably tableted, and it is produced by the method for producing a vitamin-mineral-containing tablet of the present invention, which will be described later. This is particularly preferable from the viewpoint of suppressing the occurrence of the above.

(Method for producing vitamin-mineral-containing tablets)
The method for producing a vitamin-mineral-containing tablet of the present invention includes at least a granulation step, a coating step (coating step), a mixture preparation step, and a tableting step, and further includes other steps as necessary. .

<Granulation process>
The granulation step is a step of granulating vitamin C and iron.
As the vitamin C and the iron, those described in the vitamin mineral-containing tablet of the present invention can be preferably used.

  The granulation method is not particularly limited as long as the vitamin C or the iron can be granulated, and a known method can be appropriately selected according to the purpose. The vitamin C or the iron, If necessary, a method of kneading, kneading and / or stirring other components (hereinafter sometimes referred to as “granulating powder” together) and spraying a suitably selected thickener. Etc.

The thickener is preferably used as a solution or dispersion for spraying.
There is no restriction | limiting in particular as a solvent used in order to melt | dissolve thru | or disperse | distribute the said thickener, Although it can select suitably according to the kind etc. of thickener to be used, Water, ethanol, etc. are mentioned, for example.

  The viscosity of the solution or dispersion of the thickener is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 5 mPa · s to 55 mPa · s, and is preferably 10 mPa · s to 50 mPa · s. More preferred. When the viscosity of the thickener is less than 5 mPa · s, it is difficult for the thickener to adhere to the granulation powder, and the granulation powder cannot be coated, and it is necessary to lengthen the spraying time. The production efficiency may deteriorate, and if it exceeds 55 mPa · s, the viscosity increases, and the viscosity may not be able to be fed by the liquid feed pump.

There is no restriction | limiting in particular as the density | concentration (solid content density | concentration) of this thickener in the melt | dissolution liquid thru | or dispersion liquid of the said thickener, According to the objective, it can select suitably.
The spray amount of the solution or dispersion of the thickener is not particularly limited and may be appropriately selected depending on the viscosity, concentration, etc., but is 0 with respect to 100 parts by mass of the granulation powder. .5 parts by mass to 5 parts by mass is preferable, and 1 part by mass to 3 parts by mass is more preferable. When the spray amount is less than 0.5 parts by mass, the exposed part of the granulated product is too large and easily reacts with the iron or the vitamin C, so the color difference may not be obtained. If it exceeds 5 parts by mass, the granulation and / or coating time will be greatly extended, making it unsuitable for production, causing tableting failure due to the granulated granule becoming too large, and tablet mass becoming too large. , The feeling of taking may be worse.

The method for spraying the thickener is not particularly limited and may be appropriately selected depending on the intended purpose. For example, spraying means provided in the granulating apparatus to be used, for example, a spray gun, a spray nozzle, etc. The method of spraying etc. are mentioned suitably.
At this time, the spraying conditions are not particularly limited, and known conditions can be adopted. The spraying amount, the size of the sprayed mist particles (mist), the spraying time, the spraying can be adopted according to the purpose. An interval or the like can be selected as appropriate.

  There is no restriction | limiting in particular as said granulation apparatus, According to the objective from the well-known granulation apparatus, it can select suitably, For example, a rolling fluid coating apparatus (For example, rolling fluid coating apparatus-MP-01) , Manufactured by POWREC Co., Ltd.), centrifugal flow type coating granulator (eg, Granurex (made by Freund Sangyo Co., Ltd.)), composite type granulating coating device (eg, Spiraflow (made by Freund Sangyo Co., Ltd.)), fluidized Layer granulator / dryer (for example, GPCG / WSG-CT series (manufactured by POWREC Co., Ltd.), flow coater (manufactured by Freund Sangyo Co., Ltd.), fine particle coating / granulating apparatus-SFP series (manufactured by POWREC, Inc.), fine particle coating Equipment GPCG-SCP series (Powrec Co., Ltd.), stirring and mixing granulation (E.g., vertical granulator, manufactured by Powrex), and the like preferably. Of these, tumbling fluidized coating apparatus and / or a fluidized bed granulating drying apparatus is preferred.

  There is no restriction | limiting in particular as supply temperature of the said granulation process, Although it can select suitably according to the objective, 50 to 100 degreeC is preferable and 65 to 90 degreeC is more preferable. If the air supply temperature is less than 50 ° C., the drying efficiency of the granule during the granulation step is poor, the granule is too wet and granulation proceeds too much (the granule becomes too large), or blocking occurs. When the temperature exceeds 100 ° C., the stability of various components in the vitamin mineral-containing tablet may be impaired, and the granulated powder may be burnt.

  There is no restriction | limiting in particular as exhaust temperature of the said granulation process, Although it can select suitably according to the objective, 20 to 45 degreeC is preferable and 25 to 35 degreeC is more preferable. When the exhaust temperature is less than 20 ° C., the drying efficiency of the granule during the granulation step is poor, the granule is too wet and granulation proceeds too much, blocking may occur, and the like. If it exceeds 1, granulation may not proceed and granules having the intended particle size may not be obtained.

  There is no restriction | limiting in particular as time of the said granulation process, Although it can select suitably according to the objective, 15 minutes-50 minutes are preferable, and 20 minutes-40 minutes are more preferable. If the granulation time is less than 15 minutes, granulation may be insufficient and a particle having the desired particle size may not be obtained. If it exceeds 50 minutes, the desired particle size of the granule may be obtained. May be larger.

There is no restriction | limiting in particular as the median diameter (d50) of the said granule, Although it can select suitably according to the objective, 100 micrometers-700 micrometers are preferable, and 300 micrometers-500 micrometers are more preferable. If the median diameter (d50) is less than 100 μm, it may not be uniformly coated in the subsequent coating process, or aggregation may occur in the tableting process, resulting in poor production efficiency. Segregation may occur in the tableting process, each component in the vitamin-mineral-containing tablet may be in a non-uniform state, and a feeling of administration after preparation may be deteriorated.
The median diameter (d50) can be measured with a laser diffraction / scattering particle diameter / particle size distribution measuring apparatus Microtrac MT3000II (manufactured by Nikkiso Co., Ltd.).

  Here, in the granulation step, it is preferable to stop the growth of granules at a desired particle size before the coating step. In order to make the granulated product have a desired particle size, it can be adjusted by the supply air temperature, the exhaust temperature, the time, the spray amount of the thickener, etc. By setting to a preferable exhaust temperature, the growth of granules can be suitably stopped at a desired particle size.

<Coating process>
The coating step is a step of coating (coating) the granulated vitamin C and the granulated iron.
The coating method is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include a method of spraying a suitably selected thickener, and the spraying method includes the granulation. A method similar to the step can be used. The thickener may be the same as or different from the granulation step.
The coating step may be performed continuously with the granulation step or may be performed separately, but it is preferable that the coating step is performed continuously in terms of manufacturing efficiency and easy operation.

  There is no restriction | limiting in particular as supply air temperature of the said coating | covering process, Although it can select suitably according to the objective, 55 to 100 degreeC is preferable and 65 to 90 degreeC is more preferable. If the air supply temperature is less than 55 ° C, the granule obtained in the granulation step cannot be coated, and only granulation may proceed. The granules may not be coated.

  There is no restriction | limiting in particular as exhaust temperature of the said coating process, Although it can select suitably according to the objective, 30 to 45 degreeC is preferable and 35 to 40 degreeC is more preferable. When the exhaust temperature is less than 30 ° C., the granules obtained in the granulation step cannot be coated, and only the granulation may proceed. The granules may not be coated.

  There is no restriction | limiting in particular as time of the said coating process, Although it can select suitably according to the objective, 15 minutes-60 minutes are preferable and 25 minutes-50 minutes are more preferable. When the time for the coating step is less than 15 minutes, the granules may be insufficiently coated, and the exposed portions of the granules may increase. In addition, when the time of the coating process exceeds 60 minutes, the coating time is greatly extended, so that the production efficiency is deteriorated, the coated granule is too large, and the granulated which has become too large causes a subsequent tableting process. In some cases, poor tableting occurs, the tablet mass becomes too large, and the feeling of dosing deteriorates.

  The amount of the thickener sprayed is not particularly limited and may be appropriately selected depending on the intended purpose. It is preferably 0.3 parts by mass to 5 parts by mass with respect to 100 parts by mass of the granules, and 1 part by mass. -3 mass parts is more preferable. When the spray amount is less than 0.3 parts by mass, the granules may be insufficiently coated, and the exposed parts of the granules may increase. In addition, when the spray amount exceeds 5 parts by mass, the coating time is greatly extended, the production efficiency is deteriorated, the coated granules are too large, and the granules that have become too large are used in the subsequent tableting step. In some cases, tableting failure may occur.

  Whether the granulated product (granules) has been coated by the coating step can be confirmed, for example, by observation with an electron microscope.

<Mixture preparation process>
The mixture preparation step is a step of preparing a mixture by mixing the coated vitamin C and the coated iron.
There is no restriction | limiting in particular as said mixing method, It can mix by a conventional method. An apparatus can be used for the mixing. Examples of the apparatus include a container tumbler (manufactured by Yamazaki Metal Industry Co., Ltd.), a V-type mixer (manufactured by Tokuju Kogakusho Co., Ltd.), and a Bole container mixer (manufactured by Kotobuki Kogyo Co., Ltd.). Company-made).

<Tabletting process>
The tableting step is a step of tableting the mixture.
As the pressure of the filling pressurization in the tableting step (tableting pressure) is not particularly limited, as appropriate may be ^{selected, 6kg / cm 2 ~20kg / cm} 2 are preferred according to the purpose, 12 kg / cm ^{2 to} 16 kg / cm ² is more preferable. If the pressure is less than 6 kg / cm ² , sufficient hardness may not be obtained and tablets may become brittle or sticking may occur. If the pressure exceeds 20 kg / cm ² , capping may occur. . On the other hand, when the pressure is in the more preferable range, it is advantageous in that a tablet with sufficient hardness can be obtained, and the occurrence of sticking and capping can be suppressed, and tableting troubles can be suppressed.

  As an apparatus used for the tableting, for example, a tableting machine (for example, HT-APSS type, HT-AP-MS type, HT-X-SS type, HT-X-MS type (above, Hata Iron Works Co., Ltd.) VIRGO, AQUAARIUS, LIBRA (manufactured by Kikusui Seisakusho Co., Ltd.)) and the like.

<Other processes>
There is no restriction | limiting in particular as said other process, According to the objective, it can select suitably, For example, a crushing process, a drying process, a sizing process etc. are mentioned.

<< Crushing process >>
The pulverizing step is a step of pulverizing in advance in order to control the particle size of the granulated product to be not too large before the granulating step.
There is no restriction | limiting in particular as the said grinding | pulverization method, According to the objective, it can select suitably, For example, a grinding | pulverization granulator (power mill, Dalton Co., Ltd.) etc. are mentioned.

<< Drying process >>
The drying step is a step of drying the coated vitamin C or the coated iron after the coating step. By passing through the drying step, it is advantageous in that the handleability is improved in the mixture preparation step to be performed later and the tableting step.
The drying method is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include an air drying method and a heat drying method.

<< Sizing process >>
The granule sizing step is a step of sizing the granules made of coated vitamin C or the granules made of coated iron after the coating step to obtain a uniform particle size. This is advantageous in that the handleability is improved in the tableting step.
The method for adjusting the particle size is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include a method using a sieve having a desired opening.

  EXAMPLES The present invention will be specifically described below with reference to examples of the present invention, but the present invention is not limited to these examples.

(Preparation example A-1: Preparation of spray solution for granulation)
A 5.0% by mass aqueous solution of hydroxypropylcellulose (Selney, manufactured by Nippon Soda Co., Ltd.) as a thickener was prepared, and this was used as a spray for granulation.

(Preparation example B-1: Preparation of coated vitamin C-containing granule 1)
<Granulation process>
Vitamin C as a powder for granulation (Vitamin C-containing granule-97, manufactured by BASF Japan Ltd .; Vitamin C content: 97% by mass) is added to 1.0 part by mass of a fluidized bed granulator (rolling fluid coating device- MP-01, manufactured by POWREC Co., Ltd.) and granulated while uniformly spraying the granulation spray solution of Preparation Example A-1 under the following granulation conditions to prepare vitamin C-containing granules.
[Granulation conditions]
・ Supply temperature: 70 ℃
-Spray rate: 2.5 mL / min-Total spray time: 30 minutes

  The vitamin C-containing granule was observed to grow in particle size during the granulation step while spraying the granulating spray solution for 20 to 30 minutes.

<Coating process>
After completion of the granulation step, the fluidized bed granulation apparatus (rolling fluidized coating apparatus-MP-01, manufactured by POWREC Co., Ltd.) is subjected to the following coating conditions, and the granulation spray liquid is applied to the vitamin C-containing granules. Were coated while uniformly sprayed to prepare a coated vitamin C-containing granule 1 coated with hydroxypropylcellulose.
[Coating conditions]
・ Supply temperature: 85 ℃
-Spray rate: 2.5 mL / min-Total spray time: 40 minutes

After the granulation step, the growth of the vitamin C-containing granules was stopped by raising the exhaust temperature to 40 ° C. by the coating step. Subsequently, while spraying the granulation spray liquid of Preparation Example 1 at an exhaust temperature of 35 ° C. for 10 minutes to 40 minutes, the surface of the vitamin C-containing granules was coated with hydroxypropyl cellulose, and the coated vitamin C-containing granules 1 was gotten.
The content of vitamin C (in terms of pure content) in the obtained coated vitamin C-containing granule 1 was 95% by mass.

<Drying process, sizing process>
Next, the obtained coated vitamin C-containing granules were dried at 90 ° C. until the water content became 2% by mass or less, and sized using a sieve having an opening of 1.00 mm.

(Preparation Example B-2: Preparation of coated vitamin C-containing granule 2)
A coating vitamin C-containing granule 2 was obtained in the same manner as in Preparation Example B-1, except that the coating step was not performed in Preparation Example B-1 and the granulation step was changed to the method shown below.

<Granulation process>
-Preparation of powder containing vitamin C for granulation-
A vitamin C-containing granulation powder having the following composition and blending amount was prepared.
[Powder for vitamin C-containing granulation]
Vitamin C 1 part by mass (Vitamin C-containing granule-97, manufactured by BASF Japan Ltd .; Vitamin C content: 97% by mass)
・ Calcium 3 parts by mass (Calm powder calcined calcium, manufactured by NC Corporation)
Dextrin 0.3 parts by mass (Paindex (registered trademark) # 100, manufactured by Matsutani Chemical Co., Ltd.)

The vitamin C-containing granulation powder is put into a fluidized bed granulator (rolling fluidized coating device-MP-01, manufactured by POWREC Co., Ltd.), granulated while being uniformly sprayed under the following granulation conditions, and shells A coated vitamin C-containing granule 2 coated with powdered calcined calcium was prepared.
The content (in terms of pure content) of vitamin C in the obtained coated vitamin C-containing granule 2 was 22.5% by mass. The coated vitamin C-containing granules 2 were coated with shell powder calcined calcium and were not coated with hydroxypropylcellulose under the following granulation conditions.
[Granulation conditions]
・ Air supply temperature: 60 ℃
Exhaust temperature: 0 to 30 minutes: 26 ° C to 35 ° C
-Spraying speed: 5.0 mL / min- Total spraying time: 30 minutes

(Preparation Example B-3: Preparation of vitamin C-containing granule 1)
In Preparation Example B-1, an uncoated vitamin C-containing granule 1 was obtained in the same manner as Preparation Example B-1, except that the coating step was not performed and the granulation step was changed to the following method. .

<Granulation process>
Vitamin C as a powder for granulation (Vitamin C-containing granule-97, manufactured by BASF Japan Ltd .; Vitamin C content: 97% by mass) is added to 1.0 part by mass of a fluidized bed granulator (rolling fluid coating device- MP-01, manufactured by POWREC Co., Ltd.) and granulated while uniformly spraying the granulation spray solution of Preparation Example A-1 under the following granulation conditions to prepare vitamin C-containing granules 1.
Vitamin C content (in terms of pure content) in the obtained vitamin C-containing granule 1 was 95% by mass. Note that vitamin C was not coated with hydroxypropylcellulose under the following granulation conditions.
[Granulation conditions]
・ Air supply temperature: 60 ℃
Exhaust temperature: 0 to 30 minutes: 26 ° C to 35 ° C
-Spraying speed: 5.0 mL / min- Total spraying time: 30 minutes

(Preparation Example C-1: Preparation of coated iron-containing granule 1)
<Granulation process>
-Preparation of iron-containing granulation powder-
An iron-containing granulation powder having the following composition and blending amount was prepared.
[Powder for iron-containing granulation]
-Iron 1 part by mass (ferric pyrophosphate, manufactured by Tomita Pharmaceutical Co., Ltd .; iron content: 25% by mass)
Dextrin 0.7 parts by mass (Paindex (registered trademark) # 100, manufactured by Matsutani Chemical Co., Ltd.)

The iron-containing granulation powder is put into a fluidized bed granulator (rolling fluidized coating device-MP-01, manufactured by POWREC Co., Ltd.), and the granulation spray liquid of Preparation Example A-1 is granulated under the following granulation conditions. Then, the mixture was granulated while spraying uniformly to prepare iron-containing granules.
[Granulation conditions]
・ Supply temperature: 70 ℃
-Spray rate: 2.5 mL / min-Total spray time: 30 minutes

  The particle size of the vitamin C-containing granule grew during the granulation step while spraying the granulating spray solution for 20 to 30 minutes.

<Coating process>
After completion of the granulation step, the inside of the fluidized bed granulator (rolling fluidized coating device-MP-01, manufactured by POWREC Co., Ltd.) is subjected to the following coating conditions, and the iron-containing granule is sprayed with the granulation liquid. Were coated while being uniformly dispersed to prepare coated iron-containing granules 1 coated with hydroxypropylcellulose.
[Coating conditions]
・ Supply temperature: 85 ℃
-Spray rate: 2.5 mL / min-Total spray time: 40 minutes

After the granulation step, the growth of the iron-containing granules was stopped by raising the exhaust temperature to 40 ° C. by the coating step. Subsequently, during spraying at an exhaust temperature of 35 ° C. for 10 minutes to 40 minutes, the surface of the iron-containing granules was coated with hydroxypropylcellulose, and coated iron-containing granules 1 were obtained.
In the obtained coated iron-containing granule 1, the iron content (in terms of pure content) was 14.5% by mass.

<Drying process, sizing process>
The obtained coated iron-containing granules were dried at 90 ° C. until the water content became 2% by mass or less, and sized using a sieve having an opening of 1.00 mm.

(Preparation Example C-2: Preparation of coated iron-containing granule 2)
In Preparation Example C-1, the coating iron-containing granule 2 of Preparation Example C-2 was prepared in the same manner as Preparation Example C-1, except that the coating step was not performed and the granulation step was changed to the following method. Obtained.

<Granulation process>
Iron (San Active Fe-P80, manufactured by Taiyo Chemical Co., Ltd .; iron content: 7.6% by mass) 1.0 part by mass as a granulating powder is mixed with a fluidized bed granulator (rolling fluidized coating device-MP -01, manufactured by POWREC Co., Ltd.) and granulated while uniformly spraying the granulation spray solution of Preparation Example A-1 under the following granulation conditions to prepare coated iron-containing granules 2.
The iron content (in terms of pure content) in the obtained coated iron-containing granule 2 was 7.5% by mass. In addition, it was not coat | covered with the hydroxypropyl cellulose on the following granulation conditions.
[Granulation conditions]
・ Air supply temperature: 60 ℃
Exhaust temperature: 0 to 30 minutes: 26 ° C to 35 ° C
-Spray rate: 5.1 mL / min-Total spray time: 30 minutes

(Preparation Example C-3: Preparation of coated iron-containing granule 3)
In Preparation Example C-1, the coating iron-containing granule 3 of Preparation Example C-3 was prepared in the same manner as Preparation Example C-1, except that the coating step was not performed and the granulation step was changed to the following method. Obtained.

<Granulation process>
1.0 part by mass of iron (FP-80R, manufactured by NOF Chemical Co., Ltd .; iron content: 19.7% by mass) as a granulating powder is added to a fluidized bed granulating apparatus (rolling fluidized coating apparatus-MP- 01, manufactured by POWREC Co., Ltd.) and granulated while uniformly spraying the granulation spray solution of Preparation Example A-1 under the following granulation conditions to prepare coated iron-containing granules 3.
The iron content (in terms of pure content) in the obtained coated iron-containing granule 3 was 19.3% by mass. In addition, it was not coat | covered with the hydroxypropyl cellulose on the following granulation conditions.

(Preparation Example C-4: Preparation of iron-containing granule 1)
In Preparation Example C-1, an uncoated iron-containing granule 1 was obtained by the same method as Preparation Example C-1, except that the coating step was not performed and the granulation step was changed to the following method.

<Granulation process>
-Preparation of iron-containing granulation powder-
An iron-containing granulation powder having the following composition and blending amount was prepared.
[Powder for iron-containing granulation]
-Iron 1 part by mass (ferric pyrophosphate, manufactured by Tomita Pharmaceutical Co., Ltd .; iron content: 25% by mass)
Dextrin 0.7 parts by mass (Paindex (registered trademark) # 100, manufactured by Matsutani Chemical Co., Ltd.)

The iron-containing granulation powder is put into a fluidized bed granulator (rolling fluidized coating device-MP-01, manufactured by POWREC Co., Ltd.), and the granulation spray liquid of Preparation Example A-1 is granulated under the following granulation conditions. Then, granulation was performed while uniformly spraying to prepare iron-containing granules 1.
The iron content (in terms of pure content) in the obtained iron-containing granule 1 was 14.5% by mass. In addition, it was not coat | covered with the hydroxypropyl cellulose on the following granulation conditions.
[Granulation conditions]
・ Air supply temperature: 60 ℃
Exhaust temperature: 0 to 30 minutes: 26 ° C to 35 ° C
-Spraying speed: 5.0 mL / min- Total spraying time: 30 minutes

<Confirmation of coating with thickener>
Vitamin C (vitamin C-containing granule-97) and coating vitamin C-containing granule 1 (preparation example B-1) used as raw materials of Preparation Example B-1, and iron-containing material used in Preparation Example C-1 The appearance of granulation powder and coated iron-containing granule 1 (Preparation Example C-1) were observed with an electron microscope (Hitachi Desktop Microscope TM3000, manufactured by Hitachi High-Technologies Corporation), and the states before and after the coating process were compared. It was confirmed that the coated vitamin C-containing granule 1 and the coated iron-containing granule 1 were each coated with a thickener.
Moreover, when each median diameter (d50) was measured with a laser diffraction / scattering type particle size / particle size distribution measuring device (Microtrac MT3000II, manufactured by Nikkiso Co., Ltd.), the median of vitamin C (vitamin C-containing granule-97) was measured. The diameter (d50) was in the range of 300 μm to 500 μm, and the median diameter (d50) of the coated vitamin C-containing granule 1 was 400 μm to 600 μm. The median diameter (d50) of the iron-containing granulated powder was 300 μm to 500 μm, and the median diameter (d50) of the coated iron-containing granule 1 was 400 μm to 600 μm.

(Examples 1-4, Comparative Examples 1-2)
<Mixture preparation process>
Coated or uncoated vitamin C-containing granules and coated or uncoated iron-containing granules are mixed in the composition and blending amount shown in Table 1 below, and vitamin B ₂ (riboflavin, manufactured by BASF Japan Ltd.) 0 .3 parts by mass (manufactured by organo Corporation) vitamin _B 12 · 1,000 triturated 1.2 part by mass was added and the mixture (tablet powder) was prepared. In addition, content of the following Table 1 shows the value converted into the pure content of vitamin C or iron.

<Tabletting process>
Using a tableting machine (HT-AP12SS-U, manufactured by Hata Iron Works Co., Ltd.), the tableting powder was filled and pressed at a pressure of 15 kg / cm ² by a conventional method, and tableting was performed. R) Vitamin mineral-containing tablets of Examples 1-4 and Comparative Examples 1-2, which are 7.5 mm, 360 mg / tablet round tablets, were obtained.

(Comparative Examples 3-5)
<Mixture preparation process>
Vitamin C powder (vitamin C-containing granule-97, manufactured by BASF Japan Ltd .; vitamin C content: 97% by mass) and various iron-containing powders [(ferric pyrophosphate) with the compositions and blending amounts shown in Table 1 below Manufactured by Tomita Pharmaceutical Co., Ltd .; iron content: 25% by mass), (Sanactive Fe-P80, manufactured by Taiyo Kagaku; iron content: 7.6% by mass), or (FP-80R, NOF Chemical Co., Ltd.) company, Ltd., iron content: 19.7 wt%)] were mixed, further, vitamin _{B 2} (riboflavin, manufactured by BASF Japan Ltd.) 0.3 parts by mass of vitamin _B 12 · 1,000 triturated (organo 1.2 parts by mass) were added and mixed to prepare a mixture (tablet powder). In addition, content of the following Table 1 shows the value converted into the pure content of vitamin C or iron.

<Tabletting process>
Using a tableting machine (HT-AP12SS-U, manufactured by Hata Iron Works Co., Ltd.), the tableting powder was filled and pressed at a pressure of 15 kg / cm ² by a conventional method, and tableting was performed. R) Vitamin mineral-containing tablets of Comparative Examples 3 to 5 which were 7.5 mm, 360 mg / tablet round tablets were obtained.

(Comparative Examples 6-8)
<Mixture preparation process>
Vitamin C powder (vitamin C-containing granule-97, manufactured by BASF Japan Ltd .; vitamin C content: 97% by mass) and various iron-containing powders [(ferric pyrophosphate) with the compositions and blending amounts shown in Table 1 below Manufactured by Tomita Pharmaceutical Co., Ltd .; iron content: 25% by mass), (Sanactive Fe-P80, manufactured by Taiyo Kagaku; iron content: 7.6% by mass), or (FP-80R, NOF Chemical Co., Ltd.) company, Ltd., iron content: 19.7 wt%)] were mixed, further, vitamin _{B 2} (riboflavin, manufactured by BASF Japan Ltd.) 0.3 parts by mass of vitamin _B 12 · 1,000 triturated (organo 1.2 parts by mass) were added and mixed to prepare a mixture (mixed powder). In addition, content of the following Table 1 shows the value converted into the pure content of vitamin C or iron.

In Table 1, the content indicates the content per tablet of vitamin mineral-containing tablets.

<Evaluation of tablet physical properties>
The vitamin mineral-containing tablets of Examples 1 to 4 and Comparative Examples 1 to 5 were subjected to “evaluation of browning on the tablet surface” and “evaluation of black spots on the tablet surface” by the following methods.

<< Evaluation of browning of tablet surface >>
The vitamin mineral-containing tablets of Examples 1 to 4 and Comparative Examples 1 to 5 were initially (before storage for 3 days under the conditions of a temperature of 60 ° C. and a relative humidity of 0%) and a temperature of 60 ° C. and a relative humidity of 0%). The color difference ΔEab * after storage for 3 days under the conditions was measured using a spectrocolorimeter CM-5 (manufactured by Konica Minolta Holdings, Inc.). The color difference ΔEab * is 12.0 or less, which is a level that causes no problem in practice. The storage was performed in a hot air circulation type constant temperature dryer NEW HD-60 (manufactured by Nagano Kagaku Kikai Seisakusho).
The results are shown in Table 2 below. Moreover, the external appearance of the vitamin mineral containing tablet of Examples 1-4 and Comparative Examples 1-5 is shown in FIG.

<< Evaluation of black spots on tablet surface >>
As the evaluation of black spots on the tablet surface, the surfaces of the vitamin mineral-containing tablets of Examples 1 to 4 and Comparative Examples 1 to 5 were visually observed and evaluated according to the following evaluation criteria. The results are shown in Table 2. An example of the appearance of the vitamin mineral-containing tablets of Examples 1 to 4 and Comparative Examples 1 to 5 is as shown in FIG.
[Evaluation criteria]
○: No black spots are observed on the tablet surface. Δ: Black spots are generated on the tablet surface, and the area of the black spots is less than 1/10 of the total area of the tablet surface. Seen (black spots are seen in the range of 1/10 or more of the total area of the tablet surface)

<< Comprehensive evaluation >>
Based on the evaluation results of “Evaluation of browning of tablet surface” and “Evaluation of black spots on tablet surface”, “Comprehensive evaluation” was performed according to the following evaluation criteria.
[Evaluation criteria]
○: Eab * is 12.0 or less, and evaluation of black spots on the tablet surface is ○.
Δ: Eab * is 12.0 or less, and the evaluation of black spots on the tablet surface is Δ or ×.
X: Eab * is more than 12.0, and the evaluation of black spots on the tablet surface is Δ or x.

<Evaluation of powder properties>
About the vitamin-mineral containing powder of Comparative Examples 6-8, "Evaluation of powder browning" was performed by the following method. In addition, about the vitamin mineral containing powder of Comparative Examples 6-8, since a black spot cannot be evaluated, the black spot was not evaluated.

<< Evaluation of browning of powder properties >>
Color difference ΔEab * between the initial conditions of Comparative Examples 6-8 (before storage for 3 days under the conditions of 60 ° C. and 0% relative humidity) and after storage for 3 days under the conditions of 60 ° C. and 0% relative humidity) Was measured using a spectrocolorimeter CM-5 (manufactured by Konica Minolta Holdings, Inc.). The color difference ΔEab * is 12.0 or less, which is a level with no practical problem. The storage was performed in a hot air circulation type constant temperature dryer NEW HD-60 (manufactured by Nagano Kagaku Kikai Seisakusho).
The results are shown in Table 2 below. Moreover, the external appearance of the vitamin mineral containing powder of Comparative Examples 6-8 is shown in FIG.

From the results of Table 2, the vitamin mineral-containing tablets of Examples 1 to 4 were slightly browned, but had no black spots and had high product value. On the other hand, the vitamin mineral-containing tablets of Comparative Examples 1 and 2 were slightly browned but had black spots. Further, the vitamin mineral-containing tablets of Comparative Examples 3 to 5 had clear browning and black spots, and had practical problems.
In addition, when the same prescription as the prescription of the tablet (Comparative Examples 3 to 5) in which browning or black spots occurred in the tablet (Comparative Examples 6 to 8), browning is slight and black spots do not occur. It was. This is because the powder is not compression-molded like a tablet, so that vitamin C and iron are not forcibly brought into contact with each other, and chemical interaction between vitamin C and iron does not occur. Therefore, it was found that the vitamin mineral-containing tablets of Examples 1 to 4 were able to solve the problems of browning and black spots inherent to the tablets.

The vitamin mineral-containing tablet of the present invention contains a high amount of vitamin C and iron, and can suppress the occurrence of browning and black spots, which are problems inherent to tablets. It can be suitably used for nutritional supplements and supplements to be used.
In addition, the method for producing a vitamin-mineral-containing tablet of the present invention contains vitamin C and iron at a high content, and is compressed to be processed into a tablet, so that vitamin C and iron are contained in a minute environment. Even if it is a case where it is made to contact forcibly, since browning of a tablet and generation | occurrence | production of a black spot can be suppressed, it can utilize suitably as a manufacturing method of a vitamin mineral containing tablet with high commercial value.

Claims (5)

A vitamin-mineral-containing tablet containing at least vitamin C having a coating layer and iron having a coating layer ,
The iron content is 1% by mass or more per tablet,
The color difference ΔEab * between the color of the tablet surface before storage for 3 days at a temperature of 60 ° C. and a relative humidity of 0% and the color of the tablet surface after storage for 3 days at a temperature of 60 ° C. and a relative humidity of 0% is 12.0 or less. A vitamin-mineral-containing tablet characterized by   The vitamin-mineral-containing tablet according to claim 1, wherein the iron content is 4% by mass or more per tablet. The vitamin mineral-containing tablet according to any one of claims 1 to 2, which does not contain dicalcium phosphate anhydride .   The vitamin-mineral-containing tablet according to any one of claims 1 to 3, wherein a mass ratio of iron and vitamin C (iron: vitamin C) is 1: 0.1 to 30. A method for producing a vitamin-mineral-containing tablet,
A granulation process for granulating vitamin C and iron, respectively;
A coating step for coating each of the granulated vitamin C and the granulated iron;
A mixture preparation step of preparing a mixture by mixing the coated vitamin C and the coated iron;
A tableting step of tableting the mixture;
At least look at including the,
The iron content per tablet is 1% by mass or more,
The color difference ΔEab * between the color of the tablet surface before storage for 3 days at a temperature of 60 ° C. and a relative humidity of 0% and the color of the tablet surface after storage for 3 days at a temperature of 60 ° C. and a relative humidity of 0% is 12.0 or less. A method for producing a vitamin-mineral-containing tablet, wherein