JP7329441B2 - 患者におけるｉｓｈａｋ線維症ステージに基づいた肝線維症の軽減方法及びライソゾーム酸性リパーゼ欠損症の治療方法 - Google Patents
患者におけるｉｓｈａｋ線維症ステージに基づいた肝線維症の軽減方法及びライソゾーム酸性リパーゼ欠損症の治療方法 Download PDFInfo
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- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
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- 235000011088 sodium lactate Nutrition 0.000 description 1
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- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
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- 239000002904 solvent Substances 0.000 description 1
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- 230000001502 supplementing effect Effects 0.000 description 1
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- 229960000984 tocofersolan Drugs 0.000 description 1
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- 238000013519 translation Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
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- TWQULNDIKKJZPH-UHFFFAOYSA-K trilithium;phosphate Chemical compound [Li+].[Li+].[Li+].[O-]P([O-])([O-])=O TWQULNDIKKJZPH-UHFFFAOYSA-K 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (1)
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| JP2021134127A JP2021178874A (ja) | 2016-09-30 | 2021-08-19 | 患者におけるｉｓｈａｋ線維症ステージに基づいた肝線維症の軽減方法及びライソゾーム酸性リパーゼ欠損症の治療方法 |
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| Application Number | Priority Date | Filing Date | Title |
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| US201662402183P | 2016-09-30 | 2016-09-30 | |
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| US201662420233P | 2016-11-10 | 2016-11-10 | |
| US62/420,233 | 2016-11-10 | ||
| US201762456511P | 2017-02-08 | 2017-02-08 | |
| US62/456,511 | 2017-02-08 | ||
| PCT/US2017/053961 WO2018064303A1 (en) | 2016-09-30 | 2017-09-28 | Methods for reducing liver fibrosis and treating lysosomal acid lipase deficiency in patients based on ishak fibrosis stage |
Related Child Applications (1)
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| JP2021134127A Division JP2021178874A (ja) | 2016-09-30 | 2021-08-19 | 患者におけるｉｓｈａｋ線維症ステージに基づいた肝線維症の軽減方法及びライソゾーム酸性リパーゼ欠損症の治療方法 |
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| JP2019529479A JP2019529479A (ja) | 2019-10-17 |
| JP2019529479A5 JP2019529479A5 (enExample) | 2020-11-05 |
| JP7329441B2 true JP7329441B2 (ja) | 2023-08-18 |
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| JP2019516691A Active JP7329441B2 (ja) | 2016-09-30 | 2017-09-28 | 患者におけるｉｓｈａｋ線維症ステージに基づいた肝線維症の軽減方法及びライソゾーム酸性リパーゼ欠損症の治療方法 |
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| JP2021134127A Withdrawn JP2021178874A (ja) | 2016-09-30 | 2021-08-19 | 患者におけるｉｓｈａｋ線維症ステージに基づいた肝線維症の軽減方法及びライソゾーム酸性リパーゼ欠損症の治療方法 |
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| US (1) | US20200038491A1 (enExample) |
| EP (1) | EP3518962B1 (enExample) |
| JP (2) | JP7329441B2 (enExample) |
| ES (1) | ES2888126T3 (enExample) |
| WO (1) | WO2018064303A1 (enExample) |
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| JP7423815B2 (ja) * | 2020-10-20 | 2024-01-29 | セトラスホールディングス株式会社 | 治験管理装置、治験管理方法、治験管理プログラム及び治験管理システム |
| EP4259790A1 (en) * | 2020-12-09 | 2023-10-18 | Genethon | Lysosomal acid lipase variants and uses thereof |
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| TR201909425T4 (tr) | 2005-10-05 | 2019-07-22 | Alexion Pharma Inc | Yüksek ti̇treli̇ vi̇rüsün hizli üreti̇mi̇ |
| MX338426B (es) | 2010-04-23 | 2016-04-15 | Synageva Biopharma Corp | Enzima de enfermedad del almacenamiento lisosomico. |
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2017
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- 2017-09-28 JP JP2019516691A patent/JP7329441B2/ja active Active
- 2017-09-28 WO PCT/US2017/053961 patent/WO2018064303A1/en not_active Ceased
- 2017-09-28 US US16/337,495 patent/US20200038491A1/en not_active Abandoned
- 2017-09-28 ES ES17791485T patent/ES2888126T3/es active Active
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2021
- 2021-08-19 JP JP2021134127A patent/JP2021178874A/ja not_active Withdrawn
Non-Patent Citations (3)
| Title |
|---|
| Ｌｉｖｅｒ Ｔｒａｎｓｐｌａｎｔａｔｉｏｎ，２００８年，１４（５），ｐ．６９５－７００，ＤＯＩ： １０．１００２／ｌｔ．２１４２２ |
| Ｍｏｌ Ｇｅｎｅｔ Ｍｅｔａｂ．，２０１４年，１１２（３），ｐ．２２９－２４１，ＤＯＩ： １０．１０１６／ｊ．ｙｍｇｍｅ．２０１４．０４．００６ |
| Ｎ Ｅｎｇｌ Ｊ Ｍｅｄ．，２０１５年，３７３，ｐ．１０１０－１０２０，ＤＯＩ： １０．１０５６／ＮＥＪＭｏａ１５０１３６５ |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018064303A1 (en) | 2018-04-05 |
| JP2021178874A (ja) | 2021-11-18 |
| EP3518962A1 (en) | 2019-08-07 |
| US20200038491A1 (en) | 2020-02-06 |
| ES2888126T3 (es) | 2021-12-30 |
| JP2019529479A (ja) | 2019-10-17 |
| EP3518962B1 (en) | 2021-06-09 |
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