JP7321809B2 - Odor generation suppression method - Google Patents

Description

The present invention relates to a method for suppressing odor generation.
Further, the present invention relates to methods of controlling pH, for example in the fields of biology, biochemistry and physiology.

BACKGROUND ART In recent years, consumers are becoming more and more concerned about their living environment, and it is desired to reduce or eliminate unpleasant odors around them. Textile products that come into direct contact with human skin, such as underwear, towels, and handkerchiefs, or textile products that absorb or attach sebum-containing sweat or keratin, etc., may emit a peculiar odor. be.

So far, methods for suppressing the production of odors have been investigated by controlling the metabolic reaction to odor-causing substances that occurs in the cells of causative bacteria (microorganisms) that produce odor-causing substances.
For example, Patent Literature 1 discloses a ketone compound having a specific structure as an agent for suppressing the conversion of sebum-stained components into 4-methyl-3-hexenoic acid, which is one of the substances responsible for the dry odor. . Patent Document 2 discloses a macrocyclic ketone compound as an agent that inhibits the activity of β-gluconidase and suppresses the generation of urine odor. Also known is a technique that suppresses the production of odors by using an organic carboxylic acid having a specific structure, such as benzoic acid, to kill microorganisms.

On the other hand, it is known that the activity of fatty acid metabolism-related enzymes is suppressed by making the pH environment in the cytoplasm of odor-causing bacteria acidic (see Non-Patent Document 1), and the intracellular pH is controlled. How to do this is being considered.
For example, Patent Document 3 discloses adjusting the pH in vacuoles of plant cells using a nucleic acid molecule encoding a polypeptide having an activity to change the pH in cells such as plant cells. . Patent document 4 discloses a pH probe capable of measuring intracellular pH, indicating the need to control intracellular pH. Patent Literature 5 describes administering an effective amount of a drug that increases intracellular pH.

However, until now, it has not been known that odor generation can be suppressed by controlling the pH environment in the cytoplasm of odor-causing bacteria.

JP 2012-127012 A WO2009/037861 WO2007/137345 WO2016/138116 WO2016/142445

European J. Biochem., 1969, vol.7, p.559-574

Many of the odor production inhibitors disclosed in Patent Document 1 or Patent Document 2 themselves have an odor, and must be used in an appropriate usage scene and in an appropriate amount. In addition, from the viewpoint of coexistence with the environment, it may be necessary to consider suppression of odor generation without sterilizing microorganisms.

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a method for suppressing odor generation, which can suppress odor generation from odor-causing bacteria without sterilizing odor-causing microorganisms.
Another object of the present invention is to provide a method for controlling the pH of one of two water-containing phases separated by a surfactant film.

In view of the above-mentioned problems, the present inventors conducted intensive studies from the viewpoint of odor-causing substances, odor-causing bacteria, and generation mechanisms. As a result, the organic acid or salt thereof having a carboxyl group in water has a logD calculated by the formula described later in the range of -1.5 or more and 1.5 or less, and the organic acid or salt thereof and the microorganism are mixed in water. It has been found that the contact can suppress the production of odors produced by microorganisms while maintaining the number of microorganisms, and can lower the pH in the cell membrane of microorganisms.
The present invention has been completed based on these findings.

The present invention provides a method for suppressing odor production, comprising contacting the following component (a), water and microorganisms to suppress the amount of odorous substances produced by the microorganisms, wherein the pH of the composition containing the component (a) and water 3, the logD of the component (a) calculated by the following formula (1) is -1.5 or more and 1.5 or less.

(a) component: organic carboxylic acid or its salt

logD = ClogP-log [1 + 10 ^(pH-pKa) ] formula (1)
[In formula (1), ClogP is the calculated logP value of the logarithm of the water/octanol partition coefficient of component (a) in the acid form, pH is the pH of water containing component (a), and pKa is the pKa of component (a). ]

Further, in the present invention, in two phases containing water separated by a surfactant film, the logD of the component (a) present in one phase calculated by the formula (1) is -1.5 or more and 1 It relates to a method of controlling the pH, which is controlled below 0.5 and lowers the pH of the other phase separated by the surfactant membrane.

According to the odor generation suppression method of the present invention, odor generation from odor-causing bacteria can be suppressed without sterilizing odor-causing microorganisms.
Furthermore, the present invention can effectively control the pH of one phase in two phases containing water separated by a surfactant membrane.

<(a) component>
Component (a) used in the method of the present invention is an organic carboxylic acid or a salt thereof.
The component (a) is brought into contact with the microorganism in water in a state where the logD of the component (a) at the pH of the water containing the component (a) is -1.5 or more and 1.5 or less. pH of is lowered. As a result, the component (a) easily penetrates into the microorganisms, and the component (a) penetrated into the microorganisms suppresses the metabolic system that produces odorous substances in the microorganisms, thereby suppressing the production of odorous substances. can be done. In particular, permeation of component (a) into microorganisms lowers the intracellular pH, thereby suppressing the activity of fatty acid metabolism-related enzymes and controlling fatty acid metabolism.
Furthermore, the component (a) is added to one phase separated by the surfactant film in a state where the logD of the component (a) at the pH of the water containing the component (a) is −1.5 or more and 1.5 or less. When present, the component (a) is adsorbed on the surfactant film and easily partitioned into the other phase separated by the surfactant film where the component (a) does not exist. As a result, it is possible to control the pH of the other phase, separated by the surfactant, into which component (a) is distributed. As used herein, "controlling the pH" includes lowering the pH.

In the present invention, the logD of the component (a) calculated by the following formula (1) at the pH of the composition containing the component (a) and water is set to −1.5 or more and 1.5 or less.

logD = ClogP-log [1 + 10 ^(pH-pKa) ] formula (1)

[In formula (1), ClogP is the calculated logP value of the logarithm of the water/octanol partition coefficient of component (a) in the acid form, pH is the pH of water containing component (a), and pKa is the pKa of component (a). ]

In the present invention, logD can be calculated based on the ClogP of the acid form of component (a), the acid dissociation constant (pKa), and the pH of the composition containing component (a) and water. logD is the calculated value of the water/octanol partition coefficient, taking into account the ClogP of the acid form of component (a), the pH of the water containing component (a), and the pKa.
The concept of logD is described, for example, in Li Xing, Robert C. Glen, Novel Methods for the Prediction of logP, pKa, and logD, J. Chem. Inf. Comput. Sci. 2002, vol. 42, p. It has been disclosed and is a well known concept.
In order to calculate logD in the present invention, the value of ClogP and the value of pKa are calculated using thermodynamic property estimation software "COSMOtherm" (Morsys).

Specific examples of component (a) used in the present invention include aliphatic polycarboxylic acids having 8 to 14 carbon atoms or salts thereof. The number of carbon atoms in the component (a) is preferably 8 or more, more preferably 9 or more, and preferably 14 or less, more preferably 12 or less, in terms of easy adjustment of logD to the desired range. and more preferably 10 or less.
Component (a) used in the present invention is the ratio of the molecular weight of component (a) to the molecular weight per carboxyl group, from the viewpoint of being able to control logD within a desired range (molecular weight of component (a))/ The value represented by (molecular weight of carboxyl group) is preferably 1.9 or more, more preferably 2.0 or more, and even more preferably 2.2 or more. From the same point of view, the value represented by (molecular weight of component (a))/(molecular weight of carboxyl group) is preferably 3.5 or less, more preferably 3.2 or less, more preferably 3.0 or less, and 2 0.8 or less is more preferred. By setting the value represented by (molecular weight of component (a))/(molecular weight of carboxyl group) to the above numerical range, logD is preferably controlled within the desired range without sterilizing microorganisms. In the present invention, the molecular weight of the carboxyl group is assumed to be 45, which is the value of the molecular weight of the acid type carboxyl group, ie, COOH. For the carboxylic acid used to calculate the molecular weight of the component (a), the acid type value is used.
Component (a) used in the present invention is preferably one or more compounds selected from the group consisting of aliphatic dicarboxylic acids and salts thereof. Specific examples include suberic acid (having 8 carbon atoms) and azelaic acid. (9 carbon atoms), sebacic acid (10 carbon atoms), dodecanedioic acid (12 carbon atoms), tetradecanedioic acid (14 carbon atoms) and one or more compounds selected from the group consisting of salts thereof is mentioned. Furthermore, examples of the salt include alkali metal salts such as sodium salts and alkaline earth metal salts such as magnesium salts.

Another specific example of the component (a) used in the present invention is an organic carboxylic acid having one naphthalene group and one carboxyl group from the viewpoint of easily controlling the logD calculated by the above formula (1) within a desired range. acid or its salt. Such organic carboxylic acids may have any hydroxyl group. Furthermore, examples of the salt include alkali metal salts such as sodium salts and alkaline earth metal salts such as magnesium salts.
Specific examples include 1-naphthalenecarboxylic acid, 2-naphthalenecarboxylic acid, 2-hydroxy-1-naphthalenecarboxylic acid, 3-hydroxy-2-naphthalenecarboxylic acid, 6-hydroxy-2-naphthalenecarboxylic acid, and One or more compounds selected from the group consisting of these salts are preferred.

In the present invention, a commercially available product may be used as the component (a). Alternatively, the component (a) can be synthesized by a normal manufacturing method.

The content of component (a) relative to the mass of the composition containing component (a) and water is preferably 0.01% by mass or more, more preferably 0.03% by mass or more, and still more preferably 0 05% by mass or more, and more preferably 0.08% by mass or more. The content of component (a) is preferably 1% by mass or less, more preferably 0.8% by mass or less, and even more preferably 0.5% by mass or less.

<Water>
As the water used in the method of the present invention, ion-exchanged water, distilled water, tap water, perspiration, rain, etc. can be used.

The composition containing component (a) and water may contain optional components such as surfactants and perfumes within the range that does not impair the effects of the present invention.
For example, in a composition containing component (a) and water, a surfactant, preferably (b1) nonionic surfactant and (b2) anionic It can contain one or more surfactants selected from the group consisting of surfactants (excluding component (a)).

As component (b1), a nonionic surfactant having an HLB of 9 or more and 15 or less is preferable from the viewpoint of further improving the effect of component (a) in suppressing odor generation. In the case of a nonionic surfactant having a polyoxyethylene group, the HLB of component (b1) is determined by the Griffin method represented by the following formula (2).

HLB value = [(molecular weight of polyoxyethylene group portion of component (b1))/(molecular weight of component (b))] x 20 (2)

The molecular weight of the polyoxyethylene group portion of the component (b1) is calculated using the value of the average added mole number of the polyoxyethylene group.
Moreover, in the case of a nonionic surfactant having no polyoxyethylene group, it can be obtained by the Davis method. Here, the method for calculating HLB by the Davis method is pp. 24-25 of "Surfactant Physical Properties/Application/Chemical Ecology" (written by Fumio Kitahara et al., published by Kodansha Scientific, 7th edition, May 20, 1990). can be calculated by using the method described in

The HLB of the component (b1) is preferably 9.0 or more, more preferably 9.5 or more, more preferably 9.5 or more, from the viewpoint of excellent washability of stains adhering to textile products (hereinafter also referred to as the washability viewpoint). is 10 or more, more preferably 10.5 or more, and even more preferably 11.0 or more. HLB is preferably 15 or less, more preferably 14.5 or less, more preferably 14 or less, even more preferably 13 or less, and even more preferably 12 or less.

Specific examples of the component (b2) include one or more anionic surfactants selected from the group consisting of the following components (b21), (b22), (b23) and (b24).

(b21) component: alkyl or alkenyl sulfate (b22) component: polyoxyalkylene alkyl ether sulfate or polyoxyalkylene alkenyl ether sulfate (b23) component: anionic surfactant having a sulfonate group (b24) Ingredients: fatty acids having 10 to 20 carbon atoms or salts thereof (excluding (b23) ingredient)

The content of component (b) relative to the mass of the composition is preferably 0.1% by mass or more, more preferably 0.3% by mass or more, and still more preferably 0.4% by mass, from the viewpoint of further enhancing the effect of suppressing odor generation. % or more, more preferably 0.5 mass % or more. From the same viewpoint, the content of component (b) is preferably 10% by mass or less, more preferably 9% by mass or less, even more preferably 8% by mass or less, and even more preferably 5% by mass or less.

<Surfactant film>
As used herein, "surfactant film" means a film formed from a surfactant.
A surfactant film to which the present invention can be applied includes a film formed of a surfactant having an aliphatic hydrocarbon group having from 10 to 22 carbon atoms. The surfactant film may be a monomolecular film in which the surfactant molecules are arranged in a single layer, or the hydrophobic portion of the surfactant molecules arranged without gaps is inside and the hydrophilic portion is outside. It may also be a double membrane formed towards. Specific examples of the surfactant film include a film formed of a cationic surfactant having an aliphatic hydrocarbon group having 10 to 22 carbon atoms, and a film having an aliphatic hydrocarbon group having 10 to 22 carbon atoms. A film formed of an anionic surfactant, a film formed of a nonionic surfactant having an aliphatic hydrocarbon group having 10 to 22 carbon atoms, and an aliphatic hydrocarbon group having 10 to 22 carbon atoms. one or two or more selected from the group consisting of a film formed from an amphoteric surfactant.
Surfactants to which the present invention can be applied may be naturally occurring surfactants. For example, it may be a phospholipid exemplified by phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, and phosphatidylglycerol, or may be a glycolipid such as rhamnolipid, sophorolipid, or trehalose lipid. Among these, surfactants containing phospholipids, especially amphipathic substances, are particularly preferred.

<Microbes>
Microorganism cell membranes can be used as surfactant membranes.
Microorganisms to which the present invention can be applied can be used for common microorganisms present in the environment. For example, Moraxella bacteria, Acinetobacter bacteria, Pseudomonas bacteria, Bacillus bacteria, Sphingomonas bacteria, Ralstonia bacteria, Cupriavidus (Cupriavidus) bacteria, Psychorobacter bacteria, Serratia bacteria, Escherichia bacteria, Staphylococcus bacteria, Burkholderia bacteria, Saccaromyces genus yeast, Rhodotorula genus yeast, and the like.
Specifically, Moraxella sp., Moraxella osloensis , Acinetobacter radioresistens , Acinetobacter junii , Acinetobacter calcoaceticus ), Serratia marcescens , Escherichia coli , Staphylococcus aureus , Pseudomonas alcaligenes , Bacillus cereus , Bacillus subtilis subtilis ), Psychrobacter pacificensis , Psychrobacter glacincola , Sphingomonas yanoikuyae , Ralstonia sp., Saccaromyces cerevisiae , Rhodotorula mum Syraginosa ( Rhodotorula mucilaginosa ), Rhodotorula slooffiae , Cupriavidus oxalaticus and Burkholderia cepacia .

<Method for Suppressing Odor Generation>
In the method for suppressing odor production of the present invention, the component (a), water and microorganisms are brought into contact to suppress the amount of odorous substances produced by the microorganisms. Here, at the pH of the composition containing the component (a) and water, the logD of the component (a) in the composition calculated by the formula (1) is set to −1.5 or more and 1.5 or less.

The pH of the water containing the component (a) is not particularly limited as long as the logD of the component (a) is within the desired range and the viable count of microorganisms can be maintained without sterilizing the microorganisms. From the viewpoint of maintaining the viable count of microorganisms, the pH of the composition containing component (a) and water is preferably 4.0 or higher, more preferably 4.5 or higher, and still more preferably 5.0. That's it. From the same point of view, the pH of the composition containing component (a) and water is preferably 10.0 or less, more preferably 9.0 or less, still more preferably 8.5 or less, and even more preferably is 8.0 or less.
The pH of the present invention can be measured according to a conventional method, for example, with a pH measuring device using a glass electrode.

The logD of the component (a) calculated by the above formula (1) is -1.5 or more from the viewpoint of further enhancing the effect of regulating the metabolism of microorganisms. The logD of component (a) is preferably -1.2 or higher, more preferably -1.0 or higher, still more preferably -0.8 or higher, and even more preferably -0.5 or higher. Yes, more preferably -0.2 or more, and even more preferably 0 or more. From the same point of view, the logD of component (a) is 1.5 or less, preferably 1.3 or less, more preferably 1.1 or less, and still more preferably 1.0 or less.

(a) The contact time of the components, water and microorganisms can be appropriately determined depending on the extent to which the metabolism of microorganisms is controlled. From the viewpoint of further controlling the metabolism of microorganisms, the contact time is preferably 1 minute or longer, more preferably 5 minutes or longer, even more preferably 10 minutes or longer, and even more preferably 30 minutes or longer. , and more preferably 1 hour or longer. The contact time is preferably 15 hours or less, more preferably 12 hours or less, and even more preferably 8 hours or less.

The method for suppressing odor production of the present invention is preferably a method for suppressing the amount of odorous substances produced by microorganisms while maintaining the number of viable microorganisms after contact with component (a).
As used herein, "while maintaining the viable count of microorganisms" means the logarithm (1) of the viable count of microorganisms before contact with (a) the component, and (a) the number of microorganisms after contact with the component. It means that the logarithmic value (1) - logarithmic value (2), which is the difference between the viable cell count and the logarithmic value (2), is -1 or more and less than 2. The difference between the logarithmic values is generally referred to as the bactericidal activity value and the bacteriostatic activity value, and having bactericidal activity or having antibacterial properties means that in the bactericidal activity test or antibacterial test, respectively, the bactericidal activity value Or it is defined as having a bacteriostatic activity value of 2.2 or more. In the present invention, the bactericidal activity value or bacteriostatic activity value is -1 or more and less than 2, preferably -0.5 or more and less than 1, more preferably 0 or more and 0.8 or less, further preferably 0 or more and 0.7 or less. One case is referred to as "maintaining viable microbial counts."

The odor that can be suppressed by the present invention can be applied to the odor generated by the metabolism of the fatty acid synthesis system in the metabolic system of microorganisms. The present invention is a technology that suppresses the amount of odorous substances produced by masking the odors produced by the metabolism of the fatty acid synthesis system, unlike masking deodorants that make it difficult to perceive odors, or chemical deodorants that convert odorous substances into odorous substances. be.

<Smell substance>
The method for suppressing odors of the present invention can be applied to odors produced by the metabolism of fatty acid synthesis systems in the metabolic systems of microorganisms. The present invention masks the odor generated by the metabolism of the fatty acid synthesis system, thereby reducing the production of odorous substances, unlike masking deodorants that make it difficult to perceive odors, or chemical deodorants that make odorous substances less odorous by chemical action. It is a technique to suppress.
The odorous substance is not necessarily limited, but typical odorous substances include, for example, 4-methyl-3-hexenoic acid (hereinafter also referred to as "4M3H") consisting of a compound represented by the following formula, or 4-methylhexanoic acid (hereinafter also referred to as "4MH") can be mentioned. As shown below, 4-methyl-3-hexenoic acid has cis-trans isomers, and the present invention includes compounds having either cis-type or trans-type structure.

4M3H and 4MH, which are typical odorous substances mentioned above, are often produced in the fatty acid synthesis system of microorganisms based on odorous precursors contained in sebum stains. “Sebum stain” is the most representative stain that adheres to textile products such as clothing. Those confined such as are observed in textile products and the like. The "sebum-stained component" is not particularly limited as long as it is a sebum-stained component commonly found on clothes. Substances that can be precursors of odorous substances include, for example, saturated or unsaturated anteiso fatty acids having 9 to 21 carbon atoms (preferably 11 to 19 carbon atoms, more preferably 17 to 19 carbon atoms) (eg, 6-methyloctane acids, 8-methyldecanoic acid, 12-methyltetradecanoic acid, 14-methylhexadecanoic acid, 16-methyloctadecanoic acid, 14-methylhexadecenoic acid and 16-methyloctadecenoic acid), and salts and esters thereof. However, these also include compounds that are not actually present in sebum stains.

The method for suppressing odor production of the present invention can be applied to a method in which the component (a), water, and microorganisms are brought into contact, and the order in which they come into contact is not particularly limited. For example, a composition containing (a) a component and water is contacted with a microorganism, a method of contacting a component (a), water, and a microorganism, a composition containing water and a microorganism present (a) is contacted, ( a) a method in which the component, water and microorganisms are brought into contact with each other;
An example of a method of contacting a composition containing (a) component and water with microorganisms, and contacting (a) component, water and microorganisms is, for example, spraying a composition containing (a) component and water against microorganisms. Alternatively, a method of coating, or a method of immersing the microorganisms in a composition containing the component (a) and water can be used. The method of spraying the composition includes, for example, a method of spraying using a sprayer such as a sprayer. As a method of applying the composition, the tool used for application, for example, a sheet-like tool made of cotton fibers or synthetic fibers impregnated with a composition containing the component (a) and water is brought into contact with the microorganisms. and a method of applying a composition containing component (a) and water to microorganisms.

The state in which the component (a), water, and microorganisms exist may be a state of a composition containing the component (a), water, and microorganisms, and the component (a), water, and microorganisms are mixed on the object. It may be in the state of a composition containing. The object may be a textile product, a hard surface, a skin surface, or a hair surface. Materials for textile products are not particularly limited, and include natural materials such as wool, silk, and cotton, and chemical fibers such as polyester and polyamide. , and combinations thereof. In the present invention, the material of the textile product is preferably cotton. The textile product may be unused or used once or more. The textile product with which the component (a) is to be brought into contact may contain moisture or moisture, or may be sufficiently dried. A hard surface may be glass, metal, plastic, or ceramic.

The amount of component (a) and water can be appropriately adjusted in order to suppress the production of odorous substances. For example, when the method for suppressing odor production of the present invention is carried out on textile products, the amount of component (a) per mass of textile products in which microorganisms are present is 0.01% by mass or more and 1% by mass or less. , the component (a) may be brought into contact with water having a pH or amount at which the component (a) has a specific logD, and the component (a), the water, and the microorganisms may come into contact with each other on the textile product. The pH of the composition containing the component (a) and water when the component (a) is in contact with water and microorganisms is such that the component (a) has a specific log D of the present invention, and an acid agent or an alkaline agent is added. It may be further added and adjusted, and if the pH of water is predictable even if the component (a) comes into contact with water, the logD of the component (a) is -1.5 or more and 1.5 or less. may be deposited on textiles.

One aspect of the method for suppressing odor generation of the present invention is a method for suppressing odor generation, in which a nonwoven fabric sheet containing component (a) and water is brought into contact with an object to which microorganisms are attached. In this embodiment, the logD of the component (a) calculated by the formula (1) at the pH of the composition containing the component (a) and water is -1.5 or more and 1.5 or less.

Examples of tools that can be suitably used in the method for suppressing odor generation of the present invention include a sheet made of nonwoven fabric and containing the component (a) and water. The logD of the component (a) calculated by the formula (1) at the pH of the composition containing the component (a) and water is -1.5 or more and 1.5 or less.

As for the optional components such as component (a), water, and components of formulas (1) and (b) used in the sheet of the present invention, the items described in the method for suppressing odor generation can be used.

In the sheet of the present invention, the nonwoven fabric is processed into a sheet shape, and the fibers constituting the nonwoven fabric are composed of one or more fibers selected from the group consisting of hydrophilic fibers and hydrophobic fibers. preferable.
In the present invention, "hydrophilic fibers" refer to fibers having a moisture content (20°C, 65% RH) in standard conditions exceeding 5%. The standard moisture content is measured by the method specified in JIS L 1013 and JIS L 1015. "Hydrophobic fiber" refers to a fiber having a moisture content of 5% by weight or less in a standard state (20°C, 65% RH).

Chemical fibers that are hydrophobic fibers that can be used in the sheet of the present invention include, for example, polyamide fibers (nylon, etc.), polyester fibers (polyester, etc.), polyacrylonitrile fibers (acrylic, etc.), and polyvinyl alcohol fibers. (Vinylon, etc.), polyvinyl chloride fibers (polyvinyl chloride, etc.), polyvinylidene chloride fibers (vinylidene, etc.), polyolefin fibers (polyethylene, polypropylene, etc.), polyurethane fibers (polyurethane, etc.), polyvinyl chloride/polyvinyl alcohol copolymer fibers (such as polycleral), and the like, and these can be used alone or in combination of two or more.
Hydrophilic fibers that can be used in the sheet of the present invention include seed hair fibers (cotton, cotton, kapok, etc.), bast fibers (hemp, flax, ramie, hemp, jute, etc.), leaf vein fibers (Manila hemp, sisal hemp, etc.). etc.), coconut fiber, rush, straw, animal hair fiber (wool, mohair, cashmere, camel hair, alpaca, vicuna, angora, etc.), silk fiber (domestic silkworm silk, wild silkworm silk), down, cellulose fiber (rayon, polynosic, cupra, acetate, etc.), hydrophilized polyethylene terephthalate fiber (polyethylene terephthalate fiber that has been hydrophilized, and the moisture content in the standard state is within the range of hydrophilic fiber), etc., and these are 1 A species or two or more species can be used.

The nonwoven fabric used in the present invention preferably contains hydrophilic fibers. The nonwoven fabric used in the present invention contains hydrophilic fibers in an amount of 50% by mass or more, more preferably 60% by mass or more, still more preferably 70% by mass or more, and even more preferably 75% by mass or more, from the viewpoint of further enhancing the effect of suppressing odor generation. is preferred. The content of hydrophilic fibers contained in the nonwoven fabric is preferably 100% by mass or less, more preferably 90% by mass or less, and even more preferably 85% by mass or less.
Moreover, from the viewpoint of further enhancing the effect of suppressing odor generation, the basis weight of the nonwoven fabric used in the present invention is preferably 10 g/m ² or more, more preferably 20 g/m ² or more. The basis weight of the nonwoven fabric used in the present invention is preferably 100 g/m ² or less, more preferably 80 g/m ² or less, still more preferably 60 g/m ² or less.

The mass ratio of the composition containing the component (a) and water (impregnation rate (mass%)) to the mass of the nonwoven fabric is preferably 100 mass% or more, more preferably 150 mass%, from the viewpoint of further enhancing the effect of suppressing odor generation. % by mass or more, more preferably 200% by mass or more, more preferably 250% by mass or more, still more preferably 300% by mass or more, and even more preferably 350% by mass or more. From the same point of view, the mass ratio of the composition containing the component (a) and water (impregnation rate (mass%)) to the mass of the nonwoven fabric is preferably 500% by mass or less, more preferably 420% by mass or less, It is more preferably 380% by mass or less, still more preferably 350% by mass or less.
In addition, in this invention, an impregnation rate is calculated from the following formulas.

Impregnation rate (% by mass) =
(((a) the mass of the nonwoven fabric impregnated with the composition containing the component and water) / (the mass of the dry nonwoven fabric) -1) × 100

The content of component (a) relative to the mass of the composition containing component (a) and water contained in the sheet of the present invention is preferably 0.01% by mass or more from the viewpoint of further enhancing the effect of suppressing odor generation. more preferably 0.03% by mass or more, still more preferably 0.05% by mass or more, and even more preferably 0.08% by mass or more. From the same point of view, the content of component (a) is preferably 1% by mass or less, more preferably 0.8% by mass or less, and even more preferably 0.5% by mass or less.

By bringing the sheet of the present invention into contact with an object to which microorganisms are attached, it is possible to suppress the generation of odor from the object to which microorganisms are attached.
The object to which microorganisms are attached may be any one of textile products, hard surfaces, skin surfaces, and hair surfaces. The material of the textile product is not particularly limited, and may be any of natural materials such as wool, silk and cotton, chemical fibers such as polyester and polyamide, and combinations thereof. In the present invention, the material of the textile product is preferably cotton. The textile product may be unused or used once or more. The textile product with which the component (a) is to be brought into contact may contain moisture or moisture, or may be sufficiently dried. A hard surface may be glass, metal, plastic, or ceramic.

<pH control method>
In the pH control of the present invention, in two phases containing water separated by a surfactant film, the log D calculated by the formula (1) of the component (a) present in one phase is -1.5 By controlling the pH to 1.5 or less, the pH of the other phase separated by the surfactant film can be lowered to control the pH.

The pH of the water containing the component (a) is not particularly limited as long as the logD of the component (a) is in the range of -1.5 or more and 1.5 or less and the pH is such that a surfactant film can exist. do not have. The pH of the composition containing component (a) and water is preferably 4.0 or higher, more preferably It is 4.5 or more, more preferably 5.0 or more. From the same point of view, the pH of the composition containing component (a) and water is preferably 10.0 or less, more preferably 9.0 or less, still more preferably 8.5 or less, and even more preferably is 8.0 or less.
The pH of the present invention can be measured according to a conventional method, for example, with a measuring device using a glass electrode.

The logD of the component (a) calculated by the formula (1) is -1.5 or more from the viewpoint of further lowering the pH of the internal phase separated by the surfactant membrane, especially the cell membrane of the microorganism. The logD of component (a) is preferably -1.2 or higher, more preferably -1.0 or higher, still more preferably -0.8 or higher, and even more preferably -0.5 or higher. Yes, more preferably -0.2 or more, and even more preferably 0 or more. From the same point of view, the logD of component (a) is 1.5 or less, preferably 1.3 or less, more preferably 1.1 or less, and still more preferably 1.0 or less.

The contact time between the component (a), water and the surfactant film, especially the cell membrane of microorganisms, can be appropriately determined depending on the extent to which the pH is controlled. From the viewpoint of greater pH control, the contact time is preferably 1 minute or longer, more preferably 5 minutes or longer, still more preferably 10 minutes or longer, and even more preferably 30 minutes or longer. More preferably, it is 1 hour or longer. The contact time is preferably 15 hours or less, more preferably 12 hours or less, and even more preferably 8 hours or less.

In relation to the above-described embodiments, the present invention further discloses the following methods and sheets.

<1>
A method for suppressing odor production, comprising contacting the following component (a), water, and microorganisms to suppress the amount of odorous substances produced by the microorganisms,
A method for suppressing odor generation, wherein the logD of the component (a) calculated by the following formula (1) at the pH of the composition containing the component (a) and water is -1.5 or more and 1.5 or less.

(a) component: organic carboxylic acid or its salt

logD = ClogP-log [1 + 10 ^(pH-pKa) ] formula (1)
[In formula (1), ClogP is the calculated logP of the logarithm of the water/octanol partition coefficient of component (a) in the acid form, pH is the pH of water containing component (a), and pKa is (a) pKa of component. ]

<2>
The method according to <1> above, wherein the odorous substance is at least one selected from the group consisting of 4-methyl-3-hexenoic acid and 4-methylhexanoic acid.
<3>
The above method for suppressing odor production includes contacting a composition containing (a) component and water with microorganisms, a method of contacting (a) component, water and microorganisms, a composition containing water in which microorganisms are present and (a) (a) a method in which the components are brought into contact with water and microorganisms; The method according to <1> or <2>, which is one or more methods selected from the group.
<4>
(a) The method according to any one of <1> to <3>, wherein a nonwoven fabric sheet containing the component (a) and water is brought into contact with an object to which microorganisms are attached, ) of the above <1> to <3>, wherein the logD of the (a) component calculated by the above formula (1) at the pH of the composition containing the component and water is −1.5 or more and 1.5 or less. A method according to any one of paragraphs.

<5>
In two phases containing water separated by a surfactant film, the log D of the component (a) present in one phase calculated by the formula (1) is controlled to −1.5 or more and 1.5 or less. and lowering the pH of the other phase separated by the surfactant membrane.

<6>
The surfactant film is a film formed of a cationic surfactant having an aliphatic hydrocarbon group having 10 or more and 22 or less carbon atoms, and an anionic surfactant having an aliphatic hydrocarbon group having 10 or more and 22 or less carbon atoms. a film formed with a nonionic surfactant having an aliphatic hydrocarbon group having 10 to 22 carbon atoms, and an amphoteric interface having an aliphatic hydrocarbon group having 10 to 22 carbon atoms. The method according to <5> above, wherein the membrane is formed from the active agent, preferably the cell membrane of a microorganism.

<7>
The value represented by (molecular weight of component (a))/(molecular weight of carboxyl group) is 1.9 or more, preferably 2.0 or more, more preferably 2.2 or more and 3.5 or less, preferably is 3.2 or less, more preferably 3.0 or less, and still more preferably 2.8 or less, the method according to any one of <1> to <6>.
<8>
The group consisting of aliphatic polycarboxylic acids in which the component (a) has 8 or more, preferably 9 or more carbon atoms, and 14 or less, preferably 12 or less, more preferably 10 or less, and salts thereof. The method according to any one of <1> to <7> above, which is one or more compounds selected from the above.
<9>
The component (a) is one or more compounds selected from the group consisting of aliphatic dicarboxylic acids and salts thereof, preferably suberic acid, azelaic acid, sebacic acid, dodecanedioic acid, tetradecanedioic acid and salts thereof. The method according to any one of <1> to <8> above, wherein the compound is one or more compounds selected from the group consisting of:

<10>
The method according to any one of <1> to <6>, wherein the component (a) is an organic carboxylic acid having one naphthalene group and one carboxyl group or a salt thereof.
<11>
The organic carboxylic acid or its salt is 1-naphthalenecarboxylic acid, 2-naphthalenecarboxylic acid, 2-hydroxy-1-naphthalenecarboxylic acid, 3-hydroxy-2-naphthalenecarboxylic acid, 6-hydroxy-2-naphthalenecarboxylic acid. , and one or more compounds selected from the group consisting of salts thereof, the method according to <10>.

<12>
The logD of the component (a) calculated by the formula (1) at the pH of the composition containing the component (a) and water is -1.2 or more, preferably -1.0 or more, more preferably -0 .8 or more, more preferably −0.5 or more, still more preferably −0.2 or more, still more preferably 0 or more and 1.3 or less, preferably 1.1 or less, more preferably 1.0 or less , The method according to any one of <1> to <11>.
<13>
(a) The method according to any one of <1> to <12>, wherein the number of viable microorganisms after contact with the component is maintained.
<14>
(a) The difference between the logarithmic value of the viable count of microorganisms before contact with the component (1) and the logarithmic value of the viable count of microorganisms after contact with the component (a) (2) (logarithmic value (1) - Logarithmic value (2)) is -1 or more and less than 2, preferably -0.5 or more and less than 1, more preferably 0 or more and 0.8 or less, still more preferably 0 or more and 0.7 or less, <13> The method described in .
<15>
(a) The pH of the composition containing component and water is 4.0 or higher, preferably 4.5 or higher, more preferably 5.0 or higher, and 10.0 or lower, preferably 9.0 or lower, or more The method according to any one of <1> to <14> above, which is preferably 8.5 or less, more preferably 8.0 or less.
<16>
The method according to any one of <1> to <15> above, wherein the composition containing component (a) and water has a pH of 5.0 or more and 8.5 or less.
<17>
(a) The contact time of the component, water and surfactant film, especially the microorganism, is 1 minute or longer, preferably 5 minutes or longer, more preferably 10 minutes or longer, even more preferably 30 minutes or longer, and even more preferably 1 hour. The method according to any one of <1> to <16> above, which is 15 hours or less, preferably 12 hours or less, more preferably 8 hours or less.
<18>
The content of component (a) relative to the mass of the composition containing component (a) and water is 0.01% by mass or more, preferably 0.03% by mass or more, more preferably 0.05% by mass or more, and further Any one of <1> to <17>, preferably 0.08% by mass or more and 1% by mass or less, preferably 0.8% by mass or less, more preferably 0.5% by mass or less. described method.

<19>
A sheet containing component (a) and water and made of nonwoven fabric,
A sheet, wherein the logD of the component (a) calculated by the formula (1) at the pH of the composition containing the component (a) and water is -1.5 or more and 1.5 or less.

<20>
The value represented by (molecular weight of component (a))/(molecular weight of carboxyl group) is 1.9 or more, preferably 2.0 or more, more preferably 2.2 or more and 3.5 or less, preferably is 3.2 or less, more preferably 3.0 or less, and still more preferably 2.8 or less.
<21>
The group consisting of aliphatic polycarboxylic acids in which the component (a) has 8 or more, preferably 9 or more carbon atoms, and 14 or less, preferably 12 or less, more preferably 10 or less, and salts thereof. The sheet according to <19> or <20>, which is one or more compounds selected from the above.
<22>
The component (a) is one or more compounds selected from the group consisting of aliphatic dicarboxylic acids and salts thereof, preferably suberic acid, azelaic acid, sebacic acid, dodecanedioic acid, tetradecanedioic acid and salts thereof. The sheet according to any one of <19> to <21> above, which is one or more compounds selected from the group consisting of:

<23>
The sheet according to <19> above, wherein the component (a) is an organic carboxylic acid having one naphthalene group and one carboxyl group or a salt thereof.
<24>
The organic carboxylic acid or its salt is 1-naphthalenecarboxylic acid, 2-naphthalenecarboxylic acid, 2-hydroxy-1-naphthalenecarboxylic acid, 3-hydroxy-2-naphthalenecarboxylic acid, 6-hydroxy-2-naphthalenecarboxylic acid. , and the sheet according to <23> above, which is one or more compounds selected from the group consisting of salts thereof.

<25>
The logD of the component (a) calculated by the formula (1) at the pH of the composition containing the component (a) and water is -1.2 or more, preferably -1.0 or more, more preferably -0 .8 or more, more preferably −0.5 or more, still more preferably −0.2 or more, still more preferably 0 or more and 1.3 or less, preferably 1.1 or less, more preferably 1.0 or less The sheet according to any one of <19> to <24> above.
<26>
(a) The pH of the composition containing component and water is 4.0 or higher, preferably 4.5 or higher, more preferably 5.0 or higher, and 10.0 or lower, preferably 9.0 or lower, or more The sheet according to any one of <19> to <25>, preferably 8.5 or less, more preferably 8.0 or less.
<27>
The sheet according to any one of <19> to <26> above, wherein the composition containing the component (a) and water has a pH of 5.0 or more and 8.5 or less.

<28>
The sheet according to any one of <19> to <27>, wherein the nonwoven fabric is composed of one or more fibers selected from the group consisting of hydrophilic fibers and hydrophobic fibers.
<29>
The hydrophobic fibers include polyamide fibers, polyester fibers, polyacrylonitrile fibers, polyvinyl alcohol fibers, polyvinyl chloride fibers, polyvinylidene chloride fibers, polyolefin fibers, polyurethane fibers, and polyvinyl chloride/polyvinyl The sheet according to <28> above, which is one or more fibers selected from the group consisting of alcohol copolymer fibers.
<30>
The hydrophilic fiber is selected from the group consisting of seed hair fiber, bast fiber, leaf vein fiber, palm fiber, rush, straw, animal hair fiber, silk fiber, feather, cellulosic fiber, and hydrophilized polyethylene terephthalate fiber. The sheet according to <28> above, which is made of one or more types of fibers.
<31>
The nonwoven fabric contains 50% by mass or more, preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 75% by mass or more and 100% by mass or less, preferably 90% by mass or less, and further The sheet according to any one of <28> to <30>, preferably containing 85% by mass or less.
<32>
The nonwoven fabric has a basis weight of 10 g/m ² or more, preferably 20 g/m ² or more and 100 g/m ² or less, preferably 80 g/m ² or less, more preferably 60 g/m ² or less, said <19 > The sheet according to any one of <31>.
<33>
The impregnation rate (% by mass) of the composition containing the component (a) and water with respect to the mass of the nonwoven fabric is 100% by mass or more, preferably 150% by mass or more, more preferably 200% by mass or more, more preferably 250% by mass. % by mass or more, more preferably 300% by mass or more, still more preferably 350% by mass or more and 500% by mass or less, preferably 420% by mass or less, more preferably 380% by mass or less, still more preferably 350% by mass or less, The sheet according to any one of <19> to <32>.
<34>
The content of component (a) relative to the mass of the composition containing component (a) and water is 0.01% by mass or more, preferably 0.03% by mass or more, more preferably 0.05% by mass or more, and further Any one of <19> to <33>, preferably 0.08% by mass or more and 1% by mass or less, preferably 0.8% by mass or less, and more preferably 0.5% by mass or less. sheet of description.
<35>
The sheet according to any one of <19> to <34> above, which is used for suppressing the production of odor from an object to which microorganisms are attached by bringing it into contact with an object to which microorganisms are attached.
<36>
The sheet according to <35> above, wherein the object to which microorganisms are attached is any one of a textile product, a hard surface, a skin surface, and a hair surface.

EXAMPLES The present invention will be described in more detail below based on examples, but the present invention is not limited to these.

Example 1
(1) Quantitative method of odor-causing substance Drop a methanol solution containing 14-Methylhexadecanoic acid (SIGMA-ALDRICH), the precursor of the odor-causing substance, into a 3 x 3 cm plain cotton cloth that has been sterilized from the day before the test. and attached the precursor of the odor-causing substance. The adhesion amount of the precursor of the odor-causing substance was set so that the fatty acid was 100 μg (1,000 μg/g cloth) per piece of plain cotton cloth. Furthermore, a methanol solution (1 mM) was prepared by dissolving various organic acids shown in Table 1, and 100 μL of the solution was added dropwise to each piece of cloth on which the substrate was attached, followed by drying overnight.
From the previous day, Moraxella osroensis ATCC 19976 strain was cultured under agar culture conditions, and the cells were collected in sterile deionized water, OD ₆₀₀ = 0.1 (10 ⁸ CFU/mL), 1/2NB (Nutrient Broth: Difco). was prepared.
A cloth containing precursors of odor-causing substances and various organic acids is placed in a sterilized No. 3 screw tube (Maruem), inoculated with 100 μL of the above bacterial suspension, and kept at 37° C. for 8 hours. cultured. The same operation was performed in the absence of bacteria, and the cloth (precursors of odor-causing substances and presence of organic acids) was measured for pH before culturing.

After culturing, 3 mL of methanol was added, and ultrasonic waves were applied for 30 minutes for extraction. The extract was mixed with an ADAM reagent (0.5 mg/mL MeOH solution) from Funakoshi Co., Ltd. at a ratio of 1:1 (volume ratio) and allowed to stand overnight at room temperature in a dark place. After that, HPLC was used to quantify 4-methyl-3-hexenoic acid and 4-methylhexanoic acid. The quantitative conditions for 4-methyl-3-hexenoic acid and 4-methylhexanoic acid are shown below.

・Conditions for quantitative determination of 4-methyl-3-hexenoic acid and 4-methylhexanoic acid
LC column: Zorbax C8 4.6 x 250mm
Eluent: acetonitrile 61% (v/v), water 39% (v/v)
Column temperature: 40°C
Sample injection volume: 10 μL
Flow rate: 1.0 mL/min
Detection: FID Ex. 365 nm, Em. 412 nm

(2) Test method for bacterial count change (antibacterial test method)
Put a piece of cloth prepared by the same method as the quantification method of the odor-causing substance described above in a sterilized No. 3 screw tube (Maruem), inoculate 100 μL of the above-mentioned bacterial solution, and culture for 8 hours at 37°C. did After culturing, 20 mL of LP diluted solution (manufactured by Nihon Pharmaceutical Co., Ltd.) was added and ultrasonic waves were applied for 10 minutes to extract bacteria.

The extract was serially diluted, poured on SCD-LP agar medium (manufactured by Nihon Pharmaceutical Co., Ltd.), and then statically cultured at 37° C. for 1 day. The number of colonies obtained for each cloth was counted, and the common logarithm of the number of viable bacteria in each example or comparative example was subtracted from the common logarithm of the viable count of the unwashed cloth (logarithmic value ) was taken as the bacteriostatic activity value.
The common logarithmic value of the bacterial count (CFU/cm ² ) before the test was 6.1 (X1). If (X2-X1), which is the difference between the number of bacteria (CFU/cm ² ) after the culture test and the common logarithm (X2), is -1 or more and less than 2, it means that the number of bacteria is maintained. I can say. When the pH of the cloth (the precursor of the odor-causing substance and the presence of the organic acid) was measured before the cultivation, the pH was 6 in all cases.
Table 1 shows the above results.

As shown in Table 1, when the logD of the organic carboxylic acid brought into contact with microorganisms is -1.5 or more and 1.5 or less, the generation of odor-causing substances can be suppressed without sterilizing odor-causing microorganisms. was made (see Examples 1-1 to 1-4).
On the other hand, when the logD of the organic carboxylic acid was outside the range defined by the present invention, the production of odor-causing substances could not be suppressed (see Comparative Examples 1-2 to 1-5).

Example 2 Evaluation Method of pH Change In the examples, as a representative example of the surfactant film, the cell membrane of a microorganism was used to evaluate the pH change. That is, the pH change in the cytoplasm of the microorganism was measured by appropriately selecting the pH of the component (a) and water that come into contact with the microorganism, controlling the logD of the component (a), and bringing the component into contact with the microorganism. Life Technologies' pHrodo (R) Green AM Intracellular pH Indicators kit was used to evaluate intracytoplasmic pH changes.

Moraxella osloensis ATCC 19976 strain cultured from the previous day was suspended in Live Cell Imaging Solution (Life Technologies, hereinafter referred to as "LCIS") and washed by centrifugation (5600 rpm, 10 minutes, 4°C). . After washing, 5 mL of bacterial solution with OD ₆₀₀ =10 was prepared and centrifuged again to recover the bacterial cells.
After adding 5 μL of pH rodo dye to 50 μL of powerload and stirring, 5 mL of LCIS was added. 5 mL of the resulting mixed solution was added to the recovered cell pellet to suspend the cells, and left at 37° C. for 1 hour. After allowing to stand, centrifugation was performed, and after washing once with 5 mL of LCIS, 5 mL of LCIS was added again. The solution subjected to this fluorescent staining treatment is referred to as bacterial solution A.
2.4 mL of phosphate buffer (55 mM, pH 6), 0.3 mL of bacterial solution A, and 0.3 mL of sodium salt aqueous solutions of various organic acids shown in Table 2 were added to the fluorescence measurement cell, and fluorescence was measured immediately after stirring. (excitation wavelength 509 nm, fluorescence wavelength 533 nm). A higher fluorescence intensity value indicates a more acidic cytoplasmic environment.
Table 2 shows the results.

As shown in Table 2, when the logD of the organic carboxylic acid brought into contact with the microorganism was -1.5 or more and 2 or less, the fluorescence intensity value increased and the pH in the cell membrane of the microorganism decreased (Example 2-1 to 2-3).
On the other hand, when the logD of the organic carboxylic acid was outside the range defined by the present invention, there was no change in the value of the fluorescence intensity, and the pH in the cell membrane of the microorganism could not be lowered (Comparative Example 1-2 ~ see 1-5).

Example 3
Except for using the compounds shown in Table 3, the same operation as in Example 1 was performed to quantify 4-methyl-3-hexenoic acid and measure the number of bacteria. Table 3 shows the results.

Incidentally, the amount of 4M3H on the cloth differs between Comparative Example 3-1 and Comparative Example 1-1. It is presumed that the activation state of the fatty acid metabolism system in the bacteria differs due to individual differences.
As shown in Table 3, compared to the amount of 4M3H in Comparative Example 3-1, the reduction rate of the amount of 4M3H in each of Examples 3-1 to 3-4 is high, and the logD of the organic carboxylic acid brought into contact with the microorganism is In the case of −1.5 or more and 1.5 or less, it was possible to suppress the production of odor-causing substances without sterilizing odor-causing microorganisms.
On the other hand, when the logD of the organic carboxylic acid was outside the range defined by the present invention, the production of odor-causing substances could not be suppressed (see Comparative Example 3-2).

Example 4
The compositions described in Table 4 below were prepared. The pH was adjusted using a 1% by mass sodium hydroxide aqueous solution.

Nonwoven fabric (sheet-like spunlaced nonwoven fabric (rayon/polypropylene/polyester ratio = 80/10/10, basis weight 60 g/m ² , 150 mm × 100 mm)) was coated with the composition described in Table 4, and the mass of the nonwoven fabric was A sheet for textile products was prepared by impregnating the composition so that the impregnation rate was 350% by mass.

(1) Quantitative method of odor-causing substance Drop a methanol solution containing 14-Methylhexadecanoic acid (SIGMA-ALDRICH), the precursor of the odor-causing substance, into a 3 x 3 cm plain cotton cloth that has been sterilized from the day before the test. and attached the precursor of the odor-causing substance. The adhesion amount of the precursor of the odor-causing substance was set so that the fatty acid was 100 μg (1,000 μg/g cloth) per piece of plain cotton cloth. From the previous day, Moraxella osroensis ATCC 19976 strain was cultured under agar culture conditions, and the cells were collected in sterile deionized water, OD ₆₀₀ = 0.1 (10 ⁸ CFU/mL), 1/2NB (Nutrient Broth: Difco). was prepared.
The cloth to which the precursor of the odor-causing substance adhered was placed in a sterilized No. 3 screw tube (Maruuem), and 100 μL of the aforementioned fungal suspension was inoculated. Further, the textile sheet was brought into contact with the cloth and left for 5 minutes. After the textile sheet was separated from the cloth, it was dried overnight.
The pH of the liquid between the cloth and the textile sheet was measured with a glass electrode pH meter and found to be pH 6 for both.
After culturing, 4-methyl-3-hexenoic acid was quantified under the same conditions as in Example 1.

(2) Test method for bacterial count change (antibacterial test method)
Put the cloth left overnight in a sterilized No. 3 screw tube (Maruem) in the same manner as the above-mentioned method for quantifying the odor-causing substance, add 20 mL of LP diluted solution (manufactured by Nihon Pharmaceutical Co., Ltd.), and apply ultrasonic waves. After irradiation for 10 minutes, bacteria were extracted.
The bacteriostatic activity value of the obtained extract was measured by the same method as in Example 1. When the pH of the cloth (the precursor of the odor-causing substance and the presence of the organic acid) was measured before the cultivation, the pH was 6 in all cases.
Table 5 shows the above results.

As shown in Table 5, when the logD of the organic carboxylic acid brought into contact with microorganisms is -1.5 or more and 1.5 or less, the generation of odor-causing substances can be suppressed without sterilizing odor-causing microorganisms. was made (see Example 4-1).
On the other hand, when the logD of the organic carboxylic acid was outside the range defined by the present invention, the production of odor-causing substances could not be suppressed (see Comparative Example 4-1).

Claims (23)

A method for suppressing the production of odors peculiar to textile products, comprising contacting the following component (a), water, and microorganisms to suppress the amount of odorous substances produced by the microorganisms,
(a) calculated by the following formula (1) at the pH of the composition containing the component (a) and water
A method for suppressing generation of odor peculiar to textile products, wherein the logD of the component is -1.5 or more and 1.5 or less.

(a) component: organic carboxylic acid or its salt

logD = ClogP-log [1 + 10 ^(pH-pKa) ] formula (1)
[In formula (1), ClogP is the calculated logP value of the logarithm of the water/octanol partition coefficient of component (a) in the acid form, pH is the pH of water containing component (a), and pKa is (a)
pKa of the components. ] 2. The method of claim 1, wherein said textile peculiar odor is a mushy odor. The method according to claim 1 or 2, wherein the odorant is at least one selected from the group consisting of 4-methyl-3-hexenoic acid and 4-methylhexanoic acid. The method according to any one of claims 1 to 3, wherein the nonwoven fabric sheet containing the component (a) and water is brought into contact with an object to which microorganisms are attached, wherein the component (a) and The logD of the component (a) calculated by the formula (1) at the pH of the composition containing water is -1.5 or more and 1.5 or less, according to any one of claims 1 to 3. odor generation suppression method. The component (a) is one or more compounds selected from the group consisting of aliphatic polycarboxylic acids having 8 to 14 carbon atoms and salts thereof, according to any one of claims 1 to 4 described method. 6. Any one of claims 1 to 5, wherein the component (a) is one or more compounds selected from the group consisting of suberic acid, azelaic acid, sebacic acid, dodecanedioic acid, tetradecanedioic acid, and salts thereof. The method described in section. The method according to any one of claims 1 to 5, wherein the component (a) is sebacic acid. The method according to any one of claims 1 to 4, wherein the component (a) is an organic carboxylic acid having one naphthalene group and one carboxyl group or a salt thereof. The organic carboxylic acid or its salt is 1-naphthalenecarboxylic acid, 2-naphthalenecarboxylic acid, 2- hydroxy- 1-naphthalenecarboxylic acid, 3- hydroxy -2-naphthalenecarboxylic acid, 6-hydroxy-2 - The method according to claim 8, wherein the compound is one or more compounds selected from the group consisting of naphthalenecarboxylic acids and salts thereof. The organic carboxylic acid or a salt thereof is selected from 1-naphthalenecarboxylic acid, 2-naphthalenecarboxylic acid, 2- hydroxy- 1-naphthalenecarboxylic acid, 3- hydroxy -2-naphthalenecarboxylic acid, and salts thereof 9. The method of claim 8, which is one or more compounds selected from the group consisting of: (a) The method of any one of claims 1 to 10, wherein the viable count of the microorganism is maintained after contact with the component. The method according to any one of claims 1 to 11, wherein the composition containing component (a) and water has a pH of 5.0 or more and 8.5 or less. A sheet containing component (a) and water and made of non-woven fabric and used to suppress the generation of odors peculiar to textile products,
(a) calculated by the following formula (1) at the pH of the composition containing the component (a) and water
A sheet used for suppressing generation of odor peculiar to textile products, which originates from textile products and whose component has a logD of -1.5 or more and 1.5 or less.

(a) component: organic carboxylic acid or its salt

logD = ClogP-log [1 + 10 ^(pH-pKa) ] formula (1)
[In formula (1), ClogP is the calculated logP value of the logarithm of the water/octanol partition coefficient of component (a) in the acid form, pH is the pH of water containing component (a), and pKa is (a)
pKa of the components. ] 14. The sheet according to claim 13, wherein said odor peculiar to textile products is a half-dry odor. 15. The sheet according to claim 13 or 14, wherein the causative agent of the odor peculiar to textile products is at least one selected from the group consisting of 4-methyl-3-hexenoic acid and 4-methylhexanoic acid. The component (a) is one or more compounds selected from the group consisting of aliphatic polycarboxylic acids having 8 to 14 carbon atoms and salts thereof, according to any one of claims 13 to 15 Sheet of description. Any one of claims 13 to 16, wherein the component (a) is one or more compounds selected from the group consisting of suberic acid, azelaic acid, sebacic acid, dodecanedioic acid, tetradecanedioic acid, and salts thereof. The sheet described in the section. The sheet according to any one of claims 13 to 16, wherein the component (a) is sebacic acid. The sheet according to any one of claims 13 to 15, wherein the component (a) is an organic carboxylic acid having one naphthalene group and one carboxyl group or a salt thereof. The organic carboxylic acid or its salt is 1-naphthalenecarboxylic acid, 2-naphthalenecarboxylic acid, 2- hydroxy- 1-naphthalenecarboxylic acid, 3- hydroxy -2-naphthalenecarboxylic acid, 6-hydroxy-2 - The sheet according to claim 19, which is one or more compounds selected from the group consisting of naphthalenecarboxylic acids and salts thereof. The organic carboxylic acid or a salt thereof is selected from 1-naphthalenecarboxylic acid, 2-naphthalenecarboxylic acid, 2- hydroxy- 1-naphthalenecarboxylic acid, 3- hydroxy -2-naphthalenecarboxylic acid, and salts thereof The sheet according to claim 19, which is one or more compounds selected from the group consisting of: The impregnation rate (% by mass) of the composition containing the component (a) and water with respect to the mass of the nonwoven fabric is 100% by mass or more and 500% by mass or less, according to any one of claims 13 to 21. sheet. The content of component (a) with respect to the mass of the composition containing component (a) and water is 0.01% by mass
The sheet according to any one of claims 13 to 22, wherein the content is 1% by mass or less.