JP7314171B2 - 選択的光熱分解を最適化するための方法および装置 - Google Patents
選択的光熱分解を最適化するための方法および装置 Download PDFInfo
- Publication number
- JP7314171B2 JP7314171B2 JP2020560112A JP2020560112A JP7314171B2 JP 7314171 B2 JP7314171 B2 JP 7314171B2 JP 2020560112 A JP2020560112 A JP 2020560112A JP 2020560112 A JP2020560112 A JP 2020560112A JP 7314171 B2 JP7314171 B2 JP 7314171B2
- Authority
- JP
- Japan
- Prior art keywords
- laser
- surgical
- temperature
- tissue
- pulse
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title description 77
- 230000005855 radiation Effects 0.000 claims description 54
- 238000002604 ultrasonography Methods 0.000 claims description 48
- 230000006870 function Effects 0.000 claims description 18
- 238000001816 cooling Methods 0.000 claims description 15
- 230000001419 dependent effect Effects 0.000 claims description 13
- 238000005259 measurement Methods 0.000 claims description 12
- 210000001519 tissue Anatomy 0.000 description 150
- 230000003902 lesion Effects 0.000 description 47
- 238000001356 surgical procedure Methods 0.000 description 28
- 238000013532 laser treatment Methods 0.000 description 26
- 230000003287 optical effect Effects 0.000 description 22
- 238000002430 laser surgery Methods 0.000 description 20
- 210000003491 skin Anatomy 0.000 description 19
- 239000002872 contrast media Substances 0.000 description 17
- 230000036760 body temperature Effects 0.000 description 16
- 230000001427 coherent effect Effects 0.000 description 15
- 208000009443 Vascular Malformations Diseases 0.000 description 14
- 238000005516 engineering process Methods 0.000 description 14
- 238000003384 imaging method Methods 0.000 description 14
- 230000000649 photocoagulation Effects 0.000 description 12
- 238000001727 in vivo Methods 0.000 description 10
- 239000002245 particle Substances 0.000 description 9
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 8
- 239000000975 dye Substances 0.000 description 8
- 238000012544 monitoring process Methods 0.000 description 8
- 230000005540 biological transmission Effects 0.000 description 7
- 230000009977 dual effect Effects 0.000 description 7
- 238000005457 optimization Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 238000002560 therapeutic procedure Methods 0.000 description 7
- 208000006787 Port-Wine Stain Diseases 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 230000003595 spectral effect Effects 0.000 description 6
- 238000003325 tomography Methods 0.000 description 6
- 206010068150 Acoustic shock Diseases 0.000 description 5
- 206010067193 Naevus flammeus Diseases 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 230000003111 delayed effect Effects 0.000 description 5
- 208000002026 familial multiple nevi flammei Diseases 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- 229910052786 argon Inorganic materials 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000008033 biological extinction Effects 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 230000008021 deposition Effects 0.000 description 4
- 238000010895 photoacoustic effect Methods 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- 230000001360 synchronised effect Effects 0.000 description 4
- 239000006096 absorbing agent Substances 0.000 description 3
- 238000000862 absorption spectrum Methods 0.000 description 3
- 238000009529 body temperature measurement Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000002826 coolant Substances 0.000 description 3
- 238000004146 energy storage Methods 0.000 description 3
- 238000000386 microscopy Methods 0.000 description 3
- 230000017074 necrotic cell death Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000013473 artificial intelligence Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000005094 computer simulation Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 230000005251 gamma ray Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 238000004867 photoacoustic spectroscopy Methods 0.000 description 2
- 238000007626 photothermal therapy Methods 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 238000011477 surgical intervention Methods 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- CVOFKRWYWCSDMA-UHFFFAOYSA-N 2-chloro-n-(2,6-diethylphenyl)-n-(methoxymethyl)acetamide;2,6-dinitro-n,n-dipropyl-4-(trifluoromethyl)aniline Chemical compound CCC1=CC=CC(CC)=C1N(COC)C(=O)CCl.CCCN(CCC)C1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O CVOFKRWYWCSDMA-UHFFFAOYSA-N 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 229920001076 Cutan Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010015866 Extravasation Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000036251 extravasation Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000013305 flexible fiber Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 230000002977 hyperthermial effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011503 in vivo imaging Methods 0.000 description 1
- 238000012623 in vivo measurement Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 238000012634 optical imaging Methods 0.000 description 1
- 238000011369 optimal treatment Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 239000010979 ruby Substances 0.000 description 1
- 229910001750 ruby Inorganic materials 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002277 temperature effect Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004861 thermometry Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 238000013334 tissue model Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00769—Tattoo removal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/00458—Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Electromagnetism (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Acoustics & Sound (AREA)
- Radiology & Medical Imaging (AREA)
- Laser Surgery Devices (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Radiation-Therapy Devices (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
Description
パラメータの温度依存相対対数関数の較正方法は、組織の平衡温度を測定するステップと、一定のレーザパルスエネルギーを持つ温度感知レーザパルスによって励起された手術ターゲットの光音響信号を測定するステップと、平衡温度での光音響信号の振幅の対数としてベースライン信号を計算するステップと、手術用レーザパルスのみを送り、励起された光音響信号を測定するステップと、手術用レーザパルスと温度感知レーザパルスの両方を送り、励起された光音響信号をデュアルパルスによって測定するステップと、減算演算と対数演算の後に温度感知レーザパルスによって励起された光音響信号の振幅の対数を計算するステップと、温度感知レーザパルスによって励起された光音響信号の振幅の対数からベースライン信号を減算した後にデータ点を取得するステップと、レーザ誘起キャビテーションがある否かを確定するステップと、レーザ誘起キャビテーションがない場合、温度が平衡状態に戻るまで待機するステップと、手術用レーザパルスをki倍に増加させるステップと、上記の手順を繰り返して、レーザ誘起キャビテーションが音響検出器によって信号の非線形性から観測されるまで、組織のグリュナイゼンパラメータの相対対数関数のデータ点をより多く取得するステップと、手術用レーザパルスによる絶対温度上昇を計算し、十分なデータ点で組織のグリュナイゼンパラメータの相対対数関数の曲線をフィッティングするステップとを含む。
例として、図1は、革新的なパルス化光SP手術システムの例を示す。このシステムは、音響検出器を含めることで、従来技術における従来のSP光手術システムと区別する。このSPパルス光手術システムは、その制御システム1110の制御下で光ビーム1010を生成するためのチューナブルパルス光源1100と、組織1000と接触するように動作可能な患者インターフェース1200とを備える。図1の一実施では、光ビーム1010は手術用パルス光ビームのみを含む。光音響信号を効率的に励起するために、パルス光ビームのパルス幅は、10-7秒未満、又は10-8秒未満、又は10-9秒未満である。患者インターフェース1200は、光送出ユニット1210、音響検出器1220、及びインターフェース媒体1230を備える。光送出ユニット1210は、光ビームプロファイルを成形し、多関節アームで光ビームを送出し、光ビームの直径を調整し、光ビームを、インターフェース媒体1230を介して組織1000表面に伝送する。インターフェース媒体1230は、光ビームに対して透過性であり、超音波に対して伝導性であることが好ましい。パルス光ビーム1010は、インターフェース媒体1230を介して伝播しかつ音響検出器1220によって検出される光音響波1020を励起する。検出された光音響信号1030は、チューナブルパルス光ビーム1100の制御のために制御システム1110によってデジタル化され、分析される。なお、本明細書におけるチューナブル光源は、その中心波長、又は光パルス幅、又は光パルスエネルギー、又はそれらの組み合わせにおいて、チューニング能力を持つ光源を広く意味する。チューナブル光源自体を作るのは困難でない。ただし、欠けている部分は、組織内の手術ターゲットに応じて、中心波長と他の手術用光パルスパラメーターをどのようにチューニングかである。音響検出器を含めることは、SP手術の従来技術ではまさに欠けている部分である。音響検出器を含めることは、SP手術でのチューナブル光源の利用に初めて意味がある。チューナブル光源と音響検出器の両方は、最適化されたSP手術を可能にする。これは、何十年もの間望まれてきた目標である。
<特許文献>
5840023 A Oraevskyらにより1996年1月に出願された。
6309352 B1 Oraevskyらにより1998年10月に出願された。
2015/0216420 A1 Oraevskyらにより2015年2月に出願された。
4303343 Patelらにより1980年2月に出願された。
62/617,681 Rao Binにより20181月に出願された。
7322972 B2 Viatorらにより2003年2月に出願された。
2017/0014317A1 Youngbullらにより2016年7月に出願された。
2002/0019625A1 Zion Azarにより2001年4月に出願された。
5759200 Zion Azarにより1996年9月に出願された。
WO 2013/033145A1 Nikolaiらにより2011年8月に出願された。
Adams et al., "Thermal diffusivity and thickness measurements for solid samples utilizing the optoacoustic effect," The Analyst 102,678 (1977).
Barua et al., "Laser-tissue interaction in tattoo removal by Q-switched lasers," J Cutan Aesthet Surg 8, 5-8(2015).
Bernstein, "Laser Tattoo Removal," SEMINARS IN PLASTICS SURGERY 21, 175-192(2007).
C. T. Andrew, "Applications of photoacoustic sensing techniques," Rev. Mod. Phys. 58, 381-431(1986).
Cox et al., "Quantitative spectroscopic photoacoustic imaging: a review," Journal of Biomedical Optics 17(6), 061202(2012).
Esenaliev et al., "Real-time optoacoustic monitoring of temperature in tissues", Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical(1999).
Gary A. West, "Photoacoustic spectroscopy," Review of Scientific Instruments 54, 797 (1983).
Hordvik et al., "Photoacoustic technique for determining optical absorption coefficients in solids," Applied Optics 16, 101-107 (1977).
Larin et al., "Monitoring of temperature distribution in tissues with optoacoustic technique in real time", Proc. SPIE 3916, Biomedical Optoacoustics(2000).
Liu et al., "In vivo, high-resolution, three-dimensional Imaging of port wine stain microvasculature in human skin," Lasers in Surgery and Medicine 45, 626-632(2013).
Maslov et al., "Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries", Optics Letters 33, 929-931(2008).
Maslov et al., "In vivo dark-field reflection-mode photoacoustic microscopy," Optics Letters 30, 625-627(2005).
Nelson et al., "Imaging blood flow in human port-wine stain in situ and in real time using optical Doppler tomography," Arch Dermatol. 137, 741-744(2001).
Ortiz et al., "Port-wine stain laser treatment and novel approaches," Facial Plast Surg 28, 611-620(2012).
Peach et al., "Colour shift following tattoo removal with Q-switched Nd-YAG laser (1064/532), " British Journal of Plastic Surgery 52,482-487(1999).
Rao et al., "Smart laser treatment of port-wine stain in children," NIH grant abstract, published on Aug 1st, 2012. http://grantome.com/grant/NIH/K99-AR062530-01.
Shah et al., "Photoacoustic imaging and temperature measurement for photothermal cancer therapy," Journal of Biomedical Optics 13(3), 034024(2008).
Viator et al., "In vivo port-wine stain depth determination with a photoacoustic probe," Appl. Opt. 42, 3215-3224(2003).
Wang, "Prospects of photoacoustic tomography," Medical Physics 35, 5758 (2008).
Wenzel, "Current concepts in laser tattoo removal," Skin Therapy Letter 15, 3-5(2010).
Zapka et al., "Noncontact optoacoustic monitoring of flame temperature profiles," Optics Letters 7, 477-479 (1982).
Zhang et al., "Backward-mode multiwavelength photoacoustic scanner using a planar Fabry-Perot polymer film ultrasound sensor for high-resolution three-dimensional imaging of biological tissues," Applied Optics 47,561-577(2008).
Claims (3)
- 放射線を放出するように構成されるチューナブル放射線源(1100)と、
前記放射線を組織(1000)に送出するように構成される放射線送出ユニット(1210)と、前記組織(1000)内の1つ又は複数の標的から前記放射線によって励起された光音響波(1020)を検出するための超音波検出器(1220)とを含む患者インターフェース(1200)と、
前記組織(1000)の、グリュナイゼンパラメータの温度依存の相対対数関数と、皮膚冷却パラメータと、前記検出された光音響波の測定に基づく、前記1つ又は複数の標的の熱緩和時間及び動的温度とを含む特性を取得し、前記組織(1000)内の前記1つ又は複数の標的に対する最適な外科手術結果のための前記チューナブル放射線源(1100)の中心波長、パルス幅又はパルス持続時間、及びパルスエネルギーを含む最適な特性を決定し、前記特性と前記最適な特性とを規定し、前記最適な特性に基づいて最適な外科手術結果に向かって前記チューナブル放射線源(1100)を調整するように構成された制御システム(1110)と、
を備える選択的光熱分解(SP)デバイス。 - 前記チューナブル放射線源(1100)は、前記制御システム(1110)による制御下で、組織(1000)内の1つ又は複数の標的から光音響波(1020)を励起する外科的な又は治療量以下の放射線パルスを生成するように構成される、請求項1に記載の選択的光熱分解デバイス。
- 前記チューナブル放射線源(1100)は、第1の放射線パルス(1010)又は第1の放射線変調、及び第2の温度感知放射線パルス又は第2の温度感知放射線変調を生成するように構成され、それらの間で正確かつ調整可能な遅延時間があり、前記第2の温度感知放射線パルス又は前記第2の温度感知放射線変調は、前記制御システム(1110)による制御下で組織(1000)内の1つ又は複数の標的からの検出可能な光音響波(1020)を励起する、請求項1に記載の選択的光熱分解デバイス。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2023065965A JP2023100670A (ja) | 2018-01-16 | 2023-04-13 | 選択的光熱分解を最適化するための方法および装置 |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862617681P | 2018-01-16 | 2018-01-16 | |
US62/617,681 | 2018-01-16 | ||
US15/881,748 | 2018-01-27 | ||
US15/881,748 US10806513B2 (en) | 2018-01-16 | 2018-01-27 | Methods and apparatus for optimizing selective photothermolysis |
PCT/US2019/013557 WO2019143579A1 (en) | 2018-01-16 | 2019-01-15 | Methods and apparatus for optimizing selective photothermolysis |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2023065965A Division JP2023100670A (ja) | 2018-01-16 | 2023-04-13 | 選択的光熱分解を最適化するための方法および装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2021510615A JP2021510615A (ja) | 2021-04-30 |
JP7314171B2 true JP7314171B2 (ja) | 2023-07-25 |
Family
ID=67213409
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020560112A Active JP7314171B2 (ja) | 2018-01-16 | 2019-01-15 | 選択的光熱分解を最適化するための方法および装置 |
JP2023065965A Pending JP2023100670A (ja) | 2018-01-16 | 2023-04-13 | 選択的光熱分解を最適化するための方法および装置 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2023065965A Pending JP2023100670A (ja) | 2018-01-16 | 2023-04-13 | 選択的光熱分解を最適化するための方法および装置 |
Country Status (5)
Country | Link |
---|---|
US (2) | US10806513B2 (ja) |
EP (1) | EP3740280A4 (ja) |
JP (2) | JP7314171B2 (ja) |
CN (2) | CN111655334A (ja) |
WO (1) | WO2019143579A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10799292B2 (en) | 2018-05-04 | 2020-10-13 | Bin Rao | High power tunable optical parametric oscillator for selective photothermolysis laser surgeries |
CA3102392A1 (en) * | 2018-06-08 | 2019-12-12 | Quanta System S.P.A. | Photo-thermal targeted treatment system with integrated pre-conditioning, and automatic triggering of photo-thermal targeted treatment via measurement of skin surface temperature and associated methods |
DE112021003889T5 (de) * | 2020-07-21 | 2023-05-04 | Gyrus Acmi, Inc. D/B/A Olympus Surgical Technologies America | Laserbehandlung mit akustischer rückkopplung |
EP4046684B1 (de) * | 2021-02-23 | 2023-08-23 | Medizinisches Laserzentrum Lübeck GmbH | Vorrichtung zum behandeln von biologischem gewebe |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040039379A1 (en) | 2002-04-10 | 2004-02-26 | Viator John A. | In vivo port wine stain, burn and melanin depth determination using a photoacoustic probe |
JP2004288996A (ja) | 2003-03-24 | 2004-10-14 | Topcon Corp | 固体レーザ装置 |
US20100082019A1 (en) | 2007-01-19 | 2010-04-01 | Joseph Neev | Devices and methods for generation of subsurface microdisruptions for biomedical applications |
JP2012522546A (ja) | 2009-04-03 | 2012-09-27 | カール ツァイス メディテック アクチエンゲゼルシャフト | 治療光線によって治療される生体組織における非侵襲性の温度決定方法および装置 |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4303343A (en) * | 1980-02-29 | 1981-12-01 | Bell Telephone Laboratories, Incorporated | Optoacoustic spectroscopy of condensed matter in bulk form |
US5772656A (en) * | 1993-06-04 | 1998-06-30 | Summit Technology, Inc. | Calibration apparatus for laser ablative systems |
US6309352B1 (en) * | 1996-01-31 | 2001-10-30 | Board Of Regents, The University Of Texas System | Real time optoacoustic monitoring of changes in tissue properties |
US5840023A (en) * | 1996-01-31 | 1998-11-24 | Oraevsky; Alexander A. | Optoacoustic imaging for medical diagnosis |
US5759200A (en) * | 1996-09-04 | 1998-06-02 | Azar; Zion | Method of selective photothermolysis |
US6214034B1 (en) * | 1996-09-04 | 2001-04-10 | Radiancy, Inc. | Method of selective photothermolysis |
AU6894500A (en) * | 1999-08-06 | 2001-03-05 | Board Of Regents, The University Of Texas System | Optoacoustic monitoring of blood oxygenation |
US6542767B1 (en) * | 1999-11-09 | 2003-04-01 | Biotex, Inc. | Method and system for controlling heat delivery to a target |
US8439959B2 (en) * | 2004-10-29 | 2013-05-14 | Erchonia Corporation | Full-body laser scanner and method of mapping and contouring the body |
US6807203B2 (en) * | 2001-12-05 | 2004-10-19 | Lightwave Electronics Corporation | Calibrating a frequency difference between two or more lasers over an extended frequency range |
US20080132886A1 (en) * | 2004-04-09 | 2008-06-05 | Palomar Medical Technologies, Inc. | Use of fractional emr technology on incisions and internal tissues |
US8932278B2 (en) | 2004-07-12 | 2015-01-13 | Nikolai Tankovich | Skin treatment system with time modulated laser pulses |
US20120010603A1 (en) * | 2005-08-12 | 2012-01-12 | Dermalucent, LLC | Tissue optical clearing devices for subsurface light-induced phase-change and method of use |
AU2006279865B8 (en) * | 2005-08-12 | 2013-01-31 | Board Of Regents, The University Of Texas System | Systems, devices, and methods for optically clearing tissue |
WO2007084981A2 (en) * | 2006-01-19 | 2007-07-26 | The Regents Of The University Of Michigan | System and method for photoacoustic imaging and monitoring of laser therapy |
US20090105588A1 (en) * | 2007-10-02 | 2009-04-23 | Board Of Regents, The University Of Texas System | Real-Time Ultrasound Monitoring of Heat-Induced Tissue Interactions |
FR2924327B1 (fr) * | 2007-12-03 | 2011-03-18 | Heatwave Technology | Dispositif et procede de traitement thermique dermatologique par faisceau laser. |
US10114213B2 (en) * | 2008-04-04 | 2018-10-30 | Cvi Laser, Llc | Laser systems and optical devices for manipulating laser beams |
US20160028210A1 (en) * | 2008-04-04 | 2016-01-28 | CVI Laser, LLC. | Compact, thermally stable multi-laser engine |
US20110087202A1 (en) * | 2009-04-07 | 2011-04-14 | Lumenis Ltd. | Tissue treatment apparatus and methods |
KR101031087B1 (ko) * | 2009-07-23 | 2011-04-25 | 주식회사 와이텔포토닉스 | 파장변환 레이저 시스템 |
US11406448B2 (en) * | 2011-02-03 | 2022-08-09 | Channel Investments, Llc | Devices and methods for radiation-based dermatological treatments |
US8997572B2 (en) * | 2011-02-11 | 2015-04-07 | Washington University | Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection |
EP2688505B1 (en) * | 2011-03-25 | 2016-05-18 | EOS Holdings, LLC | Medical laser with electronic shutter |
US20130166001A1 (en) * | 2011-06-23 | 2013-06-27 | University Of North Carolina At Charlotte | Continuous-wave optical stimulation of nerve tissue |
US20150272444A1 (en) * | 2012-08-14 | 2015-10-01 | Koninklijke Philips N.V. | Compact laser and efficient pulse delivery for photoacoustic imaging |
WO2015117070A1 (en) * | 2014-01-31 | 2015-08-06 | Tomowave Laboratories, Inc. | Optoacoustic image mapping of tissue temperature |
US10456198B2 (en) * | 2014-06-04 | 2019-10-29 | The Curators Of The University Of Missouri | Guided wave ablation and sensing |
CN104161520A (zh) * | 2014-08-27 | 2014-11-26 | 华南师范大学 | 一种基于光致声效应原理的测定表皮黑色素浓度的方法及其装置 |
CN104146685B (zh) * | 2014-08-27 | 2016-04-13 | 华南师范大学 | 一种基于光声原理的皮肤色素沉着成像装置 |
US9915853B2 (en) * | 2014-10-07 | 2018-03-13 | Lam Khanh Nguyen | Optical parametric oscillator with fast tuning |
US9987089B2 (en) * | 2015-07-13 | 2018-06-05 | University of Central Oklahoma | Device and a method for imaging-guided photothermal laser therapy for cancer treatment |
US10238587B2 (en) * | 2015-07-15 | 2019-03-26 | Excelsior Nanotech Corporation | Erasable tattoo ink and method for removing tattoos |
CA3048284C (en) * | 2016-06-09 | 2021-04-13 | Lumenis Ltd. | Apparatus and method for reducing laser beam attentuation in a liquid medium |
CN106725348A (zh) * | 2017-02-27 | 2017-05-31 | 集美大学 | 一种吸收体吸收系数测量和同时光声成像的无损检测方法及其装置 |
US10965093B2 (en) * | 2017-05-05 | 2021-03-30 | Institut National D'optique | Light modulation for improved photoacoustic feedback on light-induced treatments and procedures |
-
2018
- 2018-01-27 US US15/881,748 patent/US10806513B2/en active Active
-
2019
- 2019-01-15 EP EP19741432.9A patent/EP3740280A4/en active Pending
- 2019-01-15 CN CN201980008755.7A patent/CN111655334A/zh active Pending
- 2019-01-15 CN CN202310486174.2A patent/CN116421304A/zh active Pending
- 2019-01-15 JP JP2020560112A patent/JP7314171B2/ja active Active
- 2019-01-15 WO PCT/US2019/013557 patent/WO2019143579A1/en unknown
-
2020
- 2020-09-15 US US17/021,902 patent/US20210059752A1/en active Pending
-
2023
- 2023-04-13 JP JP2023065965A patent/JP2023100670A/ja active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040039379A1 (en) | 2002-04-10 | 2004-02-26 | Viator John A. | In vivo port wine stain, burn and melanin depth determination using a photoacoustic probe |
JP2004288996A (ja) | 2003-03-24 | 2004-10-14 | Topcon Corp | 固体レーザ装置 |
US20100082019A1 (en) | 2007-01-19 | 2010-04-01 | Joseph Neev | Devices and methods for generation of subsurface microdisruptions for biomedical applications |
JP2012522546A (ja) | 2009-04-03 | 2012-09-27 | カール ツァイス メディテック アクチエンゲゼルシャフト | 治療光線によって治療される生体組織における非侵襲性の温度決定方法および装置 |
Also Published As
Publication number | Publication date |
---|---|
EP3740280A4 (en) | 2021-03-03 |
US20190216542A1 (en) | 2019-07-18 |
EP3740280A1 (en) | 2020-11-25 |
CN116421304A (zh) | 2023-07-14 |
US20210059752A1 (en) | 2021-03-04 |
JP2021510615A (ja) | 2021-04-30 |
CN111655334A (zh) | 2020-09-11 |
WO2019143579A1 (en) | 2019-07-25 |
US10806513B2 (en) | 2020-10-20 |
JP2023100670A (ja) | 2023-07-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7314171B2 (ja) | 選択的光熱分解を最適化するための方法および装置 | |
US6309352B1 (en) | Real time optoacoustic monitoring of changes in tissue properties | |
Pang et al. | Three‐dimensional optoacoustic monitoring of lesion formation in real time during radiofrequency catheter ablation | |
US20090105588A1 (en) | Real-Time Ultrasound Monitoring of Heat-Induced Tissue Interactions | |
US20120022360A1 (en) | Methods for intravascular imaging and flushing | |
Nikitin et al. | Temperature dependence of the optoacoustic transformation efficiency in ex vivo tissues for application in monitoring thermal therapies | |
Larin et al. | Monitoring of tissue coagulation during thermotherapy using optoacoustic technique | |
JP2017506943A (ja) | 光学的組織評価を伴う高周波切除カテーテル | |
Fehm et al. | Volumetric optoacoustic imaging feedback during endovenous laser therapy–an ex vivo investigation | |
Talbert et al. | Photoacoustic discrimination of viable and thermally coagulated blood using a two-wavelength method for burn injury monitoring | |
US20200367750A1 (en) | Photoacoustic system for accurate localization of laser ablation catheter tip position and temperature monitoring during ablation procedures | |
JP2023100670A5 (ja) | ||
Guo et al. | Intraoperative speckle variance optical coherence tomography for tissue temperature monitoring during cutaneous laser therapy | |
Park et al. | Application of ultrasound thermal imaging for monitoring laser ablation in ex vivo cardiac tissue | |
Özsoy et al. | Real-time assessment of high-intensity focused ultrasound heating and cavitation with hybrid optoacoustic ultrasound imaging | |
John et al. | Integration of endovenous laser ablation and photoacoustic imaging systems for enhanced treatment of venous insufficiency | |
Patterson et al. | Optoacoustic signal amplitude and frequency spectrum analysis laser heated bovine liver ex vivo | |
Esenaliev et al. | Laser optoacoustic technique for real-time measurement of thermal damage in tissues | |
CN113598943A (zh) | 外科器械和测量方法 | |
Castelino et al. | Photoacoustic detection of protein coagulation in albumen-based phantoms | |
Landa et al. | Four-dimensional optoacoustic temperature mapping in laser-induced thermotherapy | |
Li et al. | Interstitial photoacoustic technique and computational simulation for temperature distribution and tissue optical properties in interstitial laser photothermal interaction | |
Arsenault et al. | Optoacoustic detection of thermal lesions | |
JP2020069116A (ja) | 治療システム | |
Landa | Real-time Optoacoustic Monitoring of Thermal Ablation and Laser Surgery |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210308 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20210308 |
|
A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20210308 |
|
A975 | Report on accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A971005 Effective date: 20210326 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210406 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210705 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210705 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210906 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210928 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20211227 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20220228 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220324 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220621 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220920 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20221213 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230413 |
|
C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20230413 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20230413 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20230509 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20230613 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230712 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7314171 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |