JP7303749B2 - Ｔｉｍ－１を標的とするキメラ抗原受容体 - Google Patents

Ｔｉｍ－１を標的とするキメラ抗原受容体 Download PDF

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JP7303749B2
JP7303749B2 JP2019558994A JP2019558994A JP7303749B2 JP 7303749 B2 JP7303749 B2 JP 7303749B2 JP 2019558994 A JP2019558994 A JP 2019558994A JP 2019558994 A JP2019558994 A JP 2019558994A JP 7303749 B2 JP7303749 B2 JP 7303749B2
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－ チン ホー、リ
マーシュ、ジュニア、ヘンリー、シー．
ケラー、タイボー
シュタットハイム、テランス、エイ．
ミュラド、ジョアナ、エム．
レダー、ジェイク
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セルダラ メディカル、エルエルシー
セルデックス セラピューティクス インコーポレイテッド
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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JP2019558994A 2017-01-13 2018-01-12 Ｔｉｍ－１を標的とするキメラ抗原受容体 Active JP7303749B2 (ja)

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Application Number Priority Date Filing Date Title
US201762445976P 2017-01-13 2017-01-13
US62/445,976 2017-01-13
PCT/US2018/013551 WO2018132695A1 (en) 2017-01-13 2018-01-12 Chimeric antigen receptors targeting tim-1

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JP2020513839A JP2020513839A (ja) 2020-05-21
JP2020513839A5 JP2020513839A5 (https=) 2021-02-25
JP7303749B2 true JP7303749B2 (ja) 2023-07-05

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US (2) US11541076B2 (https=)
EP (1) EP3568416A4 (https=)
JP (1) JP7303749B2 (https=)
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WO (1) WO2018132695A1 (https=)

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EP3688032B1 (en) 2017-09-26 2025-11-05 Cero Therapeutics Holdings, Inc. Chimeric engulfment receptor molecules and methods of use
JP7444781B2 (ja) 2018-03-28 2024-03-06 セロ・セラピューティクス・インコーポレイテッド 細胞免疫療法組成物およびその使用
WO2019191334A1 (en) 2018-03-28 2019-10-03 Cero Therapeutics, Inc. Chimeric tim4 receptors and uses thereof
WO2019222579A1 (en) * 2018-05-17 2019-11-21 St. Jude Children's Research Hospital, Inc. Chimeric antigen receptors with myd88 and cd40 costimulatory domains
CN110615842B (zh) * 2018-06-20 2023-05-09 上海隆耀生物科技有限公司 一种包含共刺激受体的嵌合抗原受体及应用
SG11202101014XA (en) * 2018-08-02 2021-02-25 Kite Pharma Inc Chimeric antigen receptor therapy t cell expansion kinetics and uses thereof
SG11202101773WA (en) * 2018-08-29 2021-03-30 Nanjing Legend Biotech Co Ltd Anti-mesothelin chimeric antigen receptor (car) constructs and uses thereof
EP3902838A4 (en) 2018-12-26 2022-12-21 Nanjing Legend Biotech Co., Ltd. Cd30-binding moieties, chimeric antigen receptors, and uses thereof
CA3139319A1 (en) * 2019-05-07 2020-11-12 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of polypeptides and chimeric antigen receptors via hinge domains
US20220265715A1 (en) * 2019-07-24 2022-08-25 Eureka Therapeutics, Inc. Chimeric antigen receptor t cells and uses thereof
CN112079934B (zh) * 2019-12-17 2021-01-29 合源生物科技(天津)有限公司 一种靶向cd19的嵌合抗原受体及其用途
CN115103857B (zh) * 2019-12-28 2025-12-19 上海细胞治疗集团股份有限公司 表达免疫调节分子的细胞和表达免疫调节分子的系统
CA3167572A1 (en) * 2020-02-14 2021-08-19 Robbie G. MAJZNER Chimeric antigen receptors with cd2 activation
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CA3174094A1 (en) * 2020-03-31 2021-10-07 Shinya Ishii Claudin-6 targeting multispecific antigen-binding molecules and uses thereof
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EP4162058A4 (en) * 2020-06-09 2025-02-26 Hangzhou Leading Edge Pharmaceutical Ltd. COMPOSITIONS AND METHODS FOR ENHANCING THE IMMUNE RESPONSE
CN112063588A (zh) * 2020-08-13 2020-12-11 南京北恒生物科技有限公司 工程化免疫细胞及其用途
CN117042780A (zh) * 2020-10-13 2023-11-10 宾夕法尼亚大学理事会 用于mRNA治疗剂的T细胞的体内靶向
CN114149505B (zh) * 2021-01-12 2022-11-04 北京门罗生物科技有限公司 治疗b细胞相关疾病的免疫细胞、制备方法及其应用
CN114807044B (zh) * 2021-04-30 2023-09-08 四川大学华西医院 一种具有高nkt细胞比例的car-cik细胞制备方法及应用
US20250304915A1 (en) * 2021-05-25 2025-10-02 Institut Curie Myeloid Cells Overexpressing BCL2
CN115521917A (zh) * 2021-06-25 2022-12-27 南京北恒生物科技有限公司 工程化免疫细胞及其用途
CN113583122B (zh) * 2021-07-29 2023-08-29 武汉华美生物工程有限公司 抗人sema4d抗体及其制备方法和应用
CN115322257B (zh) * 2021-08-16 2023-05-30 上海优替济生生物医药有限公司 Bcma靶向抗体、嵌合抗原受体及其应用
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CN115974976B (zh) * 2022-11-23 2024-06-04 华中科技大学 拮抗多肽及用于制备抗急性肾损伤药物的应用
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JP2009515897A (ja) 2005-11-10 2009-04-16 キュラジェン コーポレイション Ｔ細胞の免疫グロブリンドメインおよびムチンドメイン１（ｔｉｍ−１）抗原に対する抗体を用いて卵巣癌および腎臓癌を処置する方法
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JP2007525434A (ja) 2003-03-19 2007-09-06 アブジェニックス インコーポレイテッド Ｔ細胞、免疫グロブリンドメインおよびムチンドメイン１（ｔｉｍ−１）抗原に対する抗体およびその使用。
JP2009515897A (ja) 2005-11-10 2009-04-16 キュラジェン コーポレイション Ｔ細胞の免疫グロブリンドメインおよびムチンドメイン１（ｔｉｍ−１）抗原に対する抗体を用いて卵巣癌および腎臓癌を処置する方法
JP2014507118A (ja) 2010-12-09 2014-03-27 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 癌を治療するためのキメラ抗原受容体改変ｔ細胞の使用
JP2015527070A (ja) 2012-08-20 2015-09-17 フレッド ハッチンソン キャンサー リサーチ センター 細胞免疫療法のための方法および組成物
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US20190336534A1 (en) 2019-11-07
CN110494451B (zh) 2023-12-01
US11541076B2 (en) 2023-01-03
EP3568416A1 (en) 2019-11-20
EP3568416A4 (en) 2020-07-08
US20230355673A1 (en) 2023-11-09
WO2018132695A1 (en) 2018-07-19
CN110494451A (zh) 2019-11-22
JP2020513839A (ja) 2020-05-21

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