JP7288864B2 - 消化管シミュレーションシステム、そのための区画および方法 - Google Patents
消化管シミュレーションシステム、そのための区画および方法 Download PDFInfo
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Description
本発明による実施形態では、ピンチ弁は、カムディスク上のカムによって作動されるばね式フィンガを備えていてもよい。他の実施形態では、ピンチ弁は、カムディスク自体のカムによって形成されてもよい。
Claims (16)
- 周縁部によって囲まれた開口上部を有する容器と、
該周縁部の上に配置されるように構成された気密蓋システムであって、該気密蓋システムと前記容器との間に気密封止を形成するように構成された気密蓋システムと、
を有する、消化管シミュレーションシステムの区画であって、
前記蓋システムが本体を含み、
該本体が、該本体を通って延出しかつ前記容器の内部へのアクセスを提供する、複数の通路を有し、
該複数の通路が、流体移送管を受け入れるように構成された第1の通路と、少なくとも1つのセンサ構成要素を取り付けるように構成された第2の通路と、を含み、
前記蓋システムには、
前記複数の通路を封止するための解除可能な複数の封止要素と、
該複数の封止要素のうちの少なくとも幾つかの封止要素に共通であって、対応する前記幾つかの封止要素の各々に圧力を加えて、対応する複数の通路の封止を達成するように構成された少なくとも1つの押圧要素と、が設けられており、
前記押圧要素が板状部材を含み、
該板状部材が、前記複数の通路の封止を達成するために該板状部材が前記封止要素に圧力を加える押圧位置と、該封止要素が解除状態にある解除位置と、の間において、前記蓋システムの前記本体に移動可能に固定されている、ことを特徴とする区画。 - 前記解除可能な複数の封止要素の各々が、それぞれの通路に挿入されるそれぞれの管又はセンサ構成要素の上又は周囲に圧縮されるように設けられた封止材料の封止部材と、前記圧縮のために前記封止部材に作用するばね部材と、を含む、請求項1に記載の区画。
- 前記板状部材は、1つ以上のねじをねじ込むことにより、前記解除位置から前記押圧位置に移動可能である、請求項1に記載の区画。
- 前記板状部材が、ねじを固定するための空間を残す切り欠きを含み、これによって、前記蓋システムの前記本体と前記容器とが相互に封止される、請求項1に記載の区画。
- 前記気密蓋システムの前記本体は内部空洞を有する中空であり、
前記解除可能な複数の封止要素が前記空洞を囲む中空の前記本体に配置され、
前記空洞には保持要素が設けられ、
該保持要素は前記流体移送管及び前記センサ構成要素のための前記第1の通路及び前記第2の通路を含有する、請求項1から請求項4のいずれかに記載の区画。 - 前記保持要素が3D印刷部品である、請求項5に記載の区画。
- 前記蓋システムを通って前記容器の内部に垂直に延出するセンサプローブを具備する、請求項1から請求項6のいずれかに記載の区画。
- 前記複数の通路が前記蓋システムを通って垂直に延出する、請求項1から請求項7のいずれかに記載の区画。
- 前記複数の通路が前記センサプローブの周りで半径方向に離間している、請求項7に記載の区画。
- 前記本体及び前記押圧要素が回転対称部品である、請求項1から請求項9のいずれかに記載の区画。
- 請求項1から請求項10のいずれかに記載の少なくとも1つの区画と、対応する前記第1の通路を通って延びる流体移送管と、前記第2の通路の中に取り付けられたセンサ構成要素と、を具備する、消化管シミュレーションシステム。
- 少なくとも1つの区画が、外側容器と、該外側容器の内側に取り付けられた内側容器とを有し、該内側容器は、少なくとも一部が透析膜によって形成された壁を有する、請求項11に記載の消化管シミュレーションシステム。
- 前記内側容器の壁が円筒形のグリッド構造を含み、前記透析膜が前記円筒形のグリッド構造の周囲に取り付けられている、請求項12に記載の消化管シミュレーションシステム。
- ヒト及び動物の腸壁に付着して成長する可能性のある微生物種の定着を支持することができる粘膜区画をシミュレートするために、少なくとも1つの区画は、前記腸壁の内側を覆う粘液層を代表するムチンで覆われた担体を含有する、請求項11から請求項13のいずれかに記載の消化管シミュレーションシステム。
- 少なくとも1つの区画の蓋システムには、前記容器における高すぎる液位を検出するための高液位検出手段が設けられており、
該高液位検出手段は、前記蓋システムを通るガス入口管及びガス出口管と、前記ガス入口管及び前記ガス出口管を通り、前記容器のヘッドスペースを経由するガス流を確立する手段と、を具備し、
前記ガス入口管及び前記ガス出口管のうちの少なくとも一方の口部にはフロータが取り付けられており、
前記フロータは、液体の液位が高くなりすぎると、前記フロータが前記ガス流の障害物を形成しない自由な流れ位置から、前記フロータがガス流の障害物を形成する妨害位置まで、前記容器内の前記液体に浮かぶことによって上昇するように適合されている、請求項11から請求項14のいずれかに記載の消化管シミュレーションシステム。 - 請求項11から請求項15のいずれかに記載された消化管シミュレーションシステムの空の区画を消化管の生理学的流体をシミュレートする流体で満たすステップと、
事前に決定された値、範囲又は軌道に各々応じて、液体流、温度、pH、イオン強度、ヘッドスペース、撹拌、圧力、液体量、のパラメータの1つ以上又はすべてを各区画で制御するように前記消化管シミュレーションシステムを動作させるステップと、
を含む、ヒト又は動物の消化管の機能をシミュレートする方法。
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EP17174613.4A EP3412762A1 (en) | 2017-06-06 | 2017-06-06 | Gastrointestinal tract simulation system, compartments therefor, and method |
EP17174613.4 | 2017-06-06 | ||
PCT/EP2018/064917 WO2018224558A1 (en) | 2017-06-06 | 2018-06-06 | Gastrointestinal tract simulation system, compartments therefor, and method |
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EP3412762A1 (en) * | 2017-06-06 | 2018-12-12 | ProDigest BVBA | Gastrointestinal tract simulation system, compartments therefor, and method |
CN108735060A (zh) * | 2018-08-14 | 2018-11-02 | 晓东宜健(苏州)仪器设备有限公司 | 一种仿生人体食道和胃消化系统 |
US20220093006A1 (en) * | 2018-12-03 | 2022-03-24 | Lyndra Therapeutics, Inc. | Stomach simulating device |
CN110288890B (zh) * | 2019-06-21 | 2024-06-14 | 温州市人民医院 | 肠道支架置入术演示装置 |
TWI709645B (zh) * | 2019-07-29 | 2020-11-11 | 國立屏東科技大學 | 模擬腸道環境的生物晶片 |
CN110675704B (zh) * | 2019-11-20 | 2024-05-28 | 天津开发区合普工贸有限公司 | 一种便捷肠道静式替代实验装置 |
TWI817249B (zh) * | 2021-11-12 | 2023-10-01 | 智崴資訊科技股份有限公司 | 伸縮式致動器、致動系統和移動模擬裝置 |
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- 2018-06-06 CN CN201880051059.XA patent/CN111051491B/zh active Active
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ES2943084T3 (es) | 2023-06-08 |
US20200168126A1 (en) | 2020-05-28 |
WO2018224558A1 (en) | 2018-12-13 |
PT3635088T (pt) | 2023-04-24 |
EP3412762A1 (en) | 2018-12-12 |
IL271225B1 (en) | 2024-01-01 |
FI3635088T3 (fi) | 2023-05-04 |
CN111051491B (zh) | 2023-11-24 |
CA3066023A1 (en) | 2018-12-13 |
EP3635088B1 (en) | 2023-01-25 |
EP3635088A1 (en) | 2020-04-15 |
DK3635088T3 (da) | 2023-04-24 |
PL3635088T3 (pl) | 2023-06-19 |
US11557226B2 (en) | 2023-01-17 |
CN111051491A (zh) | 2020-04-21 |
JP2020522273A (ja) | 2020-07-30 |
IL271225B2 (en) | 2024-05-01 |
IL271225A (en) | 2020-01-30 |
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