JP7288864B2 - 消化管シミュレーションシステム、そのための区画および方法 - Google Patents

消化管シミュレーションシステム、そのための区画および方法 Download PDF

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JP7288864B2
JP7288864B2 JP2019567973A JP2019567973A JP7288864B2 JP 7288864 B2 JP7288864 B2 JP 7288864B2 JP 2019567973 A JP2019567973 A JP 2019567973A JP 2019567973 A JP2019567973 A JP 2019567973A JP 7288864 B2 JP7288864 B2 JP 7288864B2
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compartment
container
gastrointestinal tract
sealing
lid system
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JP2020522273A5 (enExample
JP2020522273A (ja
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マスカール，ルイーズ－フィーリプ
マルツォラッティ，マッシモ
ウィンデルス，ティム
ポッセミエルス，サム
ファン・デン・アベーレ，ピーテル
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プロダイジェスト ベーフェーベーアー
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    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • G09B23/30—Anatomical models
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053—Details of the reactor
    • B01J19/0066—Stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053—Details of the reactor
    • B01J19/0073—Sealings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • G09B23/30—Anatomical models
    • G09B23/303—Anatomical models specially adapted to simulate circulation of bodily fluids
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • G09B23/30—Anatomical models
    • G09B23/32—Anatomical models with moving parts
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • G09B23/30—Anatomical models
    • G09B23/34—Anatomical models with removable parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J2219/0803—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electric or magnetic energy
    • B01J2219/085—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electric or magnetic energy creating magnetic fields

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Mathematical Analysis (AREA)
  • Computational Mathematics (AREA)
  • Algebra (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Physics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Business, Economics & Management (AREA)
  • Educational Administration (AREA)
  • Educational Technology (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2019567973A 2017-06-06 2018-06-06 消化管シミュレーションシステム、そのための区画および方法 Active JP7288864B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17174613.4A EP3412762A1 (en) 2017-06-06 2017-06-06 Gastrointestinal tract simulation system, compartments therefor, and method
EP17174613.4 2017-06-06
PCT/EP2018/064917 WO2018224558A1 (en) 2017-06-06 2018-06-06 Gastrointestinal tract simulation system, compartments therefor, and method

Publications (3)

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JP2020522273A JP2020522273A (ja) 2020-07-30
JP2020522273A5 JP2020522273A5 (enExample) 2021-07-26
JP7288864B2 true JP7288864B2 (ja) 2023-06-08

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JP2019567973A Active JP7288864B2 (ja) 2017-06-06 2018-06-06 消化管シミュレーションシステム、そのための区画および方法

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US (1) US11557226B2 (enExample)
EP (2) EP3412762A1 (enExample)
JP (1) JP7288864B2 (enExample)
CN (1) CN111051491B (enExample)
CA (1) CA3066023A1 (enExample)
DK (1) DK3635088T3 (enExample)
ES (1) ES2943084T3 (enExample)
FI (1) FI3635088T3 (enExample)
IL (1) IL271225B2 (enExample)
PL (1) PL3635088T3 (enExample)
PT (1) PT3635088T (enExample)
WO (1) WO2018224558A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3412762A1 (en) * 2017-06-06 2018-12-12 ProDigest BVBA Gastrointestinal tract simulation system, compartments therefor, and method
CN108735060B (zh) * 2018-08-14 2024-08-02 晓东宜健（苏州）仪器设备有限公司 一种仿生人体食道和胃消化系统
US12142158B2 (en) * 2018-12-03 2024-11-12 Lyndra Therapeutics, Inc. Stomach simulating device
CN110288890B (zh) * 2019-06-21 2024-06-14 温州市人民医院 肠道支架置入术演示装置
TWI709645B (zh) * 2019-07-29 2020-11-11 國立屏東科技大學 模擬腸道環境的生物晶片
CN110675704B (zh) * 2019-11-20 2024-05-28 天津开发区合普工贸有限公司 一种便捷肠道静式替代实验装置
US20240044763A1 (en) * 2020-12-22 2024-02-08 Prodigest Gastrointestinal tract simulation system and method
TWI817249B (zh) * 2021-11-12 2023-10-01 智崴資訊科技股份有限公司 伸縮式致動器、致動系統和移動模擬裝置
CN118109273B (zh) * 2024-04-30 2024-07-12 中科康谱健康科技(山东)有限责任公司 一种便于通风的肠道菌群培育设备

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104851346A (zh) 2015-04-30 2015-08-19 暨南大学 模块化动物消化道体外模拟系统及其人类肠道模拟方法
CN205740983U (zh) 2015-12-21 2016-11-30 北京晨奥润泽科技股份有限公司 双发酵系统

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2324702A (en) * 1938-11-30 1943-07-20 Karl F Hoffmann Surgical simulacra and process of preparing same
DE1902200B1 (de) * 1969-01-17 1970-11-26 Ernst Huebers Vorrichtung zum Mischen von Stoffen
US4457339A (en) 1982-03-03 1984-07-03 Coulter Electronics, Inc. Multiprogrammable pinch valve module
NL9201907A (nl) * 1992-11-02 1994-06-01 Tno Peristaltisch mengende reactor en peristaltische kleppenpomp.
WO1995023329A1 (en) * 1994-02-25 1995-08-31 Distek Inc. Dissolution testing apparatus
US5993406A (en) * 1997-05-14 1999-11-30 Cedars-Sinai Medical Center Artificial gut
US6022733A (en) * 1997-12-02 2000-02-08 Tam; Yun K. Simulated biological dissolution and absorption system
US6488507B1 (en) * 1999-11-29 2002-12-03 Ethicon, Inc. Portable surgical trainer
TW590795B (en) * 2002-04-17 2004-06-11 Rohm & Haas An automated system and process for the preparation of a high viscosity fluid formulation
US7390653B2 (en) * 2002-12-04 2008-06-24 Synthecon, Inc. Culture chamber for biologicals
US7144727B2 (en) * 2003-04-14 2006-12-05 Synthecon, Inc. Interlinked culture chamber for biologicals
GB0514702D0 (en) * 2005-07-18 2005-08-24 Plant Bioscience Ltd Apparatus, system and method
FR2923065B1 (fr) * 2007-10-30 2009-12-11 Univ Dauvergne Clermont 1 Dispositif de simulation d'un estomac d'un mammifere monogastrique ou d'un etre humain
JP5257960B2 (ja) * 2009-06-09 2013-08-07 株式会社ジェイテック 回転培養ベッセル及びそれを用いた自動細胞培養装置
EP2284821A1 (en) * 2009-08-07 2011-02-16 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Method, device and computer program product for assessing the disintegration of a dosage form in the gastrointestinal tract
EP2529770A1 (en) * 2011-05-31 2012-12-05 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO A digestion system
CH705468A1 (de) * 2011-09-06 2013-03-15 Tecan Trading Ag Kammersystem und Probenbehälter mit Einlass.
US9314404B2 (en) * 2013-01-31 2016-04-19 Allergan, Inc. Drug compounding skid and compounding method
EP2884480A1 (en) * 2013-12-12 2015-06-17 Sandoz Ag Apparatus for simulating the function of human stomach and/or human intestine
PL228790B1 (pl) * 2014-09-09 2018-05-30 Iwanejko Zdzislaw Iwanejko Electronics Urządzenie do nalewania lub wylewania cieczy
WO2016168445A1 (en) * 2015-04-17 2016-10-20 Pion Inc. Apparatus and method for the assessment of concentration profiling and permeability rates
CN205778735U (zh) * 2016-05-26 2016-12-07 中国石油化工股份有限公司 一种自泄液式试压阀
US20180030403A1 (en) * 2016-07-28 2018-02-01 Bobban Subhadra Devices, systems and methods for the production of humanized gut commensal microbiota
US20190287423A1 (en) * 2016-11-22 2019-09-19 PraxiCut, LLC Surgical simulation systems, methods, and compositions
EP3412762A1 (en) * 2017-06-06 2018-12-12 ProDigest BVBA Gastrointestinal tract simulation system, compartments therefor, and method
US10955375B2 (en) * 2018-03-16 2021-03-23 U.S. Department Of Energy Multielectrode sensor for concentration and depth measurements in molten salt

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104851346A (zh) 2015-04-30 2015-08-19 暨南大学 模块化动物消化道体外模拟系统及其人类肠道模拟方法
CN205740983U (zh) 2015-12-21 2016-11-30 北京晨奥润泽科技股份有限公司 双发酵系统

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Pieter Van den Abbeele et al.，Appl. Environ. Microbiol.，2010年08月，Vol. 76, No. 15，p. 5237-5246

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Publication number Publication date
EP3635088A1 (en) 2020-04-15
IL271225B2 (en) 2024-05-01
IL271225B1 (en) 2024-01-01
IL271225A (en) 2020-01-30
ES2943084T3 (es) 2023-06-08
CN111051491B (zh) 2023-11-24
JP2020522273A (ja) 2020-07-30
PL3635088T3 (pl) 2023-06-19
WO2018224558A1 (en) 2018-12-13
EP3635088B1 (en) 2023-01-25
FI3635088T3 (fi) 2023-05-04
CN111051491A (zh) 2020-04-21
EP3412762A1 (en) 2018-12-12
DK3635088T3 (da) 2023-04-24
US11557226B2 (en) 2023-01-17
PT3635088T (pt) 2023-04-24
US20200168126A1 (en) 2020-05-28
CA3066023A1 (en) 2018-12-13

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