JP7287942B2 - 高強度標識反応物組成物および配列決定のための方法 - Google Patents

高強度標識反応物組成物および配列決定のための方法 Download PDF

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JP7287942B2
JP7287942B2 JP2020503775A JP2020503775A JP7287942B2 JP 7287942 B2 JP7287942 B2 JP 7287942B2 JP 2020503775 A JP2020503775 A JP 2020503775A JP 2020503775 A JP2020503775 A JP 2020503775A JP 7287942 B2 JP7287942 B2 JP 7287942B2
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luminescent
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エム． ロスバーグ、ジョナサン
ラッキー、ジェレミー
リード、ブライアン
シー、シンホア
ホワン、ハイドン
ドッド、デイビッド
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Quantum Si Inc
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/185—Modifications characterised by incorporating bases where the precise position of the bases in the nucleic acid string is important
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/197—Modifications characterised by incorporating a spacer/coupling moiety
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/30—Oligonucleotides characterised by their secondary structure
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/103—Nucleic acid detection characterized by the use of physical, structural and functional properties luminescence
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)
JP2020503775A 2017-07-24 2018-07-24 高強度標識反応物組成物および配列決定のための方法 Active JP7287942B2 (ja)

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US201762536426P 2017-07-24 2017-07-24
US62/536,426 2017-07-24
PCT/US2018/043526 WO2019023257A1 (en) 2017-07-24 2018-07-24 HIGH INTENSITY MARKED REAGENT COMPOSITIONS AND SEQUENCING METHODS

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JP2020530988A JP2020530988A (ja) 2020-11-05
JP2020530988A5 JP2020530988A5 (https=) 2021-09-16
JP7287942B2 true JP7287942B2 (ja) 2023-06-06

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US (2) US11655504B2 (https=)
EP (1) EP3658682A4 (https=)
JP (1) JP7287942B2 (https=)
KR (1) KR102626317B1 (https=)
CN (1) CN111148850B (https=)
AU (1) AU2018308098B2 (https=)
BR (1) BR112020000697A2 (https=)
CA (1) CA3069985A1 (https=)
TW (1) TWI829642B (https=)
WO (1) WO2019023257A1 (https=)

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Citations (1)

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JP2015073523A (ja) 2013-10-11 2015-04-20 国立大学法人 東京大学 核酸の検出方法、検出プローブ、マイクロアレイ、核酸検出キット、核酸‐検出プローブ‐捕捉プローブ複合体、核酸固定化担体、及び流体デバイス

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