JP7281208B2 - SseJタンパク質を用いたサルモネラワクチン - Google Patents
SseJタンパク質を用いたサルモネラワクチン Download PDFInfo
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- JP7281208B2 JP7281208B2 JP2020529059A JP2020529059A JP7281208B2 JP 7281208 B2 JP7281208 B2 JP 7281208B2 JP 2020529059 A JP2020529059 A JP 2020529059A JP 2020529059 A JP2020529059 A JP 2020529059A JP 7281208 B2 JP7281208 B2 JP 7281208B2
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- salmonella
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Description
Salmonella Typhimurium x3306株のDNAを鋳型として、プライマー(フォワード:CACCATGCCATTGAGTGTTGGACA/配列番号:3、リバース:TTATTCAGTGGAATAATGATGAGCT/配列番号:4)を用いてPCRを行った。
Salmonella Typhimurium x3306株、Salmonella Choleraesuis ATCC7001株、Salmonella Dublin 5230株の死菌(105CFU)および精製した組換えSseJタンパク質(10μg)をインコンプリートアジュバントと共に、BACB/cマウス(メス5週令)の皮下に免疫し、約2週間後に再度免疫した。免疫後2週間後に、Salmonella Typhimurium x3306株、Salmonella Choleraesuis ATCC7001株、Salmonella Dublin 5230株を、それぞれ106 CFU(LD50は104)、106 CFU(LD50は5x104)、106 CFU(LD50は5x104)経口感染させた。感染6時間前にマウスを絶食させ、その後10%重曹を50μl経口投与し、上記サルモネラ属菌をそれぞれ経口から感染させた。対照として、分泌タンパク質単独(10μg)、死菌単独(105CFU)、または無処置での検証も併せて行った。
・人工的に合成したプライマー配列
Claims (2)
- Salmonella enterica subsp. entericaに属するサルモネラ属菌由来のSseJタンパク質とサルモネラ属菌の死菌との組み合わせを含む、サルモネラ症から生体を防御するためのワクチン。
- 請求項1に記載のワクチンをSalmonella enterica subsp. entericaに属するサルモネラ属菌に感染する生体(但し、ヒトの生体は除く)に投与する、サルモネラ症から生体を防御する方法。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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JP2023076476A JP2023087090A (ja) | 2018-07-05 | 2023-05-08 | SseJタンパク質を用いたサルモネラワクチン |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP2018128150 | 2018-07-05 | ||
JP2018128150 | 2018-07-05 | ||
PCT/JP2019/026793 WO2020009216A1 (ja) | 2018-07-05 | 2019-07-05 | SseJタンパク質を用いたサルモネラワクチン |
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JP2023076476A Division JP2023087090A (ja) | 2018-07-05 | 2023-05-08 | SseJタンパク質を用いたサルモネラワクチン |
Publications (2)
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JPWO2020009216A1 JPWO2020009216A1 (ja) | 2021-07-08 |
JP7281208B2 true JP7281208B2 (ja) | 2023-05-25 |
Family
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Family Applications (2)
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JP2020529059A Active JP7281208B2 (ja) | 2018-07-05 | 2019-07-05 | SseJタンパク質を用いたサルモネラワクチン |
JP2023076476A Pending JP2023087090A (ja) | 2018-07-05 | 2023-05-08 | SseJタンパク質を用いたサルモネラワクチン |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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JP2023076476A Pending JP2023087090A (ja) | 2018-07-05 | 2023-05-08 | SseJタンパク質を用いたサルモネラワクチン |
Country Status (2)
Country | Link |
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JP (2) | JP7281208B2 (ja) |
WO (1) | WO2020009216A1 (ja) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016017620A1 (ja) | 2014-07-28 | 2016-02-04 | 国立研究開発法人農業・食品産業技術総合研究機構 | サルモネラワクチン |
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2019
- 2019-07-05 WO PCT/JP2019/026793 patent/WO2020009216A1/ja active Application Filing
- 2019-07-05 JP JP2020529059A patent/JP7281208B2/ja active Active
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2023
- 2023-05-08 JP JP2023076476A patent/JP2023087090A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016017620A1 (ja) | 2014-07-28 | 2016-02-04 | 国立研究開発法人農業・食品産業技術総合研究機構 | サルモネラワクチン |
Non-Patent Citations (1)
Title |
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GENG, Shizhong et al.,Veterinary Microbiology,2014年,Vol.168,p.388-394 |
Also Published As
Publication number | Publication date |
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JP2023087090A (ja) | 2023-06-22 |
WO2020009216A1 (ja) | 2020-01-09 |
JPWO2020009216A1 (ja) | 2021-07-08 |
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