JP7275253B2 - Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物 - Google Patents

Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物 Download PDF

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JP7275253B2
JP7275253B2 JP2021510499A JP2021510499A JP7275253B2 JP 7275253 B2 JP7275253 B2 JP 7275253B2 JP 2021510499 A JP2021510499 A JP 2021510499A JP 2021510499 A JP2021510499 A JP 2021510499A JP 7275253 B2 JP7275253 B2 JP 7275253B2
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JP2021532165A5 (enExample
JP2021532165A (ja
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ウェイ チェン
ウービン パン
ジアワン グオ
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スーチョウ・コネクト・バイオファーマシューティカルズ・リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
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  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2021510499A 2018-05-04 2018-05-04 Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物 Active JP7275253B2 (ja)

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JP2023023091A JP7651198B2 (ja) 2018-05-04 2023-02-17 Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物
JP2025035420A JP2025074350A (ja) 2018-05-04 2025-03-06 Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物

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Application Number Priority Date Filing Date Title
PCT/CN2018/085617 WO2019210511A1 (zh) 2018-05-04 2018-05-04 一种s1p1受体激动剂的加成盐及其晶型和药物组合物

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JP2023023091A Division JP7651198B2 (ja) 2018-05-04 2023-02-17 Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物

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JP2021532165A JP2021532165A (ja) 2021-11-25
JP2021532165A5 JP2021532165A5 (enExample) 2022-07-08
JP7275253B2 true JP7275253B2 (ja) 2023-05-17

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JP2021510499A Active JP7275253B2 (ja) 2018-05-04 2018-05-04 Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物
JP2023023091A Active JP7651198B2 (ja) 2018-05-04 2023-02-17 Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物
JP2025035420A Pending JP2025074350A (ja) 2018-05-04 2025-03-06 Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物

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JP2023023091A Active JP7651198B2 (ja) 2018-05-04 2023-02-17 Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物
JP2025035420A Pending JP2025074350A (ja) 2018-05-04 2025-03-06 Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物

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US (3) US11512078B2 (enExample)
EP (2) EP4353719B1 (enExample)
JP (3) JP7275253B2 (enExample)
KR (2) KR102672632B1 (enExample)
AU (1) AU2018421487B2 (enExample)
CA (1) CA3099196A1 (enExample)
ES (1) ES2978392T3 (enExample)
IL (3) IL278464B2 (enExample)
MX (1) MX2020011665A (enExample)
NZ (1) NZ770323A (enExample)
SG (1) SG11202010969UA (enExample)
WO (1) WO2019210511A1 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023062091A (ja) * 2018-05-04 2023-05-02 スーチョウ・コネクト・バイオファーマシューティカルズ・リミテッド Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3201000A1 (en) * 2020-11-09 2022-05-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105315266A (zh) 2014-08-01 2016-02-10 苏州康乃德生物医药有限公司 1-{2-氟-4-[5-(4-异丁基苯基)-1,2,4-噁二唑-3-基]-苄基}-3-吖丁啶羧酸的晶型
JP2016530334A (ja) 2013-09-22 2016-09-29 スーチョウ・コネクト・バイオファーマシューティカルズ・リミテッド 免疫調節のための化合物及びその使用及びそれを含む医薬組成物

Family Cites Families (5)

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EP1549640A4 (en) * 2002-06-17 2008-08-06 Merck & Co Inc 1 - ((5-ARYL-1,2,4-OXADIAZOL-3-YL) BENZYL) AZETIDINE-3-CARBOXYLATE AND 1 - ((5-ARYL-1,2,4-OXADIAZOL-3-YL) BENZYL) PYRROLIDIN-3-CARBOXYLATE AS EDG RECEPTOR AGONISTS
AU2003279915A1 (en) 2002-10-15 2004-05-04 Merck And Co., Inc. Process for making azetidine-3-carboxylic acid
CN105348276B (zh) 2014-08-22 2020-05-26 苏州康乃德生物医药有限公司 1-{2-氟-4-[5-(4-异丁基苯基)-1,2,4-噁二唑-3-基]-苄基}-3-吖丁啶羧酸的合成方法
CN115772166B (zh) * 2017-01-11 2025-01-03 苏州康乃德生物医药有限公司 一种s1p1受体激动剂的加成盐及其晶型和药物组合物
JP7275253B2 (ja) * 2018-05-04 2023-05-17 スーチョウ・コネクト・バイオファーマシューティカルズ・リミテッド Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016530334A (ja) 2013-09-22 2016-09-29 スーチョウ・コネクト・バイオファーマシューティカルズ・リミテッド 免疫調節のための化合物及びその使用及びそれを含む医薬組成物
CN105315266A (zh) 2014-08-01 2016-02-10 苏州康乃德生物医药有限公司 1-{2-氟-4-[5-(4-异丁基苯基)-1,2,4-噁二唑-3-基]-苄基}-3-吖丁啶羧酸的晶型

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
B. D. Anderson, K. P. Flora，最新創薬化学 下巻，1999年09月25日，347-365
平山令明，有機化合物結晶作製ハンドブック，2008年，p.17-23,37-40,45-51,57-65

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023062091A (ja) * 2018-05-04 2023-05-02 スーチョウ・コネクト・バイオファーマシューティカルズ・リミテッド Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物
JP7651198B2 (ja) 2018-05-04 2025-03-26 スーチョウ・コネクト・バイオファーマシューティカルズ・リミテッド Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物
JP2025074350A (ja) * 2018-05-04 2025-05-13 スーチョウ・コネクト・バイオファーマシューティカルズ・リミテッド Ｓ１ｐ１受容体アゴニストの付加塩およびその結晶形態、ならびに薬学的組成物

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US20250320200A1 (en) 2025-10-16
US12202822B2 (en) 2025-01-21
ES2978392T3 (es) 2024-09-11
IL312512A (en) 2024-07-01
IL278464A (enExample) 2021-03-01
IL312512B1 (en) 2025-11-01
CA3099196A1 (en) 2019-11-07
IL278464B1 (en) 2024-06-01
AU2018421487A1 (en) 2020-12-17
KR20240094023A (ko) 2024-06-24
AU2018421487B2 (en) 2024-09-12
EP4353719A1 (en) 2024-04-17
EP3792258A4 (en) 2021-10-06
JP7651198B2 (ja) 2025-03-26
JP2025074350A (ja) 2025-05-13
IL323665A (en) 2025-11-01
US11512078B2 (en) 2022-11-29
BR112020022429A2 (pt) 2021-02-09
EP4353719B1 (en) 2025-12-24
US20230050777A1 (en) 2023-02-16
US20210230152A1 (en) 2021-07-29
WO2019210511A1 (zh) 2019-11-07
IL312512B2 (en) 2026-03-01
NZ770323A (en) 2025-12-19
MX2020011665A (es) 2021-01-20
JP2023062091A (ja) 2023-05-02
EP3792258B1 (en) 2024-02-07
SG11202010969UA (en) 2020-12-30
KR102672632B1 (ko) 2024-06-07
EP3792258A1 (en) 2021-03-17
JP2021532165A (ja) 2021-11-25
KR20210019999A (ko) 2021-02-23
IL278464B2 (en) 2024-10-01
ZA202007347B (en) 2021-10-27

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