JP7274478B2 - 置換された－３Ｈ－イミダゾ［４，５－ｃ］ピリジン及び１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズの新規なエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）並びにがん免疫治療薬としてのインターフェロン遺伝子（ＳＴＩＮＧ）モジュレータのための刺激剤 - Google Patents

置換された－３Ｈ－イミダゾ［４，５－ｃ］ピリジン及び１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズの新規なエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）並びにがん免疫治療薬としてのインターフェロン遺伝子（ＳＴＩＮＧ）モジュレータのための刺激剤 Download PDF

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JP7274478B2
JP7274478B2 JP2020527860A JP2020527860A JP7274478B2 JP 7274478 B2 JP7274478 B2 JP 7274478B2 JP 2020527860 A JP2020527860 A JP 2020527860A JP 2020527860 A JP2020527860 A JP 2020527860A JP 7274478 B2 JP7274478 B2 JP 7274478B2
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mmol
compound
chloro
acetamide
imidazo
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バンカヤラパティ，ハリプラサッド
リウ，シャオホイ
ラマムアシー，グルサンカー
シャルマ，スニル
カーディッジ，モハン・ラオ
ウェストン，アレクシス
トーデ，トラソン
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スティングレイ・セラピューティクス・インコーポレイテッド
ザ・ユニバーシティ・オブ・ユタ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020527860A 2017-07-27 2018-07-27 置換された－３Ｈ－イミダゾ［４，５－ｃ］ピリジン及び１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズの新規なエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）並びにがん免疫治療薬としてのインターフェロン遺伝子（ＳＴＩＮＧ）モジュレータのための刺激剤 Active JP7274478B2 (ja)

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US201762537758P 2017-07-27 2017-07-27
US62/537,758 2017-07-27
PCT/US2018/044183 WO2019023635A1 (en) 2017-07-27 2018-07-27 SUBSTITUTED 3 H-IMIDAZO (4,5-C) PYRIDINE AND 1H-PYRROLO (2,3-C) PYRIDINE SERIES OF A NOVEL ECTONUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE-1 (ENPP1) AND STIMULATOR FOR A GENE MODULATOR INTERFERON (STING) AS IMMUNOTHERAPEUTIC AGENTS AGAINST CANCER

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JP2020532578A5 JP2020532578A5 (https=) 2021-09-16
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JP2021533110A (ja) * 2018-08-01 2021-12-02 スティングレイ・セラピューティクス・インコーポレイテッド 癌免疫療法剤としての新規エクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ−１（ＥＮＰＰ１）の置換３Ｈ−イミダゾ［４，５−ｃ］ピリジンおよび１Ｈ−ピロロ［２，３−ｃ］ピリジンシリーズならびにインターフェロン遺伝子刺激因子（ＳＴＩＮＧ）調節剤

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US12162863B2 (en) 2018-06-12 2024-12-10 Ryvu Therapeutics S.A. Modulators of stimulator of interferon genes (STING)
JP7777332B2 (ja) * 2019-02-01 2025-11-28 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 免疫応答をモジュレートするｅｎｐｐ１阻害剤および方法
CN113795267A (zh) 2019-03-12 2021-12-14 艾库斯生物科学有限公司 致癌基因驱动的癌症的治疗
BR112021018947A2 (pt) 2019-03-28 2022-02-08 Lupin Ltd Compostos macrocíclicos como agonistas de sting
WO2020205527A1 (en) 2019-03-29 2020-10-08 Arcus Biosciences, Inc. Treatment of cancer utilizing an identified adenosine fingerprint
BR112021024948A2 (pt) 2019-06-12 2022-01-25 Ryvu Therapeutics S A Moduladores de próxima geração de estimulador de genes de interferon (sting)
CR20220029A (es) 2019-07-22 2022-03-14 Lupin Ltd Compuestos macrocíclicos como agonistas de sting y métodos y usos de los mismos
WO2021053507A1 (en) 2019-09-16 2021-03-25 Aten Porus Lifesciences Pvt. Ltd. 2-amino-s6-substituted thiopurine compounds as inhibitors of the enpp1 protein
EP4073063A1 (en) * 2019-12-11 2022-10-19 Ryvu Therapeutics S.A. Heterocyclic compounds as modulators of stimulator of interferon genes (sting)
GB202006382D0 (en) 2020-04-30 2020-06-17 Spermatech As Use
KR102682428B1 (ko) 2020-05-08 2024-07-05 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도
WO2021225407A1 (ko) 2020-05-08 2021-11-11 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도
KR102720206B1 (ko) 2020-12-29 2024-10-21 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도
JP2024504285A (ja) 2020-12-29 2024-01-31 ティーエックスイノ バイオサイエンス インコーポレイテッド エクトヌクレオチドピロホスファターゼ－ホスホジエステラーゼの阻害活性を有する新規のナフチリジノン誘導体及びこれらの用途
MX2023008761A (es) 2021-01-29 2023-08-22 Txinno Bioscience Inc Derivado de benzotriazol novedoso que posee actividad inhibitoria contra la ectonucleotido pirofosfatasa - fosfodiesterasa y uso del mismo.
KR102686866B1 (ko) 2021-01-29 2024-07-19 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도
IL313821A (en) * 2022-01-28 2024-08-01 Insilico Medicine Ip Ltd Ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) inhibitors and their uses
US20230346771A1 (en) 2022-04-29 2023-11-02 Petragen, Inc. Inhibitors of enpp1 and modulation of bone growth
WO2026006739A1 (en) * 2024-06-28 2026-01-02 Riboscience Llc Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors for the treatment of certain diseases
WO2026078593A1 (en) 2024-10-08 2026-04-16 Sun Pharma Advanced Research Company Limited Sting agonists and antibody drug conjugates thereof

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021533110A (ja) * 2018-08-01 2021-12-02 スティングレイ・セラピューティクス・インコーポレイテッド 癌免疫療法剤としての新規エクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ−１（ＥＮＰＰ１）の置換３Ｈ−イミダゾ［４，５−ｃ］ピリジンおよび１Ｈ−ピロロ［２，３−ｃ］ピリジンシリーズならびにインターフェロン遺伝子刺激因子（ＳＴＩＮＧ）調節剤
JP7461927B2 (ja) 2018-08-01 2024-04-04 スティングレイ・セラピューティクス・インコーポレイテッド 癌免疫療法剤としての新規エクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）の置換３Ｈ－イミダゾ［４，５－ｃ］ピリジンおよび１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズならびにインターフェロン遺伝子刺激因子（ＳＴＩＮＧ）調節剤

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CN111615388B (zh) 2023-11-14
EP3658138B1 (en) 2023-04-19
JP2020532578A (ja) 2020-11-12
EP3658138A4 (en) 2021-03-31
EP3658138A1 (en) 2020-06-03
US10689376B2 (en) 2020-06-23
WO2019023635A1 (en) 2019-01-31
WO2019023635A8 (en) 2020-02-20
US20190031655A1 (en) 2019-01-31
CN111615388A (zh) 2020-09-01

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