CN111615388B - 癌症免疫治疗剂 - Google Patents

癌症免疫治疗剂 Download PDF

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Publication number
CN111615388B
CN111615388B CN201880063421.5A CN201880063421A CN111615388B CN 111615388 B CN111615388 B CN 111615388B CN 201880063421 A CN201880063421 A CN 201880063421A CN 111615388 B CN111615388 B CN 111615388B
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China
Prior art keywords
mmol
chloro
acetamide
compound
imidazo
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CN201880063421.5A
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English (en)
Chinese (zh)
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CN111615388A (zh
Inventor
哈里普拉萨德·梵卡亚拉帕提
刘晓慧
古鲁桑卡·拉玛穆尔蒂
苏尼尔·沙玛
莫汉·拉奥·卡迪奇
亚历克西斯·韦斯顿
特拉森·托德
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Steinger Therapeutics Co ltd
University of Utah
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Steinger Therapeutics Co ltd
University of Utah
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201880063421.5A 2017-07-27 2018-07-27 癌症免疫治疗剂 Active CN111615388B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762537758P 2017-07-27 2017-07-27
US62/537,758 2017-07-27
PCT/US2018/044183 WO2019023635A1 (en) 2017-07-27 2018-07-27 SUBSTITUTED 3 H-IMIDAZO (4,5-C) PYRIDINE AND 1H-PYRROLO (2,3-C) PYRIDINE SERIES OF A NOVEL ECTONUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE-1 (ENPP1) AND STIMULATOR FOR A GENE MODULATOR INTERFERON (STING) AS IMMUNOTHERAPEUTIC AGENTS AGAINST CANCER

Publications (2)

Publication Number Publication Date
CN111615388A CN111615388A (zh) 2020-09-01
CN111615388B true CN111615388B (zh) 2023-11-14

Family

ID=65040330

Family Applications (1)

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CN201880063421.5A Active CN111615388B (zh) 2017-07-27 2018-07-27 癌症免疫治疗剂

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US (1) US10689376B2 (https=)
EP (1) EP3658138B1 (https=)
JP (1) JP7274478B2 (https=)
CN (1) CN111615388B (https=)
WO (1) WO2019023635A1 (https=)

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MX2021009269A (es) * 2019-02-01 2021-08-24 Univ Leland Stanford Junior Inhibidores de enpp1 y metodos para modular una respuesta inmunitaria.
WO2020185859A1 (en) 2019-03-12 2020-09-17 Arcus Biosciences, Inc. Treatment of oncogene-driven cancers
JP7530380B2 (ja) 2019-03-28 2024-08-07 ルピン・リミテッド Ｓｔｉｎｇアゴニストとしての大環状化合物
US12310965B2 (en) 2019-03-29 2025-05-27 Arcus Biosciences, Inc. Treatment of cancer utilizing an identified adenosine fingerprint
WO2020249773A1 (en) 2019-06-12 2020-12-17 Ryvu Therapeutics S.A. Next-generation modulators of stimulator of interferon genes (sting)
LT4004002T (lt) 2019-07-22 2024-10-25 Lupin Limited Makrocikliniai junginiai kaip sting agonistai ir jų naudojimo būdai bei metodai
AU2020350190A1 (en) 2019-09-16 2022-05-12 Aten Porus Lifesciences Pvt. Ltd. 2-amino-s6-substituted thiopurine compounds as inhibitors of the ENPP1 protein
JP7426486B2 (ja) * 2019-12-11 2024-02-01 ライブ・セラピューティクス・スプウカ・アクツィーナ インターフェロン遺伝子刺激因子（ｓｔｉｎｇ）のモジュレーターとしての複素環式化合物
GB202006382D0 (en) 2020-04-30 2020-06-17 Spermatech As Use
KR102682428B1 (ko) 2020-05-08 2024-07-05 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도
WO2021225407A1 (ko) 2020-05-08 2021-11-11 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도
WO2022146022A1 (ko) 2020-12-29 2022-07-07 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도
KR102720206B1 (ko) 2020-12-29 2024-10-21 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도
KR102686866B1 (ko) 2021-01-29 2024-07-19 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도
CA3291973A1 (en) 2021-01-29 2026-03-02 Txinno Bioscience Inc. Benzotriazole Derivative Having Inhibitory Activity Against Ectonucleotide Pyrophosphatase-Phosphodiesterase, and Use Thereof
CN118871439A (zh) * 2022-01-28 2024-10-29 英矽智能科技知识产权有限公司 外核苷酸焦磷酸酶-磷酸二酯酶(enpp1)抑制剂及其用途
EP4514331A1 (en) 2022-04-29 2025-03-05 Petragen, Inc. Inhibitors of enpp1 and modulation of bone growth
WO2026006739A1 (en) * 2024-06-28 2026-01-02 Riboscience Llc Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors for the treatment of certain diseases
WO2026078593A1 (en) 2024-10-08 2026-04-16 Sun Pharma Advanced Research Company Limited Sting agonists and antibody drug conjugates thereof

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Non-Patent Citations (6)

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Lei Chang等.Imidazopyridine- and Purine-Thioacetamide Derivatives: Potent Inhibitors of Nucleotide Pyrophosphatase/Phosphodiesterase 1(NPP1).《Journal of Medicinal Chemistry》.2014,第57卷(第23期),第10080-10100页. *
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Also Published As

Publication number Publication date
WO2019023635A1 (en) 2019-01-31
EP3658138B1 (en) 2023-04-19
US10689376B2 (en) 2020-06-23
EP3658138A4 (en) 2021-03-31
US20190031655A1 (en) 2019-01-31
WO2019023635A8 (en) 2020-02-20
JP2020532578A (ja) 2020-11-12
JP7274478B2 (ja) 2023-05-16
EP3658138A1 (en) 2020-06-03
CN111615388A (zh) 2020-09-01

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