JP2020532578A5 - - Google Patents
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- JP2020532578A5 JP2020532578A5 JP2020527860A JP2020527860A JP2020532578A5 JP 2020532578 A5 JP2020532578 A5 JP 2020532578A5 JP 2020527860 A JP2020527860 A JP 2020527860A JP 2020527860 A JP2020527860 A JP 2020527860A JP 2020532578 A5 JP2020532578 A5 JP 2020532578A5
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- JP
- Japan
- Prior art keywords
- group
- compound
- compound according
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- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 0 CCC[C@](C)CNS(C)(CSC(*(C)*C)=CCCC)O Chemical compound CCC[C@](C)CNS(C)(CSC(*(C)*C)=CCCC)O 0.000 description 3
- ULMKNGVHAZDIEL-OLNZRHPYSA-O C/C=N\C/C=C(\NCCN(C)C[SH2+])/Cl Chemical compound C/C=N\C/C=C(\NCCN(C)C[SH2+])/Cl ULMKNGVHAZDIEL-OLNZRHPYSA-O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762537758P | 2017-07-27 | 2017-07-27 | |
| US62/537,758 | 2017-07-27 | ||
| PCT/US2018/044183 WO2019023635A1 (en) | 2017-07-27 | 2018-07-27 | SUBSTITUTED 3 H-IMIDAZO (4,5-C) PYRIDINE AND 1H-PYRROLO (2,3-C) PYRIDINE SERIES OF A NOVEL ECTONUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE-1 (ENPP1) AND STIMULATOR FOR A GENE MODULATOR INTERFERON (STING) AS IMMUNOTHERAPEUTIC AGENTS AGAINST CANCER |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020532578A JP2020532578A (ja) | 2020-11-12 |
| JP2020532578A5 true JP2020532578A5 (https=) | 2021-09-16 |
| JP7274478B2 JP7274478B2 (ja) | 2023-05-16 |
Family
ID=65040330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020527860A Active JP7274478B2 (ja) | 2017-07-27 | 2018-07-27 | 置換された－３Ｈ－イミダゾ［４，５－ｃ］ピリジン及び１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズの新規なエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）並びにがん免疫治療薬としてのインターフェロン遺伝子（ＳＴＩＮＧ）モジュレータのための刺激剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10689376B2 (https=) |
| EP (1) | EP3658138B1 (https=) |
| JP (1) | JP7274478B2 (https=) |
| CN (1) | CN111615388B (https=) |
| WO (1) | WO2019023635A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12162863B2 (en) | 2018-06-12 | 2024-12-10 | Ryvu Therapeutics S.A. | Modulators of stimulator of interferon genes (STING) |
| JP7461927B2 (ja) * | 2018-08-01 | 2024-04-04 | スティングレイ・セラピューティクス・インコーポレイテッド | 癌免疫療法剤としての新規エクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）の置換３Ｈ－イミダゾ［４，５－ｃ］ピリジンおよび１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズならびにインターフェロン遺伝子刺激因子（ＳＴＩＮＧ）調節剤 |
| JP7777332B2 (ja) * | 2019-02-01 | 2025-11-28 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 免疫応答をモジュレートするｅｎｐｐ１阻害剤および方法 |
| CN113795267A (zh) | 2019-03-12 | 2021-12-14 | 艾库斯生物科学有限公司 | 致癌基因驱动的癌症的治疗 |
| BR112021018947A2 (pt) | 2019-03-28 | 2022-02-08 | Lupin Ltd | Compostos macrocíclicos como agonistas de sting |
| WO2020205527A1 (en) | 2019-03-29 | 2020-10-08 | Arcus Biosciences, Inc. | Treatment of cancer utilizing an identified adenosine fingerprint |
| BR112021024948A2 (pt) | 2019-06-12 | 2022-01-25 | Ryvu Therapeutics S A | Moduladores de próxima geração de estimulador de genes de interferon (sting) |
| CR20220029A (es) | 2019-07-22 | 2022-03-14 | Lupin Ltd | Compuestos macrocíclicos como agonistas de sting y métodos y usos de los mismos |
| WO2021053507A1 (en) | 2019-09-16 | 2021-03-25 | Aten Porus Lifesciences Pvt. Ltd. | 2-amino-s6-substituted thiopurine compounds as inhibitors of the enpp1 protein |
| EP4073063A1 (en) * | 2019-12-11 | 2022-10-19 | Ryvu Therapeutics S.A. | Heterocyclic compounds as modulators of stimulator of interferon genes (sting) |
| GB202006382D0 (en) | 2020-04-30 | 2020-06-17 | Spermatech As | Use |
| KR102682428B1 (ko) | 2020-05-08 | 2024-07-05 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도 |
| WO2021225407A1 (ko) | 2020-05-08 | 2021-11-11 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도 |
| KR102720206B1 (ko) | 2020-12-29 | 2024-10-21 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도 |
| JP2024504285A (ja) | 2020-12-29 | 2024-01-31 | ティーエックスイノ バイオサイエンス インコーポレイテッド | エクトヌクレオチドピロホスファターゼ－ホスホジエステラーゼの阻害活性を有する新規のナフチリジノン誘導体及びこれらの用途 |
| MX2023008761A (es) | 2021-01-29 | 2023-08-22 | Txinno Bioscience Inc | Derivado de benzotriazol novedoso que posee actividad inhibitoria contra la ectonucleotido pirofosfatasa - fosfodiesterasa y uso del mismo. |
| KR102686866B1 (ko) | 2021-01-29 | 2024-07-19 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도 |
| IL313821A (en) * | 2022-01-28 | 2024-08-01 | Insilico Medicine Ip Ltd | Ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) inhibitors and their uses |
| US20230346771A1 (en) | 2022-04-29 | 2023-11-02 | Petragen, Inc. | Inhibitors of enpp1 and modulation of bone growth |
| WO2026006739A1 (en) * | 2024-06-28 | 2026-01-02 | Riboscience Llc | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors for the treatment of certain diseases |
| WO2026078593A1 (en) | 2024-10-08 | 2026-04-16 | Sun Pharma Advanced Research Company Limited | Sting agonists and antibody drug conjugates thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5081253A (en) * | 1989-12-21 | 1992-01-14 | American Home Products Corporation | Imidazo(4,5-c)pyridines as antiosteoporotic agents |
| JP4647726B2 (ja) * | 1997-03-25 | 2011-03-09 | 興和株式会社 | 新規なアニリド化合物及びこれを含有する医薬 |
| WO2014176258A1 (en) * | 2013-04-23 | 2014-10-30 | The General Hospital Corporation | Compounds useful as antibiotic tolerance inhibitors |
-
2018
- 2018-07-27 WO PCT/US2018/044183 patent/WO2019023635A1/en not_active Ceased
- 2018-07-27 CN CN201880063421.5A patent/CN111615388B/zh active Active
- 2018-07-27 EP EP18837593.5A patent/EP3658138B1/en active Active
- 2018-07-27 US US16/047,915 patent/US10689376B2/en active Active
- 2018-07-27 JP JP2020527860A patent/JP7274478B2/ja active Active
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