JP7260723B2 - ＨＥＲ２阻害薬としての［１，３］ジアジノ［５，４－ｄ］ピリミジン - Google Patents

ＨＥＲ２阻害薬としての［１，３］ジアジノ［５，４－ｄ］ピリミジン Download PDF

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JP7260723B2
JP7260723B2 JP2022563041A JP2022563041A JP7260723B2 JP 7260723 B2 JP7260723 B2 JP 7260723B2 JP 2022563041 A JP2022563041 A JP 2022563041A JP 2022563041 A JP2022563041 A JP 2022563041A JP 7260723 B2 JP7260723 B2 JP 7260723B2
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compound
cancer
her2
pharmaceutically acceptable
salt
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JP2023512343A (ja
Inventor
ヴィルディング，ビルギット
ブーセ，ディートリヒ
エンゲルハルト，ハーラルト
フックス，ユリアン
ノイミュラー，ラルフ
ペトロンスキ，マルク
シャルン，ディルク
トロイ，マティアス
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2022563041A 2020-04-24 2021-04-07 ＨＥＲ２阻害薬としての［１，３］ジアジノ［５，４－ｄ］ピリミジン Active JP7260723B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023062141A JP2023085489A (ja) 2020-04-24 2023-04-06 ＨＥＲ２阻害薬としての［１，３］ジアジノ［５，４－ｄ］ピリミジン

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20171221.3 2020-04-24
EP20171221 2020-04-24
PCT/EP2021/059015 WO2021213800A1 (en) 2020-04-24 2021-04-07 [1,3]DIAZINO[5,4-d]PYRIMIDINES AS HER2 INHIBITORS

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JP2023062141A Division JP2023085489A (ja) 2020-04-24 2023-04-06 ＨＥＲ２阻害薬としての［１，３］ジアジノ［５，４－ｄ］ピリミジン

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JP2023512343A JP2023512343A (ja) 2023-03-24
JP7260723B2 true JP7260723B2 (ja) 2023-04-18

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JP2022563041A Active JP7260723B2 (ja) 2020-04-24 2021-04-07 ＨＥＲ２阻害薬としての［１，３］ジアジノ［５，４－ｄ］ピリミジン
JP2023062141A Pending JP2023085489A (ja) 2020-04-24 2023-04-06 ＨＥＲ２阻害薬としての［１，３］ジアジノ［５，４－ｄ］ピリミジン

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US (3) US11608343B2 (https=)
EP (2) EP4139309B9 (https=)
JP (2) JP7260723B2 (https=)
KR (2) KR20250016507A (https=)
CN (13) CN118307543A (https=)
AR (1) AR121779A1 (https=)
AU (1) AU2021260721A1 (https=)
BR (1) BR112022021514A2 (https=)
CA (1) CA3173602A1 (https=)
CL (1) CL2022002579A1 (https=)
CO (1) CO2022015054A2 (https=)
CR (1) CR20220537A (https=)
DK (1) DK4139309T5 (https=)
DO (1) DOP2022000189A (https=)
EC (1) ECSP22072777A (https=)
ES (1) ES3013860T3 (https=)
FI (1) FI4139309T3 (https=)
HR (1) HRP20250426T1 (https=)
HU (1) HUE070805T2 (https=)
IL (2) IL320477A (https=)
JO (1) JOP20220271A1 (https=)
LT (1) LT4139309T (https=)
MA (1) MA59373B1 (https=)
MX (1) MX2022013223A (https=)
PE (1) PE20230827A1 (https=)
PH (1) PH12022552745A1 (https=)
PL (1) PL4139309T3 (https=)
PT (1) PT4139309T (https=)
RS (1) RS66557B1 (https=)
SI (1) SI4139309T1 (https=)
SM (1) SMT202500164T1 (https=)
UA (1) UA130588C2 (https=)
WO (1) WO2021213800A1 (https=)

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CN121568696A (zh) 2023-07-28 2026-02-24 勃林格殷格翰国际有限公司 制备her2抑制剂的方法
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US11608343B2 (en) 2023-03-21
CN118388489A (zh) 2024-07-26
LT4139309T (lt) 2025-02-25
AR121779A1 (es) 2022-07-06
AU2021260721A1 (en) 2022-09-15
CN118388495A (zh) 2024-07-26
TW202206432A (zh) 2022-02-16
PL4139309T3 (pl) 2025-05-05
CN118388487A (zh) 2024-07-26
CN118388490A (zh) 2024-07-26
SMT202500164T1 (it) 2025-05-12
ES3013860T9 (en) 2025-10-28
US20230374021A1 (en) 2023-11-23
CN118388492A (zh) 2024-07-26
KR20230005263A (ko) 2023-01-09
CN115485277B (zh) 2024-05-14
DK4139309T5 (da) 2025-10-27
EP4139309B9 (en) 2025-09-10
CL2022002579A1 (es) 2023-05-19
CO2022015054A2 (es) 2023-02-16
PT4139309T (pt) 2025-02-17
US20250122204A1 (en) 2025-04-17
CN118388491A (zh) 2024-07-26
JOP20220271A1 (ar) 2021-10-28
ECSP22072777A (es) 2022-10-31
CA3173602A1 (en) 2021-10-28
EP4566611A3 (en) 2025-09-10
CN118307543A (zh) 2024-07-09
EP4139309B1 (en) 2025-01-29
EP4139309A1 (en) 2023-03-01
FI4139309T3 (fi) 2025-03-04
HRP20250426T1 (hr) 2025-06-06
JP2023512343A (ja) 2023-03-24
IL297490B2 (en) 2025-10-01
HUE070805T2 (hu) 2025-07-28
PH12022552745A1 (en) 2024-03-25
UA130588C2 (uk) 2026-03-25
KR102759974B1 (ko) 2025-01-24
JP2023085489A (ja) 2023-06-20
MA59373B1 (fr) 2025-02-28
IL297490B1 (en) 2025-06-01
CN115485277A (zh) 2022-12-16
CN118388494A (zh) 2024-07-26
CN118388488A (zh) 2024-07-26
EP4566611A2 (en) 2025-06-11
IL320477A (en) 2025-06-01
MX2022013223A (es) 2022-11-14
DK4139309T3 (da) 2025-04-28
IL297490A (en) 2022-12-01
KR20250016507A (ko) 2025-02-03
RS66557B1 (sr) 2025-03-31
CN118388493A (zh) 2024-07-26
SI4139309T1 (sl) 2025-03-31
CR20220537A (es) 2022-12-06
CN118619956A (zh) 2024-09-10
PE20230827A1 (es) 2023-05-19
BR112022021514A2 (pt) 2023-01-24
CN118307544A (zh) 2024-07-09
US20210332054A1 (en) 2021-10-28
ES3013860T3 (en) 2025-04-15
DOP2022000189A (es) 2022-09-30
WO2021213800A1 (en) 2021-10-28

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