JP7247167B2 - 産物及び組成物 - Google Patents

産物及び組成物 Download PDF

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JP7247167B2
JP7247167B2 JP2020504435A JP2020504435A JP7247167B2 JP 7247167 B2 JP7247167 B2 JP 7247167B2 JP 2020504435 A JP2020504435 A JP 2020504435A JP 2020504435 A JP2020504435 A JP 2020504435A JP 7247167 B2 JP7247167 B2 JP 7247167B2
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strand
nucleic acid
nucleotides
modified
modification
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JP2020512838A (ja
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ジビレ・ダーメス
ウーテ・シェーパー
ユーディット・ハウプトマン
クリスティアン・フラウエンドルフ
ルーカス・ベトゲ
アドリエン・ヴァインガルトナー
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サイレンス・セラピューティクス・ゲーエムベーハー
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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JP2020504435A 2017-04-05 2018-04-05 産物及び組成物 Active JP7247167B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023039774A JP7495544B2 (ja) 2017-04-05 2023-03-14 産物及び組成物

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Application Number Priority Date Filing Date Title
EP17165007.0A EP3385380A1 (en) 2017-04-05 2017-04-05 Products and compositions
EP17165007.0 2017-04-05
EP17201405 2017-11-13
EP17201405.2 2017-11-13
PCT/EP2018/058764 WO2018185240A1 (en) 2017-04-05 2018-04-05 Products and compositions

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JP2020512838A JP2020512838A (ja) 2020-04-30
JP7247167B2 true JP7247167B2 (ja) 2023-03-28

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JP2020504435A Active JP7247167B2 (ja) 2017-04-05 2018-04-05 産物及び組成物
JP2020554254A Active JP7419252B2 (ja) 2017-04-05 2019-04-05 アンチセンス鎖の５’末端でビニルホスホネートを有するｓｉＲＮＡ
JP2023039774A Active JP7495544B2 (ja) 2017-04-05 2023-03-14 産物及び組成物
JP2024001366A Pending JP2024036347A (ja) 2017-04-05 2024-01-09 アンチセンス鎖の５’末端でビニルホスホネートを有するｓｉＲＮＡ

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JP2023039774A Active JP7495544B2 (ja) 2017-04-05 2023-03-14 産物及び組成物
JP2024001366A Pending JP2024036347A (ja) 2017-04-05 2024-01-09 アンチセンス鎖の５’末端でビニルホスホネートを有するｓｉＲＮＡ

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US (2) US11174483B2 (https=)
EP (2) EP3607068B1 (https=)
JP (4) JP7247167B2 (https=)
KR (1) KR102589803B1 (https=)
CN (2) CN110573619B (https=)
AU (2) AU2018247924B2 (https=)
CA (2) CA3057561C (https=)
DK (1) DK3607068T3 (https=)
ES (1) ES2936109T3 (https=)
FI (1) FI3607068T3 (https=)
HR (1) HRP20221547T1 (https=)
HU (1) HUE061894T2 (https=)
IL (2) IL269576B2 (https=)
LT (1) LT3607068T (https=)
PL (1) PL3607068T3 (https=)
RS (1) RS63887B1 (https=)
SI (1) SI3607068T1 (https=)
WO (1) WO2018185240A1 (https=)

Families Citing this family (12)

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KR102365961B1 (ko) 2011-03-29 2022-02-23 알닐람 파마슈티칼스 인코포레이티드 Tmprss6 유전자의 발현을 억제하기 위한 조성물 및 방법
EP4029942A1 (en) 2017-04-05 2022-07-20 Silence Therapeutics GmbH Products and compositions
JP7155239B2 (ja) * 2017-04-05 2022-10-18 サイレンス・セラピューティクス・ゲーエムベーハー 産物及び組成物
EP3598995A1 (en) * 2018-07-26 2020-01-29 Silence Therapeutics GmbH Products and compositions
CN111973619B (zh) * 2019-05-23 2024-01-30 苏州瑞博生物技术股份有限公司 核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途
US20240240187A1 (en) 2021-04-27 2024-07-18 Silence Therapeutics Gmbh Sirna targeting tmprss6 for the treatment of myeloproliferative disorders
TWI868755B (zh) 2022-06-24 2025-01-01 丹麥商諾佛 儂迪克股份有限公司 抑制跨膜絲胺酸蛋白酶６（ｔｍｐｒｓｓ６）表現的組成物及方法
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