JP7244428B2 - Ｖｓｉｇ８ベースのキメラタンパク質 - Google Patents

Ｖｓｉｇ８ベースのキメラタンパク質 Download PDF

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JP7244428B2
JP7244428B2 JP2019546141A JP2019546141A JP7244428B2 JP 7244428 B2 JP7244428 B2 JP 7244428B2 JP 2019546141 A JP2019546141 A JP 2019546141A JP 2019546141 A JP2019546141 A JP 2019546141A JP 7244428 B2 JP7244428 B2 JP 7244428B2
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chimeric protein
ox40l
amino acid
cells
seq
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JP2020508066A (ja
JP2020508066A5 (https=
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シュライバー，テイラー
フロム，ジョージ
シルヴァ，サレシュ デ
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シャタック ラボ，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2019546141A 2017-02-27 2018-02-27 Ｖｓｉｇ８ベースのキメラタンパク質 Active JP7244428B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023036738A JP2023071979A (ja) 2017-02-27 2023-03-09 Ｖｓｉｇ８ベースのキメラタンパク質
JP2025020276A JP2025065443A (ja) 2017-02-27 2025-02-10 Ｖｓｉｇ８ベースのキメラタンパク質

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762463999P 2017-02-27 2017-02-27
US62/463,999 2017-02-27
PCT/US2018/020038 WO2018157163A1 (en) 2017-02-27 2018-02-27 Vsig8-based chimeric proteins

Related Child Applications (1)

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JP2023036738A Division JP2023071979A (ja) 2017-02-27 2023-03-09 Ｖｓｉｇ８ベースのキメラタンパク質

Publications (3)

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JP2020508066A JP2020508066A (ja) 2020-03-19
JP2020508066A5 JP2020508066A5 (https=) 2021-04-08
JP7244428B2 true JP7244428B2 (ja) 2023-03-22

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JP2019546141A Active JP7244428B2 (ja) 2017-02-27 2018-02-27 Ｖｓｉｇ８ベースのキメラタンパク質
JP2023036738A Pending JP2023071979A (ja) 2017-02-27 2023-03-09 Ｖｓｉｇ８ベースのキメラタンパク質
JP2025020276A Withdrawn JP2025065443A (ja) 2017-02-27 2025-02-10 Ｖｓｉｇ８ベースのキメラタンパク質

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JP2023036738A Pending JP2023071979A (ja) 2017-02-27 2023-03-09 Ｖｓｉｇ８ベースのキメラタンパク質
JP2025020276A Withdrawn JP2025065443A (ja) 2017-02-27 2025-02-10 Ｖｓｉｇ８ベースのキメラタンパク質

Country Status (8)

Country Link
US (4) US11192933B2 (https=)
EP (2) EP4249503A3 (https=)
JP (3) JP7244428B2 (https=)
CN (2) CN118184797A (https=)
AU (1) AU2018224852B2 (https=)
CA (1) CA3054130A1 (https=)
IL (1) IL268170A (https=)
WO (1) WO2018157163A1 (https=)

Families Citing this family (4)

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EP3930851A4 (en) * 2019-02-28 2023-03-29 Shattuck Labs, Inc. COMBINATION THERAPIES
US20220259281A1 (en) * 2019-06-21 2022-08-18 Shattuck Labs, Inc. Chimeric protein expressing t-cells
EP4377334A4 (en) * 2021-07-26 2025-06-18 Kite Pharma, Inc. DNVSIG3 AND DNVSIG8 RECEIVERS AND METHODS OF USE THEREOF
WO2024123812A1 (en) 2022-12-05 2024-06-13 Shattuck Labs, Inc. Fusion proteins for the treatment of cardiometabolic diseases

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US11192934B2 (en) 2021-12-07
CN118184797A (zh) 2024-06-14
EP3585410B1 (en) 2023-06-07
JP2020508066A (ja) 2020-03-19
AU2018224852B2 (en) 2025-03-06
US20190367581A1 (en) 2019-12-05
EP3585410A4 (en) 2020-12-16
EP4249503A2 (en) 2023-09-27
CN110290798B (zh) 2024-04-05
JP2023071979A (ja) 2023-05-23
AU2018224852A1 (en) 2019-07-11
CN110290798A (zh) 2019-09-27
EP3585410A1 (en) 2020-01-01
US20240067698A1 (en) 2024-02-29
CA3054130A1 (en) 2018-08-30
JP2025065443A (ja) 2025-04-17
US11834488B2 (en) 2023-12-05
US20220119481A1 (en) 2022-04-21
US20200071378A1 (en) 2020-03-05
IL268170A (en) 2019-09-26
EP4249503A3 (en) 2023-12-20
US11192933B2 (en) 2021-12-07
EP3585410B9 (en) 2023-10-04
WO2018157163A1 (en) 2018-08-30

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