JP7242573B2 - Ｒｏｒ１抗体 - Google Patents

Ｒｏｒ１抗体 Download PDF

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Publication number
JP7242573B2
JP7242573B2 JP2019572456A JP2019572456A JP7242573B2 JP 7242573 B2 JP7242573 B2 JP 7242573B2 JP 2019572456 A JP2019572456 A JP 2019572456A JP 2019572456 A JP2019572456 A JP 2019572456A JP 7242573 B2 JP7242573 B2 JP 7242573B2
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seq
amino acid
acid sequence
set forth
sequence set
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Japanese (ja)
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JP2020530272A5 (enExample
JP2020530272A (ja
Inventor
ナスワニ，アミット
ゴヒル，サティエン
ペルタ，マルコ デラ
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UCL Business Ltd
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UCL Biomedica PLC
UCL Business Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019572456A 2017-07-05 2018-07-05 Ｒｏｒ１抗体 Active JP7242573B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1710835.8A GB201710835D0 (en) 2017-07-05 2017-07-05 ROR1 Antibodies
GB1710835.8 2017-07-05
PCT/GB2018/051914 WO2019008377A1 (en) 2017-07-05 2018-07-05 ANTIBODY ROR1

Publications (3)

Publication Number Publication Date
JP2020530272A JP2020530272A (ja) 2020-10-22
JP2020530272A5 JP2020530272A5 (enExample) 2021-08-12
JP7242573B2 true JP7242573B2 (ja) 2023-03-20

Family

ID=59592560

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019572456A Active JP7242573B2 (ja) 2017-07-05 2018-07-05 Ｒｏｒ１抗体

Country Status (11)

Country Link
US (3) US11466083B2 (enExample)
EP (1) EP3649152B1 (enExample)
JP (1) JP7242573B2 (enExample)
CN (1) CN110891973B (enExample)
AU (1) AU2018297630B2 (enExample)
CA (1) CA3068196A1 (enExample)
DK (1) DK3649152T3 (enExample)
ES (1) ES3048696T3 (enExample)
GB (1) GB201710835D0 (enExample)
MX (1) MX2019015348A (enExample)
WO (1) WO2019008377A1 (enExample)

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US20230416942A1 (en) * 2020-08-21 2023-12-28 Yale University Nanobody Compositions and Methods of Use of the Same
IL300760A (en) * 2020-08-24 2023-04-01 Epimab Biotherapeutics Hk Ltd Anti-ROR1 antibodies and related bispecific binding proteins
EP4209509A4 (en) * 2020-09-03 2025-03-19 Harbour Biomed (Shanghai) Co., Ltd ROR1-TARGETTING ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, METHOD OF PREPARATION THEREOF AND USE THEREOF
JP2023550628A (ja) * 2020-11-23 2023-12-04 スカウト バイオ， インコーポレイテッド 抗原結合分子およびその使用
WO2022182562A1 (en) * 2021-02-23 2022-09-01 BioLegend, Inc. ANTI-SARS-CoV-2 SPIKE GLYCOPROTEIN S1 AGENTS AND COMPOSITIONS
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
US20240309116A1 (en) * 2021-07-23 2024-09-19 Zhejiang Shimai Pharmaceutical Co., Ltd. Antibodies against ror1 and uses thereof
CN113956359B (zh) * 2021-10-29 2022-09-16 叶鑫淼 一种抗体及其在抗肿瘤中的应用
CN118302448A (zh) * 2021-12-28 2024-07-05 江苏恒瑞医药股份有限公司 抗ror1抗体和抗ror1抗体药物偶联物及其医药用途
PE20251274A1 (es) * 2022-03-09 2025-05-14 Sanyou Biopharmaceuticals Co Ltd Molecula de union dirigida a ror1 y uso de la misma
CN119604529A (zh) * 2022-07-11 2025-03-11 翰森生物有限责任公司 抗体、其抗原结合片段及其药物用途
CN116836286A (zh) * 2022-09-07 2023-10-03 中国科学院合肥物质科学研究院 能够特异性结合ror1的抗体、其偶联药物及其制备方法和应用
CN115724973B (zh) * 2022-09-26 2023-07-11 普健生物（武汉）科技有限公司 抗人ror1高亲和力兔单克隆抗体及其应用
CN118440200B (zh) * 2023-04-21 2025-05-16 星奕昂(上海)生物科技有限公司 靶向ror1的抗体及其应用
AU2024331841A1 (en) * 2023-08-31 2026-03-05 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Antibody targeting receptor tyrosine kinase-like orphan receptor 1 and use thereof

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Also Published As

Publication number Publication date
US11466083B2 (en) 2022-10-11
US20230220073A1 (en) 2023-07-13
US20200354448A1 (en) 2020-11-12
MX2019015348A (es) 2020-07-20
US20250066472A1 (en) 2025-02-27
WO2019008377A1 (en) 2019-01-10
ES3048696T3 (en) 2025-12-11
EP3649152B1 (en) 2025-10-08
CN110891973B (zh) 2023-06-27
AU2018297630A1 (en) 2020-01-16
CA3068196A1 (en) 2019-01-10
CN110891973A (zh) 2020-03-17
DK3649152T3 (da) 2025-11-10
JP2020530272A (ja) 2020-10-22
GB201710835D0 (en) 2017-08-16
EP3649152A1 (en) 2020-05-13
AU2018297630B2 (en) 2025-03-06

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