GB201710835D0 - ROR1 Antibodies - Google Patents

ROR1 Antibodies

Info

Publication number
GB201710835D0
GB201710835D0 GBGB1710835.8A GB201710835A GB201710835D0 GB 201710835 D0 GB201710835 D0 GB 201710835D0 GB 201710835 A GB201710835 A GB 201710835A GB 201710835 D0 GB201710835 D0 GB 201710835D0
Authority
GB
United Kingdom
Prior art keywords
ror1 antibodies
ror1
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1710835.8A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCL Business Ltd
Original Assignee
UCL Business Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCL Business Ltd filed Critical UCL Business Ltd
Priority to GBGB1710835.8A priority Critical patent/GB201710835D0/en
Publication of GB201710835D0 publication Critical patent/GB201710835D0/en
Priority to US16/628,512 priority patent/US11466083B2/en
Priority to CN201880045361.4A priority patent/CN110891973B/zh
Priority to CA3068196A priority patent/CA3068196A1/en
Priority to EP18742575.6A priority patent/EP3649152B1/en
Priority to AU2018297630A priority patent/AU2018297630B2/en
Priority to PCT/GB2018/051914 priority patent/WO2019008377A1/en
Priority to MX2019015348A priority patent/MX2019015348A/es
Priority to DK18742575.6T priority patent/DK3649152T3/da
Priority to JP2019572456A priority patent/JP7242573B2/ja
Priority to US17/869,872 priority patent/US20230220073A1/en
Priority to US18/815,603 priority patent/US20250066472A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GBGB1710835.8A 2017-07-05 2017-07-05 ROR1 Antibodies Ceased GB201710835D0 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GBGB1710835.8A GB201710835D0 (en) 2017-07-05 2017-07-05 ROR1 Antibodies
JP2019572456A JP7242573B2 (ja) 2017-07-05 2018-07-05 Ｒｏｒ１抗体
EP18742575.6A EP3649152B1 (en) 2017-07-05 2018-07-05 Ror1 antibodies
CN201880045361.4A CN110891973B (zh) 2017-07-05 2018-07-05 Ror1抗体
CA3068196A CA3068196A1 (en) 2017-07-05 2018-07-05 Ror1 antibodies
US16/628,512 US11466083B2 (en) 2017-07-05 2018-07-05 ROR1 antibodies
AU2018297630A AU2018297630B2 (en) 2017-07-05 2018-07-05 ROR1 antibodies
PCT/GB2018/051914 WO2019008377A1 (en) 2017-07-05 2018-07-05 ANTIBODY ROR1
MX2019015348A MX2019015348A (es) 2017-07-05 2018-07-05 Anticuerpos contra receptor 1 huerfano tipo receptor de tirosina cinasa (ror1).
DK18742575.6T DK3649152T3 (da) 2017-07-05 2018-07-05 ROR1-antistoffer
US17/869,872 US20230220073A1 (en) 2017-07-05 2022-07-21 Ror1 antibodies
US18/815,603 US20250066472A1 (en) 2017-07-05 2024-08-26 Ror1 antibodies

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1710835.8A GB201710835D0 (en) 2017-07-05 2017-07-05 ROR1 Antibodies

Publications (1)

Publication Number Publication Date
GB201710835D0 true GB201710835D0 (en) 2017-08-16

Family

ID=59592560

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1710835.8A Ceased GB201710835D0 (en) 2017-07-05 2017-07-05 ROR1 Antibodies

Country Status (10)

Country Link
US (3) US11466083B2 (enExample)
EP (1) EP3649152B1 (enExample)
JP (1) JP7242573B2 (enExample)
CN (1) CN110891973B (enExample)
AU (1) AU2018297630B2 (enExample)
CA (1) CA3068196A1 (enExample)
DK (1) DK3649152T3 (enExample)
GB (1) GB201710835D0 (enExample)
MX (1) MX2019015348A (enExample)
WO (1) WO2019008377A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201710835D0 (en) * 2017-07-05 2017-08-16 Ucl Business Plc ROR1 Antibodies
GB201710836D0 (en) * 2017-07-05 2017-08-16 Ucl Business Plc ROR1 Car T-Cells
WO2020018964A1 (en) 2018-07-20 2020-01-23 Fred Hutchinson Cancer Research Center Compositions and methods for controlled expression of antigen-specific receptors
US20230416942A1 (en) * 2020-08-21 2023-12-28 Yale University Nanobody Compositions and Methods of Use of the Same
CN114085288A (zh) * 2020-08-24 2022-02-25 岸迈生物科技(苏州)有限公司 抗ror1抗体
US20240010721A1 (en) * 2020-09-03 2024-01-11 Harbour Biomed (Shanghai) Co., Ltd Ror1-targeting antibody or antigen-binding fragment thereof, preparation method therefor, and application thereof
AU2021383841A1 (en) * 2020-11-23 2023-06-22 Scout Bio, Inc. Antigen-binding molecules and uses thereof
WO2022182562A1 (en) * 2021-02-23 2022-09-01 BioLegend, Inc. ANTI-SARS-CoV-2 SPIKE GLYCOPROTEIN S1 AGENTS AND COMPOSITIONS
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
US20240309116A1 (en) * 2021-07-23 2024-09-19 Zhejiang Shimai Pharmaceutical Co., Ltd. Antibodies against ror1 and uses thereof
CN113956359B (zh) * 2021-10-29 2022-09-16 叶鑫淼 一种抗体及其在抗肿瘤中的应用
US20250121081A1 (en) * 2021-12-28 2025-04-17 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Anti-ror1 antibody, and anti-ror1 antibody-drug conjugate and medical uses thereof
TW202413422A (zh) * 2022-07-11 2024-04-01 美商翰森生物有限責任公司 抗體、其抗原結合片段及其藥物用途
CN115724973B (zh) * 2022-09-26 2023-07-11 普健生物（武汉）科技有限公司 抗人ror1高亲和力兔单克隆抗体及其应用
CN118440200B (zh) * 2023-04-21 2025-05-16 星奕昂(上海)生物科技有限公司 靶向ror1的抗体及其应用
WO2025044937A1 (zh) * 2023-08-31 2025-03-06 正大天晴药业集团股份有限公司 靶向受体酪氨酸激酶样孤儿受体1的抗体及其应用

Family Cites Families (41)

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Publication number Priority date Publication date Assignee Title
KR101229731B1 (ko) 2003-10-16 2013-03-07 암젠 리서치 (뮌헨) 게엠베하 다중특이적 탈면역화된 ｃｄ3-바인더
WO2007146957A2 (en) 2006-06-13 2007-12-21 Irm Llc Ror1 as a therapeutic target for lung cancer
CA2759733C (en) * 2009-04-23 2019-09-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-human ror1 antibodies
EP2496605A1 (en) * 2009-11-02 2012-09-12 Oxford Biotherapeutics Ltd. Ror1 as therapeutic and diagnostic target
CN102712695B (zh) 2009-12-18 2015-01-21 堪瑟拉公司 能够诱导细胞死亡的ror1生物抑制剂
WO2012045085A1 (en) 2010-10-01 2012-04-05 Oxford Biotherapeutics Ltd. Anti-rori antibodies
US9758586B2 (en) 2010-12-01 2017-09-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric rabbit/human ROR1 antibodies
GB201020995D0 (en) 2010-12-10 2011-01-26 Bioinvent Int Ab Biological materials and uses thereof
DK2663579T3 (en) 2011-01-14 2017-07-31 Univ California THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND PROCEDURES FOR USE THEREOF
PL2884999T3 (pl) 2012-08-20 2021-07-05 Fred Hutchinson Cancer Research Center Sposób i kompozycje do immunoterapii komórkowej
PL3489261T3 (pl) * 2012-08-24 2021-08-16 The Regents Of The University Of California Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu
EP2789630A1 (en) 2013-04-09 2014-10-15 EngMab AG Bispecific antibodies against CD3e and ROR1
NZ726520A (en) 2014-05-29 2018-12-21 Macrogenics Inc Tri-specific binding molecules that specifically bind to multiple cancer antigens and methods of use thereof
BR112017001821A2 (pt) * 2014-07-29 2017-11-21 Cellectis receptores de antígenos quiméricos específicos de ror1 (ntrkr1) para imunoterapia de câncer
WO2016016343A1 (en) 2014-07-31 2016-02-04 Cellectis Ror1 specific multi-chain chimeric antigen receptor
IL250848B (en) 2014-09-08 2022-07-01 Rin Inst Inc Cancer-cell-specific antibody, anticancer agent, and cancer testing method
EP3204415B1 (en) 2014-10-09 2020-06-17 EngMab Sàrl Bispecific antibodies against cd3epsilon and ror1
JP2017536341A (ja) 2014-10-09 2017-12-07 エンクマフ アーゲー 卵巣がんの処置における使用のためのＣＤ３εおよびＲＯＲ１に対する二特異性抗体
WO2016094873A2 (en) 2014-12-12 2016-06-16 Emergent Product Development Seattle, Llc Receptor tyrosine kinase-like orphan receptor 1 binding proteins and related compositions and methods
NZ733841A (en) 2015-01-16 2024-01-26 Juno Therapeutics Inc Antibodies and chimeric antigen receptors specific for ror1
CA2973773C (en) 2015-02-02 2023-10-17 Kancera Ab 2-phenyl-3h-imidazo[4,5-b]pyridine derivatives useful as inhibitors of mammalian tyrosine kinase ror1 activity
EP3842072A1 (en) * 2015-05-18 2021-06-30 Eureka Therapeutics, Inc. Anti-ror1 antibodies
EP3298032A1 (en) 2015-05-18 2018-03-28 Bluebird Bio, Inc. Anti-ror1 chimeric antigen receptors
EP3368574A1 (en) 2015-10-30 2018-09-05 NBE-Therapeutics AG Anti-ror1 antibodies
CN108848669B (zh) 2016-01-20 2022-06-07 斯克利普斯研究所 Ror1抗体组合物和相关方法
JP2019506158A (ja) 2016-01-22 2019-03-07 ヤンセン バイオテツク，インコーポレーテツド 抗ｒｏｒ１抗体、ｒｏｒ１×ｃｄ３二重特異性抗体、及びそれらの使用法
WO2017142928A1 (en) 2016-02-17 2017-08-24 Macrogenics, Inc. Ror1-binding molecules, and methods of use thereof
WO2017156479A1 (en) 2016-03-11 2017-09-14 Bluebird Bio, Inc. Ror1 chimeric antigen receptors
KR102466810B1 (ko) 2016-07-11 2022-11-11 칸세라 아베 포유류 티로신 키나제 ror1 활성의 저해제로서 유용한 2-페닐이미다조[4,5-b]피리딘-7-아민 유도체
WO2018119314A1 (en) 2016-12-22 2018-06-28 Ardeagen Corporation Anti-ror1 antibody and conjugates thereof
CA3064743A1 (en) 2017-05-23 2018-11-29 Dragonfly Therapeutics, Inc. A protein binding nkg2d, cd16 and ror1 or ror2
AU2018289581C1 (en) 2017-06-23 2025-01-30 VelosBio Inc. ROR1 antibody immunoconjugates
CN116925227A (zh) 2017-06-25 2023-10-24 西雅图免疫公司 抗ror1抗体及其制备和使用方法
GB201710838D0 (en) * 2017-07-05 2017-08-16 Ucl Business Plc Bispecific antibodies
GB201710836D0 (en) * 2017-07-05 2017-08-16 Ucl Business Plc ROR1 Car T-Cells
GB201710835D0 (en) * 2017-07-05 2017-08-16 Ucl Business Plc ROR1 Antibodies
US20210139579A1 (en) 2017-07-20 2021-05-13 Nbe-Therapeutics Ag Multispecific antibody product that binds to different ror1 epitopes
WO2019030240A1 (en) 2017-08-07 2019-02-14 Nbe-Therapeutics Ag ANTIBODIES BINDING TO A LINEAR HUMAN CS1 EPITOPE
EP3703711A4 (en) 2017-11-03 2021-01-13 Lentigen Technology, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER WITH ANTI-MMR1 IMMUNOTHERAPY
GB201721802D0 (en) 2017-12-22 2018-02-07 Almac Discovery Ltd Ror1-specific antigen binding molecules
WO2019225777A1 (ko) 2018-05-23 2019-11-28 에이비엘바이오 주식회사 항-ror1 항체 및 그 용도

Also Published As

Publication number Publication date
CA3068196A1 (en) 2019-01-10
AU2018297630A1 (en) 2020-01-16
US20230220073A1 (en) 2023-07-13
EP3649152B1 (en) 2025-10-08
CN110891973A (zh) 2020-03-17
JP2020530272A (ja) 2020-10-22
US20200354448A1 (en) 2020-11-12
JP7242573B2 (ja) 2023-03-20
CN110891973B (zh) 2023-06-27
US20250066472A1 (en) 2025-02-27
EP3649152A1 (en) 2020-05-13
US11466083B2 (en) 2022-10-11
DK3649152T3 (da) 2025-11-10
AU2018297630B2 (en) 2025-03-06
MX2019015348A (es) 2020-07-20
WO2019008377A1 (en) 2019-01-10

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)