JP7239179B2 - Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 - Google Patents
Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 Download PDFInfo
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- JP7239179B2 JP7239179B2 JP2019518292A JP2019518292A JP7239179B2 JP 7239179 B2 JP7239179 B2 JP 7239179B2 JP 2019518292 A JP2019518292 A JP 2019518292A JP 2019518292 A JP2019518292 A JP 2019518292A JP 7239179 B2 JP7239179 B2 JP 7239179B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2023025895A JP2023078140A (ja) | 2016-10-05 | 2023-02-22 | Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662404520P | 2016-10-05 | 2016-10-05 | |
US62/404,520 | 2016-10-05 | ||
PCT/US2017/055352 WO2018067825A1 (en) | 2016-10-05 | 2017-10-05 | Methods and compositions related to nk cell and anti-pdl1 cancer therapies |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2023025895A Division JP2023078140A (ja) | 2016-10-05 | 2023-02-22 | Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2019534258A JP2019534258A (ja) | 2019-11-28 |
JP2019534258A5 JP2019534258A5 (enrdf_load_stackoverflow) | 2021-05-20 |
JP7239179B2 true JP7239179B2 (ja) | 2023-03-14 |
Family
ID=61831979
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019518292A Active JP7239179B2 (ja) | 2016-10-05 | 2017-10-05 | Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 |
JP2023025895A Pending JP2023078140A (ja) | 2016-10-05 | 2023-02-22 | Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2023025895A Pending JP2023078140A (ja) | 2016-10-05 | 2023-02-22 | Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 |
Country Status (11)
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10300089B2 (en) * | 2016-11-08 | 2019-05-28 | University Of Central Florida Research Foundation, Inc. | Methods for high scale therapeutic production of memory NK cells |
CA3089853A1 (en) | 2018-02-01 | 2019-08-08 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
KR102373502B1 (ko) | 2018-05-14 | 2022-03-11 | 주식회사 금호에이치티 | 골수유래억제세포 관련 질환의 예방 및 치료 용도 |
CA3098471C (en) * | 2018-05-22 | 2023-04-18 | Nantkwest, Inc. | Optimization of nk-92 cell growth using poloxamer |
CN109939127A (zh) * | 2018-06-13 | 2019-06-28 | 阿思科力(苏州)生物科技有限公司 | Nk细胞的应用及包括该nk细胞的药物组合物及其应用 |
CN113365663A (zh) | 2018-08-30 | 2021-09-07 | Hcw生物科技公司 | 单链嵌合多肽和其用途 |
EP4592314A2 (en) * | 2018-08-30 | 2025-07-30 | ImmunityBio, Inc. | Single-chain and multi-chain chimeric polypeptides and uses thereof |
EP3844181A1 (en) | 2018-08-30 | 2021-07-07 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and uses thereof |
CA3118943A1 (en) * | 2018-11-15 | 2020-05-22 | Torque Therapeutics, Inc. | Methods and compositions for cancer immunotherapy |
CN109652504B (zh) * | 2018-12-27 | 2021-03-16 | 杭州迪相实业有限公司 | 一种同时检测外泌体膜蛋白和mRNA的方法 |
CN110205296B (zh) * | 2019-01-29 | 2021-08-24 | 上海鑫湾生物科技有限公司 | 具有Fc突变体的抗体与效应细胞的组合、用途和制法 |
WO2021163298A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of activating regulatory t cells |
IL295077A (en) | 2020-02-11 | 2022-09-01 | Hcw Biologics Inc | Methods of treating age-related and inflammatory diseases |
AU2021219720A1 (en) | 2020-02-11 | 2022-08-04 | Immunitybio, Inc. | Chromatography resin and uses thereof |
US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
JP2023024168A (ja) * | 2021-08-06 | 2023-02-16 | 国立大学法人 長崎大学 | がんの治療剤 |
WO2023247324A1 (en) * | 2022-06-24 | 2023-12-28 | Cytovac A/S | Novel combination treatment with adoptive cellular therapy |
WO2024108058A2 (en) * | 2022-11-18 | 2024-05-23 | Nkmax Co., Ltd. | Methods of inducing pd-l1 expression |
WO2025010297A1 (en) * | 2023-07-05 | 2025-01-09 | Immunitybio, Inc. | Ex vivo generation of immune effector cells from apheresis material intermediates |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150359853A1 (en) | 2012-10-24 | 2015-12-17 | Admune Therapeutics Llc | Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes |
Family Cites Families (20)
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FR1601438A (enrdf_load_stackoverflow) | 1968-10-17 | 1970-08-24 | ||
US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
ATE356869T1 (de) | 1990-01-12 | 2007-04-15 | Amgen Fremont Inc | Bildung von xenogenen antikörpern |
US5612205A (en) | 1990-08-29 | 1997-03-18 | Genpharm International, Incorporated | Homologous recombination in mammalian cells |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5652138A (en) | 1992-09-30 | 1997-07-29 | The Scripps Research Institute | Human neutralizing monoclonal antibodies to human immunodeficiency virus |
AU6852594A (en) | 1993-06-03 | 1995-01-03 | Therapeutic Antibodies Inc. | Production of antibody fragments |
US6180377B1 (en) | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
FR2765243B1 (fr) | 1997-06-30 | 1999-07-30 | Usinor | Acier inoxydable austenoferritique a tres bas nickel et presentant un fort allongement en traction |
CN104470535A (zh) * | 2012-03-29 | 2015-03-25 | 阿尔托生物科学有限公司 | 用于治疗肿瘤的方法 |
LT3578201T (lt) * | 2012-06-28 | 2023-05-25 | University Of Central Florida Research Foundation Incorporated | Nk ląstelių metodai ir kompozicijos |
CN103536917B (zh) * | 2013-10-30 | 2015-03-11 | 苏州丁孚靶点生物技术有限公司 | 干扰素在治疗肿瘤中的用途及相关的产品和方法 |
AU2014346852A1 (en) * | 2013-11-05 | 2016-06-16 | Cognate Bioservices, Inc. | Combinations of checkpoint inhibitors and therapeutics to treat cancer |
JP7049830B2 (ja) * | 2014-10-27 | 2022-04-07 | ユニバーシティ オブ セントラル フロリダ リサーチ ファウンデーション,インコーポレイテッド | ナチュラルキラー細胞のための方法及び組成物 |
SG11201704056XA (en) * | 2014-11-20 | 2017-06-29 | Hoffmann La Roche | Combination therapy of t cell activating bispecific antigen binding molecules cd3 abd folate receptor 1 (folr1) and pd-1 axis binding antagonists |
WO2016134284A1 (en) | 2015-02-19 | 2016-08-25 | University Of Florida Research Foundation, Inc. | Chimeric antigen receptors and uses thereof |
KR20170135860A (ko) * | 2015-03-13 | 2017-12-08 | 싸이톰스 테라퓨틱스, 인크. | 항-pdl1 항체, 활성화 가능한 항-pdl1 항체, 및 이들의 사용 방법 |
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2017
- 2017-10-05 WO PCT/US2017/055352 patent/WO2018067825A1/en unknown
- 2017-10-05 US US16/339,781 patent/US20190309070A1/en not_active Abandoned
- 2017-10-05 ES ES17859189T patent/ES3014658T3/es active Active
- 2017-10-05 JP JP2019518292A patent/JP7239179B2/ja active Active
- 2017-10-05 CN CN202410266765.3A patent/CN118453850A/zh active Pending
- 2017-10-05 CN CN201780069203.8A patent/CN109952369B/zh active Active
- 2017-10-05 KR KR1020197012752A patent/KR102650803B1/ko active Active
- 2017-10-05 EP EP17859189.7A patent/EP3523416B1/en active Active
- 2017-10-05 CA CA3039532A patent/CA3039532A1/en active Pending
- 2017-10-05 KR KR1020247009187A patent/KR20240042177A/ko active Pending
- 2017-10-05 SG SG11201903032SA patent/SG11201903032SA/en unknown
- 2017-10-05 DK DK17859189.7T patent/DK3523416T3/da active
- 2017-10-05 AU AU2017340633A patent/AU2017340633B2/en active Active
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2023
- 2023-02-22 JP JP2023025895A patent/JP2023078140A/ja active Pending
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2024
- 2024-04-11 AU AU2024202350A patent/AU2024202350A1/en active Pending
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2025
- 2025-01-06 US US19/011,349 patent/US20250136698A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150359853A1 (en) | 2012-10-24 | 2015-12-17 | Admune Therapeutics Llc | Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes |
Non-Patent Citations (5)
Title |
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Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells,Cancer Immunology Research,2015年,Vol. 3, No. 10,p. 1148-1157 |
Interleukin-18 (IL-18)によるNatural Killer (NK)細胞活性化および腫瘍細胞のアポトーシス誘導,頭頸部腫瘍,Vol. 29, No. 1,2003年,p. 217-223 |
Interleukin-21 Increases Direct Cytotoxicity and IFN-γ Production of Ex Vivo Expanded NK Cells towards Breast Cancer Cells,Anticancer Research,2012年,Vol. 32,p. 839-846 |
Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells,PLOS ONE,2012年,Vol. 7, No. 1,e30264 |
Natural killer cells stimulated with PM21 particles expand and biodistribute in vivo: Clinical implications for cancer treatment,Cytotherapy,Vol. 18, No. 5,p. 653-663,doi: 10.1016/j.jcyt.2016.02.006. |
Also Published As
Publication number | Publication date |
---|---|
CN109952369B (zh) | 2024-03-22 |
KR20190066035A (ko) | 2019-06-12 |
EP3523416B1 (en) | 2025-02-19 |
DK3523416T3 (da) | 2025-03-03 |
EP3523416A1 (en) | 2019-08-14 |
SG11201903032SA (en) | 2019-05-30 |
US20190309070A1 (en) | 2019-10-10 |
AU2017340633A1 (en) | 2019-05-23 |
KR20240042177A (ko) | 2024-04-01 |
EP3523416A4 (en) | 2020-04-15 |
AU2024202350A1 (en) | 2024-05-02 |
CN109952369A (zh) | 2019-06-28 |
US20250136698A1 (en) | 2025-05-01 |
JP2019534258A (ja) | 2019-11-28 |
CA3039532A1 (en) | 2018-04-12 |
ES3014658T3 (en) | 2025-04-23 |
WO2018067825A1 (en) | 2018-04-12 |
AU2017340633B2 (en) | 2024-01-11 |
JP2023078140A (ja) | 2023-06-06 |
KR102650803B1 (ko) | 2024-03-25 |
CN118453850A (zh) | 2024-08-09 |
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