JP7236380B2 - 治療に適したtalエフェクターヌクレアーゼ(talen)改変同種異系細胞 - Google Patents
治療に適したtalエフェクターヌクレアーゼ(talen)改変同種異系細胞 Download PDFInfo
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- JP7236380B2 JP7236380B2 JP2019520685A JP2019520685A JP7236380B2 JP 7236380 B2 JP7236380 B2 JP 7236380B2 JP 2019520685 A JP2019520685 A JP 2019520685A JP 2019520685 A JP2019520685 A JP 2019520685A JP 7236380 B2 JP7236380 B2 JP 7236380B2
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- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4212—CD22, BL-CAM, siglec-2 or sialic acid binding Ig-related lectin 2
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- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4214—Receptors for cytokines
- A61K40/4217—Receptors for interleukins [IL]
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
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- Animal Behavior & Ethology (AREA)
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- General Engineering & Computer Science (AREA)
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- Molecular Biology (AREA)
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- Cell Biology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
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- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
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- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662410187P | 2016-10-19 | 2016-10-19 | |
| US62/410,187 | 2016-10-19 | ||
| DKPA201770240 | 2017-03-31 | ||
| DKPA201770240 | 2017-03-31 | ||
| PCT/EP2017/076800 WO2018073393A2 (en) | 2016-10-19 | 2017-10-19 | Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2019531742A JP2019531742A (ja) | 2019-11-07 |
| JP2019531742A5 JP2019531742A5 (enExample) | 2020-11-19 |
| JPWO2018073393A5 JPWO2018073393A5 (enExample) | 2023-01-25 |
| JP7236380B2 true JP7236380B2 (ja) | 2023-03-09 |
Family
ID=60268352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520685A Active JP7236380B2 (ja) | 2016-10-19 | 2017-10-19 | 治療に適したtalエフェクターヌクレアーゼ(talen)改変同種異系細胞 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230138915A1 (enExample) |
| EP (1) | EP3529265A2 (enExample) |
| JP (1) | JP7236380B2 (enExample) |
| AU (1) | AU2017347685B2 (enExample) |
| CA (1) | CA3041039A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112021008082A2 (pt) | 2018-11-07 | 2021-08-10 | Crispr Therapeutics Ag | terapia contra o câncer com células imunitárias anti-liv1 |
| US20230332104A1 (en) * | 2020-06-11 | 2023-10-19 | Novartis Ag | Zbtb32 inhibitors and uses thereof |
| CN117129690B (zh) * | 2023-09-26 | 2025-06-06 | 杭州师范大学 | Grhl1在her2-乳腺癌诊断及预后评估中的应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015136001A1 (en) | 2014-03-11 | 2015-09-17 | Cellectis | Method for generating t-cells compatible for allogenic transplantation |
| WO2016124765A1 (en) | 2015-02-06 | 2016-08-11 | Cellectis | Primary hematopoietic cells genetically engineered by slow release of nucleic acids using nanoparticles |
| JP2016525888A (ja) | 2013-05-29 | 2016-09-01 | セレクティスCellectis | Rnaガイドcasヌクレアーゼ系を用いることによって免疫療法のためにt細胞を操作するための方法 |
| WO2016160721A1 (en) | 2015-03-27 | 2016-10-06 | President And Fellows Of Harvard College | Modified t cells and methods of making and using the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3133545C (en) * | 2012-05-25 | 2023-08-08 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| EP4108255A1 (en) * | 2015-10-05 | 2022-12-28 | Precision Biosciences, Inc. | Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene |
| KR102824067B1 (ko) * | 2016-04-15 | 2025-06-23 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Icos 리간드 변이체 면역조절 단백질 및 그의 용도 |
-
2017
- 2017-10-19 US US16/340,412 patent/US20230138915A1/en active Pending
- 2017-10-19 AU AU2017347685A patent/AU2017347685B2/en active Active
- 2017-10-19 EP EP17794690.2A patent/EP3529265A2/en active Pending
- 2017-10-19 CA CA3041039A patent/CA3041039A1/en active Pending
- 2017-10-19 JP JP2019520685A patent/JP7236380B2/ja active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016525888A (ja) | 2013-05-29 | 2016-09-01 | セレクティスCellectis | Rnaガイドcasヌクレアーゼ系を用いることによって免疫療法のためにt細胞を操作するための方法 |
| WO2015136001A1 (en) | 2014-03-11 | 2015-09-17 | Cellectis | Method for generating t-cells compatible for allogenic transplantation |
| WO2016124765A1 (en) | 2015-02-06 | 2016-08-11 | Cellectis | Primary hematopoietic cells genetically engineered by slow release of nucleic acids using nanoparticles |
| WO2016160721A1 (en) | 2015-03-27 | 2016-10-06 | President And Fellows Of Harvard College | Modified t cells and methods of making and using the same |
Non-Patent Citations (1)
| Title |
|---|
| Cancer Research,2015年,Vol.75, No.18,pp.3853-3864 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3041039A1 (en) | 2018-04-26 |
| JP2019531742A (ja) | 2019-11-07 |
| US20230138915A1 (en) | 2023-05-04 |
| AU2017347685B2 (en) | 2023-08-03 |
| AU2017347685A1 (en) | 2019-05-02 |
| EP3529265A2 (en) | 2019-08-28 |
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