JP7224331B2 - 脂肪毒性損傷の低減のための化合物 - Google Patents
脂肪毒性損傷の低減のための化合物 Download PDFInfo
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- JP7224331B2 JP7224331B2 JP2020501125A JP2020501125A JP7224331B2 JP 7224331 B2 JP7224331 B2 JP 7224331B2 JP 2020501125 A JP2020501125 A JP 2020501125A JP 2020501125 A JP2020501125 A JP 2020501125A JP 7224331 B2 JP7224331 B2 JP 7224331B2
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P31/04—Antibacterial agents
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- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
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| US62/531,454 | 2017-07-12 | ||
| PCT/US2018/041796 WO2019014434A1 (en) | 2017-07-12 | 2018-07-12 | COMPOUNDS FOR REDUCING LIPOTOXIC LESIONS |
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| JP2020527138A JP2020527138A (ja) | 2020-09-03 |
| JP2020527138A5 JP2020527138A5 (enExample) | 2021-08-12 |
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| EP4218753B1 (en) | 2017-07-12 | 2025-12-03 | Mayo Foundation for Medical Education and Research | Novel lipase inhibitor and uses thereof |
| JP2024517699A (ja) * | 2021-04-23 | 2024-04-23 | パナフィナ，インコーポレイテッド | リプスタチン誘導体を合成する方法 |
| CN114560887B (zh) * | 2022-02-15 | 2024-01-26 | 安徽美致诚药业有限公司 | 一种制备奥利司他的中间体的制备方法 |
| CN119031909A (zh) * | 2022-03-31 | 2024-11-26 | 梅约医学教育与研究基金会 | 用于治疗胰腺疾病和病症的方法和材料 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007523131A (ja) | 2004-02-23 | 2007-08-16 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | リパーゼ抑制剤としてのアルキルカルバマート置換したβ−ラクトン |
| US20120289588A1 (en) | 2011-04-15 | 2012-11-15 | Vijay Prem Singh | Lipase Inhibitors for the Treatment of Pancreatitis and Organ Failure |
| US20150099800A1 (en) | 2012-05-24 | 2015-04-09 | Northeastern University | Novel lipase inhibitors, reporter substrates and uses thereof |
| WO2016102541A1 (en) | 2014-12-22 | 2016-06-30 | Université Libre de Bruxelles | Composition comprising vancomycin and orlistat |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA859575B (en) * | 1984-12-21 | 1986-08-27 | Hoffmann La Roche | Oxetanones |
| CA1270837A (en) | 1984-12-21 | 1990-06-26 | Hoffmann-La Roche Limited | Oxetanones |
| IL97148A (en) * | 1990-02-26 | 1996-11-14 | Hoffmann La Roche | Oxetanones a process for their manufacture and pharmaceutical compositions containing them |
| FR2754827B1 (fr) | 1996-10-17 | 1998-12-24 | Biocem | Lipases pancreatiques et/ou colipases recombinantes et polypeptides dervies produits par les plantes, leurs procedes d'obtention et leurs utilisations |
| FR2758143B1 (fr) | 1997-01-07 | 1999-02-19 | Laphal Laboratoire De Pharmaco | Inhibiteurs specifiques de la lipase pancreatique et leurs applications |
| US7060708B2 (en) | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
| US20040018197A1 (en) | 2002-04-26 | 2004-01-29 | Promega Corporation | Treatment for weight loss |
| EP1803714A1 (en) | 2005-12-27 | 2007-07-04 | KRKA, tovarna zdravil, d.d., Novo mesto | Process for preparing crystalline forms of orlistat |
| EP2212305A4 (en) | 2007-10-31 | 2011-10-26 | Burnham Inst Medical Research | BETA-lactone |
| WO2016002541A1 (ja) | 2014-06-30 | 2016-01-07 | 日立工機株式会社 | 電動工具 |
| US20180319894A1 (en) | 2015-11-03 | 2018-11-08 | Mayo Foundation For Medical Education And Research | Using colipase inhibitors to treat pancreatitis |
| EP4218753B1 (en) | 2017-07-12 | 2025-12-03 | Mayo Foundation for Medical Education and Research | Novel lipase inhibitor and uses thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007523131A (ja) | 2004-02-23 | 2007-08-16 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | リパーゼ抑制剤としてのアルキルカルバマート置換したβ−ラクトン |
| US20120289588A1 (en) | 2011-04-15 | 2012-11-15 | Vijay Prem Singh | Lipase Inhibitors for the Treatment of Pancreatitis and Organ Failure |
| US20150099800A1 (en) | 2012-05-24 | 2015-04-09 | Northeastern University | Novel lipase inhibitors, reporter substrates and uses thereof |
| WO2016102541A1 (en) | 2014-12-22 | 2016-06-30 | Université Libre de Bruxelles | Composition comprising vancomycin and orlistat |
Non-Patent Citations (2)
| Title |
|---|
| Journal of Medicinal Chemistry，2008年，51(21)，P.6970-6979 |
| Journal of the Chemical Society, Perkin Transactions 1，1998年，(8)，P.1373-1382 |
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