JP7214712B2 - 血漿および全血中の抗凝固薬の検出のための方法ならびにデバイス - Google Patents

血漿および全血中の抗凝固薬の検出のための方法ならびにデバイス Download PDF

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JP7214712B2
JP7214712B2 JP2020504364A JP2020504364A JP7214712B2 JP 7214712 B2 JP7214712 B2 JP 7214712B2 JP 2020504364 A JP2020504364 A JP 2020504364A JP 2020504364 A JP2020504364 A JP 2020504364A JP 7214712 B2 JP7214712 B2 JP 7214712B2
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factor
blood sample
clotting
clot formation
formation time
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JP2020529593A (ja
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フリードマン,ガリト・エイチ
トナー,メーメット
トンプキンス,ロナルド・ジー
ベンダプディ,パバン
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Massachusetts Institute of Technology
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4846Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/4905Determining clotting time of blood
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/16Surface properties and coatings
    • B01L2300/161Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165Specific details about hydrophobic, oleophobic surfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/084Passive control of flow resistance
    • B01L2400/088Passive control of flow resistance by specific surface properties

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Fluid Mechanics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
JP2020504364A 2017-07-28 2018-07-26 血漿および全血中の抗凝固薬の検出のための方法ならびにデバイス Active JP7214712B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762538618P 2017-07-28 2017-07-28
US62/538,618 2017-07-28
US201862699665P 2018-07-17 2018-07-17
US62/699,665 2018-07-17
PCT/US2018/043973 WO2019023508A1 (en) 2017-07-28 2018-07-26 METHODS AND DEVICES FOR DETECTION OF ANTICOAGULANTS IN PLASMA AND WHOLE BLOOD

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JP2020529593A JP2020529593A (ja) 2020-10-08
JP2020529593A5 JP2020529593A5 (enExample) 2021-08-26
JP7214712B2 true JP7214712B2 (ja) 2023-01-30

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US (4) US20190111431A1 (enExample)
EP (1) EP3658920A1 (enExample)
JP (1) JP7214712B2 (enExample)
KR (1) KR20200034749A (enExample)
CN (1) CN111094990A (enExample)
AU (1) AU2018307799A1 (enExample)
CA (1) CA3071295A1 (enExample)
IL (1) IL272320A (enExample)
SG (1) SG11202000688UA (enExample)
WO (1) WO2019023508A1 (enExample)

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RU2750839C1 (ru) * 2020-05-18 2021-07-05 Общество с ограниченной ответственностью "Меднорд-Техника" (ООО "Меднорд-Т") Устройство и способ экспресс-оценки агрегационной активности форменных элементов крови
US20220283190A1 (en) * 2021-03-08 2022-09-08 Galit H. Frydman Methods and devices for detection of coagulation impairment
CN113945551A (zh) * 2021-10-19 2022-01-18 重庆医科大学附属永川医院 一种血小板功能的微流控分析检测模型
CN114558629B (zh) * 2022-03-03 2024-06-04 四川微康朴澜医疗科技有限责任公司 一种微流控式血栓弹力分析检测试剂盒
IL319816A (en) 2022-09-30 2025-05-01 Coagulo Medical Tech Inc Modular microfluidic cartridge testing device, useful for point-of-care medical diagnostics and other applications
WO2025132678A1 (en) * 2023-12-19 2025-06-26 F. Hoffmann-La Roche Ag Qualitative test for direct oral anticoagulants (doacs)

Citations (6)

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Publication number Priority date Publication date Assignee Title
US20140038204A1 (en) 2012-07-31 2014-02-06 Baxter Healthcare S.A. Selective measurement of active human protease coagulation factors
US20140038214A1 (en) 2012-06-27 2014-02-06 Colorado School Of Mines Microfluidic flow assay and methods of use
JP2014038109A (ja) 2007-09-20 2014-02-27 Iline Microsystems Sl マイクロ流体デバイスおよび流体の凝固時間測定方法
US20140236494A1 (en) 2011-11-04 2014-08-21 Massachusetts Institute Of Technology Multi-parameter thrombotic assay apparatus, systems, and methods
US20160069913A1 (en) 2014-09-09 2016-03-10 Perosphere Inc. Microfluidic chip-based, universal coagulation assay
JP2016534714A (ja) 2013-10-16 2016-11-10 プレジデント アンド フェローズ オブ ハーバード カレッジ 全血凝固のリアルタイムの臨床モニタリングおよび定量的評価

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014038109A (ja) 2007-09-20 2014-02-27 Iline Microsystems Sl マイクロ流体デバイスおよび流体の凝固時間測定方法
US20140236494A1 (en) 2011-11-04 2014-08-21 Massachusetts Institute Of Technology Multi-parameter thrombotic assay apparatus, systems, and methods
US20140038214A1 (en) 2012-06-27 2014-02-06 Colorado School Of Mines Microfluidic flow assay and methods of use
US20140038204A1 (en) 2012-07-31 2014-02-06 Baxter Healthcare S.A. Selective measurement of active human protease coagulation factors
JP2016534714A (ja) 2013-10-16 2016-11-10 プレジデント アンド フェローズ オブ ハーバード カレッジ 全血凝固のリアルタイムの臨床モニタリングおよび定量的評価
US20160069913A1 (en) 2014-09-09 2016-03-10 Perosphere Inc. Microfluidic chip-based, universal coagulation assay

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Abhishek Jain,A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function,Nat. Commun.,2016年01月06日,Vol.7,Page.10176
Jerome Duchemin,Influence of coagulation factors and tissue factor concentration on the thrombin generation test in plasma,Thromb Haemost,2008年03月12日,Vol.99,Page.767-773
S Nayak,Using a Systems Pharmacology Model of the Blood Coagulation Network to Predict the Effects of Various Therapies on Biomarkers,CPT Pharmacometrics Syst. Pharmacol.,2015年06月19日,Vol.4,Page.396-405
Shannon M. Bates,Coagulation Assays,Circulation,2005年,Vol.112,Page.e53-e60

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Publication number Publication date
WO2019023508A1 (en) 2019-01-31
KR20200034749A (ko) 2020-03-31
US20190111431A1 (en) 2019-04-18
IL272320A (en) 2020-03-31
JP2020529593A (ja) 2020-10-08
AU2018307799A1 (en) 2020-02-13
SG11202000688UA (en) 2020-02-27
US20230166255A1 (en) 2023-06-01
CA3071295A1 (en) 2019-01-31
EP3658920A1 (en) 2020-06-03
US20230158499A1 (en) 2023-05-25
US20230158498A1 (en) 2023-05-25
CN111094990A (zh) 2020-05-01

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