KR20200034749A - 혈장 및 전혈에서 항응고제 탐지 방법 및 장치 - Google Patents

혈장 및 전혈에서 항응고제 탐지 방법 및 장치 Download PDF

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KR20200034749A
KR20200034749A KR1020207004767A KR20207004767A KR20200034749A KR 20200034749 A KR20200034749 A KR 20200034749A KR 1020207004767 A KR1020207004767 A KR 1020207004767A KR 20207004767 A KR20207004767 A KR 20207004767A KR 20200034749 A KR20200034749 A KR 20200034749A
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Prior art keywords
factor
coagulation
microfluidic device
channels
sample
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KR1020207004767A
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Korean (ko)
Inventor
갈리트 에이치. 프리드먼
메메트 토너
로널드 지. 톰킨스
파반 벤다푸디
Original Assignee
메사추세츠 인스티튜트 오브 테크놀로지
더 제너럴 하스피털 코포레이션
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Publication of KR20200034749A publication Critical patent/KR20200034749A/ko
Abandoned legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Fluid Mechanics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
KR1020207004767A 2017-07-28 2018-07-26 혈장 및 전혈에서 항응고제 탐지 방법 및 장치 Abandoned KR20200034749A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762538618P 2017-07-28 2017-07-28
US62/538,618 2017-07-28
US201862699665P 2018-07-17 2018-07-17
US62/699,665 2018-07-17
PCT/US2018/043973 WO2019023508A1 (en) 2017-07-28 2018-07-26 METHODS AND DEVICES FOR DETECTION OF ANTICOAGULANTS IN PLASMA AND WHOLE BLOOD

Publications (1)

Publication Number Publication Date
KR20200034749A true KR20200034749A (ko) 2020-03-31

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KR1020207004767A Abandoned KR20200034749A (ko) 2017-07-28 2018-07-26 혈장 및 전혈에서 항응고제 탐지 방법 및 장치

Country Status (10)

Country Link
US (4) US20190111431A1 (enExample)
EP (1) EP3658920A1 (enExample)
JP (1) JP7214712B2 (enExample)
KR (1) KR20200034749A (enExample)
CN (1) CN111094990A (enExample)
AU (1) AU2018307799A1 (enExample)
CA (1) CA3071295A1 (enExample)
IL (1) IL272320A (enExample)
SG (1) SG11202000688UA (enExample)
WO (1) WO2019023508A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2750839C1 (ru) * 2020-05-18 2021-07-05 Общество с ограниченной ответственностью "Меднорд-Техника" (ООО "Меднорд-Т") Устройство и способ экспресс-оценки агрегационной активности форменных элементов крови
US20220283190A1 (en) * 2021-03-08 2022-09-08 Galit H. Frydman Methods and devices for detection of coagulation impairment
CN113945551A (zh) * 2021-10-19 2022-01-18 重庆医科大学附属永川医院 一种血小板功能的微流控分析检测模型
CN114558629B (zh) * 2022-03-03 2024-06-04 四川微康朴澜医疗科技有限责任公司 一种微流控式血栓弹力分析检测试剂盒
IL319816A (en) 2022-09-30 2025-05-01 Coagulo Medical Tech Inc Modular microfluidic cartridge testing device, useful for point-of-care medical diagnostics and other applications
WO2025132678A1 (en) * 2023-12-19 2025-06-26 F. Hoffmann-La Roche Ag Qualitative test for direct oral anticoagulants (doacs)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2040073A1 (en) 2007-09-20 2009-03-25 Iline Microsystems, S.L. Microfluidic device and method for fluid clotting time determination
WO2013067536A1 (en) 2011-11-04 2013-05-10 Massachusetts Institute Of Technology Multi-parameter thrombotic assay apparatus, systems, and methods
US9709579B2 (en) 2012-06-27 2017-07-18 Colorado School Of Mines Microfluidic flow assay and methods of use
US20140038204A1 (en) 2012-07-31 2014-02-06 Baxter Healthcare S.A. Selective measurement of active human protease coagulation factors
US9562914B2 (en) * 2013-10-16 2017-02-07 President And Fellows Of Harvard College Microfluidic device for real-time clinical monitoring and quantitative assessment of whole blood coagulation
EP3191836B1 (en) 2014-09-09 2022-11-23 Perosphere Technologies Inc. Microfluid chip-based, universal coagulation assay

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Publication number Publication date
WO2019023508A1 (en) 2019-01-31
US20190111431A1 (en) 2019-04-18
IL272320A (en) 2020-03-31
JP2020529593A (ja) 2020-10-08
AU2018307799A1 (en) 2020-02-13
JP7214712B2 (ja) 2023-01-30
SG11202000688UA (en) 2020-02-27
US20230166255A1 (en) 2023-06-01
CA3071295A1 (en) 2019-01-31
EP3658920A1 (en) 2020-06-03
US20230158499A1 (en) 2023-05-25
US20230158498A1 (en) 2023-05-25
CN111094990A (zh) 2020-05-01

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