JP7175887B2 - ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法 - Google Patents

ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法 Download PDF

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JP7175887B2
JP7175887B2 JP2019524067A JP2019524067A JP7175887B2 JP 7175887 B2 JP7175887 B2 JP 7175887B2 JP 2019524067 A JP2019524067 A JP 2019524067A JP 2019524067 A JP2019524067 A JP 2019524067A JP 7175887 B2 JP7175887 B2 JP 7175887B2
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arginine
peptide
amino acids
bicyclic
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デフア・ペイ
ジーチン・チアン
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オハイオ・ステイト・イノベーション・ファウンデーション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2019524067A 2016-11-09 2017-11-09 ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法 Active JP7175887B2 (ja)

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JP2022179784A JP7490735B2 (ja) 2016-11-09 2022-11-09 ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法

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US201662419781P 2016-11-09 2016-11-09
US62/419,781 2016-11-09
US201662425550P 2016-11-22 2016-11-22
US62/425,550 2016-11-22
US201662438141P 2016-12-22 2016-12-22
US62/438,141 2016-12-22
PCT/US2017/060881 WO2018089648A2 (en) 2016-11-09 2017-11-09 Di-sulfide containing cell penetrating peptides and methods of making and using thereof

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JP2020502051A5 JP2020502051A5 (https=) 2020-12-03
JP7175887B2 true JP7175887B2 (ja) 2022-11-21

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JP2022179784A Active JP7490735B2 (ja) 2016-11-09 2022-11-09 ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法

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US (2) US11351222B2 (https=)
EP (1) EP3538125A4 (https=)
JP (2) JP7175887B2 (https=)
CN (2) CN110114075B (https=)
CA (1) CA3043464A1 (https=)
TW (1) TWI781963B (https=)
WO (1) WO2018089648A2 (https=)

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JP2023025022A (ja) * 2016-11-09 2023-02-21 オハイオ・ステイト・イノベーション・ファウンデーション ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法

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US12410143B2 (en) 2017-01-17 2025-09-09 Michael David FORREST Therapeutic inhibitors of the reverse mode of ATP synthase
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WO2019148195A2 (en) 2018-01-29 2019-08-01 Ohio State Innovation Foundation Cyclic peptidyl inhibitors of cal-pdz binding domain
WO2019148194A2 (en) 2018-01-29 2019-08-01 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-nfat interaction
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US11987647B2 (en) 2018-05-09 2024-05-21 Ohio State Innovation Foundation Cyclic cell-penetrating peptides with one or more hydrophobic residues
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SG11202100721SA (en) * 2018-07-23 2021-02-25 Univ Alberta Genetically-encoded bicyclic peptide libraries
WO2020195302A1 (ja) * 2019-03-28 2020-10-01 株式会社カネカ 細胞膜透過性環状ペプチド作製用リンカー分子、及びその利用
IL293239A (en) * 2019-11-21 2022-07-01 Unnatural Products Inc Cell-permeable cyclic peptides and their uses
CN110734474B (zh) * 2019-11-29 2021-10-19 中山大学 一种抗菌肽的筛选方法及其应用
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CA3166422A1 (en) * 2019-12-30 2021-07-08 Ohio State Innovation Foundation Looped proteins comprising cell penetrating peptides
WO2022065172A1 (ja) * 2020-09-23 2022-03-31 株式会社カネカ 細胞膜透過性分子及びその利用、並びに細胞膜透過性分子の細胞膜透過性の向上方法
WO2022065173A1 (ja) * 2020-09-23 2022-03-31 株式会社カネカ 細胞膜透過性分子及びその利用、並びに細胞膜透過性分子の細胞膜透過性の向上方法
MX2023007788A (es) 2021-01-24 2023-11-17 Michael David Forrest Inhibidores de la atp sintasa, usos cosmeticos y terapeuticos.
WO2022178379A1 (en) * 2021-02-22 2022-08-25 Ohio State Innovation Foundation Cyclic cell-penetrating peptides with three or more hydrophobic residues
US20240368224A1 (en) * 2021-06-22 2024-11-07 Ohio State Innovation Foundation Bicyclic peptidyl pan-ras inhibitors
TR2022013896A2 (tr) * 2022-09-07 2022-09-21 Bio T Biyoteknoloji Coezuemleri Ve Ueretim Anonim Sirketi Proteaza Dirençli Küçük Peptitler ile Antikor Saflaştıran Reçine ve Kromatografi Kolonu
WO2026002154A1 (en) * 2024-06-27 2026-01-02 Syneron Opal Cell penetrating peptide compounds and using thereof

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JP2023025022A (ja) * 2016-11-09 2023-02-21 オハイオ・ステイト・イノベーション・ファウンデーション ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法
JP7490735B2 (ja) 2016-11-09 2024-05-27 オハイオ・ステイト・イノベーション・ファウンデーション ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法

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US11351222B2 (en) 2022-06-07
US20190282654A1 (en) 2019-09-19
JP7490735B2 (ja) 2024-05-27
CN117866042A (zh) 2024-04-12
EP3538125A4 (en) 2020-10-07
TW201823266A (zh) 2018-07-01
JP2020502051A (ja) 2020-01-23
WO2018089648A2 (en) 2018-05-17
US11878046B2 (en) 2024-01-23
JP2023025022A (ja) 2023-02-21
WO2018089648A3 (en) 2018-06-21
CA3043464A1 (en) 2018-05-17
TWI781963B (zh) 2022-11-01
CN110114075B (zh) 2024-01-12
EP3538125A2 (en) 2019-09-18
US20220160819A1 (en) 2022-05-26
CN110114075A (zh) 2019-08-09

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