JP7129909B2 - 流体試料中の粒子を特徴付けるためのシステム及び方法 - Google Patents
流体試料中の粒子を特徴付けるためのシステム及び方法 Download PDFInfo
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- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N2021/3595—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using FTIR
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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- G01N21/64—Fluorescence; Phosphorescence
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- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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Description
本出願は、2016年7月11日に出願された米国仮特許出願第62/360,832号、及び2016年2月18日に出願された米国仮特許出願第62/296,701号への優先権を主張する。それらの両方は、その全体が参照により本明細書に組み込まれる。
これから、本発明が以下の実施例を参照して説明される。これらの実施例は例示のみを目的として提供され、本発明は、決してこれらの実施例に限定されるものとして解釈されるべきでなく、むしろ本明細書において提供される教示の一つの結果として明らかになる任意の及び全ての変形を包含すると解釈されるべきである。
Claims (25)
- 流体試料からの少なくとも一つの粒子を特徴付けるためのシステムであって、
出口の上流に配置された膜フィルタ、
明視野照明を使用して前記少なくとも一つの粒子を照明するように構成された照明器具、
負圧源に接続されており、前記膜フィルタと流体連通するように構成されている真空マニホールドであり、前記膜フィルタの底面に接触して、前記膜フィルタの孔を介して液体を引き込み、前記膜フィルタを乾燥させるように構成されたウィッキング物質を含む真空マニホールド、及び
前記少なくとも一つの粒子を特徴付けるために、それが前記膜フィルタ上に載っているときに、照明された前記少なくとも一つの粒子の画像を取得及び処理するように構成された画像化装置、
を有する、システム。 - 前記膜フィルタの一つの平面と同一平面上の角度で前記少なくとも一つの粒子を照明するように構成された照明器具、
を更に有する、請求項1に記載のシステム。 - 前記照明器具は、複数の照明装置を有する、請求項1に記載のシステム。
- 前記複数の照明装置は、前記膜フィルタの周りに放射状に配置され、かつ、前記膜フィルタに向かって内側に向けられている、請求項3に記載のシステム。
- 斜めの角度で前記少なくとも一つの粒子を照明するように構成された照明器具、
を更に有する、請求項1に記載のシステム。 - 前記画像化装置は、斜め角度照明及び明視野照明を含む合成画像を生成するように構成されている、請求項5に記載のシステム。
- 前記画像化装置は、斜め角度照明及び明視野照明の組み合わせに基づいて複数の粒子を特徴付けるように構成されている、請求項6に記載のシステム。
- フィルタ上でそれぞれ終端となる複数のウェルをもつウェルプレートを更に有する、請求項1に記載のシステム。
- 前記フィルタは、膜である、請求項8に記載のシステム。
- 前記膜表面は、低い表面粗さをもつ、請求項8に記載のシステム。
- 前記ウェルプレートは、透明物質を有する、請求項8に記載のシステム。
- 前記画像化装置は、機械学習アルゴリズムを使用して、前記少なくとも一つの粒子の物質の種類を特徴付け、同定するように構成されている、請求項1に記載のシステム。
- 前記機械学習アルゴリズムは、モデルを構築するために、粒子の大きさ、形状、テクスチャ、暗視野強度及び内部蛍光のうちの少なくとも一つを含む、観察される特徴を使用する、請求項12に記載のシステム。
- 前記画像化装置は、それが前記膜フィルタ上に載っているときに、蛍光画像化を使用して、前記少なくとも一つの粒子の物質の種類を特徴付け、同定するように構成されている、請求項1に記載のシステム。
- 前記蛍光画像化は、内部のマルチチャネルベースの蛍光を含む、請求項14に記載のシステム。
- 前記蛍光画像化は、標識化されたマルチチャネルベースの蛍光を含む、請求項14に記載のシステム。
- 前記画像化装置は、前記少なくとも一つの粒子が前記膜フィルタ上に捕捉される前及び後の両方に、前記膜フィルタを画像化するように構成されている、請求項1に記載のシステム。
- 前及び後の画像は、差異を発見するためにそれらを処理するアルゴリズムを使用して、共に処理される、請求項17に記載のシステム。
- 前記画像化装置は、前記膜フィルタの上の複数の高さにおける、複数の画像を取得するように構成されている、請求項1に記載のシステム。
- 前及び後の画像は、数学的に位置合わせされる、請求項17に記載のシステム。
- 前記蛍光画像化は、UV蛍光を含む、請求項14に記載のシステム。
- 前記膜フィルタは、画像化された少なくとも一つの粒子の信号対雑音比を高めるための物質を含む膜である、請求項1に記載のシステム。
- 前記物質は、薄い金属層被覆である、請求項22に記載のシステム。
- 前記薄い金属層被覆は、金、クロミウム又はアルミニウムのうちの一つを含む、請求項23に記載のシステム。
- 前記画像化装置は、UV蛍光を介してタンパク質性粒子及び非タンパク質性粒子を識別するように構成されている、請求項1に記載のシステム。
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CA3014099A1 (en) | 2017-08-24 |
WO2017143332A1 (en) | 2017-08-24 |
EP3427024A4 (en) | 2019-11-06 |
US20170242234A1 (en) | 2017-08-24 |
US12007548B2 (en) | 2024-06-11 |
SG11201806862QA (en) | 2018-09-27 |
EP3427024A1 (en) | 2019-01-16 |
US11513333B2 (en) | 2022-11-29 |
JP2019511707A (ja) | 2019-04-25 |
US20230236409A1 (en) | 2023-07-27 |
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