JP7123339B2 - 銅に関連した疾患を処置するための手段及び方法 - Google Patents
銅に関連した疾患を処置するための手段及び方法 Download PDFInfo
- Publication number
- JP7123339B2 JP7123339B2 JP2018531559A JP2018531559A JP7123339B2 JP 7123339 B2 JP7123339 B2 JP 7123339B2 JP 2018531559 A JP2018531559 A JP 2018531559A JP 2018531559 A JP2018531559 A JP 2018531559A JP 7123339 B2 JP7123339 B2 JP 7123339B2
- Authority
- JP
- Japan
- Prior art keywords
- methanobactin
- copper
- treatment
- disease
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/30—Copper compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/315—Zinc compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15201070 | 2015-12-18 | ||
| EP15201070.8 | 2015-12-18 | ||
| LU92979 | 2016-02-19 | ||
| LU92979 | 2016-02-19 | ||
| PCT/EP2016/081407 WO2017103094A2 (en) | 2015-12-18 | 2016-12-16 | Means and methods for treating copper-related diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018538306A JP2018538306A (ja) | 2018-12-27 |
| JP2018538306A5 JP2018538306A5 (enExample) | 2020-01-23 |
| JP7123339B2 true JP7123339B2 (ja) | 2022-08-23 |
Family
ID=57758583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531559A Active JP7123339B2 (ja) | 2015-12-18 | 2016-12-16 | 銅に関連した疾患を処置するための手段及び方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11000568B2 (enExample) |
| EP (2) | EP3389648A2 (enExample) |
| JP (1) | JP7123339B2 (enExample) |
| CN (1) | CN108472281B (enExample) |
| WO (1) | WO2017103094A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108472281B (zh) * | 2015-12-18 | 2023-09-08 | 德国亥姆霍兹慕尼黑中心健康与环境研究中心(有限公司) | 用于治疗铜相关疾病的手段和方法 |
| CN111094547B (zh) * | 2017-06-14 | 2024-02-09 | 德国亥姆霍兹慕尼黑中心健康与环境研究中心(有限公司) | 用于纯化源自人胚胎干细胞的内胚层和胰腺内胚层细胞的方法 |
| CN109576226A (zh) * | 2018-12-24 | 2019-04-05 | 博尔赛(上海)细胞生物技术有限公司 | 一种iPS细胞及其重编程方法和用途 |
| CN109706099A (zh) * | 2019-01-25 | 2019-05-03 | 黑龙江大学 | 同时去除低温地下水中有机磷农药和硝酸盐的假单胞菌及其应用 |
| JPWO2021149824A1 (enExample) * | 2020-01-24 | 2021-07-29 | ||
| JP2022104813A (ja) * | 2020-12-29 | 2022-07-11 | アイ ピース,インコーポレイテッド | リプログラミング因子を導入された細胞の培養方法 |
| US20240131112A1 (en) * | 2021-02-01 | 2024-04-25 | Helmholtz Zentrum Muenchen - Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Use of methanobactin for treatment of iron-related diseases |
| WO2025110984A1 (en) * | 2023-11-21 | 2025-05-30 | Hydrogene Therapeutics, Inc. | Compositions and methods for treating wilson's disease |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056849A2 (en) * | 2002-12-19 | 2004-07-08 | The University Of Kansas | Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria |
| US7932052B1 (en) * | 2006-07-24 | 2011-04-26 | The Regents Of The University Of Michigan | Use of methanobactin |
| CN108472281B (zh) * | 2015-12-18 | 2023-09-08 | 德国亥姆霍兹慕尼黑中心健康与环境研究中心(有限公司) | 用于治疗铜相关疾病的手段和方法 |
-
2016
- 2016-12-16 CN CN201680073746.2A patent/CN108472281B/zh active Active
- 2016-12-16 WO PCT/EP2016/081407 patent/WO2017103094A2/en not_active Ceased
- 2016-12-16 JP JP2018531559A patent/JP7123339B2/ja active Active
- 2016-12-16 EP EP16823220.5A patent/EP3389648A2/en not_active Withdrawn
- 2016-12-16 EP EP25155580.1A patent/EP4574207A3/en active Pending
- 2016-12-16 US US16/063,220 patent/US11000568B2/en active Active
-
2021
- 2021-04-02 US US17/221,675 patent/US20210369809A1/en not_active Abandoned
Non-Patent Citations (2)
| Title |
|---|
| ACS Chem. Biol., (2012), 7, [2], p.260-268 |
| J. Trace Elem. Med. Biol., (2011), 25, [1], p.36-41 |
Also Published As
| Publication number | Publication date |
|---|---|
| US11000568B2 (en) | 2021-05-11 |
| US20210369809A1 (en) | 2021-12-02 |
| EP4574207A3 (en) | 2025-09-10 |
| CN108472281B (zh) | 2023-09-08 |
| EP3389648A2 (en) | 2018-10-24 |
| JP2018538306A (ja) | 2018-12-27 |
| US20190328835A1 (en) | 2019-10-31 |
| WO2017103094A2 (en) | 2017-06-22 |
| EP4574207A2 (en) | 2025-06-25 |
| WO2017103094A3 (en) | 2017-07-27 |
| CA3000792A1 (en) | 2017-06-22 |
| CN108472281A (zh) | 2018-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7123339B2 (ja) | 銅に関連した疾患を処置するための手段及び方法 | |
| Glushchenko et al. | Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease | |
| US11730790B2 (en) | Mutant NGAL proteins and uses thereof | |
| Mori et al. | Protein carbamylation exacerbates vascular calcification | |
| Cho et al. | The antimicrobial peptide arenicin-1 promotes generation of reactive oxygen species and induction of apoptosis | |
| US10829525B2 (en) | Mutant NGAL proteins and uses thereof | |
| WO2015131848A1 (en) | Mtor-independent activator of tfeb for autophagy enhancement and uses thereof | |
| Oppedisano et al. | Inactivation by Hg2+ and methylmercury of the glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: Prediction of the involvement of a CXXC motif by homology modelling | |
| JP6989377B2 (ja) | Kv1.3カリウムチャネルアンタゴニスト | |
| US9770500B2 (en) | S-nitrosylation of glucosylating toxins and uses therefor | |
| TWI592419B (zh) | 製造具有氧化還原活性之低金屬化金屬硫蛋白的方法及含彼之醫藥組合物 | |
| CA3000792C (en) | Means and methods for treating copper-related diseases | |
| US20230165934A1 (en) | Means and methods for treating copper-related diseases | |
| Martelli | Vascular effects of p-carboxyphenyl-isothiocyanate, a novel H2S-donor | |
| Kafková | Physiological interactions and stabilities of inner mitochondrial membrane complexes. | |
| US20240016772A1 (en) | Compositions And Methods Comprising D-Cysteine Or A D-Derivative Thereof | |
| Shafer | From Chlamydomonas reinhardtii to Caenorhabditis elegans: Investigations into the Environmental Regulation of Eukaryotic Cu-Handling Mechanisms | |
| Leitzinger | Mitochondrial copper overload in a rat model for Wilson disease is paralleled by upregulated COX17 and can be restored using the bacterial peptide methanobactin | |
| JP2024509996A (ja) | Trem2に特異的な二環式ペプチドリガンド | |
| Hughes et al. | An Analysis of Glutathionylation in the Modulation of the Critical Innate Immune Regulators Mal and NEK7 | |
| Abdo | The role of low-density lipoprotein modified by myeloperoxidasederived oxidants on vascular dysfunction in atherosclerosis | |
| Jiang et al. | Enhanced Binding Strength of Aggregated Amyloid-β Enables Its Copper Sequestration from Albumin: a Pathway to Accumulation of Copper in Senile Plaques | |
| Brenner | Human amyloidogenic light chains impair cardiomyocyte function through alterations in cellular redox |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191203 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20191203 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20201023 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20201104 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210118 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210608 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210906 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211108 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220405 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220426 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20220705 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220801 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7123339 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |