JP7109429B2 - 狭窄評価用の機能的指標を決定する装置 - Google Patents

狭窄評価用の機能的指標を決定する装置 Download PDF

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JP7109429B2
JP7109429B2 JP2019516643A JP2019516643A JP7109429B2 JP 7109429 B2 JP7109429 B2 JP 7109429B2 JP 2019516643 A JP2019516643 A JP 2019516643A JP 2019516643 A JP2019516643 A JP 2019516643A JP 7109429 B2 JP7109429 B2 JP 7109429B2
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vessel
processing unit
image data
determining
stenosis
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JP2019534740A5 (enExample
JP2019534740A (ja
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クリスチャン ハーゼ
ミカエル グラス
レンズ ブラム アントニウス フィロメナ ファン
ローランド ウィルヘルムス マリア バーレンス
ペーター マリア ヨハネス ロンゲン
デル ホルスト アーエン ファン
ラウル フローレント
ロマーヌ イザベル マリエ‐ベルナルド ガウリアウ
べスコス ハビアー オリヴァン
ホルガー シュミット
ヴィンセント モーリス アンドレ オーヴレイ
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Koninklijke Philips NV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1075—Measuring physical dimensions, e.g. size of the entire body or parts thereof for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1079—Measuring physical dimensions, e.g. size of the entire body or parts thereof using optical or photographic means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/481—Diagnostic techniques involving the use of contrast agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/504—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of blood vessels, e.g. by angiography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5217—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data extracting a diagnostic or physiological parameter from medical diagnostic data
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B15/00—Measuring arrangements characterised by the use of electromagnetic waves or particle radiation, e.g. by the use of microwaves, X-rays, gamma rays or electrons
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/60—Analysis of geometric attributes
    • G06T7/62—Analysis of geometric attributes of area, perimeter, diameter or volume
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1076—Measuring physical dimensions, e.g. size of the entire body or parts thereof for measuring dimensions inside body cavities, e.g. using catheters
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10116—X-ray image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30101—Blood vessel; Artery; Vein; Vascular
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30101—Blood vessel; Artery; Vein; Vascular
    • G06T2207/30104—Vascular flow; Blood flow; Perfusion
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Optics & Photonics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Geometry (AREA)
  • Hematology (AREA)
  • Primary Health Care (AREA)
  • Data Mining & Analysis (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Electromagnetism (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Image Analysis (AREA)
JP2019516643A 2016-09-30 2017-10-02 狭窄評価用の機能的指標を決定する装置 Active JP7109429B2 (ja)

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Application Number Priority Date Filing Date Title
EP16191781.0 2016-09-30
EP16191781 2016-09-30
PCT/EP2017/075021 WO2018060529A1 (en) 2016-09-30 2017-10-02 Apparatus for determining a functional index for stenosis assessment

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JP2019534740A JP2019534740A (ja) 2019-12-05
JP2019534740A5 JP2019534740A5 (enExample) 2020-11-12
JP7109429B2 true JP7109429B2 (ja) 2022-07-29

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US (4) US11179043B2 (enExample)
EP (1) EP3518751B1 (enExample)
JP (1) JP7109429B2 (enExample)
CN (1) CN109843161B (enExample)
WO (1) WO2018060529A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10210956B2 (en) 2012-10-24 2019-02-19 Cathworks Ltd. Diagnostically useful results in real time
WO2017199246A1 (en) 2016-05-16 2017-11-23 Cathworks Ltd. Vascular selection from images
EP3457930B1 (en) 2016-05-16 2023-11-15 Cathworks Ltd. System for vascular assessment
US11083377B2 (en) * 2018-06-15 2021-08-10 Pie Medical Imaging B.V. Method and apparatus for quantitative hemodynamic flow analysis
US12020791B2 (en) 2018-10-26 2024-06-25 Koninklijke Philips N.V. Determination of a treatment response index
EP3686898A1 (en) * 2019-01-24 2020-07-29 Koninklijke Philips N.V. Determination of a treatment response index
EP3948886B1 (en) 2019-04-01 2025-10-29 CathWorks Ltd. Methods and apparatus for angiographic image selection
WO2021059165A1 (en) 2019-09-23 2021-04-01 Cathworks Ltd. Methods, apparatus, and system for synchronization between a three-dimensional vascular model and an imaging device
EP4276751B1 (en) * 2019-11-28 2025-12-31 Siemens Healthineers AG Computer-implemented method for evaluating a ct data set regarding perivascular tissue, evaluation device, computer program and electronically readable storage medium
CN112472112B (zh) * 2020-11-25 2024-02-27 苏州润迈德医疗科技有限公司 调节血管狭窄区间的方法、系统及存储介质
US12315076B1 (en) 2021-09-22 2025-05-27 Cathworks Ltd. Four-dimensional motion analysis of a patient's coronary arteries and myocardial wall
KR20240148399A (ko) 2022-02-10 2024-10-11 캐스웍스 엘티디. 기계 학습 기반 센서 분석 및 혈관 트리 분할을 위한 시스템 및 방법
EP4311493A1 (en) 2022-07-27 2024-01-31 Koninklijke Philips N.V. Spectral x-ray projection data
CN117670782B (zh) * 2022-08-30 2026-07-21 武汉联影智融医疗科技有限公司 血管医学图像处理方法及其装置、医学图像处理设备
KR20260052078A (ko) 2023-08-09 2026-04-17 캐스웍스 엘티디. 혈관 지수 측정을 위한 향상된 사용자 인터페이스 및 크로스토크 분석
IL326432A (en) 2023-08-09 2026-04-01 Cathworks Ltd Post-pci coronary analysis
US12567489B2 (en) 2024-06-12 2026-03-03 Cathworks Ltd. Systems and methods for displaying distal fractional flow reserve values in vascular analysis
CN120078440B (zh) * 2025-03-13 2025-12-23 苏州仲如悦科技有限责任公司 一种基于听诊声学信号的动静脉血管通路狭窄检测系统

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007069000A (ja) 2005-09-06 2007-03-22 Pie Medical Imaging Bv X線濃度測定法を使用する血管の輪郭検出のための方法、装置およびコンピュータプログラム
JP2015509820A (ja) 2012-03-15 2015-04-02 シーメンス アクティエンゲゼルシャフト 安静および充血時における冠血流のパーソナライゼーション用フレームワーク
JP2016511649A (ja) 2013-01-15 2016-04-21 キャスワークス・リミテッドCathWorks Ltd. 血流予備量比の算出
WO2016113646A1 (en) 2015-01-15 2016-07-21 Koninklijke Philips N.V. Ifr-ct
US20160247279A1 (en) 2013-10-24 2016-08-25 Cathworks Ltd. Vascular characteristic determination with correspondence modeling of a vascular tree

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5150292A (en) * 1989-10-27 1992-09-22 Arch Development Corporation Method and system for determination of instantaneous and average blood flow rates from digital angiograms
AU2010298333B2 (en) 2009-09-23 2014-04-17 Lightlab Imaging, Inc. Lumen morphology and vascular resistance measurements data collection systems, apparatus and methods
CN103347461B (zh) 2011-01-28 2016-03-09 皇家飞利浦有限公司 用于医学仪器的尖端和形状特征化的光学形状感测光纤
US9247918B2 (en) 2012-07-09 2016-02-02 Siemens Aktiengesellschaft Computation of hemodynamic quantities from angiographic data
US20140236011A1 (en) * 2012-08-31 2014-08-21 General Electric Company Methods and systems for simultaneous interventional imaging and functional measurements
US9943233B2 (en) * 2012-10-24 2018-04-17 Cathworks Ltd. Automated measurement system and method for coronary artery disease scoring
US10210956B2 (en) * 2012-10-24 2019-02-19 Cathworks Ltd. Diagnostically useful results in real time
US10595807B2 (en) * 2012-10-24 2020-03-24 Cathworks Ltd Calculating a fractional flow reserve
US9814433B2 (en) * 2012-10-24 2017-11-14 Cathworks Ltd. Creating a vascular tree model
BR112015010012A2 (pt) * 2012-11-06 2017-07-11 Koninklijke Philips Nv método; e sistema
CN105792738B (zh) * 2013-12-04 2020-03-13 皇家飞利浦有限公司 用于改善功能狭窄分析的局部ffr估计和可视化
NL2012459B1 (en) 2014-03-18 2016-01-08 Medis Ass B V Method and device for determining deviation in pressure in a blood vessel.
DE102014210591B4 (de) 2014-06-04 2022-09-22 Siemens Healthcare Gmbh Fluiddynamische Analyse eines Gefäßbaums mittels Angiographie
EP3160335B1 (en) * 2014-06-30 2023-09-20 Koninklijke Philips N.V. Apparatus for determining a fractional flow reserve value
EP3062248A1 (en) * 2015-02-27 2016-08-31 Pie Medical Imaging BV Method and apparatus for quantitative flow analysis
JP6818492B2 (ja) * 2015-10-05 2021-01-20 キヤノンメディカルシステムズ株式会社 画像処理装置、画像処理方法、及びプログラム

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007069000A (ja) 2005-09-06 2007-03-22 Pie Medical Imaging Bv X線濃度測定法を使用する血管の輪郭検出のための方法、装置およびコンピュータプログラム
JP2015509820A (ja) 2012-03-15 2015-04-02 シーメンス アクティエンゲゼルシャフト 安静および充血時における冠血流のパーソナライゼーション用フレームワーク
JP2016511649A (ja) 2013-01-15 2016-04-21 キャスワークス・リミテッドCathWorks Ltd. 血流予備量比の算出
US20160247279A1 (en) 2013-10-24 2016-08-25 Cathworks Ltd. Vascular characteristic determination with correspondence modeling of a vascular tree
WO2016113646A1 (en) 2015-01-15 2016-07-21 Koninklijke Philips N.V. Ifr-ct

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US20200029830A1 (en) 2020-01-30
US12042249B2 (en) 2024-07-23
EP3518751B1 (en) 2025-01-29
US20240374148A1 (en) 2024-11-14
US20230355107A1 (en) 2023-11-09
JP2019534740A (ja) 2019-12-05
US20220079455A1 (en) 2022-03-17
CN109843161A (zh) 2019-06-04
US11690518B2 (en) 2023-07-04
CN109843161B (zh) 2022-07-12
WO2018060529A1 (en) 2018-04-05
US11179043B2 (en) 2021-11-23
EP3518751A1 (en) 2019-08-07

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