JP7103751B6 - 修飾された抗原結合ポリペプチド構築物及びその使用 - Google Patents

修飾された抗原結合ポリペプチド構築物及びその使用 Download PDF

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JP7103751B6
JP7103751B6 JP2016569603A JP2016569603A JP7103751B6 JP 7103751 B6 JP7103751 B6 JP 7103751B6 JP 2016569603 A JP2016569603 A JP 2016569603A JP 2016569603 A JP2016569603 A JP 2016569603A JP 7103751 B6 JP7103751 B6 JP 7103751B6
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amino acid
acid substitutions
heterodimer
antigen
construct
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JP2018502550A (ja
JP7103751B2 (ja
JP2018502550A5 (enExample
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マリオ サンチェス
フォン クレウデンステイン トーマス スプレター
ドウニャ ウロセブ
ステイシー エー．エル． トム‐ユー
アダム ルイ コーパー
イゴール エドモンド パオロ ダンジェロ
ヤン‐チエ チョウ
スージット ビームラーオ ディクシット
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ザイムワークス，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2016569603A 2015-04-28 2015-05-29 修飾された抗原結合ポリペプチド構築物及びその使用 Active JP7103751B6 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562154055P 2015-04-28 2015-04-28
US62/154,055 2015-04-28
PCT/IB2015/054107 WO2015181805A1 (en) 2014-05-28 2015-05-29 Modified antigen binding polypeptide constructs and uses thereof

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JP2020137041A Division JP7183221B2 (ja) 2015-04-28 2020-08-14 修飾された抗原結合ポリペプチド構築物及びその使用

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JP2018502550A JP2018502550A (ja) 2018-02-01
JP2018502550A5 JP2018502550A5 (enExample) 2018-07-05
JP7103751B2 JP7103751B2 (ja) 2022-07-20
JP7103751B6 true JP7103751B6 (ja) 2022-08-15

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JP2016569603A Active JP7103751B6 (ja) 2015-04-28 2015-05-29 修飾された抗原結合ポリペプチド構築物及びその使用
JP2020137041A Active JP7183221B2 (ja) 2015-04-28 2020-08-14 修飾された抗原結合ポリペプチド構築物及びその使用
JP2022186638A Pending JP2023027107A (ja) 2015-04-28 2022-11-22 修飾された抗原結合ポリペプチド構築物及びその使用
JP2024104675A Pending JP2024125389A (ja) 2015-04-28 2024-06-28 修飾された抗原結合ポリペプチド構築物及びその使用

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JP2020137041A Active JP7183221B2 (ja) 2015-04-28 2020-08-14 修飾された抗原結合ポリペプチド構築物及びその使用
JP2022186638A Pending JP2023027107A (ja) 2015-04-28 2022-11-22 修飾された抗原結合ポリペプチド構築物及びその使用
JP2024104675A Pending JP2024125389A (ja) 2015-04-28 2024-06-28 修飾された抗原結合ポリペプチド構築物及びその使用

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JP (4) JP7103751B6 (enExample)
KR (2) KR20240093883A (enExample)
CN (1) CN106661121A (enExample)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
US9914785B2 (en) 2012-11-28 2018-03-13 Zymeworks Inc. Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
JP7654539B2 (ja) * 2018-09-07 2025-04-01 ファイザー・インク 抗αｖβ８抗体、組成物及びその使用
MX2021007672A (es) * 2018-12-24 2021-09-30 Sanofi Sa Proteinas de union multiespecificas con dominios fab mutantes.
WO2020219896A1 (en) * 2019-04-26 2020-10-29 Beijing Xuanyi Pharmasciences Co., Ltd. Cd80 variant proteins and uses thereof
CN117440969A (zh) * 2021-01-11 2024-01-23 阿迪马布有限责任公司 被工程化为优先进行ch3异源二聚化的变体ch3结构域、包括所述变体ch3结构域的多特异性抗体和其制备方法
EP4326772A4 (en) * 2021-04-23 2025-03-05 Chimagen Biosciences, Ltd. Heterodimeric antibodies and antigen-binding fragment thereof
EP4437344A1 (en) 2021-11-25 2024-10-02 F. Hoffmann-La Roche AG Quantification of low amounts of antibody sideproducts
CN114106192B (zh) * 2021-12-20 2024-06-14 广州爱思迈生物医药科技有限公司 双特异性抗体及其应用
WO2025167974A1 (zh) * 2024-02-07 2025-08-14 上海齐鲁制药研究中心有限公司 多特异性抗体或抗原结合片段

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014082179A1 (en) 2012-11-28 2014-06-05 Zymeworks Inc. Engineered immunoglobulin heavy chain-light chain pairs and uses thereof

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JP2009541275A (ja) * 2006-06-22 2009-11-26 ノボ・ノルデイスク・エー／エス 二重特異性抗体の生産
MX2011006416A (es) * 2008-12-19 2011-07-12 Macrogenics Inc Diacuerpos covalentes y sus usos.
CA2759233C (en) * 2009-04-27 2019-07-16 Oncomed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
WO2013060867A2 (en) * 2011-10-27 2013-05-02 Genmab A/S Production of heterodimeric proteins
CN104640561A (zh) * 2012-07-23 2015-05-20 酵活有限公司 包含轻链和重链的选择性配对的免疫球蛋白构建体
BR112016027888A2 (pt) 2014-05-28 2017-10-24 Zymeworks Inc construto de polipeptídeo de ligação ao antígeno isolado, polinucleotídeo isolado ou um conjunto de polinucleotídeos isolados, vetor ou conjunto de vetores, célula isolada, composição farmacêutica, uso do construto, método para tratar um sujeito com uma doença ou distúrbio, método para obter um construto, método para preparar um construto, meio de armazenamento legível por computador, método para produzir um construto de polipeptídeo de ligação com antígeno bi-específico e método para preparar um construto de polipeptídeo de ligação com antígeno isolado

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014082179A1 (en) 2012-11-28 2014-06-05 Zymeworks Inc. Engineered immunoglobulin heavy chain-light chain pairs and uses thereof

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Publication number Publication date
JP2020202848A (ja) 2020-12-24
KR20230019503A (ko) 2023-02-08
JP2018502550A (ja) 2018-02-01
KR102669686B1 (ko) 2024-05-29
JP7103751B2 (ja) 2022-07-20
KR20240093883A (ko) 2024-06-24
CN106661121A (zh) 2017-05-10
JP2023027107A (ja) 2023-03-01
JP7183221B2 (ja) 2022-12-05
JP2024125389A (ja) 2024-09-18

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