JP7096807B2 - 骨格、及び医療用移植片 - Google Patents
骨格、及び医療用移植片 Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30011—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30014—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30772—Apertures or holes, e.g. of circular cross section
- A61F2002/30784—Plurality of holes
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30795—Blind bores, e.g. of circular cross-section
- A61F2002/30807—Plurality of blind bores
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
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- A61F2002/30795—Blind bores, e.g. of circular cross-section
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30841—Sharp anchoring protrusions for impaction into the bone, e.g. sharp pins, spikes
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30907—Nets or sleeves applied to surface of prostheses or in cement
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/3092—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having an open-celled or open-pored structure
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
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- Cardiology (AREA)
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Description
Bone and Joint Surgery Am 第563巻(1971)101~114ページ)。
うに整列する、実質的に同一の孔模様を有する。
によっても、本発明の範囲を制限するようには解釈されるべきではない。
層Iにおいて、上面の孔模様は孔模様Aであり、および底面の孔模様は孔模様Bである。
骨格20に3つより多い層を含むことも、実行可能である。任意の付加的な層形成骨格20は、多孔質であっても無くてもよく、およびそれらが多孔質であるならば、(1つまたは複数の)隣接する層の隣接する表面の孔模様と一致する孔模様を有していてもいなくてもよい。例えば、隣接する表面と同一の孔模様を有するが、隣接する表面の孔模様と整列しない、付加的な4つの層を有していてもよい。あるいはまた、付加的な4つの層の孔模様は、(1つまたは複数の)隣接する層の(1つまたは複数の)隣接する表面とは異なる孔模様を有していてもよい。
徴部22である。
ャネルを提供する。
成してもよい。
(項目1)
医療用移植片用の3次元骨格であって、前記骨格は互いに結合される複数の層を備え、および各前記層は上面および底面を有し、前記層のそれぞれは前記上面から前記底面まで延びる複数の孔を有し、各前記層は、前記上面における前記複数の孔の第1の孔模様と、前記底面における異なる第2の孔模様と、を有し、少なくとも3つの隣接する前記層の隣接する前記表面は、前記少なくとも3つの隣接する層の前記複数の孔を相互接続し、および前記少なくとも3つの隣接する前記層にわたって連続的な孔隙を形成するように整列する、実質的に同一の孔模様を有する、骨格。
(項目2)
前記複数の層のそれぞれは、少なくとも1つの遷移点を有し、そこで、前記上面から前記底面の間に延びる前記複数の孔の形状は、前記第1の孔模様から少なくとも1つの前記第2の孔模様まで遷移し、前記少なくとも1つの遷移点は、前記それぞれの層の厚さにわたって約0.05から0.95の間の範囲の位置にある、項目1に記載の骨格。
(項目3)
前記少なくとも1つの遷移点は、2つの遷移点である、項目2に記載の骨格。
(項目4)
前記複数の層のそれぞれの前記厚さは、約0.000254cm(0.0001インチ)から25.4cm(10インチ)の間の範囲にある、項目3に記載の骨格。
(項目5)
前記複数の層の異なる前記孔は、複数の異なる形状を有する、項目2に記載の骨格。
(項目6)
前記骨格の前記複数の層は、隣接する前記層が一緒に入れ子を形成することを可能にする少なくとも1つの連結特徴部を含む、項目1に記載の骨格。
(項目7)
前記連結特徴部は、前記複数の層のうちの隣接する1つのストラットおよび前記複数の層のうちの前記隣接する1つから延びる突起のうちの1つがその中に延びる、前記複数の層のうちの少なくとも1つにおける少なくとも1つの逃げ溝である、項目6に記載の骨格。
(項目8)
医療用移植片であって、
本体と、
前記本体に連結される少なくとも1つの骨格と、を備え、前記少なくとも1つの骨格は、互いに結合される複数の層を含み、各前記層は、上面と、底面と、前記上面から前記底面まで延びる複数の孔と、を有し、各前記層は、前記上面における前記複数の孔の第1の孔模様と、前記底面における異なる第2の孔模様と、を有し、少なくとも3つの隣接する前記層のうちの隣接する前記表面は、前記少なくとも3つの層の前記複数の孔を相互接続し、および前記少なくとも3つの隣接する前記層にわたって続的な孔隙を形成するように整列する、実質的に同一の孔模様を有する、医療用移植片。
(項目9)
前記本体は、硬い材料で形成される、項目8に記載の医療用移植片。
(項目10)
前記硬い材料は、移植可能な高分子材料および硬い金属のうちの1つである、項目9に記載の医療用移植片。
(項目11)
前記移植可能な高分子材料は、ポリエーテルエーテルケトン(PEEK)である、項目10に記載の医療用移植片。
(項目12)
前記少なくとも1つの骨格は、移植可能な金属材料で形成される、項目8に記載の医療用移植片。
(項目13)
移植可能な脊椎装置である、項目8に記載の医療用移植片。
(項目14)
前記少なくとも1つの骨格は、複数の抗後退溝をさらに備える、項目13に記載の医療用移植片。
(項目15)
前記少なくとも1つの骨格は、硬い補剛層をさらに備え、前記少なくとも1つの骨格は、少なくとも1つの第1の骨格および少なくとも1つの第2の骨格を含む少なくとも2つの骨格であり、前記補剛層は、前記少なくとも1つの第1の骨格と前記少なくとも1つの第2の骨格との間に位置付けられ、前記少なくとも1つの第1の骨格を前記少なくとも1つの第2の骨格から密封する、項目14に記載の医療用移植片。
(項目16)
前記補剛層は、生体適合性金属および高分子材料のうちの1つで形成される、項目15に記載の医療用移植片。
(項目17)
前記補剛層は、1対の反対面を有し、前記補剛層の前記反対面のうちの少なくとも1つは、前記補剛層の厚さ全体にわたって延びない、複数の表面孔を含む、項目16に記載の医療用移植片。
(項目18)
前記補剛層の前記反対面は、第1の表面および第2の表面を含み、前記補剛層の前記第1の表面および前記第2の表面のそれぞれは、複数の表面孔を含み、前記補剛層は、前記補剛層の前記第1の表面から前記補剛層の前記第2の表面まで通る流れを防止するように、前記反対面の前記表面孔の間に硬い領域を含む、項目17に記載の医療用移植片。
(項目19)
前記補剛層を所定の位置に保持するための少なくとも1つの整列ピンをさらに含む、項目18に記載の医療用移植片。
(項目20)
前記複数の層は、少なくとも4つの層であり、および前記少なくとも4つの層のうちの1つの層は、前記1つの層の複数の硬い領域が、前記複数の層のうちの隣接する1つの前記複数の孔に当接して、前記1つの層と前記少なくとも4つの層のうちの隣接する層との間を通る流れを防止するように構成される、項目8に記載の医療用移植片。
(項目21)
医療用移植片用の骨格を製造する方法であって、前記方法は、
上面および底面を有する生体適合性材料の複数の層を提供するステップと、
生体適合性材料の前記複数の層に、前記層のそれぞれが前記上面から前記底面まで延びる複数の孔を有し、前記層のそれぞれの前記上面における前記複数の孔の第1の孔模様は前記層のそれぞれの前記底面の第2の孔模様と異なっているように、複数の孔を作り出すステップと、
少なくとも3つの隣接する前記層の隣接する前記表面が、前記少なくとも3つの層の前記複数の孔を相互接続し、前記少なくとも3つの隣接する前記層にわたって連続的な孔隙を形成するように整列する実質的に同一の孔模様を有するように、前記複数の層を一緒に結合するステップと、を含む、方法。
Claims (17)
- 医療用移植片用の3次元骨格において、
それぞれ上面から底面まで延びる複数の孔を有する複数の層であって、互いに結合されるとともに結合された前記層にわたって連続的な孔隙を形成する、複数の層と、
追加された強度および剛性を提供するために前記複数の層に連結された補剛層とを備え、
前記補剛層は、第1の表面および第2の表面である1対の反対面であって、前記補剛層の厚さ全体にわたっては延びない複数の表面孔をそれぞれ含む、反対面を有し、前記補剛層は、前記第1の表面から前記第2の表面まで通る流れを防止するように、前記反対面どうしの前記表面孔の間に硬い領域を含み、
前記補剛層は、結合された前記層の2つの領域の間に配置された、骨格。 - 前記補剛層は、硬い非多孔質層を備えた、請求項1に記載の骨格。
- 前記補剛層は、チタン、タンタル、ポリエーテルエーテルケトン(PEEK)、および/または、ポリエーテルケトンケトン(PEKK)を備えた、請求項2に記載の骨格。
- 前記複数の層は、多孔質の骨の内部成長領域および多孔質重合体保持領域を形成する、請求項1に記載の骨格。
- 前記補剛層は、前記多孔質の骨の内部成長領域と前記多孔質重合体保持領域とを分離する、請求項4に記載の骨格。
- 前記補剛層は、前記多孔質の骨の内部成長領域と前記多孔質重合体保持領域との間に流体障壁を提供する、請求項5に記載の骨格。
- 前記補剛層は、前記層の外表面上に位置付けられた、請求項1に記載の骨格。
- 医療用移植片において、
本体と、
前記本体に連結される少なくとも1つの骨格であって、それぞれ上面から底面まで延びる複数の孔を有して互いに結合されるとともに前記層にわたって連続的な孔隙を形成する複数の層を備えた、少なくとも1つの骨格と、
前記少なくとも1つの骨格に追加された強度および剛性を提供するために前記少なくとも1つの骨格に連結された補剛層とを備え、
前記補剛層は、第1の表面および第2の表面である1対の反対面であって、前記補剛層の厚さ全体にわたっては延びない複数の表面孔をそれぞれ含む、反対面を有し、前記補剛層は、前記第1の表面から前記第2の表面まで通る流れを防止するように、前記反対面どうしの前記表面孔の間に硬い領域を含み、
前記補剛層は、結合された前記層の2つの領域の間に配置された、医療用移植片。 - 前記補剛層は、硬い非多孔質層を備えた、請求項8に記載の医療用移植片。
- 前記補剛層は、チタン、タンタル、ポリエーテルエーテルケトン(PEEK)、および/または、ポリエーテルケトンケトン(PEKK)を備えた、請求項9に記載の医療用移植片。
- 前記複数の層は、多孔質の骨の内部成長領域および多孔質重合体保持領域を形成する、請求項8に記載の医療用移植片。
- 前記補剛層は、前記多孔質の骨の内部成長領域と前記多孔質重合体保持領域とを分離する、請求項11に記載の医療用移植片。
- 前記補剛層は、前記多孔質の骨の内部成長領域と前記多孔質重合体保持領域との間に流体障壁を提供する、請求項12に記載の医療用移植片。
- 前記補剛層は、前記層の外表面上に位置付けられた、請求項8に記載の医療用移植片。
- 前記少なくとも1つの骨格は、少なくとも1つの第1の骨格および少なくとも1つの第2の骨格を含む少なくとも2つの骨格であり、前記補剛層は、前記少なくとも1つの第1の骨格と前記少なくとも1つの第2の骨格との間に位置付けられた、請求項8に記載の医療用移植片。
- 前記補剛層は、前記少なくとも1つの第1の骨格を前記少なくとも1つの第2の骨格から密封する、請求項8に記載の医療用移植片。
- 前記補剛層を所定の位置に保持するための少なくとも1つの整列ピンをさらに備えた、請求項8に記載の医療用移植片。
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CA2896842C (en) | 2022-03-22 |
US9724203B2 (en) | 2017-08-08 |
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